Review
Nutrition & Dietetics
Michelle Mages, Mahdieh Shojaa, Matthias Kohl, Simon von Stengel, Clemens Becker, Markus Gosch, Franz Jakob, Katharina Kerschan-Schindl, Bernd Kladny, Nicole Kloeckner, Uwe Lange, Stefan Middeldorf, Stefan Peters, Daniel Schoene, Cornel C. Sieber, Reina Tholen, Friederike E. Thomasius, Michael Uder, Wolfgang Kemmler
Summary: Evidence for the effect of exercise on Bone Mineral Density (BMD) in men is limited compared to postmenopausal women. The study found a low but significant impact of exercise on BMD in men, with no specific exercise recommendations currently available for male cohorts.
Article
Biochemistry & Molecular Biology
Ewa Jowko, Barbara Dlugolecka, Igor Cieslinski, Jadwiga Kotowska
Summary: The aim of this study was to identify relevant factors that affect bone mineral content (BMC) and bone mineral density (BMD) in young, healthy men reaching peak bone mass. The results showed that age, BMI, engaging in combat and team sports at a competitive level, and certain genetic polymorphisms were significant predictors of BMD/BMC at different skeletal sites. Specifically, the SOD2 AG genotype was associated with lower BMC values, while the VDR FokI GG genotype was associated with lower BMD. However, the CALCR AG genotype was linked to higher arm BMD. These findings suggest that sports training may mitigate the negative impact of genetic factors on bone tissue and reduce the risk of osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Kazuyoshi Shigehara, Kouji Izumi, Yoshifumi Kadono, Atsushi Mizokami
Summary: Bone fracture due to osteoporosis is a significant issue for elderly men, and testosterone replacement therapy has shown benefits in improving bone mineral density in symptomatic hypogonadal men with osteopenia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Vinoomika Chandrasekaran, Julie A. Pasco, Amanda L. Stuart, Sharon L. Brennan-Olsen, Michael Berk, Jason M. Hodge, Rasika M. Samarasinghe, Lana J. Williams
Summary: The study found that men using anticonvulsants had lower bone density and quality in the spine and hip compared to non-users, while women using anticonvulsants tended to have lower bone density and quality in the hip. No significant associations were observed at the spine for women. Monitoring bone health for anticonvulsant users is recommended.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Endocrinology & Metabolism
Jakob Starup-Linde, Marie Juul Ornstrup, Thomas Nordstrom Kjaer, Simon Lykkeboe, Aase Handberg, Soren Gregersen, Torben Harslof, Steen Bonlokke Pedersen, Peter Vestergaard, Bente Lomholt Langdahl
Summary: This study compared bone structure, bone density, and bone turnover markers between non-diabetic overweight men with MetS and overweight men with T1D or T2D. The results showed lower bone turnover in men with T2D, but no clinically significant differences in bone density or structure.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Kristine E. Ensrud, Li-Yung Lui, Carolyn J. Crandall, Eric S. Orwoll, Lisa Langsetmo, John T. Schousboe, Howard A. Fink, Nancy E. Lane, Deborah M. Kado, Jane A. Cauley, Marcia L. Stefanick, Peggy M. Cawthon
Summary: This study evaluated the impact of a second bone mineral density (BMD) screening 7 years after the initial screening on fracture prediction in older men. The results showed that repeating the BMD screening did not significantly improve fracture prediction in community-dwelling older men.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Shanshan Xue, Yuzheng Zhang, Wenjing Qiao, Qianqian Zhao, Dingjie Guo, Binbin Li, Xue Shen, Lijie Feng, Fengyi Huang, Na Wang, Kemal Sherefa Oumer, Charkos Tesfaye Getachew, Shuman Yang
Summary: The study updated BMD T-score references using the most recent NHANES data, finding significant differences in the percentages of individuals classified as having osteoporosis and low bone mass between the updated and existing guidelines.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Jiaqiang Zhang, Qinlei Cai, Wangxue Chen, Maoxue Huang, Renyang Guan, Tianbo Jin
Summary: This study evaluated the relationship between the polymorphism of rs7586085, CCDC170, GALNT3 genes and the risk of osteoporosis in the Chinese Han population. The results showed that these gene variations were associated with the risk of osteoporosis in certain genetic models, particularly in specific populations.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Georgia Colleluori, Lina Aguirre, Nicola Napoli, Clifford Qualls, Dennis T. Villareal, Reina Armamento-Villareal
Summary: The study found that hypogonadal men with T2D showed significant improvements in bone mass and density after 18 months of testosterone therapy, while those without T2D did not show significant changes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Desiree Lopez-Gonzalez, Jonathan C. Wells, Mario Cortina-Borja, Mary Fewtrell, Armando Partida-Gaytan, Patricia Clark
Summary: This study provides reference values for relevant bone health variables for healthy Mexican children and adolescents, aiding in more precise assessment of bone health. The reference data include percentiles and gender-specific values. Additionally, height-relative and Tanner-stage reference values are provided.
