Article
Hematology
Katharina Holstein, Leonora Witt, Anna Matysiak, Constantin Schmidt, Florian Barvencik, Michael Amling, Tim Rolvien, Florian Langer
Summary: Low bone mineral density is common in hemophilia patients, influenced by factors such as bone turnover, body mass index, inflammation, treatment regimen, joint status, and HCV infection. Self-reported sportive activity has a positive effect on bone mineral density.
THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Nutrition & Dietetics
Michelle Mages, Mahdieh Shojaa, Matthias Kohl, Simon von Stengel, Clemens Becker, Markus Gosch, Franz Jakob, Katharina Kerschan-Schindl, Bernd Kladny, Nicole Kloeckner, Uwe Lange, Stefan Middeldorf, Stefan Peters, Daniel Schoene, Cornel C. Sieber, Reina Tholen, Friederike E. Thomasius, Michael Uder, Wolfgang Kemmler
Summary: Evidence for the effect of exercise on Bone Mineral Density (BMD) in men is limited compared to postmenopausal women. The study found a low but significant impact of exercise on BMD in men, with no specific exercise recommendations currently available for male cohorts.
Article
Nutrition & Dietetics
Mariangela Rondanelli, Milena Anna Faliva, Gaetan Claude Barrile, Alessandro Cavioni, Francesca Mansueto, Giuseppe Mazzola, Letizia Oberto, Zaira Patelli, Martina Pirola, Alice Tartara, Antonella Riva, Giovanna Petrangolini, Gabriella Peroni
Summary: This review evaluates the ideal dietary approach to reduce bone mineral density loss and suggests a food pyramid for osteopenia/osteoporosis patients. The pyramid emphasizes daily consumption of carbohydrates, fruits, vegetables, light yogurt, skim milk, extra virgin olive oil, and calcium water. Weekly portions include fish, white meat, legumes, eggs, cheeses, and red/processed meats. The pyramid also highlights the need for personalized supplementation and identifies certain foods to be avoided. Additionally, regular aerobic and resistance exercises are recommended.
Article
Nutrition & Dietetics
Jae Hyun Lee, Ae Wha Ha, Woo Kyoung Kim, Sun Hyo Kim
Summary: This study found that bone mineral density in adolescents is significantly associated with both milk intake and physical activity. Among males, those in the group with no milk intake and low-level physical activity had the lowest BMD, while females in the group with milk intake and high-level physical activity showed significantly higher lumbar BMD values compared to other groups. These results suggest that encouraging moderate to vigorous physical activity and milk intake during adolescence is important for healthy bone growth.
Article
Biochemistry & Molecular Biology
Ewa Jowko, Barbara Dlugolecka, Igor Cieslinski, Jadwiga Kotowska
Summary: The aim of this study was to identify relevant factors that affect bone mineral content (BMC) and bone mineral density (BMD) in young, healthy men reaching peak bone mass. The results showed that age, BMI, engaging in combat and team sports at a competitive level, and certain genetic polymorphisms were significant predictors of BMD/BMC at different skeletal sites. Specifically, the SOD2 AG genotype was associated with lower BMC values, while the VDR FokI GG genotype was associated with lower BMD. However, the CALCR AG genotype was linked to higher arm BMD. These findings suggest that sports training may mitigate the negative impact of genetic factors on bone tissue and reduce the risk of osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Kazuyoshi Shigehara, Kouji Izumi, Yoshifumi Kadono, Atsushi Mizokami
Summary: Bone fracture due to osteoporosis is a significant issue for elderly men, and testosterone replacement therapy has shown benefits in improving bone mineral density in symptomatic hypogonadal men with osteopenia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Tiina Savikangas, Sarianna Sipila, Timo Rantalainen
Summary: The study found that light physical activity may help decelerate bone loss in older adults who do not meet physical activity recommendations, while the amount of high impact activity may be insufficient to stimulate bone remodelling in this population.
