Review
Nutrition & Dietetics
Rakesh Balachandar, Raghu Pullakhandam, Bharati Kulkarni, Harshpal Singh Sachdev
Summary: This study found that cholecalciferol was more effective than ergocalciferol in improving vitamin D status and regulating PTH levels, regardless of participant demographics, dosage, and vehicle of supplementation.
Article
Nutrition & Dietetics
Ola Hysaj, Patricia Marques-Gallego, Aline Richard, Magdeldin Elgizouli, Alexandra Nieters, Katharina C. Quack Lotscher, Sabine Rohrmann
Summary: This study assessed parathyroid hormone concentrations in pregnant women during early and late pregnancy, finding an inverse correlation between serum 25(OH)D and PTH levels. Statistically significant determinants of PTH concentrations included 25(OH)D levels, season, parity, and partner's education in early pregnancy, while late pregnancy was affected by 25(OH)D levels and country of origin. These factors seem to primarily impact PTH through 25(OH)D, but may also have other mechanisms of influence.
Article
Endocrinology & Metabolism
Jing Cheng, Jianhua Zhai, Weilong Zhong, Jingwen Zhao, Lu Zhou, Bangmao Wang
Summary: The study suggests that Lactobacillus rhamnosus GG culture supernatant (LCS) can promote intestinal absorption of cholecalciferol by affecting protein levels of VD transporters, thus improving the levels of 25OHD(3) in senile osteoporosis (SOP).
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Angelo Fassio, Davide Gatti, Maurizio Rossini, Camilla Benini, Elena Fracassi, Eugenia Bertoldo, Ombretta Viapiana, Stefano Milleri, Matteo Gatti, Giovanni Adami
Summary: Supplementation with cholecalciferol in healthy individuals deficient in vitamin D affected multiple regulators of calcium, phosphate, and bone metabolism, with no significant differences observed among the three dosing regimens.
Article
Endocrinology & Metabolism
Hope A. Weiler, Wen Hsuan Fu, Maryam Razaghi, Nathalie Gharibeh, Catherine A. Vanstone
Summary: This study found an association between vitamin D deficiency and elevated parathyroid hormone levels in newborn infants. The global consensus recommendation on vitamin D deficiency (<25 nmol/L) aligns better with the threshold at which parathyroid hormone is elevated compared to the definition set by the National Academy of Medicine (<30 nmol/L).
Review
Biochemistry & Molecular Biology
Ligia J. Dominguez, Mario Farruggia, Nicola Veronese, Mario Barbagallo
Summary: Research on vitamin/hormone D deficiency has been receiving widespread attention in recent years due to its confirmed role in various enzymatic, metabolic, physiological, and pathophysiological processes related to human organs and systems. The global prevalence of modest-to-severe vitamin D deficiency has sparked growing interest in the importance of optimal vitamin D levels for bone, muscle, and overall health, as well as for the effectiveness of bone-forming treatments. Current strategies to address deficiency include food supplementation with vitamin D or the use of vitamin D supplements.
Article
Nutrition & Dietetics
Angelo Fassio, Davide Gatti, Maurizio Rossini, Davide Bertelle, Riccardo Bixio, Ombretta Viapiana, Stefano Milleri, Camilla Benini, Francesca Pistillo, Giulia Zanetti, Giovanni Adami
Summary: Supplementation of cholecalciferol in young healthy individuals deficient in vitamin D resulted in a decrease in serum concentrations of IL-6 and IL-17A.
Article
Veterinary Sciences
Dennis E. Jewell, Kiran S. Panickar
Summary: The optimum concentration of vitamin D for dogs is still debated, but a minimum concentration of 100 ng/mL (250 nM) of circulating vitamin D has been suggested for optimal health. The relationship between dietary intake of vitamin D-3 and circulating 25(OH) D in adult dogs has not been well studied. The safe upper limit of vitamin D in dog foods for adult maintenance is 3,200 IU/kg on a dry matter basis, but this guideline was not based on studies of adult maintenance requirements. Understanding the relationship between dietary vitamin D and circulating vitamin D is important for promoting health in dogs.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Nutrition & Dietetics
Mattia Perazzi, Enrico Gallina, Giulia Francesca Manfredi, Filippo Patrucco, Antonio Acquaviva, Donato Colangelo, Mario Pirisi, Mattia Bellan
Summary: This paper reviews the potential role of vitamin D in the pathogenesis and management of systemic sclerosis (SSc). Pre-clinical data suggest that vitamin D and its analogs may suppress fibrogenesis, while clinical data show a high prevalence of hypovitaminosis D and osteoporosis in SSc patients, but inconsistent findings regarding the association with clinical manifestations and phenotypes of SSc.
