期刊
TOXICOLOGY IN VITRO
卷 29, 期 4, 页码 762-768出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tiv.2015.01.017
关键词
Surface coating agents; Nanoparticle; Cytotoxicity; Aliphatic amines; SDS
类别
资金
- NSF for the Partnership for Research and Education in Materials [DMR-0611539]
- NSF [CHE-0840450]
- NIH [NCRR 2G12RR013459-11]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1156111] Funding Source: National Science Foundation
- Office Of The Director
- EPSCoR [0903787] Funding Source: National Science Foundation
Impact on health by nanomaterials has become a public concern with the great advances of nanomaterials for various applications. Surface coating agents are an integral part of nanoparticles, but not enough attention has been paid during toxicity tests of nanopartides. As a result, there are inconsistent toxicity results for certain nanomaterials. In this study, we explored the cytotoxicity of eleven commonly used surface coating agents in two cell lines, human epidermal keratinocyte (HaCaT) and lung fibroblast (CRL-1490) cells, at surface coating agent concentrations of 3, 10, 30, and 100 mu M. Two exposure time points, 2 h and 24 h, were employed for the study. Six of the eleven surface coating agents are cytotoxic, especially those surfactants with long aliphatic chains, both cationic (cetyltrimethylammonium bromide, oleylamine, tetraoctylammonium bromide, and hexadecylamine) and anionic (sodium dodecylsulfate). In addition, exposure time and the use of different cell lines also affect the cytotoxicity results. Therefore, factors such as cell lines used and exposure times must be considered when conducting toxicity tests or comparing cytotoxicity results. (C) 2015 Elsevier Ltd. All rights reserved.
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