Editorial Material
Medicine, General & Internal
Soyoung Im, Jeong-A Kim, Gyeongsin Park, Uiju Cho
Summary: This article presents an image of systemic mastocytosis with marked eosinophilia in the lymph node, which is a rare subtype that requires a high level of suspicion for diagnosis.
Review
Hematology
Roberta Zanotti, Ilaria Tanasi, Lara Crosera, Massimiliano Bonifacio, Donatella Schena, Giovanni Orsolini, Francesca Mastropaolo, Morena Tebaldi, Elisa Olivieri, Patrizia Bonadonna
Summary: Systemic mastocytosis is a group of diseases that primarily affect adults, characterized by symptoms related to mast cell activation and organ infiltration. Diagnosis is challenging and requires referral to specialized centers for personalized and multidisciplinary approach.
MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES
(2021)
Article
Endocrinology & Metabolism
Martin Gehlen, Niels Schmidt, Michael Pfeifer, Subathira Balasingam, Michael Schwarz-Eywill, Anna Maier, Mathias Werner, Heide Siggelkow
Summary: Indolent systemic mastocytosis (ISM) is a rare disease causing osteoporosis, with a prevalence of 0.5% in patients with osteoporosis and 3.1% in those who underwent bone biopsies. Patients with ISM have more vertebral fractures, and women tend to be younger. This study highlights the importance of considering ISM in premenopausal women and men with vertebral fractures even without typical skin involvement.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Yen-Zung Wu, Hsuan-Ti Huang, Tsung-Lin Cheng, Yen-Mou Lu, Sung-Yen Lin, Cheng-Jung Ho, Tien-Ching Lee, Chia-Hao Hsu, Peng-Ju Huang, Han Hsiang Huang, Jhong-You Li, Yu-De Su, Shih-Chieh Chen, Lin Kang, Chung-Hwan Chen
Summary: miRNAs play crucial roles in osteoporosis, and analyzing human blood samples can help identify miRNAs with diagnostic value and therapeutic potential. Further studies are needed to validate their clinical application value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Ghada El-Hajj Fuleihan, Marlene Chakhtoura, Cristiana Cipriani, Richard Eastell, Tatiana Karonova, Jian-Min Liu, Salvatore Minisola, Ambrish Mithal, Carolina A. Moreira, Munro Peacock, Marian Schini, Barbara Silva, Marcella Walker, Ola El Zein, Claudio Marcocci
Summary: This narrative review summarizes data on classical and nonclassical manifestations of primary hyperparathyroidism (PHPT). The presentation of PHPT has shifted from predominantly symptomatic to asymptomatic, posing challenges in diagnosis and treatment. Limited knowledge exists regarding the natural history and response to interventions of asymptomatic PHPT.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Fnu Deepika, Siresha Bathina, Reina Armamento-Villareal
Summary: The burden of obesity and osteoporosis is increasing and becoming a major public health concern. Recent evidence has identified novel adipokines that play a role in bone metabolism. Obesity, characterized by adipose tissue inflammation, negatively impacts bone health. Adipokines secreted from white adipose tissue and bone marrow adipose tissue have effects on osteoblasts and osteoclasts. Understanding the complex interplay between fat cells and bone is crucial in the context of osteoporosis. This review summarizes recent advances in the understanding of adipokines' role in bone metabolism.
Article
Biology
Maria-Bernadette Madel, Julia Halper, Lidia Ibanez, Lozano Claire, Matthieu Rouleau, Antoine Boutin, Adrien Mahler, Rodolphe Pontier-Bres, Thomas Ciucci, Majlinda Topi, Christophe Hue, Jerome Amiaud, Salvador Iborra, David Sancho, Dominique Heymann, Henri-Jean Garchon, Dorota Czerucka, Florence Apparailly, Isabelle Duroux-Richard, Abdelilah Wakkach, Claudine Blin-Wakkach
Summary: This study explores the specific traits of inflammatory and steady-state osteoclasts using transcriptomic profiling, differentiation assays, and in vivo analysis in mice. The authors identify and validate pattern-recognition receptors (PRR) Tlr2, Dectin-1, and Mincle as major regulators of inflammatory osteoclasts. They demonstrate that the administration of the yeast probiotic Saccharomyces boulardii CNCM I-745 (Sb) reduces bone loss in ovariectomized mice by regulating the inflammatory environment and inhibiting inflammatory osteoclastogenesis. The study also shows that Sb derivatives and agonists of Tlr2, Dectin-1, and Mincle specifically inhibit the differentiation of inflammatory osteoclasts in vitro. These findings have important implications for the development of therapeutic strategies for inflammatory bone loss.
