Article
Nutrition & Dietetics
Ching-Ti Liu, David Karasik, Hanfei Xu, Yanhua Zhou, Kerry Broe, L. Adrienne Cupples, Lisette Cpgm de Groot, Annelies Ham, Marian T. Hannan, Yi-Hsiang Hsu, Paul Jacques, Robert R. McLean, Ligi Paul, Jacob Selhub, Katerina Trajanoska, Nathalie van der Velde, Natasja van Schoor, Douglas P. Kiel
Summary: Genetic variants in the 1-carbon methylation pathway have been shown to modify the association of B vitamin and biomarker concentrations with bone density and strength. These interactions provide insights into the mechanistic understanding of the role of the 1-carbon metabolism pathway on bone mineral density and fracture risks, warranting further replication and functional validation.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Orthopedics
Elena Boehm, Eduard Kraft, Johanna Theresia Biebl, Bernd Wegener, Robert Stahl, Isa Feist-Pagenstert
Summary: This study compared the sensitivity and discriminatory power of DXA and QCT in detecting osteoporosis and predicting fractures. The results indicate that QCT is more sensitive than DXA in predicting osteoporosis and fractures.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Orthopedics
Zhuo-Jie Liu, Cheng Zhang, Chi Ma, Huan Qi, Ze-Hong Yang, Hao-Yu Wu, Ke-Di Yang, Jun-Yu Lin, Tak-Man Wong, Zhao-Yang Li, Chun-Hai Li, Yue Ding
Summary: The newly-developed automatic PLQCT system showed higher precision in measuring bone mineral density and diagnosing osteoporosis compared to traditional QCT systems. The system demonstrated good reproducibility and accuracy in diagnosing osteoporosis, with potential for broad clinical application and translational research.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Endocrinology & Metabolism
Yandong Liu, Aihong Yu, Kai Li, Ling Wang, Pengju Huang, Jian Geng, Yong Zhang, Yang-yang Duanmu, Glen M. Blake, Xiaoguang Cheng
Summary: This study evaluated the prevalence of vertebral fractures (VF) among middle-aged and elderly Chinese men and women, and compared the lumbar spine volumetric bone mineral density (vBMD) between those with a grade 1 vertebral fracture and non-fractured individuals. The study found that the prevalence of VF increased rapidly in women after the age of 50, while it grew more slowly in men. Participants with a grade 1 VF had lower vBMD compared to non-fractured individuals, except for men under the age of 50.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Orthopedics
Jelena Jadzic, Slavisa Zagorac, Marija Djuric, Danijela Djonic
Summary: This study compared bone density and hip structure parameters between postmenopausal women with hip osteoarthritis and those with femoral neck fragility fracture. The results showed lower bone density in the femoral neck fracture group. The impact of hip osteoarthritis on hip structure displayed significant regional heterogeneity, with the intertrochanteric region showing the most notable difference.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Nutrition & Dietetics
Pilar Sanchis, Rafael Maria Prieto, Jadwiga Konieczna, Felix Grases, Itziar Abete, Jordi Salas-Salvado, Vicente Martin, Miguel Ruiz-Canela, Nancy Babio, Jesus Francisco Garcia-Gavilan, Albert Goday, Antonia Costa-Bauza, Jose Alfredo Martinez, Dora Romaguera
Summary: The main objective of this study was to examine the relationship between dietary phytate intake and bone mineral density (BMD) in a Mediterranean population of postmenopausal women. The results showed that phytate intake was positively associated with BMD in Mediterranean postmenopausal women, indicating a potential protective effect on bone. However, further large-scale, long-term, and randomized prospective clinical studies are needed to assess the potential benefits of phytate consumption on BMD in postmenopausal women.
