Review
Endocrinology & Metabolism
Elahe Hesari, Mahnaz Sanjari, Mohammad Javad Mansourzadeh, Noushin Fahimfar, Kazem Khalagi, Arash Ghazbani, Afshin Ostovar, Akbar Fotouhi
Summary: Poor adherence to osteoporosis treatment leads to lower bone mineral density and higher fracture rates. Reliable and practical measurement tools are needed to assess medication adherence. This systematic review aimed to identify osteoporosis medication adherence measurement tools and evaluate their applicability.
OSTEOPOROSIS INTERNATIONAL
(2023)
Editorial Material
Biology
Erika Kague
Summary: By combining transcriptomic data with genome-wide association studies, researchers can identify genes that play a crucial role in regulating bone mineral density.
Review
Rheumatology
Silvia Migliaccio, Antimo Moretti, Annalisa Biffi, Raffaella Ronco, Gloria Porcu, Giovanni Adami, Rosaria Alvaro, Riccardo Bogini, Achille Patrizio Caputi, Luisella Cianferotti, Bruno Frediani, Davide Gatti, Stefano Gonnelli, Andrea Lenzi, Salvatore Leone, Tiziana Nicoletti, Marco Paoletta, Annalisa Pennini, Eleonora Piccirilli, Raffaella Michieli, Umberto Tarantino, Maurizio Rossini, Giovanni Corrao, Maria Luisa Brandi, Giovanni Iolascon
Summary: This article summarizes the results of a systematic review that examined the association between the continuity of medication treatment and various outcomes in patients with fragility fractures. The findings indicate that adherence to antiosteoporotic drugs can reduce the risk of nonvertebral fractures and refracture, and improve survival rates in patients who continue treatment. Therefore, clinicians should encourage patients to adhere to antiosteoporotic medication.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Article
Multidisciplinary Sciences
Ya-Lian Deng, Chun-Sheng Hsu, Chiann-Yi Hsu, Chih-Hui Chen, Shiang-Ferng Ou, Chin-Feng Liu, Shu-Hui Yang, Chun-Hsi Shih, Yi-Ming Chen, Hsu-Tung Lee
Summary: Osteoporotic fractures have significant impact on quality of life, but half of the patients may discontinue their anti-osteoporosis medication. Factors associated with medication discontinuation include younger age, female gender, non-use of calcium supplements, and anti-resorptive medication.
Article
Endocrinology & Metabolism
Maria Jose Montoya-Garcia, Cristina Carbonell-Abella, Jose Manuel Cancio-Trujillo, Maria Jesus Moro-Alvarez, Jesus Mora-Fernandez, Rafael Izquierdo-Avino, Xavier Nogues, Manuel Mesa-Ramos, Rosa Maria San Segundo-Mozo, Elena Calero-Munoz, Manuel Naves-Diaz, F. Jesus Olmo-Montes, Enric Duaso
Summary: REFRA-FLS is a new registry in Spain aimed at identifying individuals over 50 years old with a fragility fracture. The study found that hip fracture is the most prevalent type of fracture, with a treatment rate of 87.7% and adherence rate of 65.3%. The results provide a comprehensive picture of fragility fractures identified by FLS units in Spain.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Pharmacology & Pharmacy
Sajjad Haider, Sheikh Abdul Khaliq, Syed Baqir Naqvi, Anab Fatima
Summary: This study aims to determine the adherence rate of antiosteoporotic medication using the Medication Possession Ratio. The findings show differences in medication adherence among different socioeconomic classes of postmenopausal osteoporotic women, with higher adherence among those using Alendronate. Additionally, the study found that low-cost antiosteoporotic medications had high adherence rates across all socioeconomic classes, and patients on once weekly oral medications were more adherent compared to those on daily oral or intranasal medications.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Endocrinology & Metabolism
A. Bastounis, T. Langley, S. Davis, Z. Paskins, N. Gittoes, J. Leonardi-Bee, O. Sahota
Summary: This study investigated the persistence and compliance of bisphosphonate treatment and found that users of intravenously administered bisphosphonates were the most adherent. The variations in adherence among different bisphosphonates contribute to a more precise estimation of their clinical and cost-effectiveness.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Mingmin Zhao, Kreshnik Hoti, Hao Wang, Aniruddh Raghu, Dina Katabi
Summary: The study utilizes artificial intelligence and wireless sensors to monitor patient medication use, particularly common errors with inhalers or insulin pens. Results show that the AI framework can automatically detect whether patients are using inhalers or insulin pens correctly, demonstrating potential for improving medication safety.