Article
Endocrinology & Metabolism
Thomas Levin Andersen, Pia Rosgaard Jensen, Tanja Tvistholm Sikjaer, Lars Rejnmark, Charlotte Ejersted, Jean-Marie Delaisse
Summary: Proper bone remodeling relies not only on the actions of osteoclasts and osteoblasts, but also on the delivery of osteoblast lineage cells to the remodeling site. A CD271-positive/PDGF beta-R-positive cell layer surrounding the bone marrow provides osteoblastogenic potential on all bone surfaces, including both quiescent and remodeling sites. This cell layer, known as the canopy, plays a critical role in initiating bone remodeling by activating early markers of osteoblastogenesis and supporting cell delivery to the bone surface.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Lichan Yuan, Na Zhao, Junyi Wang, Yuying Liu, Li Meng, Shuyu Guo, Erik A. C. Wiemer, Qi Chen, Yelin Mao, Jingjing Ben, Junqing Ma
Summary: The study revealed that MVP acts as a negative regulator of osteoclastogenesis, inhibiting bone resorption and potentially serving as a therapeutic target for preventing bone loss.
Article
Medicine, Research & Experimental
Biao Wu, Jie Shang, Shiyuan Lin, Ning Jiang, Baizhou Xing, Rong Peng, Xianghe Xu, Huading Lu
Summary: Increased bone resorption caused by excessive osteoclasts is the main cause of osteoporosis. The expression of RILP, a protein, is induced by receptor activator of NF-KB ligand, and its inhibition decreases the number and function of osteoclasts. Inhibition of RILP also reduces preosteoclast migration and bone resorption. The study suggests that RILP plays a crucial role in osteoclast formation and bone resorption, and could be a therapeutic target for bone diseases caused by excessive osteoclasts.
LABORATORY INVESTIGATION
(2023)
Article
Cell Biology
Chen Yang, Huaqiang Tao, Haifeng Zhang, Yu Xia, Jiaxiang Bai, Gaoran Ge, Wenming Li, Wei Zhang, Long Xiao, Yaozeng Xu, Zhirong Wang, Ye Gu, Huilin Yang, Yu Liu, Dechun Geng
Summary: Increased bone resorption by osteoclasts is the main cause of postmenopausal osteoporosis. This study revealed that TET2 promotes osteoclast differentiation by regulating autophagy. Knockdown of Tet2 inhibits autophagy and osteoclast differentiation. Mechanistically, Tet2 knockdown increases BCL2 expression and negatively regulates autophagy.
Article
Cell Biology
Zhihai Cao, Yuan Xue, Jiaqian Wang
Summary: Osteoporosis is caused by decreased bone formation and increased bone absorption, with ferroptosis playing a key role. Ferroptosis may inhibit bone formation and promote bone absorption through oxidative stress, leading to osteoporosis.
Article
Engineering, Environmental
Yan Huang, Maowen Chen, Yiding Shen, Xinkun Shen, Menghuan Li, Yanan Li, Yuan Liu, Kaiyong Cai, Zhong Luo, Yan Hu
Summary: This study presents a bone-targeted nanoformulation based on CaCO3 nanomaterials, which can be activated in the acidic microenvironment of osteoporosis and regulate the activity of osteoclasts and osteoblasts to reverse bone deterioration. The study provides an effective approach for the treatment of osteoporosis in clinics.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Jing Li, Jiamin Liang, Liwei Wu, Yang Xu, Chengxiang Xiao, Xue Yang, Ran Sun, Jinmin Zhao, Jiake Xu, Qian Liu, Bo Zhou
Summary: The study suggests that CYT387 has potential as a drug candidate for treating osteoclast-related bone diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Arne Martens, Pieter Hertens, Dario Priem, Vagelis Rinotas, Theodore Meletakos, Meropi Gennadi, Lisette Van Hove, Els Louagie, Julie Coudenys, Amelie De Muynck, Djoere Gaublomme, Mozes Sze, Jolanda van Hengel, Leen Catrysse, Esther Hoste, Jeffrey D. Zajac, Rachel A. Davey, Luc Van Hoorebeke, Tino Hochepied, Mathieu J. M. Bertrand, Marietta Armaka, Dirk Elewaut, Geert van Loo
Summary: The anti-inflammatory protein A20 plays a critical role in inhibiting NF-kappa B signaling and inflammation. Deficiency of A20 can lead to osteoporosis without causing inflammatory arthritis. A20 regulates RANK-induced NF-kappa B signaling through its specific domains, controlling osteoclast differentiation and bone development.
