Article
Nutrition & Dietetics
Inge A. L. P. van Beijsterveldt, Manouk van der Steen, Kirsten S. de Fluiter, Sander A. M. J. Spaans, Anita C. S. Hokken-Koelega
Summary: Childhood obesity is a global public health threat, and this study provides sex-specific reference values and charts for body composition and bone mineral density in children aged 2-5 years.
CLINICAL NUTRITION
(2022)
Article
Medicine, General & Internal
Chun-Hsiang Chan, Wen-Chi Huang, Yi-Chien Lu, Hsing-Fen Hsiao, Wing P. Chan
Summary: BatchBMD is a rule-based automated reporting system that accelerates the generation of DXA reports and improves accuracy. Compared to a Web-based reporting system, BatchBMD outperforms in reporting time and accuracy, significantly reducing workload for radiologists and technicians.
Article
Agriculture, Dairy & Animal Science
C. Kasper, P. Schlegel, I. Ruiz-Ascacibar, P. Stoll, G. Bee
Summary: Studies in animal science show that DXA measurements may not perfectly match dissections or chemical analyses, requiring calibration equations. Predictions related to body composition and single nutrient content in pigs show promising results, with potential for creating generic regression equations that yield reliable estimates. DXA could be a useful tool for high-throughput phenotyping in genetic studies, efficiently measuring body composition in a wide range of animals.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chumin Zhao, Magdalena Herbst, Thomas Weber, Christoph Luckner, Sebastian Vogt, Ludwig Ritschl, Steffen Kappler, Jeffrey H. Siewerdsen, Wojciech Zbijewski
Summary: The study investigated the feasibility of slot-scan dual-energy bone densitometry on motorized radiographic equipment for fast quantitative measurements of areal bone mineral density. Results showed accurate and reproducible aBMD measurements across different body sizes and positioning with small errors. Empirical evaluations confirmed the reduction in aBMD errors with proposed procedures on robotic x-ray systems.
Article
Multidisciplinary Sciences
Luis Fernando Escobar Guzman, Neuza Helena Moreira Lopes, Georgea H. Fernandes Torres, Liliam Takayama, Solange de Sousa Andrade, Jose Ramon Lanz-Luces, Rosa Maria R. Pereira, Carlos Eduardo Rochitte
Summary: Epidemiological studies have shown a correlation between osteoporosis and the risk of ischemic cardiovascular disease. In this study based on the SPAH study, researchers found an association between coronary calcification and bone microarchitecture in older adults. The results suggest an inverse relationship between CAC and cortical bone content, as assessed by HR-pQCT, with higher coronary calcification in individuals older than 65 years.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Mateus Augusto Bim, Andre de Araujo Pinto, Hector Cris Colares de Angelo, Isadora Gonzaga, Adriana Coutinho de Azevedo Guimaraes, Erico Pereira Gomes Felden, Wellington Roberto Gomes de Carvalho, Karen Hind, Andreia Pelegrini
Summary: This study aimed to assess the relationship between bone mass and lean mass (LM) and fat mass (FM) in normal-weight and overweight adolescents. The results showed that only LM was associated with bone mass in both normal-weight and overweight adolescents. LM was found to be the main predictor of bone mass in these groups.
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthew Allan Thomas, Jorge Ernesto Jimenez, Samuel John Fahrenholtz, Khushnood Hamdani, William Daniel Erwin
Summary: This study examines the unique measurement and quality-control strategies in dual-energy X-ray absorptiometry (DXA) and analyzes the dependence of measured entrance-air-kerma (EAK) on dose sensor type and scan length. The feasibility of using EAK to compare scanner output and the congruence between measured and vendor-reported EAK were also established. The results suggest that DXA scanner stability can be quantified using EAK as a quality-control metric with a variety of solid-state and ion chamber (IC) dose sensors. Measured EAK may vary significantly between different scanners, indicating that measured and reported EAK may not always be comparable.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Geriatrics & Gerontology
Wentao Lin, Chaoqin He, Faqin Xie, Tao Chen, Guanghao Zheng, Houjie Yin, Haixiong Chen, Zhiyun Wang
Summary: In this study, the authors assessed the diagnostic discordance between lumbar osteoporosis detected by QCT and DXA, and evaluated their predictive performance for prevalent vertebral fracture. The results showed that in older patients undergoing spinal surgery, QCT-vBMD is more helpful than DXA in terms of osteoporosis detection rate and prediction of patients with prevalent VFs.
Article
Multidisciplinary Sciences
Lei Deng, Yue Yao, A. -Li Shang, Tongtong Du, Jingbin Zhang, Quanxin Yang, Jianying Li, Qian Wang, Xiaohui Li
Summary: The study evaluated the feasibility of using DECT and CT values for opportunistic screening of osteoporosis in postmenopausal females. The results showed a moderate-high correlation between HAP and CT value with DXA measurements for diagnosing osteoporosis. The cutoff values of HAP and CT value for diagnosing osteoporosis were determined to be 142.05 mg/cm3 and 132 HU, respectively.