Review
Pharmacology & Pharmacy
Jiangbi Li, Yang Sun, Zhuo Chen, Xiaoping Xie, Feng Gu, Songqi Bi, Tiecheng Yu
Summary: This review examined the effects of bisphosphonates on bone density, fractures, and bone markers in osteopenic older women. The study found that bisphosphonates had significant positive effects on bone density and bone markers, as well as reducing the risk of fractures. However, further research is needed to determine their safety.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Luis Gracia-Marco, Sheila Gonzalez-Salvatierra, Antonia Garcia-Martin, Esther Ubago-Guisado, Beatriz Garcia-Fontana, Jose Juan Gil-Cosano, Manuel Munoz-Torres
Summary: This study analyzed differences in 3D DXA parameters at the hip site among patients with acromegaly or AGHD and healthy controls. The study found cortical bone impairment in AGHD patients and highlighted the trochanter as the site with greater cortical bone differences between acromegaly patients and controls. 3D-DXA provided useful information about bone involvement in GH-related disorders, with AGHD patients showing distinct involvement of the cortical structure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Yufeng Ge, Yimin Chen, Gang Liu, Shiwen Zhu, Bo Li, Maoyi Tian, Jing Zhang, Xinbao Wu, Minghui Yang
Summary: This study aimed to investigate the association of hip bone mineral density with mortality risk after hip fracture. The results showed that all hip bone densities were significantly associated with mortality risks, and hip trochanter bone mineral density showed the strongest correlation.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Esther Ubago-Guisado, Enrique Moratalla-Aranda, Sheila Gonzalez-Salvatierra, Jose J. Gil-Cosano, Beatriz Garcia-Fontana, Cristina Garcia-Fontana, Luis Gracia-Marco, Manuel Munoz-Torres
Summary: A study found that patients with type 2 diabetes have a higher risk of bone fractures, but conventional DXA is not useful for identifying this risk. This study aims to evaluate 3D-DXA parameters for determining cortical and trabecular compartments in these patients and identify their determinants.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Victoria L. Bland, Jennifer W. Bea, Robert M. Blew, Denise J. Roe, Vinson R. Lee, Janet L. Funk, Scott B. Going
Summary: The study indicates that changes in total body lean mass and fat mass during adolescence are associated with bone outcomes. Total body lean mass has a greater influence on bone development than total body fat mass, with lean mass being the predominant predictor of bone outcomes.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Katherine N. Haseltine, Tariq Chukir, Pinar J. Smith, Justin T. Jacob, John P. Bilezikian, Azeez Farooki
Summary: Bone mineral density measurement and FRAX assessment tools can help evaluate fracture risk and guide decisions for osteoporosis pharmacologic treatment. Specific populations like postmenopausal women and men over 50 should receive pharmacologic treatment according to guidelines. Monitoring BMD regularly and considering secondary causes or non-compliance is important during treatment.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Aravinda Ganapathy, Jeri W. Nieves, Tony M. Keaveny, Felicia Cosman
Summary: This study evaluated the effects of cyclic and daily teriparatide treatment on vBMD and bone strength at the hip and spine. The results showed that there were no significant differences in the improvement of vBMD and bone strength between the two treatment methods in the spine, while the improvement in the hip was smaller.
