Review
Audiology & Speech-Language Pathology
Benedicte Vos, Dorie Noll, JoAnne Whittingham, Marie Pigeon, Marlene Bagatto, Elizabeth M. Fitzpatrick
Summary: This study synthesized the evidence on the association between congenital cytomegalovirus (CMV) infection and permanent childhood hearing loss. Results showed that congenital CMV infection is an important risk factor for hearing loss in children and should be considered in screening and follow-up programs.
Review
Medicine, Research & Experimental
Elise De Cuyper, Frederic Acke, Annelies Keymeulen, Ingeborg Dhooge
Summary: This systematic review found evidence supporting the treatment of symptomatic children with congenital cytomegalovirus (cCMV) and hearing loss with (val)ganciclovir. However, there is still insufficient evidence for the potential beneficial role of (val)ganciclovir in children with isolated hearing loss, late-onset hearing loss, and asymptomatic cCMV. Future prospective, randomized clinical trials are urgently needed to provide more conclusive evidence.
Review
Neurosciences
Francis A. M. Manno, Raul Rodriguez-Cruces, Rachit Kumar, J. Tilak Ratnanather, Condon Lau
Summary: Hearing loss, a heterogeneous disorder, is found to impact grey and white matter in nearly every brain region according to MRI studies. Congenital loss decreases grey matter in frontal lobe most, while acquired loss shows significant decreases in both frontal and insula grey matter. Different impacts on hemispheres are observed between congenital and acquired hearing loss.
Review
Otorhinolaryngology
A. Ronner Evette, Cheryl K. Glovsky, Barbara S. Herrmann, Melissa A. Woythaler, Mark S. Pasternack, Michael S. Cohen
Summary: Targeted screening is an effective method to identify CMV+ infants early in life, resulting in significantly higher rates of CMV testing and earlier referral to infectious disease in children who do not pass the NHS screening.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Review
Medicine, General & Internal
Christine Yoshinaga-Itano, Vinaya Manchaiah, Cynthia Hunnicutt
Summary: This systematic review found that universal newborn hearing screening (UNHS) can lead to better outcomes for children with permanent congenital hearing loss, including earlier identification and initiation of intervention services, as well as improved language and literacy development. UNHS was cost-effective in terms of societal savings, and no adverse effects on parents were noted.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Immacolata Tartaglione, Roberta Carfora, Davide Brotto, Maria Rosaria Barillari, Giuseppe Costa, Silverio Perrotta, Renzo Manara
Summary: This review examines the prevalence, features, course, and potential pathogenic factors of hearing impairment in patients with beta-thalassemia, highlighting the limited knowledge in this area and the need for large prospective studies with consistent diagnostic tools and criteria.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Daniel Suarez, Andrew Kjar, Boston Scott, Katrina Hillam, Elizabeth Vargis, Christopher Nielson, Elizabeth Sommer, Emily Zhang, Anna Holley, Abigail Traxler, Maura Hughes, Yong Wang, Matthew A. Firpo, David Britt, Albert H. Park
Summary: Combination therapy with ganciclovir (GCV) and a Quercetin-P188 solution effectively improves hearing outcomes in a murine cytomegalovirus (CMV) model. The treatment group receiving GCV+QP188 demonstrated significantly lower auditory thresholds compared to monotherapy groups at 4, 6, and 8 weeks of age.
Review
Medicine, General & Internal
Susana Marcos-Alonso, Cristina Nicole Almeida-Ayerve, Chiara Monopoli-Roca, Guillermo Salib Coronel-Touma, Sofia Pacheco-Lopez, Paula Pena-Navarro, Jose Manuel Serradilla-Lopez, Hortensia Sanchez-Gomez, Jose Luis Pardal-Refoyo, Angel Batuecas-Caletrio
Summary: This study analyzed 21 studies that met the inclusion criteria and found that the most common reasons for positive adherence to hearing aid use included higher degree of hearing loss, patient awareness of their condition, and daily life necessity. The most common causes for rejection were lack of perceived benefits or discomfort with the device. The meta-analysis results showed a prevalence of 0.623 (95% CI 0.531, 0.714) for patients who used their hearing aids. Both groups were highly heterogeneous (I2 = 99.31% in each group, p < 0.05). In conclusion, a significant proportion (38%) of patients do not use their hearing aids, and further homogeneous multicenter studies are needed to analyze the reasons for rejection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Dipesh Kumar Yadav, Vishnu Prasad Adhikari, Rajesh Kumar Yadav, Alina Singh, Xing Huang, Qi Zhang, Prabesh Pandit, Qi Ling, Tingbo Liang
Summary: This meta-analysis compared the outcomes of antiviral prophylaxis and preemptive therapy for the prevention of cytomegalovirus (CMV) infection in liver transplant recipients. The results showed that antiviral prophylaxis reduced the incidence of CMV infection in the high-risk group, while preemptive therapy reduced the incidence of late-onset CMV disease. There were no significant differences in other outcomes between the two interventions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Audiology & Speech-Language Pathology
Audrey Mossman, Virgil K. DeMario, Carrie Price, Stella M. Seal, Amber Willink, Nicholas S. Reed, Carrie L. Nieman
Summary: This article evaluates the possible association between income and adult-onset hearing loss, and finds that there is indeed a link between income and adult-onset hearing loss.
Review
Geriatrics & Gerontology
Rong Tian, Osvaldo P. Almeida, Dona M. P. Jayakody, Andrew H. Ford
Summary: This systematic review and meta-analysis found that hearing loss is associated with an increased risk of frailty in later life, although the causal relationship remains to be determined.
Review
Rheumatology
Flora Yan, Priyanka D. Reddy, Shaun A. Nguyen, Celine Ward, Ted A. Meyer
Summary: Patients with ankylosing spondylitis (AS) have a higher prevalence of hearing loss (HL) compared to those without AS, with significantly impaired hearing thresholds across all frequencies.
JOURNAL OF RHEUMATOLOGY
(2021)
Review
Rheumatology
Vasileios Paraschou, Styliani Partalidou, Pavlos Siolos, Zoi Papadopoulou, Nikolaos Chaitidis
Summary: Hearing loss, particularly sensorineural hearing loss, is highly prevalent in patients with Sjogren syndrome. Early screening and follow-up using pure tone audiometry are crucial for these patients.
RHEUMATOLOGY INTERNATIONAL
(2023)
Review
Virology
Xinyu Shi, Xiaozhou Liu, Yu Sun
Summary: Virus infection is a common cause of hearing loss, with various characteristics and outcomes. The pathogenesis of viral-induced hearing loss is not fully understood. This review focuses on cytomegalovirus, the most common virus causing hearing loss, as well as other reported hearing loss-related viruses, discussing their pathogenic characteristics, research progress, and possible treatment and prevention measures, aiming to provide guidance for clinical workers.
Review
Microbiology
Wenwen Xia, Hui Yan, Yiyuan Zhang, Congcong Wang, Wei Gao, Changning Lv, Wentao Wang, Zhijun Liu
Summary: HCMV is a common cause of congenital infections, with SNHL being a known disorder associated with it. While the precise mechanism remains unclear, immune responses, inflammatory factors, and vascular dysfunction are believed to play a role in HCMV-induced hearing loss. Further research is needed to fully understand the impact of HCMV infection on hearing loss and to improve diagnosis and treatment strategies.
FRONTIERS IN MICROBIOLOGY
(2021)