Article
Endocrinology & Metabolism
Margaret Zacharin, Angelina Lim, James Gryllakis, Aris Siafarikas, Craig Jefferies, Julie Briody, Natasha Heather, Janne Pitkin, Jaiman Emmanuel, Katherine J. Lee, Xiaofang Wang, Peter J. Simm, Craig F. Munns
Summary: The study found that using zoledronic acid in DMD patients significantly improved bone mineral density. Compared to the control group, the ZA group had a significantly higher LS BMD Z-score difference at 12 and 24 months, with no impact on pain, mobility, and bone turnover. Additionally, the ZA group showed improvements in pQCT measurements compared to the control group.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Veterinary Sciences
Ashley A. Smith, Stephanie E. S. Lindley, Greg T. Almond, Noelle S. Bergman, Brad M. Matz, Annette N. Smith
Summary: This study investigated the efficacy of single agent zoledronate in dogs with pulmonary metastases from osteosarcoma and found that it had limited efficacy and may cause adverse reactions.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Endocrinology & Metabolism
Yiling Qian, Yu Zhang, Xiaofang Fan, Hongmei Yan, Xuesong Li, Yujuan Fan, Yuping Song, Shuai Ma, Zheng Hu, Xin Gao, Jialin Yang
Summary: This study found that pregnant women with normal weight and NAFLD have a higher risk for adverse pregnancy outcomes. Even women with normal weight at the start of pregnancy still had a higher odds of adverse pregnancy outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Alessandro Mantovani, Antonio Taverna, Davide Cappelli, Giorgia Beatrice, Alessandro Csermely, Elena Sani, Christopher D. Byrne, Giovanni Targher
Summary: This study found that the presence of Fibroscan(R)-assessed significant fibrosis was associated with a higher risk of developing worse glycaemic control in postmenopausal women with T2DM and NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Yongze Zhang, Peng Gao, Sunjie Yan, Qian Zhang, Ou Wang, Yan Jiang, Xiaoping Xing, Weibo Xia, Mei Li
Summary: This study reported a case of early-onset Paget's disease in an Asian patient, who exhibited Paget's disease without inclusion body myopathy and frontotemporal dementia. The patient showed rapid relief of bone pain and significant decline in ALP, P1NP, and β-CTX levels after treatment with zoledronic acid.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Review
Gastroenterology & Hepatology
Richie Manikat, Mindie H. Nguyen
Summary: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by excess fat accumulation in the liver. It is associated with metabolic syndrome and often presents with comorbidities such as obesity, type 2 diabetes mellitus, and dyslipidemia. NAFLD is also linked to non-liver comorbidities including cardiovascular disease, chronic kidney disease, and sleep apnea. Managing these comorbidities is crucial for improving liver-related and overall health outcomes in patients with NAFLD.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Review
Endocrinology & Metabolism
Ilias D. Vachliotis, Athanasios D. Anastasilakis, Antonis Goulas, Dimitrios G. Goulis, Stergios A. Polyzos
Summary: There is increasing evidence supporting a pathophysiological link between NAFLD and osteoporosis, possibly due to chronic low-grade inflammation. Most epidemiological evidence indicates an association between NAFLD and lower bone mineral density or osteoporosis. Some medications have the potential to treat both NAFLD and osteoporosis, while others may increase fracture risk.
