Article
Endocrinology & Metabolism
Astrid Coassy, Axel Svedbom, Herve Locrelle, Roland Chapurlat, Bernard Cortet, Patrice Fardellone, Philippe Orcel, Christian Roux, Fredrik Borgstrom, John A. Kanis, Thierry Thomas
Summary: This observational study in France prospectively evaluated the costs related to patient management over 18 months following hip, clinical vertebral, humeral, or distal forearm fracture events. The study found that these costs were much higher than previous estimates, increasing the burden of osteoporosis-related fractures on public health expenditures.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Florian Schmidutz, Shuang G. Yan, Christoph Schopf, Christoph Ihle, Marc-Daniel Ahrend, Christoph M. Sprecher
Summary: Cortical thickness at the humerus can predict local bone status reliably when quantitative bone mineral density measurements are unavailable. Standard radiographs and computed tomography can be used to determine humeral cortical bone thickness, providing a quick screening tool for fragility fractures. Additionally, distal forearm aBMD and contralateral humerus can be used to estimate BMD when the ipsilateral side is compromised.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Endocrinology & Metabolism
H. -S. Jung, S. Jang, H. -Y. Chung, S. Y. Park, H. -Y. Kim, Y. -C. Ha, Y. -K. Lee, J. -H. Nho
Summary: A better understanding of the features of subsequent fractures after distal radius fracture (DRF) is important for the prevention of further osteoporotic fractures. This study in South Korea found that the cumulative incidence of subsequent osteoporotic fractures increased over time and that the mortality rates of subsequent DRFs were lower than those of first-time DRFs, with women having higher risk of subsequent fractures.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Alexander Martin Keppler, Moritz Kraus, Matthias Blaschke, Nicole Thomasser, Christian Kammerlander, Wolfgang Boecker, Carl Neuerburg, Ulla Cordula Stumpf
Summary: The study found that overall willingness of osteoporosis patients to undergo further diagnosis was low, with patients with distal radius fractures showing significantly lower awareness compared to proximal femur fracture patients. Younger patients tended to underestimate the risks of osteoporosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Chi-Hoon Oh, Junhyun Kim, Junhan Kim, Siyeong Yoon, Younghoon Jung, Hyun Il Lee, Junwon Choi, Soonchul Lee, Soo-Hong Han
Summary: This study investigated the correlation between distal radius fractures (DRF) and low skeletal muscle mass, and found that female sex, cardiovascular disease (CVD), and low skeletal muscle mass were significant predictors for DRF, while BMI and osteoporosis were not significantly related.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Francesca Von Matthey, Johannes Ruediger Rammensee, Peter Biberthaler, Helen Abel
Summary: This study aimed to analyze the outcome after surgically treated intraarticular DRF, with a focus on gender and age impact using patient-reported outcome measurement (PROM). The results showed that the fracture group had significantly lower MWQ scores compared to the control group. The male and female fracture groups had significantly worse outcomes compared to their respective control groups. Although significantly younger, male patients had similar outcomes to female patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Alessandra Aldieri, Pinaki Bhattacharya, Margaret Paggiosi, Richard Eastell, Alberto Luigi Audenino, Cristina Bignardi, Umberto Morbiducci, Mara Terzini
Summary: This study proposes a statistical model based on three-dimensional shape and intensity for predicting hip fracture risk in Caucasian postmenopausal women. The results show that intensity components outperform shape components in stratifying patients based on their fracture status, and the combination of intensity and shape further improves risk stratification.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Orthopedics
Chao Wang, Yong Zhu, Haitao Long, Zhangyuan Lin, Ruibo Zhao, Buhua Sun, Shushan Zhao, Liang Cheng
Summary: This study defined and analyzed the fracture lines and morphological features of distal humerus fractures using mapping technique. The fracture lines were found to be characteristic and highly related to the micro-architecture difference of the distal humerus, which may offer guidance for treatment plan selection and surgical fixation design.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Orthopedics
Zhenyu Luo, Wei Zhu, Chao Jiang, Wei He, Hua Zuo
Summary: This study investigated the characteristics and seasonal patterns of distal radius fractures (DRFs) over the preceding five years in east China. Female and left-sided fractures were predominant, with the highest proportion in the age group of 61-70 years, and the highest incidence occurred in summer and autumn. Gender differences were also observed between different seasons.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Medicine, General & Internal
Il-Jung Park, Yoo Joon Sur, Jongmin Kim, Jin Hwa Jeon, Ho Youn Park
Summary: Bipolar fractures involving distal radius and radial head are rare injuries that require consideration of both wrist and elbow. Treatment options vary depending on the specific case, with surgical intervention or conservative treatment being viable options. Preserving radial length during surgery is important for optimizing patient outcomes.