Article
Chemistry, Physical
Ole Jung, Jean-Philippe Becker, Ralf Smeets, Martin Gosau, Germain Becker, Baerbel Kahl-Nieke, Anne-Kathrin Jung, Max Heiland, Alexander Kopp, Mike Barbeck, Till Koehne
Article
Orthopedics
C. Ries, C. K. Boese, J. Stuerznickel, T. Koehne, J. Hubert, M. -F. Pastor, M. Hahn, S. L. Meier, F. T. Beil, K. Pueschel, M. Amling, T. Rolvien
OSTEOARTHRITIS AND CARTILAGE
(2020)
Article
Dentistry, Oral Surgery & Medicine
Maximilian G. Decker, Cita Nottmeier, Julia Luther, Anke Baranowsky, Baerbel Kahl-Nieke, Michael Amling, Thorsten Schinke, Jean-Pierre David, Till Koehne
Summary: The overexpression of c-Fos accelerates tooth movement without causing more root resorption.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Cita Nottmeier, Maximilian G. Decker, Julia Luther, Simon von Kroge, Barbel Kahl-Nieke, Michael Amling, Thorsten Schinke, Julian Petersen, Till Koehne
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2020)
Article
Dentistry, Oral Surgery & Medicine
C. Nottmeier, N. Liao, A. Simon, M. G. Decker, J. Luther, M. Schweizer, T. Yorgan, M. Kaucka, E. Bockamp, B. Kahl-Nieke, M. Amling, T. Schinke, J. Petersen, T. Koehne
Summary: The WNT/beta-catenin signaling pathway is crucial in periodontium biology, with specific extracellular WNT ligands like WNT1 demonstrating a strong promoting effect on cementum and alveolar bone formation in vivo. Experimental results indicate that Wnt1 promotes proliferation but not differentiation of cementoblasts.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Carmen Ulrike Schmid-Herrmann, Nicole Maria Muschol, Vera Ulrike Fuhrmann, Anja Friederike Koehn, Susanne Lezius, Barbel Kahl-Nieke, Till Koehne
Summary: This study aimed to compare the severity of condylar involvement in MPS patients with non-MPS individuals and to describe the variation in condylar changes among different MPS types. The results showed pronounced bilateral degenerative condylar resorption in MPS I and VI individuals, while MPS II and IV individuals exhibited heterogeneous findings.
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2022)
Article
Multidisciplinary Sciences
Nannan Liao, Till Koehne, Jan Tuckermann, Ioanna Triviai, Michael Amling, Jean-Pierre David, Thorsten Schinke, Julia Luther
Summary: This study demonstrates a critical role of p53 as a key regulator of mesenchymal cell differentiation in a specific mouse model, regardless of tumorigenesis.
Article
Biochemistry & Molecular Biology
Thibault Bouderlique, Julian Petersen, Louis Faure, Daniel Abed-Navandi, Anass Bouchnita, Benjamin Mueller, Murtazo Nazarov, Lukas Englmaier, Marketa Tesarova, Pedro R. Frade, Tomas Zikmund, Till Koehne, Jozef Kaiser, Kaj Fried, Christian Wild, Olga Pantos, Andreas Hellander, John Bythell, Igor Adameyko
Summary: Research has revealed that corals can connect individual polyps and form a coral colony through complex liquid flow networks on the surface and branching flow systems inside the colony. These networks and systems play important roles in the growth, nutrient supply, and symbiont transfer of corals.
Article
Chemistry, Physical
Thomas Kohne, Alexander Dahlstrom, Aimo Winkelmann, Peter Hedstrom, Annika Borgenstam
Summary: This study presents a novel approach for correlating the local martensite tetragonality determined by electron backscatter diffraction and carbon distribution determined by atom probe tomography (APT). The approach involves site-specific sample preparation for APT based on the local tetragonality. The investigation focused on the local carbon distribution in high carbon steel with varying local martensite tetragonality. The results showed that regions with low tetragonality exhibited clear agglomeration of carbon, while regions with high tetragonality showed only small elongated agglomerations and no significant clustering. The average bulk carbon content in APT analysis did not show any quantitative difference between regions with low and high tetragonality, indicating the absence of significant long-range diffusion of carbon.
