Review
Otorhinolaryngology
Jose Luis Trevino Gonzalez, Laura Lisset Reyes Suarez, Jesus Eduardo Hernandez de Leon
Summary: Malignant otitis externa is an infection affecting the external auditory canal and skull base, most commonly caused by Pseudomonas aeruginosa in diabetic, elderly, and immunocompromised individuals. Clinical manifestations include persistent ear pain, chronic otorrhea, and facial nerve palsy. Diagnosis involves CT scan and Technetium-99m, while treatment requires individualized approach and strict diabetes control, with surgical management recommended for refractory cases.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)
Article
Otorhinolaryngology
Adi Brenner, Oren Cavel, Genady Shendler, Michal Dekel, Ophir Handzel, Rani Abu Eta, Yahav Oron, Nidal Muhanna, Omer J. Ungar
Summary: This study aimed to identify the earliest sites and spread patterns of bony erosions in skull base osteomyelitis and correlate the radiological findings with clinical/laboratory data. The study found that edema and irregularity or dehiscence of the anterior external auditory canal wall were the most common early CT findings associated with skull base osteomyelitis caused by malignant otitis externa.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Miguel Vaca, Maria M. Medina, Adela I. Cordero, Ruben Polo, Cecilia Perez, Sandra Dominguez, Gonzalo de los Santos
Summary: The study aims to determine the accuracy of parameters available at the Emergency Department for diagnosing necrotizing external otitis. Erythrocyte sedimentation rate and C-reactive protein levels are significantly associated with this condition. Elevated levels of these parameters indicate a higher probability of suffering from necrotizing external otitis.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Review
Otorhinolaryngology
Tengku Mohamed Izam Tengku Kamalden, Khairunnisak Misron
Summary: This study evaluates the clinical trends and radiological stratification of malignant otitis externa (MOE) using HRCT and TPBS. Most patients were found to be in Phase III (36.7%), followed by Phase V (24.5%), Phase II (18.4%), Phase IV (16.3%), and Phase I (4.1%). A treatment algorithm was developed based on the institution's experience, with a low mortality rate mainly in advanced phases of the disease (Phases IV and V).
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Review
Endocrinology & Metabolism
Christos Tsilivigkos, Konstantinos Avramidis, Eleftherios Ferekidis, John Doupis
Summary: Malignant external otitis is a special type of external otitis associated with extensive inflammation and osteomyelitis. It originates from the external auditory meatus and progresses to the soft tissues and bone, eventually involving the skull base. Pseudomonas aeruginosa and diabetes mellitus are commonly involved in its pathogenesis.
Article
Otorhinolaryngology
Alireza Zonnour, Reza Shahnazar, Abolfazl Jamshidi, Sasan Dabiri, Elham Saedi, Hamed Emami, Nasrin Yazdani
Summary: This retrospective study found that about 30% of patients with malignant otitis externa experienced cranial nerve palsy. Male gender and advanced age were associated with a higher incidence of cranial nerve palsy. Tinnitus could be a specific indicator of skull base osteomyelitis.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2023)
Editorial Material
Geriatrics & Gerontology
Rajesh Dwivedi, Melroy Rasquinha, Rowan Harwood
Summary: An 88-year-old man presented with delirium, followed by hoarseness and oropharyngeal dysphagia due to skull-based osteomyelitis from necrotizing otitis externa (NOE). Despite the absence of typical symptoms, high suspicion for NOE and its complications is necessary in patients presenting with otolaryngeal symptoms.
Article
Otorhinolaryngology
Alireza Zonnour, Abolfazl Jamshidi, Sasan Dabiri, Mehrdad Hasibi, Ardavan Tajdini, Narges Karrabi, Nasrin Yazdani
Summary: The study aimed to evaluate the prevalence and impact of various predictive factors, including diabetes control, in the treatment response of malignant external otitis (MEO). A cross-sectional study on MEO patients was conducted to evaluate the effects of diabetes control and other predictive factors on treatment response. The results showed that CRP level could be used as a predictor for the hospitalization period, the need for systemic antifungal drugs, and the decrease in erythrocyte sedimentation rate (ESR).