Article
Biophysics
Christine Massie, Emma Knapp, Hani A. Awad, Andrew J. Berger
Summary: Raman spectroscopy (RS) can detect biochemical changes in bones through transcutaneous measurements and can potentially be used for fracture risk assessment in osteoporosis. This study found that Raman spectra obtained from phalangeal bones correlate with distal radius fracture strength, which can predict subsequent osteoporotic fractures at the spine and hip. By incorporating phalangeal RS parameters, body mass index, and age, a multivariate regression model significantly predicted distal radius strength.
JOURNAL OF BIOMECHANICS
(2023)
Article
Orthopedics
Sang Beom Ma, Sang Ki Lee, Young Sun An, Woo-suk Kim, Won Sik Choy
Summary: Recent studies suggest that a distal forearm DEXA scan may be a better method for screening bone mineral density and the risk of distal forearm fracture compared to a central DEXA scan. This study aimed to determine the effectiveness of a distal forearm DEXA scan for predicting distal radius fracture in elderly females who were not initially diagnosed with osteoporosis after a central DEXA scan.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Review
Medicine, General & Internal
Hayden P. Baker, Joseph Gutbrod, Jason A. Strelzow, Nicholas H. Maassen, Lewis Shi
Summary: Proximal humerus fractures, the third most common fracture type in adults, have diverse approaches to classification and treatment, with optimal treatments still under debate. This review summarizes current and historical treatment modalities for proximal humerus fractures, providing updates on advancements and trends in epidemiology, classification, and both operative and nonoperative treatments.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Eic Ju Lim, Sunhyung Lee, Jae Kwang Kim, Huijeong Kim, Young Ho Shin
Summary: This study identified older age, diabetes mellitus, previous fracture history, and low total hip BMD as significant risk factors for subsequent fractures after distal radius fracture. Active glycemic control for diabetic patients and more aggressive treatment for those with low BMD may be necessary to prevent subsequent fractures.
JOURNAL OF BONE AND MINERAL METABOLISM
(2022)
Article
Engineering, Biomedical
L. Hug, G. Dahan, S. Kollmannsberger, E. Rank, Z. Yosibash
Summary: A variation of the phase field method embedded into the finite cell method is proposed to simulate impacted humeral fractures in fresh frozen human humeri. The method is validated by comparing the force-strain response, failure loads, and fracture path with experimental observations. The results show good agreement and accurately predict the compressive failure pattern and force-strain relationship in proximal humerus fractures.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Cardiac & Cardiovascular Systems
Michael Kuehne, Philipp Krisai, Michael Coslovsky, Nicolas Rodondi, Andreas Mueller, Jurg H. Beer, Peter Ammann, Angelo Auricchio, Giorgio Moschovitis, Daniel Hayoz, Richard Kobza, Dipen Shah, Frank Peter Stephan, Juerg Schlaepfer, Marcello Di Valentino, Stefanie Aeschbacher, Georg Ehret, Ceylan Eken, Andreas Monsch, Laurent Roten, Matthias Schwenkglenks, Anne Springer, Christian Sticherling, Tobias Reichlin, Christine S. Zuern, Pascal B. Meyre, Steffen Blum, Tim Sinnecker, Jens Wuerfel, Leo H. Bonati, David Conen, Stefan Osswald
Summary: In atrial fibrillation patients, brain infarcts are associated with cognitive decline. The majority of these infarcts are clinically silent and occur in patients receiving anticoagulation therapy.
