Review
Medicine, Research & Experimental
Yushi Wu, Haiqiong Liu, Xianbao Wang
Summary: Acute myocardial infarction requires timely reperfusion to reduce myocardial damage, but reperfusion may lead to myocardial ischemia/reperfusion injury. Pharmacological postconditioning is an effective and flexible strategy to reduce myocardial injury by administering medication before or during early reperfusion.
Review
Biochemistry & Molecular Biology
Loic Benoit, Audrey Dieu, Maxime Foguenne, Eliano Bonaccorsi-Riani
Summary: Ischemia-reperfusion injury (IRI) is an inflammatory process in organ transplantation. Sevoflurane has shown potential benefits in reducing hepatic IRI (HIRI). Experimental studies support its protective effects, but clinical studies have conflicting results. Further clinical trials are needed to determine the clinical relevance of sevoflurane as a protective factor against HIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Chao Wen, Fu-Shan Xue, Yu-Hui Wang, Jin-Hua Jin, Xu Liao
Summary: The present study found that hypercholesterolemia can exacerbate myocardial ischemia/reperfusion injury, attenuate cardioprotection of ischemic preconditioning and eliminate cardioprotection from alpha 7nAChR agonist postconditioning by enhancing inflammation and inhibiting the PI3K/Akt/eNOS pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Maria Tsoumani, Anastasios Georgoulis, Panagiota-Efstathia Nikolaou, Ioannis V. Kostopoulos, Theano Dermintzoglou, Ioanna Papatheodorou, Anastasia Zoga, Panagiotis Efentakis, Maria Konstantinou, Evangelos Gikas, Nikolaos Kostomitsopoulos, Andreas Papapetropoulos, Antigone Lazou, Alexios- Leandros Skaltsounis, Derek J. Hausenloy, Ourania Tsitsilonis, Ioulia Tseti, Fabio Di Lisa, Efstathios K. Iliodromitis, Ioanna Andreadou
Summary: Oleuropein demonstrates cardioprotective effects against ischemia reperfusion injury by reducing infarct size, possibly through activating antioxidant defense genes via the Nrf-2 axis. Additionally, oleuropein enhances the cardioprotective manifestation of ischemic postconditioning, showing a synergistic effect in experimental models of IRI.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Magda C. Diaz-Vesga, Ursula Zuniga-Cuevas, Andres Ramirez-Reyes, Nicolas Herrera-Zelada, Ivan Palomo, Roberto Bravo-Sagua, Jaime A. Riquelme
Summary: Despite advances in treating myocardial infarction, limiting infarct size after reperfusion to prevent heart failure remains a challenge, with factors such as comorbidities and experimental models needing to be considered for effective cardioprotection studies. Studies show that current therapeutic strategies may not fully protect the aging heart from myocardial infarction, prompting the need for potential new cardioprotective strategies targeting the aging heart.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Takashi Koyama
Summary: Ischemic myocardium requires reperfusion for survival, but reperfusion can paradoxically lead to myocyte death, known as lethal reperfusion injury. Current clinical approaches for ST-segment elevation myocardial infarction (STEMI) have not been effective. Recently, a novel approach called postconditioning with lactate-enriched blood (PCLeB) has shown positive outcomes in STEMI patients by reducing lethal reperfusion injury. This article provides a different perspective on preventing lethal reperfusion injury and highlights PCLeB as a new approach for cardioprotection.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Annika Raupach, Katharina Feige, Christian Reiter, Timo Brandenburger, Nicole Heinen, Andre Heinen, Markus W. Hollmann, Ragnar Huhn, Carolin Torregroza
Summary: The study found that RIPC did not induce the phosphorylation of AKT or STAT5 in a rat model, nor did it modulate the activation of AKT and STAT5 following I/R, suggesting that RIPC-induced cardioprotection may not be mediated by the activation of AKT or STAT5 at the investigated time points.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Nur Izzah Ismail, Nathaly Anto Michel, Khairunnisa Katwadi, Mim-Mim Lim, To-Kiu Chan, Attaur Rahman, Dachun Xu, Sang-Ging Ong, Derek J. Hausenloy, Sang-Bing Ong