Article
Oncology
Ruedi Jung, Simeon J. Zuercher, Christina Schindera, Prisca Eser, Christian Meier, Anna Schai, Julia Braun, Wei Hai Deng, Helge Hebestreit, Cornelia Neuhaus, Jonathan Schaeff, Corina S. Rueegg, Nicolas X. von der Weid, Susi Kriemler
Summary: The effects of a one-year general exercise intervention on lower body bone parameters of childhood cancer survivors remain controversial. The study found that compliant participants showed improvements in femoral neck and trabecular bone mineral density, suggesting personalized exercise programs may benefit those in need. However, the study also suggests that nonstandardized exercise programs may not be specific enough to promote bone health in childhood cancer survivors. Future trials should target risk groups and incorporate motivational features to maximize compliance.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Endocrinology & Metabolism
P. Ferrer, I. Iglesia, B. Muniz-Pardos, M. L. Miguel-Berges, P. Flores-Barrantes, A. Gomez-Bruton, L. A. Moreno, G. Rodriguez
Summary: The study found that meeting World Health Organization physical activity recommendations has a beneficial effect on bone composition in childhood, not only for boys, but also for girls.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Jakob Starup-Linde, Marie Juul Ornstrup, Thomas Nordstrom Kjaer, Simon Lykkeboe, Aase Handberg, Soren Gregersen, Torben Harslof, Steen Bonlokke Pedersen, Peter Vestergaard, Bente Lomholt Langdahl
Summary: This study compared bone structure, bone density, and bone turnover markers between non-diabetic overweight men with MetS and overweight men with T1D or T2D. The results showed lower bone turnover in men with T2D, but no clinically significant differences in bone density or structure.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Yuto Sakurai, Michitaka Honda, Hidetaka Kawamura, Hiroshi Kobayashi, Satoshi Toshiyama, Ryuya Yamamoto, Eiichi Nakao, Cong Yue, Minoru Takano, Keishi Hayao, Shinichi Konno
Summary: This study investigated the relationship between postoperative physical activity and bone mineral density (BMD) change in gastric cancer patients. The results showed that low physical activity after surgery is an independent risk factor for decreased BMD. Therefore, the introduction of exercise is necessary to prevent osteoporosis after gastric cancer surgical treatment.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Endocrinology & Metabolism
Bjorn E. Rosengren, Erik Lindgren, Lars Jehpsson, Magnus Dencker, Magnus K. Karlsson
Summary: The study shows that daily school physical activity has long-lasting benefits on musculoskeletal traits even 4 years after the intervention. Significant increases in bone mass and muscle strength were observed in the intervention group compared to the control group.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Kristine E. Ensrud, Li-Yung Lui, Carolyn J. Crandall, Eric S. Orwoll, Lisa Langsetmo, John T. Schousboe, Howard A. Fink, Nancy E. Lane, Deborah M. Kado, Jane A. Cauley, Marcia L. Stefanick, Peggy M. Cawthon
Summary: This study evaluated the impact of a second bone mineral density (BMD) screening 7 years after the initial screening on fracture prediction in older men. The results showed that repeating the BMD screening did not significantly improve fracture prediction in community-dwelling older men.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Georgia Colleluori, Lina Aguirre, Nicola Napoli, Clifford Qualls, Dennis T. Villareal, Reina Armamento-Villareal
Summary: The study found that hypogonadal men with T2D showed significant improvements in bone mass and density after 18 months of testosterone therapy, while those without T2D did not show significant changes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Aleksandra Ryl, Tomasz Miazgowski, Aleksandra Szylinska, Agnieszka Turon-Skrzypinska, Alina Jurewicz, Andrzej Bohatyrewicz, Iwona Rotter
Summary: The results suggest that the Zn/Cu ratio in both the serum and the bone may have a significant positive effect on total bone mineral density (BMD) and bone mineral content (BMC).
Article
Gastroenterology & Hepatology
Gudmundur Vignir Sigurdsson, Susanne Schmidt, Dan Mellstrom, Claes Ohlsson, Robert Saalman, Mattias Lorentzon
Summary: Young adult men with childhood-onset IBD have decreased bone quality in both cortical and trabecular bone structures compared to age- and height-matched controls. This has implications for their skeletal health and quality of life.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Endocrinology & Metabolism
John A. A. Kanis, Helena Johansson, Nicholas C. C. Harvey, Mattias Lorentzon, Enwu Liu, Liesbeth Vandenput, Suzanne Morin, William D. D. Leslie, Eugene V. V. McCloskey
Summary: This study confirms the association between a greater propensity to falling and higher fracture risk, and provides adjustments to FRAX-based fracture probabilities accounting for the number of prior falls.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
John A. Kanis, Nicholas C. Harvey, Enwu Liu, Liesbeth Vandenput, Mattias Lorentzon, Eugene McCloskey, Roger Bouillon, Bo Abrahamsen, Lars Rejnmark, Helena Johansson
Summary: Patients with primary hyperparathyroidism have increased incidence of hip and major osteoporotic fractures, even if not referred for parathyroidectomy. The risk of death is also increased, which affects fracture probability. These findings support the need to widen the indications for parathyroidectomy in mild primary hyperparathyroidism.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Kristian F. Axelsson, Henrik Litsne, Konstantina Kousoula, Stefan Franzen, Bjoern Eliasson, Mattias Lorentzon
Summary: This study aimed to determine whether patients with type 2 diabetes mellitus (T2DM) have an increased risk of fracture and to identify T2DM-related risk factors. The findings showed that the overall risk of fracture was only slightly increased for T2DM patients compared to controls, but for patients with specific risk factors, such as low BMI, long T2DM duration, insulin treatment, and/or low physical activity, the risk increase was more substantial and clinically relevant.