Article
Physiology
Rohit Nagpal, Gina Georgi, Sarah Knauth, Carmen Schmid-Herrmann, Nicole Muschol, Thomas Braulke, Baerbel Kahl-Nieke, Michael Amling, Thorsten Schinke, Till Koehne, Julian Petersen
Summary: This study investigated the effects of enzyme replacement therapy (ERT) on dental and craniofacial structures in a mouse model and compared the results with clinical observations from MPS VI patients. The findings suggest that an early start of ERT achieves the best therapeutic effects for tooth, bone, and temporomandibular joint development.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Julian Petersen, Lukas Englmaier, Artem V. Artemov, Irina Poverennaya, Ruba Mahmoud, Thibault Bouderlique, Marketa Tesarova, Ruslan Deviatiiarov, Anett Szilvasy-Szabo, Evgeny E. Akkuratov, David Pajuelo Reguera, Hugo Zeberg, Marketa Kaucka, Maria Eleni Kastriti, Jan Krivanek, Tomasz Radaszkiewicz, Kristina Goemoeryova, Sarah Knauth, David Potesil, Zbynek Zdrahal, Ranjani Sri Ganji, Anna Grabowski, Miriam E. Buhl, Tomas Zikmund, Michaela Kavkova, Hakan Axelson, David Lindgren, Rafael Kramann, Christoph Kuppe, Ferenc Erdelyi, Zoltan Mate, Gabor Szabo, Till Koehne, Tibor Harkany, Kaj Fried, Jozef Kaiser, Peter Boor, Csaba Fekete, Jan Rozman, Petr Kasparek, Jan Prochazka, Radislav Sedlacek, Vitezslav Bryja, Oleg Gusev, Igor Adameyko
Summary: Using comparative genomics, we discovered a gene called FAME (Factor Associated with Metabolism and Energy) with unknown function. We found that FAME has significantly diverged in birds and mammals. Comparison of single nucleotide polymorphisms revealed gene flow of FAME from Neandertals to modern humans. Knockout experiments in animals showed altered body weight and decreased energy expenditure, consistent with genome-wide association studies linking FAME to higher body mass index in humans. Gene expression and subcellular localization analyses demonstrated that FAME is a membrane-bound protein enriched in the kidneys. Although the knockout did not result in structural abnormalities in the kidneys, we observed elevated albumin in urine and decreased ferritin in the blood. Experimental validation confirmed interactions between FAME and ferritin, and showed co-localization in vesicular and plasma membranes.
NATURE COMMUNICATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Carmen Ulrike Schmid-Herrmann, Jesper Delfs, Luai Mahaini, Eliane Schumacher, Christian Hirsch, Till Koehne, Baerbel Kahl-Nieke
Summary: This study aimed to investigate the three-dimensional effects of the Carriere Motion 3D (TM) appliance (CMA). The results showed that CMA was able to effectively correct class II malocclusion, with significant skeletal and dentoalveolar changes. Additionally, CMA resulted in protrusion of the lower incisors.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Endocrinology & Metabolism
Eva Maria Woelfel, Simon von Kroge, Levi Matthies, Till Koehne, Karin Petz, Thomas Beikler, Carmen Ulrike Schmid-Herrmann, Baerbel Kahl-Nieke, Konstantinos Tsiakas, Rene Santer, Nicole Maria Muschol, Jochen Herrmann, Bjoern Busse, Michael Amling, Tim Rolvien, Nico Maximilian Jandl, Florian Barvencik
Summary: Hypophosphatasia (HPP) is a genetic disorder that affects bone mineralization and increases fracture risk. Dental involvement in HPP has not been well studied, and the effects of asfotase alfa treatment on dental status are still unclear. This study compares the dental mineralization before and during asfotase alfa treatment in HPP patients and finds minor improvements in mineralization after treatment.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Tim Rolvien, Osman Avci, Simon von Kroge, Till Koehne, Stefan Selbert, Stephan Sonntag, Doron Shmerling, Uwe Kornak, Ralf Oheim, Michael Amling, Thorsten Schinke, Timur Alexander Yorgan
Article
Medicine, Research & Experimental
Till Koehne, Jozef Zustin, Michael Amling, Reinhard E. Friedrich