Article
Endocrinology & Metabolism
M. M. Delsmann, A. Strahl, M. Muhlenfeld, N. M. Jandl, F. T. Beil, C. Ries, T. Rolvien
Summary: The study found a high prevalence of low bone mineral density in elderly patients with end-stage osteoarthritis scheduled for total hip arthroplasty. Routine DXA measurements should be considered in these patients to prevent undiagnosed and untreated osteoporosis, which could impact the success of osseointegration and other clinical outcomes.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Se-Won Lee, Younghyun Yoon, Junhyuk Kwon, Jun-Young Heu, Jihyo Hwang
Summary: The clinical significance of BMD discordance between the hip and spine for hip fractures was evaluated in this study. The results showed that the rates of BMD discordance and low hip discordance were significantly higher in the hip fracture group than in the non-fracture group, indicating a higher risk of hip fractures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Mahdi Imani, Ebrahim Bani Hassan, Sara Vogrin, Aaron Samuel Tze Nor Ch'Ng, Nancy E. Lane, Jane A. Cauley, Gustavo Duque
Summary: Tissue Compass is a standalone software for semiautomatic segmentation and automatic quantification of musculoskeletal organs, demonstrating high accuracy and reliability in measuring bone, muscle, and fat tissues, which could become a valuable tool for diagnosing tissue loss/gain syndromes in the future.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Richard Eastell, Eric Vittinghoff, Li-Yung Lui, Charles E. McCulloch, Imre Pavo, Arkadi Chines, Sundeep Khosla, Jane A. Cauley, Bruce Mitlak, Douglas C. Bauer, Mary Bouxsein, Dennis M. Black
Summary: The surrogate threshold effect (STE) is defined as the minimum treatment effect on a surrogate that reliably predicts the treatment effect on the clinical outcome. This study aimed to validate the STE for change in total hip (TH) BMD as a surrogate for fracture risk reduction, finding that STE differs by fracture type and has been validated in trials not used to develop the approach.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Geriatrics & Gerontology
Rebekah Harris, Elsa S. Strotmeyer, Leena Sharma, C. Kent Kwoh, Jennifer S. Brach, Robert Boudreau, Jane A. Cauley
Summary: This study examined how the severity of radiographic knee osteoarthritis (KOA) affects recurrent falls in middle-aged and older individuals. The results showed that older adults with radiographic evidence of KOA had a higher likelihood of experiencing recurrent falls compared to those without KOA, regardless of established risk factors. On the other hand, middle-aged adults with KOA did not have an increased odds of recurrent falls, except for those with possible KOA.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Mary E. Winger, Paolo Caserotti, Jane A. Cauley, Robert M. Boudreau, Sara R. Piva, Peggy M. Cawthon, Eric S. Orwoll, Kristine E. Ensrud, Deborah M. Kado, Elsa S. Strotmeyer
Summary: This study investigated the application of lower-extremity power and upper-extremity strength in fall injuries and found that lower leg power and grip strength predicted future fall injury risk in older men, independent of physical performance.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Oncology
Claire E. Thomas, Douglas C. Bauer, Jian-Min Yuan, Jane A. Cauley
Summary: This study assessed the associations between serum concentrations of cytokines and systemic immune biomarkers with the risk of prostate cancer. The results showed that the anti-inflammatory cytokine IL-10 was associated with a lower risk of prostate cancer. Further research on the relationship between IL-10, inflammation, and prostate cancer development is warranted.
CANCER CAUSES & CONTROL
(2023)
Article
Nutrition & Dietetics
Samaneh Farsijani, Jane A. Cauley, Shyamal D. Peddada, Lisa Langsetmo, James M. Shikany, Eric S. Orwoll, Kristine E. Ensrud, Peggy M. Cawthon, Anne B. Newman
Summary: The study found significant associations between dietary protein intake and gut microbiome diversity in community-dwelling older men. Different sources of protein intake also had varying effects on gut microbiome composition. Further research is needed to explore the role of gut microbiome in mediating the relationship between protein intake and health outcomes in older adults.
JOURNAL OF NUTRITION
(2022)
Article
Oncology
Rebecca A. Nelson, Andrew M. Blakely, Joseph C. Larson, Rowan T. Chlebowski, Yi-Jen Chen, Jane A. Cauley, Aladdin H. Shadyab, Lily L. Lai
Summary: This study followed 135,743 postmenopausal women for 17.7 years and found that postmenopausal women with pelvic cancer, especially those who received pelvic radiation, have a higher risk of pelvic fracture and overall mortality. This suggests that prevention of pelvic fractures should be emphasized in pelvic cancer survivors, in addition to cancer treatment.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Geriatrics & Gerontology
Lauren S. Roe, Stephanie Harrison, Peggy M. Cawthon, Kyle D. Moored, Yujia Susanna Qiao, Kristine Ensrud, Katie L. Stone, Kelley Pettee Gabriel, Jane A. Cauley
Summary: Increasing the frequency of active bouts and reducing the duration of sedentary bouts may lower mortality risk among older men, regardless of total sedentary time.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Review
Economics
Nannan Li, Charlotte Beaudart, Jane A. Cauley, Steven W. Ing, Nancy E. Lane, Jean-Yves Reginster, Stuart Silverman, Andrea J. Singer, Mickael Hiligsmann
Summary: This study systematically reviewed economic evaluations of interventions for osteoporosis in men and found that anti-osteoporosis drugs and nutritional supplements are cost-effective for men with osteoporosis. In addition, screening strategies and post-fracture care programs also provide economic benefits for men. The cost-effectiveness and intervention thresholds were generally similar between men and women, with slightly higher incremental cost-effectiveness ratios in men.
