Article
Endocrinology & Metabolism
Dan-dan Li, Yang Yang, Zi-yi Gao, Li-hua Zhao, Xue Yang, Feng Xu, Chao Yu, Xiu-lin Zhang, Xue-qin Wang, Li-hua Wang, Jian-bin Su
Summary: A sedentary lifestyle may lead to increases in trunk and body fat percentage, as well as decreases in appendicular skeletal muscle mass and bone mineral density in patients with T2D.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Geriatrics & Gerontology
Ling Wang, Lu Yin, Minghui Yang, Yufeng Ge, Yandong Liu, Yongbin Su, Zhe Guo, Dong Yan, Zhengyang Xu, Pengju Huang, Jian Geng, Xingli Liu, Gang Wang, Glen M. Blake, Weiming Cao, Bo He, Liang Lyu, Xiaoguang Cheng, Xinbao Wu, Lihong Jiang, Annegreet Vlug, Klaus Engelke
Summary: This study investigates specific risk factors for second hip fractures and finds significant associations with areal bone mineral density (aBMD), muscle size, and density. The study also shows that muscle parameters can predict the risk of contralateral fractures independently of aBMD.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Endocrinology & Metabolism
A. V. Schwartz, Q. Pan, V. R. Aroda, J. P. Crandall, A. Kriska, C. Piromalli, A. Wallia, M. Temprosa, H. Florez
Summary: In individuals at high risk of diabetes, intensive lifestyle intervention or metformin did not show long-term negative effects on bone mineral density (BMD), and metformin may have potential positive effects on bone that warrant further investigation.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Chunlan Zhang, Xi Chen, Shiping Liu, Wei Liu, Dalong Zhu, Xiaoying Li, Shen Qu, Zhiming Zhu, Jingjing Zhang, Zhiguang Zhou
Summary: Metabolic surgery has been shown to effectively treat obesity, but there is limited research on nutritional evaluations after surgery in Chinese patients. In this retrospective study, we found that Chinese patients undergoing metabolic surgery experienced changes in their nutritional status. Premenopausal females had a higher incidence of anemia at 12 months post-surgery, and preoperative anemia increased the risk of postoperative anemia. Ferritin levels decreased and iron deficiency increased among premenopausal females. However, there were no significant changes in folate deficiency and vitamin B12 deficiency throughout the study. Bone mineral density (BMD) significantly decreased from baseline to 12 months after surgery, but there were no new cases of osteopenia or osteoporosis. Nutrient supplements and long-term follow-up are necessary postoperation.
Article
Endocrinology & Metabolism
Pradyumna Gurusamy, Britta A. Larsen, Richard T. Allen, Samuel R. Ward, Matthew A. Allison, Jan M. Hughes-Austin
Summary: This study used data from the Multi-Ethnic Study of Atherosclerosis (MESA) to investigate the association between trunk muscle density and fat fraction and lumbar bone mineral density (BMD). The results showed a positive correlation between trunk muscle density and higher lumbar BMD in both men and women.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Orthopedics
Huawei Han, Shuai Chen, Xinzhe Wang, Jie Jin, Xianghui Li, Zhiwei Li
Summary: This study examined the impact of lower extremity muscle strength and mass on bone mineral density (BMD). The results showed a positive correlation between muscle strength and mass with BMD. These findings have important implications for the prevention, early diagnosis, and treatment of osteopenia and osteoporosis.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Medicine, General & Internal
Hyun Uk Moon, Seung Jin Han, Hae Jin Kim, Yoon-Sok Chung, Dae Jung Kim, Yong Jun Choi
Summary: This study found that the positive correlation between muscle mass and bone status was largely conserved in men with diabetes, and this association may be stronger in diabetic individuals.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Malgorzata Jamka, Sylwia E. Piotrowska-Brudnicka, Joanna Karolkiewicz, Damian Skrypnik, Pawel Bogdanski, Judyta Cielecka-Piontek, Gulnara Sultanova, Jaroslaw Walkowiak, Edyta Madry
Summary: This pilot study compared the effect of endurance and endurance-strength training on body composition and bone metabolism in centrally obese women, with endurance-strength training showing more effectiveness in increasing lean mass.