SCIENTIFIC REPORTS
(2022)
Review
Pediatrics
Hedieh Khalatbari, Larry A. Binkovitz, Marguerite T. Parisi
Summary: The manuscript offers a practical review and update on the interpretation of DXA in pediatric patients, including historical perspectives and discussion of the 2019 Official Position Statements from the International Society of Clinical Densitometry.
PEDIATRIC RADIOLOGY
(2021)
Article
Endocrinology & Metabolism
Hyun Woo Park, Hyojung Jung, Kyoung Yeon Back, Hyeon Ju Choi, Kwang Sun Ryu, Hyo Soung Cha, Eun Kyung Lee, A. Ram Hong, Yul Hwangbo
Summary: In individuals under the recommended age for DXA examination, the XGBoost model demonstrated reliable performance in predicting osteoporosis, surpassing conventional risk assessment tools.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Jia-Liang Chen, Yao Liu, Yu-Fei Bi, Xian-Bo Wang
Summary: This study assessed the prevalence and clinical characteristics of osteoporosis in Chinese patients with PBC. The results showed that osteoporosis is very common in PBC patients, with older age, lower BMI, previous steroid therapy, and advanced liver disease being the main independent risk factors.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Transplantation
Alexander D. Lalayiannis, Nicola J. Crabtree, Charles J. Ferro, Varvara Askiti, Andromachi Mitsioni, Lorenzo Biassoni, Amrit Kaur, Manish D. Sinha, David C. Wheeler, Neill D. Duncan, Joyce Popoola, David Milford, Jin Long, Mary Beth Leonard, Mary Fewtrell, Rukshana Shroff
Summary: This study found that in CKD patients, those on dialysis had lower CortBMD and cortical mineral content Z-scores, and DXA measurements were not predictive of bone density. Biomarkers PTH, ALP, and Ca were moderate predictors of CortBMD, with DXA not improving the predictive model.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Endocrinology & Metabolism
Dilki Madhuchani, Sumudu Nimali Seneviratne, Leanne M. Ward
Summary: Bone accrual in childhood affects bone health later in life. Early loss of bone strength can lead to health issues and lower quality of life in childhood and adolescence. Improved assessment tools and treatment options, along with awareness of fracture history and risk factors, have enhanced the detection and management of bone fragility in children globally.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bin Guo, Qijun Cai, Jinci Mai, Lu Hou, Chunyuan Zeng, Jiefeng Gan, Zhiqiang Tan, Yuefeng Li, Yong Cheng, Jingjie Shang, Yongjin Tang, Xueying Ling, Jian Gong, Lu Wang, Hao Xu
Summary: The study investigated the precision of DXA detection in cynomolgus monkeys and identified the difference in precision in lumbar bone mineral density with various segment selections. Results showed excellent reproducibility of DXA measurements in nonhuman primates, making it a reliable tool for total and regional measurement in skeletal research and evaluation of osteoporosis treatment with monkeys as animal models.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Medical Laboratory Technology
Kathrin Geiger, Andreas Leiherer, Eva-Maria Brandtner, Peter Fraunberger, Heinz Drexel, Axel Muendlein
CLINICA CHIMICA ACTA
(2019)
Article
Biochemistry & Molecular Biology
Axel Muendlein, Andreas Leiherer, Christina Zach, Eva Maria Brandtner, Peter Fraunberger, Heinz Drexel, Kathrin Geiger
MOLECULAR BIOLOGY REPORTS
(2019)
Review
Cardiac & Cardiovascular Systems
Heinz Drexel, Giuseppe M. C. Rosano, Basil S. Lewis, Kurt Huber, Alexander Vonbank, Joern F. Dopheide, Arthur Mader, Alexander Niessner, Gianluigi Savarese, Sven Wassmann, Stefan Agewall
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2020)
Article
Cell Biology
Kathrin Geiger, Christina Zach, Andreas Leiherer, Peter Fraunberger, Heinz Drexel, Axel Muendlein
Article
Cardiac & Cardiovascular Systems
Jorn F. Dopheide, Jonas Veit, Hana Ramadani, Luise Adam, Lucija Papac, Alexander Vonbank, Mathias Kaspar, Aljoscha Rastan, Iris Baumgartner, Heinz Drexel
Summary: Adherence to statin therapy is associated with reduced mortality in symptomatic PAD patients, and a strategy of intensive and sustained statin therapy is recommended for these patients.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Christoph H. Saely, Simon Sternbauer, Alexander Vonbank, Christine Heinzle, Daniela Zanolin-Purin, Barbara Larcher, Arthur Mader, Andreas Leiherer, Axel Muendlein, Heinz Drexel
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2020)
Article
Endocrinology & Metabolism
Eva Maria Brandtner, Axel Muendlein, Andreas Leiherer, Franz Paul Armbruster, Thomas Bernd Dschietzig, Kathrin Geiger, Peter Fraunberger, Christoph H. Saely, Heinz Drexel