EUROPEAN HEART JOURNAL
(2022)
Article
Economics
Michaela Barbier, Nicholas Durno, Craig Bennison, Mathias Ortli, Christian Knapp, Matthias Schwenkglenks
Summary: Venetoclax in combination with rituximab showed prolonged overall survival and progression-free survival in patients with relapsed/refractory CLL compared to standard chemoimmunotherapy. From a Swiss healthcare payer perspective, VEN + R was found to be a cost-effective treatment option in comparison to other strategies.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2022)
Article
Economics
Claudine Bommer, Judith Lupatsch, Nicole Burki, Matthias Schwenkglenks
Summary: The study showed that more invasive prophylactic measures, such as PBM&PBSO, can increase life expectancy and quality of life for women with a BRCA1 or BRCA2 mutation in Switzerland, while also being cost-saving for the healthcare system compared to intensified surveillance.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2022)
Article
Health Care Sciences & Services
Flaka Siqeca, Olivia Yip, Maria Jose Mendieta, Matthias Schwenkglenks, Andreas Zeller, Sabina De Geest, Franziska Zuniga, Samuel Stenz, Matthias Briel, Carlos Quinto, Eva Blozik, Mieke Deschodt, Katrina Obas, Suzanne Dhaini
Summary: This study aimed to assess the HRQoL and investigate the correlates of HRQoL among home-dwelling older adults. The study found that better socio-economic status, engagement in social activities, and higher level of education were all associated with better HRQoL, while older age, female gender, presence of multimorbidity and polypharmacy, as well as social isolation and loneliness, had a negative impact on HRQoL.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2022)
Article
Cardiac & Cardiovascular Systems
Helena Aebersold, Miquel Serra-Burriel, Fabienne Foster-Wittassek, Giorgio Moschovitis, Stefanie Aeschbacher, Angelo Auricchio, Juerg Hans Beer, Eva Blozik, Leo H. Bonati, David Conen, Stefan Felder, Carola A. Huber, Michael Kuehne, Andreas Mueller, Jolanda Oberle, Rebecca E. Paladini, Tobias Reichlin, Nicolas Rodondi, Anne Springer, Annina Stauber, Christian Sticherling, Thomas D. Szucs, Stefan Osswald, Matthias Schwenkglenks
Summary: This study analyzed the long-term costs and associated factors of atrial fibrillation (AF). It identified three patient clusters and determined patient characteristics and cost trajectories related to cost allocation. These findings are important for stratification in clinical and economic studies.
Article
Multidisciplinary Sciences
Olivia Yip, Maria Jose Mendieta, Leah L. Zullig, Andreas Zeller, Sabina De Geest, Mieke Deschodt, Flaka Siqeca, Franziska Zuniga, Matthias Briel, Matthias Schwenkglenks, Carlos Quinto, Suzanne Dhaini
Summary: This study aims to assess the feasibility of an integrated care model for home-dwelling older adults in Switzerland. The study will evaluate the implementation of the care model, as well as its acceptability, feasibility, fidelity, and implementation costs.
Article
Health Care Sciences & Services
Paola Salari, Severine Henrard, Cian O'Mahony, Paco Welsing, Arjun Bhadhuri, Katharina Tabea Jungo, Thomas Beck, Denis O'Mahony, Stephen Byrne, Anne Spinewine, Wilma Knol, Nicolas Rodondi, Matthias Schwenkglenks
Summary: Factors such as age, falls, and comorbidities are associated with higher healthcare costs, while being female, housebound, and moderate alcohol consumption are associated with lower health-related quality of life (HRQoL). Being independent in daily activities is associated with lower costs and higher HRQoL.
HEALTH SERVICES INSIGHTS
(2023)
Article
Endocrinology & Metabolism
Jonathan Roos, Daniel Schurch, Andreas Frei, Sophie Lagger, Matthias Schwenkglenks, Andreas Vogt, David Herzig, Lia Bally
Summary: A comparison was made between fully automated closed-loop insulin therapy and standard insulin therapy for perioperative glucose management. The study found that closed-loop insulin therapy reduced the time required for glucose management compared to standard insulin therapy, across different perioperative care periods.