Article
Medicine, General & Internal
Tzyy-Ling Chuang, Mei-Hua Chuang, Yuh-Feng Wang, Malcolm Koo
Summary: This study aimed to estimate age-specific, normative TBS curves for Taiwanese men and women. Findings revealed that TBS declined at different rates across age groups in women, while it declined at a constant rate in men.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Aleksandra Ryl, Tomasz Miazgowski, Aleksandra Szylinska, Agnieszka Turon-Skrzypinska, Alina Jurewicz, Andrzej Bohatyrewicz, Iwona Rotter
Summary: The results suggest that the Zn/Cu ratio in both the serum and the bone may have a significant positive effect on total bone mineral density (BMD) and bone mineral content (BMC).
Article
Endocrinology & Metabolism
Namki Hong, Jung Ho Kim, Graham Treece, Hyeon Chang Kim, Jun Yong Choi, Yumie Rhee
Summary: Middle-aged men living with human immunodeficiency virus (MLWH) have a significantly higher risk of hip fracture, almost a decade earlier than those without infection. Limited data on cortical and trabecular bone deficit in MLWH were observed. This study found that MLWH had lower hip bone density and deficits in certain bone parameters compared to age and body mass index-matched controls.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Edward Czerwinski, Jose Cardona, Rafal Plebanski, Chris Recknor, Tamara Vokes, Kenneth G. Saag, Neil Binkley, E. Michael Lewiecki, Jonathan Adachi, Dorota Knychas, David Kendler, Eric Orwoll, Yinzhong Chen, Leny Pearman, Y. Heather Li, Bruce Mitlak
Summary: The study shows that Abaloparatide significantly increases bone mineral density in men with osteoporosis and has a safety profile consistent with previous studies. These results suggest that Abaloparatide can be considered as an effective anabolic treatment option for male patients with osteoporosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Heidi J. Kalkwarf, John A. Shepherd, Didier Hans, Elena Gonzalez Rodriguez, Joseph M. Kindler, Joan M. Lappe, Sharon Oberfield, Karen K. Winer, Babette S. Zemel
Summary: This study aimed to develop reference ranges for trabecular bone score (TBS) in youth aged 5 to 20 years and investigate its association with height, body mass index (BMI), and other bone density measures. The findings suggest that TBS Z-scores provide unique information and can be a valuable tool for clinical assessment.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
J. A. Pasco, M. Mohebbi, M. C. Tembo, K. L. Holloway-Kew, N. K. Hyde, L. J. Williams, M. A. Kotowicz
OSTEOPOROSIS INTERNATIONAL
(2020)
Review
Medicine, General & Internal
Joseph M. Danicic, Warrick J. Inder, Mark A. Kotowicz
Summary: Subclinical hypothyroidism (SCH) is common in the Australian population, with higher prevalence in females and the elderly. Current evidence suggests that thyroid hormone therapy may not improve health-related quality of life (HRQoL) in SCH patients, but there may be a subgroup that could benefit. Further research is needed to identify individuals with SCH who may have impaired HRQoL and to explore the effects of thyroid hormone therapy and exercise therapy in these individuals.
INTERNAL MEDICINE JOURNAL
(2021)
Article
Endocrinology & Metabolism
J. Talevski, K. M. Sanders, J. J. Watts, G. C. Nicholson, E. Seeman, S. Iuliano, R. Prince, L. March, T. Winzenberg, G. Duque, P. R. Ebeling, F. Borgstrom, J. A. Kanis, A. L. Stuart, A. Beauchamp, S. L. Brennan-Olsen
Summary: This study of 695 Australian older adults found that men and women had a similar trajectory of health-related quality of life recovery following fragility fracture at any skeletal site. The results provide critical knowledge that improves understanding of health outcomes post-fracture.
OSTEOPOROSIS INTERNATIONAL
(2022)
Editorial Material
Surgery
Shipra Sankpal, Benjamin Scott, Henry R. E. Drysdale, Mark Kotowicz, Sonal Nagra, David A. Watters
ANZ JOURNAL OF SURGERY
(2022)
Article
Endocrinology & Metabolism
Kara L. Holloway-Kew, Pamela Rufus-Membere, Kara B. Anderson, Monica C. Tembo, Sophia X. Sui, Natalie K. Hyde, Adolfo Diez-Perez, Mark A. Kotowicz, Julie A. Pasco
Summary: Weak associations were found between some pQCT-derived bone parameters and BMSi, which remained significant after adjusting for weight, height, and other potential confounders.
Article
Endocrinology & Metabolism
Julie A. Pasco, Sophia X. Sui, Emma C. West, Kara B. Anderson, Pamela Rufus-Membere, Monica C. Tembo, Natalie K. Hyde, Lana J. Williams, Zoe S. J. Liu, Mark A. Kotowicz
Summary: The study found a negative correlation between fatty liver index and muscle density, indicating that accumulation of fat in the liver is associated with fat infiltration into skeletal muscle. Participants in the highest FLI quartile were six times more likely to have sarcopenia, even after adjusting for age and sedentary lifestyle.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Public, Environmental & Occupational Health
Natalie Chilko, Samantha Dean, Leigh M. Matheson, Richard Grills, Adee J. Davidson, Paul Kearns, David Campbell, Margaret J. Rogers, Ian M. Collins
Summary: The study explores the reasons for survival disparities in prostate cancer patients in the Barwon South West area of Victoria. The findings suggest that there is no significant difference in diagnosis and treatment, but the survival rate is lower compared to the national average.