Article
Multidisciplinary Sciences
Nara Nobrega Crispim Carvalho, Vinicius Jose Baccin Martins, Joo Modesto Filho, Adelia da Costa Pereira de Arruda Neta, Flavia Cristina Fernandes Pimenta, Jose Luiz de Brito Alves
Summary: This study evaluated the anthropometric, metabolic, and musculoskeletal outcomes in obese females with and without sarcopenic-obesity parameters who underwent bariatric surgery during a 1-year follow-up. The results showed that reduced muscle mass and strength are risk factors for metabolic and musculoskeletal impairment in obese females. Bariatric surgery promotes similar musculoskeletal and metabolic changes in females with preserved muscle mass and strength or in females with sarcopenia-related parameters.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Di Yang, Rongrong Xu, Yinfang Tu, Yunfeng Xiao, Hongwei Zhang, Weijie Liu, Pin Zhang, Haoyong Yu, Yuqian Bao, Ying Yang, Junfeng Han
Summary: Sleeve gastrectomy leads to a decrease in femoral neck and total hip bone mineral density (BMD) in both women and men. Changes in body composition are associated with BMD loss at different time points and bone sites.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Kanae Kuriyama, Yasumoto Matsui, Yasuo Suzuki, Takafumi Mizuno, Tsuyoshi Watanabe, Marie Takemura, Shinya Ishizuka, Satoshi Yamashita, Shiro Imagama, Hidenori Arai
Summary: Sarcopenia, the decline in skeletal muscle mass, is closely associated with muscle/fat area and osteoporosis. This study found significant reductions in muscle area and increases in fat area in individuals with sarcopenia, as well as a correlation between sarcopenia and osteoporosis in men.
Article
Endocrinology & Metabolism
Yi Zhang, Min Tan, Boyu Liu, Manxia Zeng, You Zhou, Mengru Zhang, Yikai Wang, Jing Wu, Min Wang
Summary: This study aims to examine the association between bone mineral density (BMD) and hyperuricemia (HU) in obesity. The results showed a negative correlation between lumbar BMD and HU in obese individuals, particularly in men, while no significant relationship was found between hip BMD and HU.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Sport Sciences
Julie Abildgaard, Mette Yun Johansen, Kirsa Skov-Jeppesen, Lars Bo Andersen, Kristian Karstoft, Katrine Bagge Hansen, Bolette Hartmann, Jens Juul Holst, Bente Klarlund Pedersen, Mathias Ried-Larsen
Summary: The 12-month intensive exercise-based lifestyle intervention led to a significant increase in bone turnover in persons with T2D, primarily mediated by weight and fat mass loss. Bone mineral density was unaffected by the intervention, indicating improved bone health despite substantial weight loss. Further studies on the impact of exercise on fracture risk in persons with T2D are warranted.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Pediatrics
Francisco Sanchez Ferrer, Ernesto Cortes Castell, Francisco Carratala Marco, Mercedes Juste Ruiz, Jose Antonio Quesada Rico, Ana Pilar Nso Roca
Summary: Childhood obesity is a public health issue that can have long-term consequences. This study of 553 children over 10 years found that weight status influences bone mineral content, with BMC and BMD being highest in the normal-weight and overweight groups. Waist circumference was negatively correlated with bone mineralization.
Article
Nutrition & Dietetics
Maryam Pourhassan, Bjoern Buehring, Ulrik Stervbo, Sven Rahmann, Felix Moelder, Sebastian Ruetten, Ulrike Trampisch, Nina Babel, Timm Henning Westhoff, Rainer Wirth
Summary: The study found that osteoporosis and sarcopenia are common in older hospitalized patients, with some overlap between the two conditions known as osteosarcopenia. Nearly all sarcopenic patients also had osteoporosis, while only a small percentage of patients with low BMD also had sarcopenia.
Editorial Material
Endocrinology & Metabolism
Nicola Napoli, Ann L. Elderkin, Douglas P. Kiel, Sundeep Khosla
NATURE REVIEWS ENDOCRINOLOGY
(2020)
Review
Endocrinology & Metabolism
Silvia Irina Briganti, Anda Mihaela Naciu, Gaia Tabacco, Roberto Cesareo, Nicola Napoli, Pierpaolo Trimboli, Marco Castellana, Silvia Manfrini, Andrea Palermo
Summary: Long-term or high-dose use of PPIs may increase the risk of fractures, particularly hip fractures. The mechanisms of PPI-related bone damage are still unclear, and further studies are needed to clarify the effects of PPIs on bone health.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Ellen F. Binder, Jesse C. Christensen, Jennifer Stevens-Lapsley, Jenna Bartley, Sarah D. Berry, Adrian S. Dobs, Richard H. Fortinsky, Kerry L. Hildreth, Douglas P. Kiel, George A. Kuchel, Robin L. Marcus, Christine M. McDonough, Denise Orwig, David R. Sinacore, Robert S. Schwartz, Elena Volpi, Jay Magaziner, Kenneth B. Schechtman
Summary: The study aims to compare the effects of different treatments on female hip fracture patients aged 65 and older, including testing the synergistic effects of strength training and testosterone replacement on functional recovery. The results are expected to have significant clinical and public health implications for managing hip fracture patients.
CONTEMPORARY CLINICAL TRIALS
(2021)
Article
Endocrinology & Metabolism
Daniel C. Bittel, Adam J. Bittel, Arun S. Varadhachary, Terri Pietka, David R. Sinacore
Summary: Two-thirds of individuals with type 2 diabetes will develop chronic kidney disease, leading to early frailty, mobility deficits, and increased mortality risk. The mechanisms linking renal decline to mobility deficits are crucial for identifying high-risk individuals and formulating effective treatment strategies. Skeletal muscle energetics and mitochondrial function play a key role in impairing physical function in the progression of T2DM-induced CKD.