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Wilhelmina L. van der Meer, Jerome J. Waterval, Henricus P. M. Kunst, Cristina Mitea, Sjoert A. H. Pegge, Alida A. Postma
Summary: This study compared NEO extension patterns on MR and CT and found that while all cases showed an anterior extension pattern on both imaging modalities, medial and intracranial spreading patterns seen on MR could only be identified on CT in a small number of patients. The posterior spreading pattern could be overlooked on MR, highlighting the complementary roles of CT and MR in accurately delineating disease extent in NEO.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Alice B. Auinger, Valerie Dahm, Isabella Stanisz, Ursula Schwarz-Nemec, Christoph Arnoldner
Summary: The management of skull base osteomyelitis requires a combination of different imaging modalities for diagnosis and follow-up. MRI is preferable for follow-up as changes can be detected more readily, while nuclear medicine imaging is most effective in assessing disease activity.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Medicine, General & Internal
Gennifer Wahbah Makhoul, Olivia Mobarakai, Umesh Manchandani, Neville Mobarakai
Summary: Skull base osteomyelitis is an aggressive infection that typically occurs in elderly patients with compromised immunity. This case report highlights an unusual presentation of S. pneumoniae-related skull base osteomyelitis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Otorhinolaryngology
Junko Takata, Michael Hopkins, Victoria Alexander, Oliver Bannister, Lucy Dalton, Laura Harrison, Emily Groves, Hala Kanona, Gwennan Llwyd Jones, Hassan Mohammed, Monique I. Andersson, Susanne H. Hodgson
Summary: This systematic review and critical analysis of clinical studies on necrotising otitis externa (NOE) aimed to inform best practice for diagnosis and management. The review included 70 articles and revealed low methodological quality and wide variations in case definitions. A consensus case definition and robust, high-quality data are urgently needed to support best practices for the diagnosis and management of NOE.
CLINICAL OTOLARYNGOLOGY
(2023)
Review
Medicine, General & Internal
Yasutoshi Koshiba, Ryoukichi Ikeda, Jun Suzuki, Yohei Honkura, Yukino Funayama, Kensuke Ikeda, Hitoshi Warita, Masashi Aoki, Tetsuaki Kawase, Yukio Katori
Summary: Chronic renal failure and diabetes mellitus are potential risk factors for pseudoaneurysm of the internal carotid artery caused by malignant otitis externa. Despite being rare, pseudoaneurysm of ICA should always be considered in the treatment of MOE patients.
CLINICAL CASE REPORTS
(2022)
Article
Otorhinolaryngology
Chilaf Peled, Re'em Sadeh, Sabri El-Saied, Victor Novack, Daniel M. Kaplan
Summary: This study found that HbA1c at admission is associated with the duration of hospitalization among NOE patients, while mean blood glucose during hospitalization is associated with an increased likelihood of Pseudomonas Aeruginosa infection, but has no effect on disease outcome.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Mohamed Amine Chaabouni, Imen Achour, Ghada Yousfi, Wadii Thabet, Majdi Trigui, Souha Kallel, Ilhem Charfeddine
Summary: The study describes the clinical features and therapeutic management of necrotizing otitis externa (NOE) with negative culture. A total of 25 cases of NOE were included, with 13 cases (52%) having negative culture results. All patients received local treatment prior to hospitalization, and 8 patients (61.5%) received oral antibiotic. Otorrhea sampling was done for all patients, with fungal serology performed for 6 patients, 2 of which were positive. The first-line treatment was ciprofloxacin with ceftazidime for 10 patients, while alternative regimens were used for 2 patients and 1 patient received ciprofloxacin alone. Improvement was noted in 10 cases (77%), with second-line treatment required for 3 cases and antifungal treatment for 2 patients with positive aspergillus serology. Recurrence was observed in 3 cases.
EGYPTIAN JOURNAL OF OTOLARYNGOLOGY
(2023)
Article
Otorhinolaryngology
C. Vandersteen, L. Castillo, C. Roger, C. Savoldelli, N. Guevara
Summary: In this study, TMM was used to evaluate obstructive eustachian tube dysfunction in patients with chronic rhinosinusitis. The results showed a significant percentage of patients with pathologic tubomanometric results, highlighting the potential of TMM as an additional tool in the clinical assessment of chronic rhinosinusitis patients.