AUSTRALIAN JOURNAL OF RURAL HEALTH
(2022)
Article
Endocrinology & Metabolism
Kara L. Holloway-Kew, Kara B. Anderson, Monica C. Tembo, Sophia X. Sui, Jacob W. Harland, Natalie K. Hyde, Mark A. Kotowicz, Julie A. Pasco
Summary: Individuals with T2DM have higher risk of fracture, but do not have reduced bone mineral density. This study investigated the associations between pQCT and glycaemia status.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Endocrinology & Metabolism
Jasmine R. Cleminson, Julie A. Pasco, Chiara C. Bortolasci, Kara L. Holloway-Kew, Jason M. Hodge, Kara B. Anderson, Mark A. Kotowicz, Rasika M. Samarasinghe, Lana J. Williams
Summary: This study aimed to investigate the association between serum lipopolysaccharide-binding protein (LBP) and potential effects on bone density, quality, and turnover in men. The results showed that LBP was associated with lower bone density at the mid-forearm and broadband ultrasound attenuation measure in heavier participants. However, the data did not support clear associations between serum LBP and bone health.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Emergency Medicine
Bianca E. Kavanagh, Kara L. Holloway-Kew, Timothy Baker, Mohammedreza Mohebbi, Julie A. Pasco, Kayla B. Corney, Mark A. Kotowicz, Shae E. Quirk, Lana J. Williams
Summary: This study aims to examine mental health emergency presentations in the Barwon South West region of Victoria, Australia, which includes urban and rural areas. A retrospective synthesis was conducted on mental health emergency presentations from February 1, 2017 to December 31, 2019. The results showed that neurotic, stress-related and somatoform disorders, as well as mental and behavioural disorders due to psychoactive substance use, were the most frequent types of presentations recorded.
EMERGENCY MEDICINE AUSTRALASIA
(2023)
Article
Endocrinology & Metabolism
Kara L. Holloway-Kew, Kara B. Anderson, Pamela Rufus-Membere, Monica C. Tembo, Sophia X. Sui, Natalie K. Hyde, Mark A. Kotowicz, Stella M. Gwini, Jun Yang, Adolfo Diez-Perez, Maciej Henneberg, Wan-Hui Liao, Julie A. Pasco
Summary: This study investigated the association between components of the RAAS and bone mineral density. The results showed that men with likely primary aldosteronism had lower bone area, suggesting that high levels of ARR may have a negative impact on bone health.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Pamela Rufus-Membere, Kara L. Holloway-Kew, Adolfo Diez-Perez, Natasha M. Appelman-Dijkstra, Mary L. Bouxsein, Erik F. Eriksen, Joshua N. Farr, Sundeep Khosla, Mark A. Kotowicz, Xavier Nogues, Mishaela Rubin, Julie A. Pasco
Summary: Impact microindentation (IMI) is a novel technique for assessing bone material strength index (BMSi) in vivo. The aim of this study was to define the reference intervals for men and women by evaluating healthy adults from multiple countries. BMSi values ranged from 48 to 101, with mean values of 84.4 +/- 6.9 for men and 79.0 +/- 9.1 for women.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Kara L. Holloway-Kew, Pamela G. Rufus-Membere, Kara B. Anderson, Jacob W. Harland, Adolfo Diez-Perez, Mark A. Kotowicz, Julie A. Pasco
Summary: This study compared the bone material strength index (BMSi) values of men and women from the same geographical location in Australia. The results showed that men had significantly higher BMSi values than women, indicating that male bones are more resistant to indentation. This difference persisted even after adjusting for weight and height. Therefore, BMSi may have predictive value for fractures.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Critical Care Medicine
Matthew Thackeray, Mohammadreza Mohebbi, Neil Orford, Mark A. Kotowicz, Julie A. Pasco
Summary: Lean mass was not predictive of ICU admission in this population-based cohort study, but greater appendicular lean mass was associated with reduced 28-day mortality. This suggests pre-ICU muscle status may not predict development of critical illness, but is associated with better survival after critical illness occurs.
Article
Endocrinology & Metabolism
Pamela Rufus-Membere, Kara L. Holloway-Kew, Adolfo Diez-Perez, Mark A. Kotowicz, Julie A. Pasco
Summary: The study found a small positive association between BMSi and quantitative ultrasound parameters, which were not independent of age. There were no correlations between BMSi and BMD, suggesting common age-dependent properties of bone among BMSi and QUS. Further research on the utility of IMI in predicting fracture risk is needed.
JOURNAL OF THE ENDOCRINE SOCIETY
(2021)