Article
Biochemistry & Molecular Biology
Julie L. L. Barr, Michael Feehan, Casey Tak, Leah A. A. Owen, Robert C. C. Finley, Parker A. A. Cromwell, John H. H. Lillvis, Patrice M. M. Hicks, Elizabeth Au, Michael H. H. Farkas, Asher Weiner, Andrew L. L. Reynolds, Sandra E. F. Sieminski, Richard M. M. Sherva, Mark A. A. Munger, Murray H. H. Brilliant, Margaret M. M. DeAngelis
Summary: Glaucoma is a major cause of irreversible blindness, affecting 76 million people worldwide. Non-adherence to glaucoma medications is a significant problem despite research and patient education efforts. This study aimed to determine the genetic component behind glaucoma medication non-adherence and identified several genes and variants associated with non-adherence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Klarissa A. A. Sinnappah, Dyfrig A. A. Hughes, Sophie L. L. Stocker, Bernard Vrijens, Jeffrey K. K. Aronson, Daniel F. B. Wright
Summary: This study identifies biases in medication adherence research and proposes a framework for assessing the impact of these biases on different adherence phases. Through literature search and review, a total of 23 biases were identified, with 11 specifically related to adherence measurement and metrics. The mapping framework reveals variations in the number and types of biases associated with each measure and metric and highlights common biases in adherence study designs.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Editorial Material
Geriatrics & Gerontology
Alexandra K. Lee, Sei J. Lee, Sascha Dublin
Summary: This editorial provides commentary on the article titled " ".
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Pharmacology & Pharmacy
Przemyslaw Kardas, Emma Aarnio, Tamas Agh, Job F. M. van Boven, Alexandra Lelia Dima, Cristina Mihaela Ghiciuc, Fatjona Kamberi, Guenka Ivanova Petrova, Urska Nabergoj Makovec, Indre Treciokiene, ENABLE Collaboration
Summary: This study proposes a cohesive set of terms and definitions for medication adherence enabling and supporting activities, filling the gap in existing terminology. This terminology may contribute to research, clinical practice, and policy-making, enhancing medication adherence.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Giulia Rita Agata Mangano, Marianna Avola, Chiara Blatti, Alessia Caldaci, Marco Sapienza, Rita Chiaramonte, Michele Vecchio, Vito Pavone, Gianluca Testa
Summary: This review evaluated reasons for inadequate adherence to osteoporosis therapy and strategies for improving adherence. Aging, polypharmacy, and smoking habits were identified as the most recurrent and significant factors. Strategies such as monitoring via telephone calls, email, and meetings, as well as proactive care interventions and changes in drugs regimen and dispensation were found to improve adherence and persistence. Patient involvement and a flexible drugs regimen were crucial for increasing medication persistence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Emmanuel Delamarche, Yuksel Temiz, Robert D. Lovchik, Michael G. Christiansen, Simone Schuerle
Summary: Medication adherence is a global issue, and recent advancements in microfluidics technology can help enhance it. Capillary microfluidics, known for being self-powered and easy to use, has wide applications in drug monitoring.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Health Care Sciences & Services
Haiyan Qu, Stuart L. Silverman, Richard M. Shewchuk, Jeffrey R. Curtis, Shamly Austin, Susan L. Greenspan, Jeri W. Nieves, Ryan C. Outman, Amy H. Warriner, Nelson B. Watts, Kenneth G. Saag
Summary: This study derives an empirical framework for understanding patient-identified barriers to osteoporosis medication initiation and adherence through surveys and analysis. The findings provide directions for designing interventions to improve medication initiation and adherence in postmenopausal women with fragility fractures.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2022)