DIABETES OBESITY & METABOLISM
(2022)
Review
Immunology
Wenhui Zhang, Ren Lang
Summary: NAFLD and NASH are significant contributors to liver disease worldwide. Macrophages play a crucial role in the pathogenesis of NAFLD and NASH, and their metabolic characteristics influence their activation state and functionality. Targeting macrophage metabolism could be a promising therapeutic approach for the management of NAFLD/NASH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Shiwei Li, Yuhong Fu, Yue Liu, Xinxin Zhang, Haijun Li, Lei Tian, Lin Zhuo, Ming Liu, Jingqiu Cui
Summary: This study used Mendelian randomization analysis to investigate the causal relationship between serum uric acid (SUA) and nonalcoholic fatty liver disease (NAFLD). The results showed that NAFLD is associated with elevated SUA levels, but elevated SUA levels do not have a causal association with the risk of NAFLD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Ali Aminian, Abbas Al-Kurd, Rickesha Wilson, James Bena, Hana Fayazzadeh, Tavankit Singh, Vance L. Albaugh, Faiz U. Shariff, Noe A. Rodriguez, Jian Jin, Stacy A. Brethauer, Srinivasan Dasarathy, Naim Alkhouri, Philip R. Schauer, Arthur J. McCullough, Steven E. Nissen
Summary: Among patients with NASH and obesity, bariatric surgery was associated with a significantly lower risk of incident major adverse liver outcomes and MACE compared with nonsurgical management.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Gastroenterology & Hepatology
Dong Hyun Sinn, Danbee Kang, Sung Chul Choi, Yun Soo Hong, Di Zhao, Eliseo Guallar, Yewan Park, Juhee Cho, Geum-Youn Gwak
Summary: The clinical implications of nonalcoholic fatty liver disease (NAFLD) in subjects who fulfill the diagnostic criteria of metabolic (dysfunction)-associated fatty liver disease (MAFLD) are unknown.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ying Hong, Lili Sheng, Jing Zhong, Xin Tao, Weize Zhu, Junli Ma, Juan Yan, Aihua Zhao, Xiaojiao Zheng, Gaosong Wu, Bingbing Li, Bangxing Han, Kan Ding, Ningning Zheng, Wei Jia, Houkai Li
Summary: The study supports the use of herb-derived polysaccharides as prebiotics for treating NAFLD by modulating gut microbiome. It demonstrated the anti-NAFLD effect of Astragalus polysaccharides (APS) and the contribution of gut microbiota in HFD-fed mice. The results indicated that APS enriched bacteria such as D. vulgaris are effective in attenuating hepatic steatosis through producing acetic acid and modulating hepatic lipids metabolism.
Article
Endocrinology & Metabolism
Ningning You, Jiali Xu, Liyan Wang, Lili Zhuo, Jingxin Zhou, Yu Song, Aliaweis Ali, Yan Luo, Jin Yang, Wenjun Yang, Minghua Zheng, Jing Xu, Li Shao, Junping Shi
Summary: The study found that there are significant differences in the gut fungal structure of NAFLD patients, and some fungi may be associated with NAFLD development, liver injury, and lipid metabolism. Therefore, research on gut fungi may have important value for diagnosing and monitoring NAFLD.
Article
Medicine, General & Internal
George Adrian Ciobanu, Adrian Camen, Mihaela Ionescu, Daniel Vlad, Cristina Maria Munteanu, Mircea Ionut Gheorghita, Cristian Virgil Lungulescu, Ionela Elisabeta Staicu, Elena Claudia Sin, Luminita Chivu, Razvan Mercut, Sanda Mihaela Popescu
Summary: This study aimed to establish the importance of risk factors in the development of MRONJ in cancer patients receiving zoledronic acid therapy. The analysis of 174 cancer patients revealed that treatment duration, chemotherapy, and hypertension were risk factors, while endocrine therapy and obesity were protective factors for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Fangli Zhou, Xiaoli He, Dan Liu, Yan Ye, Haoming Tian, Li Tian
Summary: Serum ferritin and uric acid levels are closely associated with the risk of NAFLD. The AUC value of serum ferritin and uric acid in the NAFLD group was 0.771.
Article
Cardiac & Cardiovascular Systems
Christos Sachpekidis, Vasileios Sachpekidis, Annette Kopp-Schneider, George Arsos, Efstratios Moralidis
Summary: The study found good repeatability but moderate reproducibility in the assessment of LVEF. In contrast, the findings for diastolic function assessment were less impressive.
JOURNAL OF NUCLEAR CARDIOLOGY
(2021)
Article
Food Science & Technology
Spyridon N. Karras, Theocharis Koufakis, Lilian Adamidou, Stergios A. Polyzos, Paraskevi Karalazou, Katerina Thisiadou, Pantelis Zebekakis, Kali Makedou, Kalliopi Kotsa
Summary: The study found that both a hypocaloric diet based on Orthodox fasting and a time-restricted eating pattern can promote weight loss, but the impact of Orthodox fasting on lipid concentrations is not as significant 6 weeks after its end.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2021)
Editorial Material
Medicine, General & Internal
Michael Doulberis, Apostolis Papaefthymiou, David S. Srivastava, Aristomenis K. Exadaktylos, Panagiotis Katsinelos, Jannis Kountouras, Stergios A. Polyzos
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Review
Medicine, General & Internal
Athanasios D. Anastasilakis, Polyzois Makras, Maria P. Yavropoulou, Gaia Tabacco, Anda Mihaela Naciu, Andrea Palermo
Summary: Denosumab is a potent antiresorptive agent that can increase bone density and reduce fracture rates, but its effects reverse quickly upon discontinuation, leading to bone loss and increased bone turnover. Subsequent antiresorptive treatment is necessary to prevent fractures.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Athanasios D. Anastasilakis, Elena Tsourdi, Gaia Tabacco, Anda Mihaela Naciu, Nicola Napoli, Fabio Vescini, Andrea Palermo
Summary: The study found that there is currently insufficient data to prove the significant impact of bone therapies on glucose metabolism in diabetic patients. It is uncertain whether antiosteoporotic drugs have different effects on fracture incidence between diabetic and nondiabetic patients. More research is needed to address these issues and provide stronger recommendations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Dimitrios Ntelios, Konstantinos Kouskouras, Efstratios Moralidis, Georgios Vosvotekas, Haralampos Karvounis, Georgios Giannakoulas
HEART LUNG AND CIRCULATION
(2021)
Review
Biochemistry & Molecular Biology
Elena Tsourdi, Athanasios D. Anastasilakis
Summary: Pregnancy involves enhanced intestinal calcium absorption, while lactation involves additional calcium obtained through resorption from the maternal skeleton, leading to reversible bone loss. These maternal adaptations during pregnancy and lactation can affect or complicate the presentation, diagnosis, and management of parathyroid disorders.