Review
Biochemistry & Molecular Biology
Fulvia Zappulo, Maria Cappuccilli, Alessandra Cingolani, Anna Scrivo, Anna Laura Croci Chiocchini, Miriam Di Nunzio, Chiara Donadei, Marianna Napoli, Francesco Tondolo, Giuseppe Cianciolo, Gaetano La Manna
Summary: Vitamin D plays a crucial role in bone metabolism, as well as having important extra-bone effects such as glucose homeostasis and cardiovascular protection. This narrative review provides an overview of the role of vitamin D in different settings, with a special focus on chronic kidney disease and kidney transplant.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Jacklyn N. Hellwege, Xiangzhu Zhu, Xiang Huang, Martha J. Shrubsole, Lei Fan, Bingshan Li, Reid Ness, Douglas L. Seidner, Edward L. Giovannucci, Todd L. Edwards, Qi Dai
Summary: Optimal 25(OH)D levels are associated with a significantly reduced risk of colorectal cancer, particularly among women. Individuals with BPRVID are at higher risks of incident adenoma and colorectal cancer compared to those with HPRVID, especially among women. Treatment strategies should be tailored based on individuals' different response types.
CLINICAL NUTRITION
(2021)
Article
Multidisciplinary Sciences
Tadatoshi Sato, Christian D. Castro Andrade, Sung-Hee Yoon, Yingshe Zhao, William J. Greenlee, Patricia C. Weber, Usha Viswanathan, John Kulp, Daniel J. Brooks, Marie B. Demay, Mary L. Bouxsein, Bruce Mitlak, Beate Lanske, Marc N. Wein
Summary: This study identifies SIK2/SIK3 as potential drug targets for treating osteoporosis and successfully develops an orally available SIK2/SIK3 inhibitor. The inhibitor stimulates bone formation and increases bone density without apparent toxicity. These findings provide a new approach for the pharmacological treatment of osteoporosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Qing Hao, Yun Qin, Wanjun Zhao, Lingyun Zhang, Han Luo
Summary: The study suggests that supplying calcitriol based on a 70% RDP cutoff may be a wise practice in thyroidectomy patients, helping to stratify high-risk patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Orthopedics
Z. Qu, F. Yang, Y. Yan, J. Huang, J. Zhao, J. Hong, S. Li, G. Jiang, W. Wang, S. Yan
Summary: This study indicated an inverse causal relationship between serum PTH concentrations and development of OA, especially knee OA, but no evidence of the causal effect of serum 25(OH)D levels on OA was found. Further investigation is needed to explore potential mechanisms by which serum PTH affects OA.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Nutrition & Dietetics
Gabriele Brosolo, Andrea Da Porto, Luca Bulfone, Laura Scandolin, Antonio Vacca, Nicole Bertin, Cinzia Vivarelli, Leonardo A. Sechi, Cristiana Catena
Summary: Recent evidence suggests that mildly increased fasting and post-oral load blood glucose concentrations are associated with organ damage in nondiabetic patients with hypertension. This study aimed to examine the relationships between serum 25(OH)D levels and glucose tolerance and insulin sensitivity in hypertension.
Review
Obstetrics & Gynecology
I. R. Reid
Summary: Optimizing bone health involves not smoking, limiting alcohol intake, maintaining a healthy body weight, consuming adequate protein and calcium, and using vitamin D supplements for those with poor sunlight exposure. Calcium supplements are not recommended due to potential side effects and lack of proven value.