Article
Geriatrics & Gerontology
Leo D. Westbury, Charlotte Beaudart, Olivier Bruyere, Jane A. Cauley, Peggy Cawthon, Alfonso J. Cruz-Jentoft, Elizabeth M. Curtis, Kristine Ensrud, Roger A. Fielding, Helena Johansson, John A. Kanis, Magnus K. Karlsson, Nancy E. Lane, Laetitia Lengele, Mattias Lorentzon, Eugene McCloskey, Dan Mellstrom, Anne B. Newman, Claes Ohlsson, Eric Orwoll, Jean-Yves Reginster, Eva Ribom, Bjorn E. Rosengren, John T. Schousboe, Eric J. Shiroma, Nicholas C. Harvey, Elaine M. Dennison, Cyrus Cooper
Summary: The performance of recent sarcopenia definitions in terms of thresholds employed, concordance in individuals, and prediction of important health-related outcomes such as death is limited. This study addressed these limitations in a large multinational cohort study.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Endocrinology & Metabolism
M. Schini, P. Bhatia, H. Shreef, H. Johansson, N. C. Harvey, M. Lorentzon, J. A. Kanis, O. Bandmann, E. V. McCloskey
Summary: This study examined the relative contributions of muscle strength, falls risk, and low bone mineral density to increased fracture risk in Parkinson's Disease (PD) patients. It found that PD patients had lower bone density and weaker muscle strength, leading to a higher risk of fractures. Therefore, Parkinson's Disease may be an independent risk factor for fractures.
Article
Endocrinology & Metabolism
Kristian F. Axelsson, Henrik Litsne, Mattias Lorentzon
Summary: There is limited evidence on which fracture types carry the highest risk for subsequent fractures. Recent fractures, including major osteoporotic fractures and non-major osteoporotic fractures, as well as older fractures, increase the risk of subsequent fracture. Therefore, it is recommended to include all recent fractures in fracture liaison services and consider case-finding strategies for those with older fractures to prevent further fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Raju Jaiswal, Michail Zoulakis, Kristian F. Axelsson, Anna Darelid, Robert Rudang, Daniel Sundh, Henrik Litsne, Lisa Johansson, Mattias Lorentzon
Summary: This prospective cohort study aimed to evaluate the association between the bone material strength index (BMSi) and the risk of incident fracture in older women. The study found that increasing BMSi was associated with a greater risk of fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
William D. Leslie, Neil Binkley, Eugene V. McCloskey, Helena Johansson, Nicholas C. Harvey, Mattias Lorentzon, John A. Kanis, Didier Hans
Summary: The study found that TBS can be used to predict fracture risk independently of FRAX. Adding TBS to the FRAX calculation can adjust for femoral neck BMD and improve fracture risk prediction, even without measuring hip DXA.
JOURNAL OF CLINICAL DENSITOMETRY
(2023)
Article
Endocrinology & Metabolism
Louise Grahnemo, Anna L. Eriksson, Maria Nethander, Robert Johansson, Mattias Lorentzon, Dan Mellstroem, Ulrika Pettersson-Kymmer, Claes Ohlsson
Summary: This study found a robust association between circulating valine and hip fractures, which was confirmed in a replication study. Further analysis showed that high circulating valine levels were associated with increased cortical bone area and trabecular thickness. Therefore, circulating valine may be an important marker for predicting hip fractures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Kristian F. Axelsson, Henrik Litsne, Mattias Lorentzon
Summary: This retrospective cohort study investigated the risk of fracture and injurious falls in immobilized adults who used wheelchairs compared with matched ambulatory controls. The results showed that wheelchair users had a lower risk of any fracture, major osteoporotic fracture, and hip fracture compared with the controls, while the risk of fall injury was also lower. However, wheelchair users had a significantly increased risk of death.
Article
Rheumatology
Karin Bengtsson, Johan Askling, Mattias Lorentzon, Bjoern Rosengren, Anna Deminger, Eva Klingberg, Lennart Jacobsson, Helena Forsblad-d'Elia
Summary: Both men and women with AS have a slightly higher risk of non-vertebral fractures than the general population, with men having a particularly higher risk of fractures of the proximal humerus, distal forearm or hip.
Editorial Material
Endocrinology & Metabolism
Mattias Lorentzon, Andrew J. Burghardt
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Letter
Endocrinology & Metabolism
Raju Jaiswal, Michail Zoulakis, Kristian F. Axelsson, Daniel Sundh, Henrik Litsne, Lisa Johansson, Mattias Lorentzon
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)