Article
Endocrinology & Metabolism
Resthie R. Putri, Pernilla Danielsson, Claude Marcus, Emilia Hagman
Summary: This study aimed to investigate the effect of obesity severity and treatment outcome on growth. It was found that obesity severity is positively associated with height and growth velocity, and successful obesity treatment can normalize the growth velocity pattern. Therefore, a hampered growth spurt should be anticipated during puberty, especially in adolescents with severe obesity, and there is no difference in final height between different levels of obesity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Environmental Sciences
Seung Min Chung
Summary: This study examined the impact of blood cadmium levels on body composition using a propensity score-matched cohort. It found that high blood cadmium levels increased the risk of body composition deterioration, especially in individuals aged 60-69 years, women, and those with adiposity obesity at baseline.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Ke Zhou, Jie Xiang, Guo-yong Li, Xiao-bo Pu, Li Zhang
Summary: This study analysed the characteristics and mortality of hypertrophic cardiomyopathy (HCM) patients with different body compositions. Patients with low body mass index (BMI) and lean mass index (LMI) had higher mortality rates, while body fat (BF) was not significantly associated with mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Ruth Durdin, Camille Parsons, Elaine M. Dennison, Suzanne Williams, Therese Tillin, Nishi Chaturvedi, Cyrus Cooper, Nicholas C. Harvey, Kate A. Ward
Summary: The study aimed to investigate whether central adiposity or inflammatory status contribute to ethnic differences in bone mineral density (BMD). The study found that despite adjustment for body composition, central adiposity, and inflammation, ethnic differences in BMD still existed. Additionally, ethnic differences were observed in the relationship between BMI, LMI or VAT mass and lumbar spine BMD in women.
Article
Medicine, General & Internal
Yun Kyung Seo, Chang Won Won, Yunsoo Soh
Summary: The study investigated the relationship between body mass index (BMI), body composition, and cognitive function in elderly Korean population, finding a positive correlation between obesity-related indexes and cognitive functions, particularly in males.
Article
Nutrition & Dietetics
Daniel Haigis, Leon Matting, Silas Wagner, Gorden Sudeck, Annika Frahsa, Ansgar Thiel, Gerhard Eschweiler, Andreas Michael Niess
Summary: The study found a low prevalence of sarcopenic obesity among elderly residents in nursing homes. However, sarcopenia and obesity still play important roles in maintaining the health of residents.
Article
Respiratory System
Caren Ishikawa, Marco Antonio Barbieri, Heloisa Bettiol, Gabriel Bazo, Alexandre A. Ferraro, Elcio Oliveira Vianna
Summary: The study found negative associations between both simple obesity measures like BMI and more precise body composition measurements like DXA and spirometric parameters FVC and FEV1, especially in men. Simple measures like waist-height ratio were also found to be sufficient in detecting the association between body composition and a reduction in pulmonary function.
BMC PULMONARY MEDICINE
(2021)
Article
Critical Care Medicine
Michael Genuardi, Aman Rathore, Rachel P. Ogilvie, Rebecca S. DeSensi, Priya Borker, Jared W. Magnani, Sanjay R. Patel
Summary: In this large clinical cohort, the severity of OSA was found to be associated with an increased risk of VTE, though this association may be explained by obesity. However, severe nocturnal hypoxemia may be a mechanism by which OSA heightens VTE risk.
Article
Geriatrics & Gerontology
Xiaowen Zhang, Warrington W. Q. Hsu, Chor-Wing Sing, Gloria H. Y. Li, Kathryn C. B. Tan, Annie W. C. Kung, Janus S. H. Wong, Ian Chi-Kei Wong, Ching-Lung Cheung
Summary: This study investigated the relationship between bone mineral density (BMD) and the risk of incident dementia, and found that higher BMD was associated with a reduced risk of dementia, particularly in women. Further research is needed to evaluate the clinical usefulness of BMD in predicting and managing dementia.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Nutrition & Dietetics
Aeltsje Brinksma, Esther Sulkers, Dorus Kouwenberg, Otto T. H. M. Lelieveld, Annemieke M. Boot, Johannes G. M. Burgerhof, Wim J. E. Tissing
Summary: This study aimed to investigate the changes in body size and body composition in a heterogeneous sample of childhood cancer survivors prospectively seven years after diagnosis. The results showed that children with hematological and brain malignancies experienced continued increase in BMI z-score after treatment, leading to a quadrupling of obesity prevalence. The study highlights the importance of raising awareness about the risk of developing overweight in children during cancer treatment.