Article
Geriatrics & Gerontology
Sharon C. Welburn, Erin E. Fanning, Jane A. Cauley, Patrick J. Brown, Elsa S. Strotmeyer, Robert M. Boudreau, Todd M. Bear, Kyle D. Moored, Peggy M. Cawthon, Katie L. Stone, Nancy W. Glynn
Summary: This study found that both physical and mental fatigability are associated with increased fall risk in elderly men, with physical fatigability increasing the risk by 20% and mental fatigability increasing the risk of recurrent falling by 35% and 44% respectively.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Correction
Economics
Nannan Li, Charlotte Beaudart, Jane A. Cauley, Steven W. Ing, Nancy E. Lane, Jean-Yves Reginster, Stuart Silverman, Andrea J. Singer, Mickael Hiligsmann
Article
Endocrinology & Metabolism
Jane A. Cauley, Howard M. Kravitz, Kristine Ruppert, Yinjuan Lian, Martica J. Hall, Sioban D. Harlow, Joel S. Finkelstein, Gail Greendale
Summary: A study found that self-reported sleep disturbances were associated with an increased risk of fractures across the menopausal transition. However, after adjusting for confounding factors, this association was largely attenuated, suggesting that shared risk factors or other factors in the causal pathway may contribute to the observed relationship.
Article
Endocrinology & Metabolism
Lauren S. Roe, Stephanie Harrison, Peggy M. Cawthon, Kristine Ensrud, Kelley Pettee Gabriel, Deborah M. Kado, Jane A. Cauley
Summary: In addition to the volume of physical activity, frequent breaks from sedentary behavior and active bouts can reduce the risk of falls and fractures. A study found that there is a long-term relationship between the frequency of breaks from sedentary behavior and the occurrence of recurrent falls and fractures. The study also concluded that breaking up extended periods of sedentary time can reduce fall risk, regardless of the total sedentary time.
Article
Endocrinology & Metabolism
Lisa T. Langsetmo, John C. Schousboe, Brent A. Taylor, Jane A. Cauley, Howard M. Fink, Peggy M. Cawthon, Deborah E. Kado, Kristine Ensrud
Summary: Targeted fracture prevention strategies among late-life adults should consider both fracture risk and competing mortality risk. A machine learning method was used to evaluate risk factors and create models for hip fractures and competing mortality among adults aged 80 years and older. Random forest models were compared to Fine-Gray models with six variables. Top variables for predicting hip fractures were bone mineral density, while frailty was associated with competing mortality. Random forest models performed slightly better than Fine-Gray models for predicting mortality, but similarly for predicting hip fractures.
Article
Endocrinology & Metabolism
Joshua I. Barzilay, Petra Buzkova, Howard A. Fink, Jane A. Cauley, Laura Carbone, Rachel Elam, John A. Robbins, Phyllis Stein, Kerry Sheets, Diana Jalal, Kenneth J. Mukamal
Summary: Endothelial dysfunction, which is associated with atherosclerotic vascular disease, was not found to have a significant association with hip fracture risk in older adults based on the examination of two markers of endothelial dysfunction.
ARCHIVES OF OSTEOPOROSIS
(2023)