Summary: This study found that ischemic preconditioning (IPC) and ischemic postconditioning (IPost) protect the heart from reperfusion injury by modulating mitochondrial morphology. IPC increased the expression of fusion protein Mfn1, while IPost reduced the expression of fission protein Drp1. These changes maintained the interconnected mitochondrial network and provided cardioprotection.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Wei Xiong, Rui Zhou, Yan Qu, Yuqiao Yang, Zhuoran Wang, Ning Song, Rongbi Liang, Jinqiao Qian
Summary: The study demonstrated that dexmedetomidine preconditioning can alleviate degranulation of mast cells and apoptosis of cardiomyocytes caused by I/R injury, and inhibit the activation of inflammatory related factors HMGB1, TLR4, and NF-KB p65.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
L. Gadzieva, Jovana Bradic, Isidora Milosavljevic, Vladimir Zivkovic, Ivan Srejovic, Vladimir Jakovljevic, Stefani Bolevich, Sergey Bolevich, Nevena Jeremic, Israpil Alisultanovich-Omarov, Jovana Jeremic
Summary: The aim of this study was to investigate and compare the effects of preconditioning, perconditioning, and postconditioning with PCr on ex vivo I-R injury in rat hearts. The results showed that PCr protected cardiac contractility and prevented oxidative damage in all treatment modalities. The most beneficial effects were observed when PCr was applied during the period of ischemia.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Paramjit S. Tappia, Anureet K. Shah, Bram Ramjiawan, Naranjan S. Dhalla
Summary: Ischemia/reperfusion injury can compromise cardiac function recovery, but ischemic preconditioning (IP) can reduce oxidative stress and intracellular Ca2+ overload, improving cardiac function and providing cardioprotective effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Zhongyang Xu, Xiaoqi Wang, Lijiao Zang, Lei Wang, Guohai Su, Keqing Hu
Summary: This study demonstrates the significant protective effects of combined therapy with irisin and melatonin on cardiac I/R injury in aged rats. The protective effects are mediated in part by the activation of mitoKATP channels and the eNOS/NO signaling pathway.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Bingda Li, Tianpeng Chen, Wenfeng Hu, Zhenhua Wang, Ji Wu, Qing Zhou, Ping Li
Summary: Poncirin alleviates cardiac ischemia-reperfusion injury by mitigating oxidative stress, which is dependent on activation of the PI3K/AKT/PGC-1 alpha signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Eliana P. Bin, Tamara Zaobornyj, Mariana Garces, Veronica D'Annunzio, Bruno Buchholz, Timoteo Marchini, Pablo Evelson, Ricardo J. Gelpi, Martin Donato
Summary: The rupture of the plasma membrane is the key point in cell death, which can be prevented by remote ischemic preconditioning through inhibiting MMP-2 activity. Besides, remote ischemic preconditioning also improves mitochondrial function, increasing membrane potential, ATP production and respiratory control.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Katharina Feige, Sebastian Roth, Rene M'Pembele, Anna Galow, Sarah Koenig, Martin Stroethoff, Annika Raupach, Giovanna Lurati Buse, Alexander M. Mathes, Markus W. Hollmann, Ragnar Huhn, Carolin Torregroza
Summary: The adverse impact of common diseases like diabetes mellitus and acute hyperglycemia on morbidity and mortality from myocardial infarction (MI) has been well documented. The relationship between blood glucose and mortality appears linear, and this seems to be independent of a diagnosis of diabetes. This study investigates the influence of acute and prolonged hyperglycemia on the protective effect of transferred human RIPC-plasma and suggests that hyperglycemia might obstruct translation into the clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)