Article
Geriatrics & Gerontology
Francois-Xavier Sibille, Marie de Saint-Hubert, Severine Henrard, Carole Elodie Aubert, Namiko Anna Goto, Emma Jennings, Olivia Dalleur, Nicolas Rodondi, Wilma Knol, Denis O'Mahony, Matthias Schwenkglenks, Anne Spinewine
Summary: This study analyzed the use of benzodiazepine receptor agonists (BZRAs) in middle-aged adults and investigated the rate of BZRA cessation during and after hospitalization. The results showed that nearly a quarter of BZRA users successfully ceased BZRA within 6 months after hospitalization. Therefore, targeted BZRA deprescribing programs could enhance cessation, while specific attention is needed for females, central nervous system-acting co-medication, and comorbidity with chronic obstructive pulmonary disease (COPD).
Article
Medicine, General & Internal
Katharina Tabea Jungo, Anna-Katharina Ansorg, Carmen Floriani, Zsofia Rozsnyai, Nathalie Schwab, Rahel Meier, Fabio Valeri, Odile Stalder, Andreas Limacher, Claudio Schneider, Michael Bagattini, Sven Trelle, Marco Spruit, Matthias Schwenkglenks, Nicolas Rodondi, Sven Streit
Summary: This study aimed to investigate the effects of a primary care medication review intervention centered around an electronic clinical decision support system (eCDSS) on medication appropriateness and prescribing omissions in older adults with multimorbidity and polypharmacy compared to usual care. The results showed inconclusive evidence regarding the improvement in medication appropriateness and reduction in prescribing omissions at 12 months. However, the intervention was safely delivered without causing harm to patients, and fewer safety events were reported in the intervention group at six and twelve months.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Editorial Material
Pharmacology & Pharmacy
Francois R. Girardin, Karen Cohen, Matthias Schwenkglenks, Isabelle Durand-Zaleski
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Sandro Tiziano Stoffel, Matthias Schwenkglenks, Thomas Mutschler
Summary: The study investigated the awareness, drivers, and barriers of pneumococcal vaccination among general practitioners (GPs) in Switzerland. The findings showed that while most GPs were aware of the recommendations for vaccinating at-risk adult patients, their knowledge of all risk groups was limited. GPs reported good arguments to convince patients to get vaccinated, but factors such as patient refusal, lack of reimbursement, and fear of side effects hindered vaccination rates.
Article
Clinical Neurology
Amy Pinsent, Georgie Weston, Elisabeth J. Adams, Warren Linley, Neil Hawkins, Matthias Schwenkglenks, Charlotte Hamlyn-Williams, Toby Toward
Summary: Dravet syndrome (DS) is a rare epileptic disorder characterized by frequent and severe seizures, leading to premature mortality. This study examined the relationship between seizure-free days (SFDs) and quality of life (QoL) for patients and their carers. The results showed that increasing SFDs significantly improved QoL for both patients and carers.
NEUROLOGY AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Nicola Julia Aebi, Iris Baenteli, Gunther Fink, Gunther Meinlschmidt, Rainer Schaefert, Matthias Schwenkglenks, Anja Studer, Sarah Trost, Sibil Tschudin, Kaspar Wyss, SomPsyNet Consortium
Summary: Implementing psychosocial distress assessments in a hospital setting in Switzerland faces challenges, but regular training, feedback, and collaboration with experts can support successful implementation.
Article
Economics
Miquel Serra-Burriel, Helena Aebersold, Fabienne Foster-Witassek, Michael Coslovsky, Nicolas Rodondi, Manuel R. Blum, Christian Sticherling, Giorgio Moschovitis, Juerg H. Beer, Tobias Reichlin, Philipp Krisai, Stefanie Aeschbacher, Rebecca E. Paladini, Michael Kuehne, Stefan Osswald, David Conen, Stefan Felder, Matthias Schwenkglenks
Summary: The study aimed to evaluate the effectiveness and cost-effectiveness of pulmonary vein isolation (PVI) versus medical therapy for atrial fibrillation (AF). Results showed that PVI had a survival advantage and improved quality of life compared to medical therapy over a 5-year period. The incremental cost of PVI was estimated, and the study concluded that it might be a cost-effective intervention within the Swiss healthcare system in a 10-year time horizon.