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2021)
Article
Otorhinolaryngology
R. Quatre, C. Fabre, K. Aubry, P. Bordure, A. Bozorg-Grayeli, O. Deguine, C. Eyermann, V. Franco-Vidal, B. Godey, N. Guevara, A. Karkas, N. Klopp, M. Labrousse, J-P Lebreton, Y. Lerosey, E. Lescanne, N. Loundon, R. Marianowski, F. Merklen, K. Mezouaghi, T. Mom, S. Moreau, I Mosnier, N. Noel-Petroff, C. Parietti-Winkler, P. Piller, C. Poncet, E. Radafy, S. Roman, S. Roux-Vaillard, L. Tavernier, E. Truy, C. Vincent, S. Schmerber
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2020)
Article
Audiology & Speech-Language Pathology
Adrien Bolzer, Michel Hoen, Bettina Montaut-Verient, Charles Hoffmann, Marine Ardoint, Ariane Laplante-Levesque, Nicholas Guevara, Thierry Mom, Chadlia Karoui, Christophe Vincent, Cecile Parietti-Winkler
Summary: The Telislife questionnaire showed excellent reliability among cochlear implant users, with significant correlations found between Telislife scores, Nijmegen Cochlear Implant Questionnaire scores, and speech recognition scores. It appears to be a reliable tool for evaluating cochlear implant outcomes in clinical practice due to its short form and correlations with important measures.
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
(2021)
Article
Clinical Neurology
A. Gavotto, V Feuillade, S. Bresch, N. Guevara, L. Mondot, F. Almairac
Summary: In most cases, vestibular schwannomas with papilledema are associated with hydrocephalus and intracranial hypertension. However, this atypical case presented with bilateral papilledema without hydrocephalus and with normal intracranial pressure. The patient's ophthalmic signs resolved completely after tumor removal, raising questions about the mechanisms involved in visual impairment related to vestibular schwannoma.
Article
Otorhinolaryngology
G. D'Andrea, R. Giacchero, C. Roger, C. Vandersteen, N. Guevara
Summary: The study aimed to evaluate the therapeutic efficacy and acceptability of Eye Movement Desensitization and Reprocessing (EMDR) in tinnitus treatment. Results showed that after treatment, there was a significant reduction in tinnitus severity for the majority of patients, and the treatment acceptability was high. This suggests that EMDR may be an effective and acceptable alternative treatment.
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2022)
Article
Engineering, Biomedical
Zihao Wang, Clair Vandersteen, Thomas Demarcy, Dan Gnansia, Charles Raffaelli, Nicolas Guevara, Herve Delingette
Summary: A 3D metal artifact reduction algorithm based on generative adversarial neural network is proposed for high-resolution CT imaging of tiny implants. The method outperforms other general metal artifact reduction approaches in clinical experiments.
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2021)
Article
Neurosciences
Julie Fiorentino, Magali Payne, Elisa Cancian, Alexandra Plonka, Louise-emilie Dumas, David Chirio, Elisa Demonchy, Karine Risso, Florence Askenazy-Gittard, Nicolas Guevara, Laurent Castillo, Philippe Robert, Valeria Manera, Clair Vandersteen, Auriane Gros
Summary: Semantic memory impairment can occur in patients with post COVID-19 olfactory disorders, especially in younger age groups. Olfactory threshold is only significantly correlated with semantic memory scores.