CLINICAL NUTRITION
(2022)
Article
Geriatrics & Gerontology
Warrington W. Q. Hsu, Xiaowen Zhang, Chor-Wing Sing, Gloria H. Y. Li, Kathryn C. B. Tan, Annie W. C. Kung, Janus S. H. Wong, Ian Chi-Kei Wong, Ching-Lung Cheung
Summary: The study found that hip fracture was associated with an increased risk of dementia among older adults, especially in women. Further research on the potential role of hip fracture in the development of dementia could benefit the management of both conditions in older adults.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Oncology
Angeliki Kotti, Annica Holmqvist, Mischa Woisetschlager, Xiao-Feng Sun
Summary: This study aimed to evaluate the impact of computed tomography (CT)-measured body composition on survival in rectal cancer patients. The results showed that low skeletal muscle index was associated with worse survival, while high visceral adipose tissue area predicted better survival in men but worse survival in women.
CANCER & METABOLISM
(2022)
Article
Nutrition & Dietetics
Hannah Oh, So-Young Kwak, Garam Jo, Juhee Lee, Dahyun Park, Dong Hoon Lee, NaNa Keum, Jong-Tae Lee, Edward L. Giovannucci, Min-Jeong Shin
Summary: The study examined the relationships between BMI, waist circumference, predicted body fat mass, and mortality in a Korean population. The results showed a J-shaped association between BMI and all-cause and cardiovascular mortality, with the lowest point at BMI = 25.0-29.9. It was also found that higher waist circumference and predicted body fat mass were positively associated with mortality, suggesting a need for re-evaluation of current overweight criteria for Asians.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Oncology
Danja Sarink, Lynne R. Wilkens, Kami K. White, Loic Le Marchand, Anna H. Wu, V. Wendy Setiawan, S. Lani Park, Song-Yi Park, Jeffrey L. Killeen, Melissa A. Merritt
Summary: The study found that higher BMI and BMI at age 21 were strongly associated with increased endometrial cancer risk. While parity was inversely associated with risk in most groups, this was not the case for African Americans. Current use of postmenopausal hormones was associated with increased risk in Whites and Japanese Americans.
BRITISH JOURNAL OF CANCER
(2021)
Article
Nutrition & Dietetics
Jun-Hyuk Lee, A-Ra Cho, Yu-Jin Kwon
Summary: High dairy protein intake is inversely related to the development of LMAO in Korean women, indicating that dairy protein intake may be effective in preventing incident LMAO.
CLINICAL NUTRITION
(2022)
Article
Oncology
Hiroshi Moritake, Shiro Tanaka, Takako Miyamura, Hideki Nakayama, Norio Shiba, Akira Shimada, Kiminori Terui, Yuki Yuza, Katsuyoshi Koh, Hiroaki Goto, Harumi Kakuda, Akiko Saito, Daisuke Hasegawa, Shotaro Iwamoto, Takashi Taga, Souichi Adachi, Daisuke Tomizawa
Summary: The prognosis of relapsed pediatric AML depends on the duration from diagnosis to relapse and achieving a second complete remission (CR2) prior to HCT. Treatment with ECM or FLAG-based regimens may improve outcomes, while genetic factors like FLT3-internal tandem duplication can serve as poor prognostic markers.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Endocrinology & Metabolism
Masaru Kitazawa, Takashi Katagiri, Hiromi Suzuki, Satoshi Matsunaga, Mayuko Yamada, Tomoo Ikarashi, Masahiko Yamamoto, Kazuo Furukawa, Midori Iwanaga, Mariko Hatta, Kazuya Fujihara, Takaho Yamada, Shiro Tanaka, Hirohito Sone
Summary: This study compared the long-term efficacy of sodium-glucose co-transporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors as second-line drugs in patients not at high risk of ASCVD. The results showed no significant difference in achieving the primary endpoint at 52 weeks, but sitagliptin had a higher HbA1c reduction rate at 24 weeks.