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Biochemistry & Molecular Biology
Andreas Leiherer, Daria Slefarska, Marcis Leja, Christine Heinzle, Axel Muendlein, Ilze Kikuste, Linda Mezmale, Heinz Drexel, Chris A. Mayhew, Pawel Mochalski
Summary: Several studies have reported the presence of certain volatile biomarkers in the breath of patients with gastric cancer, and investigations into gastric cancer cells can help reveal the biochemical pathways underlying these compounds. The use of gas chromatography with mass spectrometric detection can map the volatile footprints of gastric cancer cells and normal gastric epithelial cells, allowing for differentiation between cancerous and healthy cells. This study found altered metabolism in gastric cancer cells compared to normal cells, with unique volatile markers identified in cancer cells.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Multidisciplinary Sciences
Axel Muendlein, Kathrin Geiger, Stella Gaenger, Tobias Dechow, Christoph Nonnenbroich, Andreas Leiherer, Heinz Drexel, Andreas Gaumann, Wolfgang Jagla, Thomas Winder, Frank Mayer, Thomas Decker
Summary: Mutational analysis of circulating tumor DNA shows promise in predicting the prognosis of metastatic breast cancer, with the number of mutations correlating with progression free survival and overall survival. Mutational status of ESR1 and TP53 can serve as predictive markers for patient outcomes in advanced breast cancer management.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Andreas Leiherer, Hanno Ulmer, Axel Muendlein, Christoph H. Saely, Alexander Vonbank, Peter Fraunberger, Bernhard Foeger, Eva Maria Brandtner, Wolfgang Brozek, Gabriele Nagel, Emanuel Zitt, Heinz Drexel, Hans Concin
Summary: Early measurement of total cholesterol (TC) was significantly associated with increased risk of significant coronary artery disease, cardiovascular events, and cardiovascular death, while TC measured later in life showed no significant association with these outcomes. Additionally, using earlier TC readings was found to improve the accuracy of cardiovascular mortality prediction.
Article
Endocrinology & Metabolism
Christoph H. Saely, Maximilian Maechler, Alexander Vonbank, Lukas Sprenger, Arthur Mader, Barbara Larcher, Daniela Zanolin-Purin, Andreas Leiherer, Axel Muendlein, Heinz Drexel
Summary: The study found that type 2 diabetes mellitus and congestive heart failure are independent predictors of albuminuria, and they independently affect the levels of urine albumin.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Medicine, General & Internal
Andreas Leiherer, Axel Muendlein, Eva Maria Brandtner, Christoph H. Saely, Hana Ramadani, Alexander Vonbank, Arthur Mader, Jorn F. Dopheide, Antti Jylha, Mitja Laaperi, Reijo Laaksonen, Winfried Maerz, Peter Fraunberger, Marcus Kleber, Heinz Drexel
Summary: This study found significant differences in markers of inflammation, ceramide, and phosphatidylcholine levels between PAD and CAD patients, while basic lipid markers did not significantly differ. Ratios and scores derived from ceramides and phosphatidylcholines improved the discrimination between PAD and CAD.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Andreas Leiherer, Axel Muendlein, Reijo Laaksonen, Mitja Laaperi, Antti Jylha, Peter Fraunberger, Heinz Drexel
Summary: Ceramides are new biomarkers for cardiovascular disease. CERT and CERT2 are powerful predictors of cardiovascular events, cardiovascular mortality, and overall mortality in CVD patients. Including phosphatidylcholine in the score improves predictive performance.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Wijtske Annema, Joanna Gawinecka, Axel Muendlein, Christoph H. Saely, Heinz Drexel, Arnold von Eckardstein
Summary: This study found that serum apoD levels are closely associated with cardiovascular risk factors, and high levels of apoD are indicators of poor prognosis in patients with coronary artery disease.
Article
Endocrinology & Metabolism
Lukas Sprenger, Arthur Mader, Barbara Larcher, Maximilian Maechler, Alexander Vonbank, Daniela Zanolin-Purin, Andreas Leiherer, Axel Muendlein, Heinz Drexel, Christoph H. Saely
Summary: The study found that patients with both type 2 diabetes and peripheral artery disease are at significantly higher risk of cardiovascular events, and the presence of T2DM and PAD are mutually independent predictors of major adverse cardiovascular events.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)