Review
Medicine, General & Internal
Danae Georgakopoulou, Athanasios D. Anastasilakis, Polyzois Makras
Summary: Langerhans cell histiocytosis (LCH) is a rare inflammatory neoplasia characterized by somatic mutations in the MAPK/ERK pathway. Bone involvement is common in LCH patients, and the treatment approach varies depending on the location, extent, and symptoms of the disease. Individualized treatment is recommended.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Elena Tsourdi, Athanasios D. Anastasilakis, Lorenz C. Hofbauer, Martina Rauner, Franziska Lademann
Summary: Irisin is a hormone-like myokine produced by skeletal muscle during exercise. It plays a role in the browning process, thermogenesis, and regulates the functions of osteoblasts, osteoclasts, and osteocytes. Recent studies have shown that serum irisin levels decrease with age and in conditions involving bone diseases. However, the validity and reproducibility of current methods of irisin measurement are under question.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Athanasios D. Anastasilakis, Polyzois Makras, Julien Paccou, Ilias Bisbinas, Stergios A. Polyzos, Socrates E. Papapoulos
Summary: The management of patients with RVFx requires a multidisciplinary approach, including pain relief, medication administration, back protection, early mobilization, and appropriate exercise.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Athanasios D. Anastasilakis, Stergios A. Polyzos, Panagiotis A. Vorkas, Athina Gkiomisi, Maria P. Yavropoulou, Martina Rauner, Panagiotis Nikolakopoulos, Stergios Papachatzopoulos, Polyzois Makras, Spyridon Gerou, Lorenz C. Hofbauer, Andrea Palermo, Elena Tsourdi
Summary: Menstrual cessation affects lipid metabolism. This study evaluated the effects of goserelin-induced menstrual cessation and subsequent menstrual restoration on lipid metabolism. The results showed that levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and apolipoprotein A1 increased during menstrual cessation, but remained unchanged during menstrual restoration.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Georgia Kaiafa, Dimitrios Pilalas, Triantafyllia Koletsa, Stylianos Daios, Georgios Arsos, Adam Hatzidakis, Adonis Protopapas, Kostas Stamatopoulos, Christos Savopoulos
Summary: ECD is a rare hematopoietic neoplasm characterized by an insidious course. The COVID-19 pandemic has disrupted healthcare services, affecting diagnosis and management of non-COVID-19 diseases. Despite contracting COVID-19, the patient in the case study recovered fully with no further ECD complications, highlighting the importance of suspicion and multidisciplinary collaboration in diagnosing rare conditions like ECD.
MEDICINA-LITHUANIA
(2021)
Letter
Surgery
Michael Doulberis, Apostolis Papaefthymiou, Stergios A. Polyzos, Georgios Kotronis, Dimitra Gialamprinou, Maria Tzitiridou-Chatzopoulou, Maria Touloumtzi, Jannis Kountouras
Article
Endocrinology & Metabolism
Zoe A. Efstathiadou, Charilaos Kostoulas, Stergios A. Polyzos, Fotini Adamidou, Ioannis Georgiou, Marina Kita
Summary: Hajdu-Cheney Syndrome (HCS) is a rare genetic disorder characterized by distinctive facial features, acroosteolysis, and severe osteoporosis. In a Greek pedigree, diverse phenotypes were observed among family members, including fractures and Crohn's disease. The mutation in NOTCH2 gene may play a significant role in bone involvement and development of associated conditions.