Review
Nutrition & Dietetics
Sarah M. Bristow, Mark J. Bolland, Greg D. Gamble, William Leung, Ian R. Reid
Summary: The review found no significant association between calcium intake and change in bone mineral density in older adults, especially among women over 60 years old. The positive findings in studies with high rates of hormone treatment or osteoporosis therapy use were likely due to confounding effects from co-administration of calcium supplements with these medications.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Dennis M. Black, Ian R. Reid, Nicola Napoli, Susan K. Ewing, Masataka Shiraki, Toshitaka Nakamura, Yasuhiro Takeuchi, Anne L. Schafer, Tiffany Y. Kim, Jane A. Cauley
Summary: The study indicates that women who experience an acute-phase reaction (APR) when starting Zoledronic acid (ZOL) will have a larger reduction in vertebral fracture risk with ZOL.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Rheumatology
Jeremy Holyer, William J. Taylor, Angelo Gaffo, Graham Hosie, Anne Horne, Borislav Mihov, Isabel Su, Gregory D. Gamble, Nicola Dalbeth, Sarah Stewart
Summary: When considering the burden of gout flares over time, patients rank activity limitation and pain experienced during their worst gout flare as the most important contributing factors, whereas factors related to the cumulative impact of all flares over time are relatively less important.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Sarah Stewart, Amanda Phipps-Green, Greg D. Gamble, Lisa K. Stamp, William J. Taylor, Tuhina Neogi, Tony R. Merriman, Nicola Dalbeth
Summary: Elevated serum urate is the most important causal risk factor for developing gout, but only a small proportion of people with normal urate levels develop gout and the majority of those with high urate levels do not. This may be due to subsequent variations in serum urate over time. This analysis examined whether single or repeat testing of serum urate more accurately predicts incident gout over time.
Review
Nutrition & Dietetics
Luling Lin, Greg D. Gamble, Caroline A. Crowther, Frank H. Bloomfield, Massimo Agosti, Stephanie A. Atkinson, Augusto Biasini, Nicholas D. Embleton, Mary S. Fewtrell, Fernando Lamy-Filho, Christoph Fusch, Maria L. Gianni, H. Gozde Kanmaz Kutman, Winston Koo, Ita Litmanovitz, Colin Morgan, Kanya Mukhopadhyay, Erica Neri, Jean-Charles Picaud, Niels Rochow, Paola Roggero, Atul Singhal, Kenneth Stroemmen, Maw J. Tan, Francesco M. Tandoi, Claire L. Wood, Gitte Zachariassen, Jane E. Harding
Summary: Supplementation with neonatal nutritional supplements may not alter cognitive function or metabolic risk in later life, but it may improve early motor development, especially in girls.
Article
Orthopedics
Scott M. Bolam, Subhajit Konar, Greg Gamble, Sarah -Jane Paine, Nicola Dalbeth, A. Paul Monk, Brendan Coleman, Jillian Cornish, Jacob T. Munro, David S. Musson
Summary: This nationwide study explored the socioeconomic disparities in traumatic rotator cuff injuries in New Zealand. The findings showed that there are variations in these injuries based on ethnicity, sex, and socioeconomic status. These disparities need to be addressed in order to improve health outcomes and achieve equity.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Pharmacology & Pharmacy
Ian R. Reid, Jingyuan Wen, Anna Mellar, Mengyang Liu, Amani Jabr, Anne M. Horne
Summary: The aim of this study was to assess the safety and efficacy of two oral zoledronate preparations in postmenopausal women. The results showed that oral zoledronate had a smaller and less sustained anti-resorptive effect compared to intravenous zoledronate. However, oral zoledronate could be a viable option with dosing intervals of weeks to months.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Ian R. Reid, Sonja Bastin, Anne M. Horne, Borislav Mihov, Gregory D. Gamble, Mark J. Bolland
Summary: Vertebral fractures are associated with height loss, reduced quality of life, and increased mortality. The impact of different components of the definition of vertebral fracture on trial outcomes was assessed using data from a six-year trial of zoledronate. Age, medication, and incident vertebral fractures were found to be factors affecting height change.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Editorial Material
Pharmacology & Pharmacy
I. R. Reid
EXPERT OPINION ON DRUG SAFETY
(2022)
Editorial Material
Endocrinology & Metabolism
Ian R. Reid
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Rachel Murdoch, Anna Mellar, Anne M. Horne, Emma Billington, Pui Ling Chan, Gregory D. Gamble, Ian R. Reid
Summary: This study found that the use of dexamethasone can significantly reduce the acute phase response (APR) following zoledronate infusion, which is characterized by fever, musculoskeletal pain, headache, and nausea. Dexamethasone is highly effective in reducing the incidence of APR.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Editorial Material
Endocrinology & Metabolism
Ian R. Reid
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ian R. Reid, Anne M. Horne, Borislav Mihov, Sonja Bastin, Gregory D. Gamble
Summary: Bisphosphonates are commonly used for osteoporosis prevention and treatment, while NSAIDs are widely used by older adults at high fracture risk. A study reanalyzed data from a clinical trial of zoledronate and found that NSAID use did not affect the bone density or fracture risk reduction effects of zoledronate. The study concluded that NSAIDs do not interfere with the efficacy of potent bisphosphonates in terms of bone density or fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)