DIABETES OBESITY & METABOLISM
(2021)
Article
Gastroenterology & Hepatology
Raghav Sundar, Nesaretnam Barr Kumarakulasinghe, Yiong Huak Chan, Kazuhiro Yoshida, Takaki Yoshikawa, Yohei Miyagi, Yasushi Rino, Munetaka Masuda, Jia Guan, Junichi Sakamoto, Shiro Tanaka, Angie Lay-Keng Tan, Michal Marek Hoppe, Anand D. Jeyasekharan, Cedric Chuan Young Ng, Mark De Simone, Heike Grabsch, Jeeyun Lee, Takashi Oshima, Akira Tsuburaya, Patrick Tan
Summary: In the SAMIT trial, a gene signature predicting survival benefit from paclitaxel chemotherapy in gastric cancer patients was identified using machine-learning techniques. Patients were divided into Pac-Sensitive and Pac-Resistant groups, with Pac-Sensitive patients showing significant improvement in disease-free survival. This gene signature was validated in an external cohort, providing the first predictive biomarker for paclitaxel benefit in gastric cancer patients.
Article
Endocrinology & Metabolism
Shiro Tanaka, Jakob Langer, Tim Morton, Nicki Hoskins, Lars Wilkinson, Sachiko Tanaka-Mizuno, Ryo Kawasaki, Tatsumi Moriya, Chika Horikawa, Rei Aida, Atsushi Araki, Kazuya Fujihara, Hirohito Sone
Summary: This study presents an economic model developed specifically for evaluating the cost-effectiveness of two interventions for type 2 diabetes in a Japanese population. By simulating analyses in different age groups, the model can estimate rates of diabetic complications, costs, quality-adjusted life years, and provide disaggregated results for competing interventions.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Endocrinology & Metabolism
Akira Taguchi, Yukari Uemura, Shiro Tanaka, Hiroaki Ohta, Satoshi Mori, Hiroshi Hagino, Masataka Shiraki, Toshitaka Nakamura, Satoshi Soen
Summary: This study found that postmenopausal Japanese women with symptomatic periodontal disease had a significantly smaller increase in total hip bone density compared to those without periodontal disease during medication therapy for osteoporosis. Interventions to treat symptomatic periodontal disease before and/or during osteoporosis therapy could help maintain the effectiveness of osteoporosis medications.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Oncology
Norihiro Shimoike, Tatsuto Nishigori, Yoshito Yamashita, Masato Kondo, Dai Manaka, Yoshio Kadokawa, Atsushi Itami, Seiichiro Kanaya, Hisahiro Hosogi, Seiji Satoh, Hiroaki Hata, Takatsugu Kan, Hironori Kawada, Michihiro Yamamoto, Eiji Tanaka, Shigeru Tsunoda, Shigeo Hisamori, Koya Hida, Kentaro Ueno, Shiro Tanaka, Kazutaka Obama
Summary: The study evaluated the safety of robotic gastrectomy in daily clinical practice and assessed the learning process in surgeons introduced to robotic procedures. Results showed that robotic gastrectomy was safely performed in actual clinical settings, although initial cases had longer operative time and promoted greater levels of surgeon fatigue compared to subsequent cases.
Letter
Endocrinology & Metabolism
Yasuhiro Matsubayashi, Alkihiro Yoshida, Hideki Suganami, Momoko Oe, Takaaki Sato, Yuta Yaguchi, Kazuya Fujihara, Takaho Yamada, Shiro Tanaka, Kohei Kaku, Hirohito Sone
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Satoshi Mori, Hiroshi Hagino, Toshitsugu Sugimoto, Shiro Tanaka, Yuji Mitomo, Kaito Takahashi, Teruki Sone, Toshitaka Nakamura, Satoshi Soen
Summary: This study aimed to determine whether sequential therapy with teriparatide, followed by alendronate, is more effective in preventing fractures compared to monotherapy with alendronate. The results showed that in women with osteoporosis at high risk of fracture, once-weekly teriparatide injection followed by alendronate significantly reduced the incidence of morphometric vertebral fractures compared to alendronate monotherapy.