Article
Medicine, General & Internal
Clair Vandersteen, Magali Payne, Louise-Emilie Dumas, Elisa Cancian, Alexandra Plonka, Gregoire D'Andrea, David Chirio, Elisa Demonchy, Karine Risso, Florence Askenazy-Gittard, Charles Savoldelli, Nicolas Guevara, Philippe Robert, Laurent Castillo, Valeria Manera, Auriane Gros
Summary: This study evaluated the efficacy of olfactory training (OT) on persistent post-viral olfactory disorders (PPVOD) after COVID-19 infection. The results showed that OT led to improvements in olfactory function and quality of life in patients with PPVOD. However, further research is needed to confirm the role of OT and explore new therapeutic strategies for the central aspects of PPVOD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jan Margeta, Raabid Hussain, Paula Lopez Diez, Anika Morgenstern, Thomas Demarcy, Zihao Wang, Dan Gnansia, Octavio Martinez Manzanera, Clair Vandersteen, Herve Delingette, Andreas Buechner, Thomas Lenarz, Francois Patou, Nicolas Guevara
Summary: This study presents Nautilus, a web-based platform for automated cochlear analysis. It combines deep learning and Bayesian inference methods to delineate cochlear structures from clinical CT images and extract electrode locations from post-operative images. By fusing pre- and post-operative images, Nautilus can provide personalized metrics for research in cochlear implantation therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Raabid Hussain, Attila Frater, Roger Calixto, Chadlia Karoui, Jan Margeta, Zihao Wang, Michel Hoen, Herve Delingette, Francois Patou, Charles Raffaelli, Clair Vandersteen, Nicolas Guevara
Summary: Understanding cochlear anatomy is essential for developing less invasive cochlear implantation techniques. This study analyzed over 1000 clinical temporal bone CT images to determine population statistics and correlations between cochlear dimensions and morphology. The findings indicate that cochlear morphology follows a normal distribution and that certain dimensions are more correlated with duct lengths, wrapping factor, and volume. The results also highlight the variability in scala tympani size and suggest differences in size and shape between ears of the same individual. Overall, this research provides important insights for implant development and reducing trauma during insertion.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Nicolas Guevara, Eric Truy, Michel Hoen, Ruben Hermann, Clair Vandersteen, Stephane Gallego
Summary: This study investigates the use of electrically evoked Auditory Brainstem Responses (eABRs) for measuring local channel interactions on cochlear implant (CI) electrode arrays. eABRs were recorded from 16 experienced CI patients using different stimulation configurations. Results show that increasing the stimulation level on the middle electrode leads to reduced eABR latency and amplitude, indicating local electrical interactions. Compound eABRs provide individual quantification of these interactions, which can inform audiological decisions regarding CI system mapping.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Otorhinolaryngology
A. Alshukry, G. D'Andrea, C. Vandersteen, N. Guevara
Summary: This article presents a technical note on the transcanal endoscopic approach to resection of a cholesteatoma limited to the posterior mesotympanum, providing a suitable and minimal-invasive alternative to the classic microscopic transmastoid approach.
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2023)
Article
Medicine, General & Internal
Manon Baranger, Valeria Manera, Chloe Serignac, Alexandre Derreumaux, Elisa Cancian, Clair Vandersteen, Auriane Gros, Nicolas Guevara
Summary: Hearing loss is correlated with cognitive performance. Our study evaluated lexical access abilities in adults with severe to profound hearing loss and after cochlear implantation. Results showed an improvement in phonemic fluency after implantation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Gregoire D'Andrea, Lun Jing, Isabelle Peyrottes, Jean-Marie Guigonis, Fanny Graslin, Sabine Lindenthal, Julie Sanglier, Isabel Gimenez, Juliette Haudebourg, Clair Vandersteen, Alexandre Bozec, Nicolas Guevara, Thierry Pourcher
Summary: In this study, the researchers evaluated the metabolomic profiles of liquid-based fine-needle aspiration cytology (FNAC) samples to identify a potential molecular diagnostic method for differentiating between malignant and benign thyroid nodules. The study found a promising metabolomic signature that can accurately differentiate papillary thyroid carcinomas (PTCs) from benign thyroid nodules. Further research with larger cohorts is needed to identify more biomarkers and establish more reliable diagnostic signatures.
Review
Medicine, Research & Experimental
Gregoire D'Andrea, Sandra Lassalle, Nicolas Guevara, Baharia Mograbi, Paul Hofman
Summary: The PD-1/PD-L1 immune checkpoint proteins are promising targets for precision oncology, but their use in ICIs treatment often leads to immune-related adverse events, including autoimmune damage. The thyroid, a common endocrine gland affected by both autoimmunity and cancer, serves as a model for studying the role of the PD-1/PD-L1 axis in thyroid diseases within the context of personalized medicine.