Article
Endocrinology & Metabolism
Giulia Leanza, Francesca Fontana, Seung-Yon Lee, Maria S. Remedi, Celine Schott, Mathieu Ferron, Malcolm Hamilton-Hall, Yael Alippe, Rocky Strollo, Nicola Napoli, Roberto Civitelli
Summary: Activation of Wnt signaling in diabetic mouse model can improve bone health, prevent osteoporosis, and have various effects related to diabetes.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Editorial Material
Endocrinology & Metabolism
Nicola Napoli
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Debra L. Waters, Lina Aguirre, Burke Gurney, David R. Sinacore, Kenneth Fowler, Giulia Gregori, Reina Armamento-Villareal, Clifford Qualls, Dennis T. Villareal
Summary: The study found that different exercise modes have significant effects on body composition, physical function, and metabolic function in older adults with obesity. Combining aerobic and resistance exercises was the most effective approach in improving ectopic fat deposition and physical and metabolic function in this population.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Editorial Material
Endocrinology & Metabolism
A. Falchetti, M. Mohseni, F. Tramontana, N. Napoli
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Eric S. Orwoll, Neeta Parimi, Jack Wiedrick, Jodi Lapidus, Nicola Napoli, Jeremy E. Wilkinson, Curtis Huttenhower, Lisa Langsetmo, Douglas P. Kiel
Summary: This study investigated the associations between fecal microbiota and bone density, microarchitecture, and strength. The findings suggest a role for gut microbiota in skeletal homeostasis, although the effect sizes were small and larger cohort sizes may be needed for more confident associations.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Muriel E. Babey, Susan K. Ewing, Elsa S. Strotmeyer, Nicola Napoli, Anne L. Schafer, Eric Vittinghoff, Caren M. Gundberg, Ann Schwartz
Summary: Mouse models suggest that undercarboxylated osteocalcin (ucOC), produced by the skeleton, protects against type 2 diabetes development, whereas human studies have been inconclusive. This study aimed to investigate the association between ucOC or total OC and incident type 2 diabetes or changes in glucose metabolism in older adults. The results showed no significant association between baseline undercarboxylated or total osteocalcin and the risk of incident type 2 diabetes or changes in glucose metabolism in older adults.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Dennis M. Black, Ian R. Reid, Nicola Napoli, Susan K. Ewing, Masataka Shiraki, Toshitaka Nakamura, Yasuhiro Takeuchi, Anne L. Schafer, Tiffany Y. Kim, Jane A. Cauley
Summary: The study indicates that women who experience an acute-phase reaction (APR) when starting Zoledronic acid (ZOL) will have a larger reduction in vertebral fracture risk with ZOL.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Giulia Puliani, Valeria Hasenmajer, Ilaria Simonelli, Valentina Sada, Riccardo Pofi, Marianna Minnetti, Alessia Cozzolino, Nicola Napoli, Patrizio Pasqualetti, Daniele Gianfrilli, Andrea M. Isidori
Summary: This meta-analysis evaluated the efficacy and safety of PTH1-34 and PTH1-84 in treating chronic hypoparathyroidism. The results showed that PTH therapy can normalize serum phosphate and urinary calcium excretion, reduce calcium and vitamin D use, and improve quality of life.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Roberto Cesareo, Silvia Egiddi, Anda M. Naciu, Gaia Tabacco, Andrea Leoncini, Nicola Napoli, Andrea Palermo, Pierpaolo Trimboli
Summary: This systematic review focuses on the clinical efficacy of thermal-ablation (TA) in reducing the volume and symptoms of benign thyroid nodules (TN). The study found limited and inconsistent clinical data regarding the efficacy of TA, and suggests the need for international guidelines on patient selection and evaluation for TN TA treatment.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Review
Endocrinology & Metabolism
L. Cianferotti, C. Cipriani, S. Corbetta, G. Corona, G. Defeudis, A. G. Lania, C. Messina, N. Napoli, G. Mazziotti
Summary: Endocrine diseases can lead to osteoporosis and fractures, but traditional bone density measurement methods may not accurately capture skeletal alterations caused by endocrine disorders. Therefore, it is important to use new techniques to assess bone quality for the diagnosis and prediction of skeletal fragility and fracture risk.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
Francesca Cannata, Gianluca Vadala, Luca Ambrosio, Nicola Napoli, Rocco Papalia, Vincenzo Denaro, Paolo Pozzilli
Summary: Tendinopathy is a chronic and painful condition that is closely associated with type 2 diabetes, with multiple metabolic factors potentially exacerbating the disease. Immobilization due to tendon disorder negatively impacts diabetes management and quality of life.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)