OSTEOPOROSIS INTERNATIONAL
(2023)
Meeting Abstract
Hematology
Hiroyuki Takahashi, Shiro Tanaka, Yuki Yuza, Yuka Iijima-Yamashita, Daisuke Hasegawa, Hiroshi Moritake, Kiminori Terui, Shotaro Iwamoto, Akira Shimada, Jun Matsubayashi, Takao Deguchi, Yoshiko Hashii, Nobutaka Kiyokawa, Hayato Miyachi, Akiko Moriya Saito, Takashi Taga, Souichi Adachi, Daisuke Tomizawa
Meeting Abstract
Hematology
Daisuke Tomizawa, Shiro Tanaka, Shotaro Iwamoto, Hidefumi Hiramatsu, Jun Matsubayashi, Daisuke Hasegawa, Hiroshi Moritake, Daiichiro Hasegawa, Kiminori Terui, Asahito Hama, Shin-ichi Tsujimoto, Nobutaka Kiyokawa, Hayato Miyachi, Takao Deguchi, Yoshiko Hashii, Yuka Iijima-Yamashita, Tomohiko Taki, Yasushi Noguchi, Kazutoshi Koike, Katsuyoshi Koh, Yuki Yuza, Akiko Moriya Saito, Keizo Horibe, Takashi Taga, Souichi Adachi
Article
Public, Environmental & Occupational Health
Hisashi Noma, Munechika Misumi, Shiro Tanaka
Summary: Ordinary logistic regression analyses are widely used in case-cohort studies, but their odds ratio estimates cannot be interpreted as relative risk measures unless the event rate is low. This study introduces pseudo-Poisson and pseudo-normal linear regression methods that can estimate risk ratios and risk differences. By using weighting and auxiliary variable information, these estimators provide accurate and precise results. These alternative approaches are recommended for case-cohort studies, especially when the event rate is not low.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Hiroaki Ohta, Yukari Uemura, Teruki Sone, Shiro Tanaka, Satoshi Soen, Satoshi Mori, Hiroshi Hagino, Masao Fukunaga, Toshitaka Nakamura, Hajime Orimo, Masataka Shiraki
Summary: The positive link between osteoporosis and hypercholesterolemia has been acknowledged, and bone resorption inhibitors, such as nitrogen-containing bisphosphonates (N-BP) and selective estrogen receptor modulators (SERMs), have been found to lower serum cholesterol levels. However, the association between baseline cholesterol level and incident fracture rate under treatment with these inhibitors has not been studied. This research investigated the relationship between vertebral fracture incidents and baseline cholesterol levels, as well as the cholesterol-lowering effects of N-BP and SERM in osteoporosis patients.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Takumi Imai, Takayuki Hosoi, Hiroshi Hagino, Takanori Yamamoto, Tatsuhiko Kuroda, Hiroshi Watanabe, Shiro Tanaka
Summary: This study aimed to estimate the incidence rates of femoral shaft fracture in patients treated with antiresorptive drugs. The study found variations in the incidence rates of femoral shaft fracture among patients treated with different types of antiresorptive drugs.
JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Endocrinology & Metabolism
Shiro Tanaka, Mitsuru Saito, Hiroshi Hagino, Satoshi Mori, Toshitaka Nakamura, Hiroaki Ohta, Teruki Sone, Kaito Takahashi, Yuji Mitomo, Toshitsugu Sugimoto, Satoshi Soen
Summary: This study investigated the association between urinary pentosidine level and the risk of fracture in patients with severe osteoporosis. The results showed that urinary pentosidine level was associated with the incidence of vertebral and nonvertebral fractures, with the strongest association observed for nonvertebral fractures.
Article
Oncology
Daisuke Tomizawa, Shin-ichi Tsujimoto, Shiro Tanaka, Jun Matsubayashi, Takahiro Aoki, Shotaro Iwamoto, Daisuke Hasegawa, Kozo Nagai, Kentaro Nakashima, Koji Kawaguchi, Takao Deguchi, Nobutaka Kiyokawa, Kentaro Ohki, Hidefumi Hiramatsu, Norio Shiba, Kiminori Terui, Akiko Moriya Saito, Motohiro Kato, Takashi Taga, Tsugumichi Koshinaga, Souichi Adachi
Summary: This study aims to establish an appropriate treatment for children with de novo acute myeloid leukemia, based on recurrent leukemic cytogenetic abnormalities and flow-cytometric minimal residual disease. It also aims to validate the safety and efficacy of gemtuzumab ozogamicin combined with post-induction chemotherapy for non-low-risk patients.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2022)