Review
Biochemistry & Molecular Biology
Roberto Castelli, Antonio Gidaro, Gavino Casu, Pierluigi Merella, Nicia I. Profili, Mattia Donadoni, Margherita Maioli, Alessandro P. Delitala
Summary: Aging leads to significant changes in the structural proprieties of the arterial wall, such as loss of elasticity and reduced compliance. Arterial hypertension, diabetes mellitus, and chronic kidney disease are major factors contributing to these changes. Arterial stiffness, evaluated by non-invasive methods like pulse wave velocity, is crucial in assessing vessel elasticity. Early assessment of stiffness is important as it can precede clinical signs of cardiovascular disease. While there is no specific pharmacological target for arterial stiffness, managing its risk factors can improve arterial wall elasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Viktoria Muster, Katharina Guetl, Gudrun Pregartner, Andrea Berghold, Leyla Schweiger, Philipp Jud, Marianne Brodmann, Gerald Seinost
Summary: This study showed a correlation between arterial stiffness and body weight/composition, with lower lean mass in male LEAD patients being associated with increased arterial stiffness. Progressive resistance training may be beneficial in reducing arterial stiffness in PAD patients for secondary prevention.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Hack-Lyoung Kim, Dong-Won Ahn, Su Hwan Kim, Dong Seok Lee, Soon Ho Yoon, Joo-Hee Zo, Myung-A Kim, Ji Bong Jeong
Summary: This study found that baPWV was associated with WHR and VFA, but not with BMI and WC. This suggests that arterial stiffness may have a stronger connection to abdominal obesity than overall obesity.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Marie Mathieu, Pascale Guillot, Typhaine Riaudel, Anne-Sophie Boureau, Guillaume Chapelet, Celine Brouessard, Laure de Decker, Gilles Berrut
Summary: This study aimed to explore the relationship between osteoporosis and sarcopenia in women aged 75 or older, revealing a significant association between fat mass and bone density, with osteosarcopenic patients having lower fat mass and body mass index.
Article
Biochemistry & Molecular Biology
Napatsorn Imerb, Chanisa Thonusin, Wasana Pratchayasakul, Krittikan Chanpaisaeng, Ratchaneevan Aeimlapa, Narattaphol Charoenphandhu, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The study found that hyperbaric oxygen therapy can counteract obesity-induced aging-induced osteoporosis, restore the expression levels of certain genes in bone tissue, partially improve bone microarchitecture, and protect against obesity-induced demineralization in obese-aged rats.
Article
Biochemistry & Molecular Biology
Napatsorn Imerb, Chanisa Thonusin, Wasana Pratchayasakul, Krittikan Chanpaisaeng, Ratchaneevan Aeimlapa, Narattaphol Charoenphandhu, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Research has shown that hyperbaric oxygen therapy (HBOT) has a therapeutic effect on osteoporosis in both obese and lean aged rats. HBOT can partially improve bone microarchitecture and protect bone health in obese aged rats, while completely restoring bone microarchitecture in lean aged rats.
Article
Medicine, General & Internal
Paivi E. Korhonen, Tuija Mikkola, Hannu Kautiainen, Johan G. Eriksson
Summary: This study found that both fat mass and lean mass index are positively associated with blood pressure levels, independently of other factors. Lean body mass is shown to be an important determinant of blood pressure levels, with a magnitude similar to fat mass. Excess muscle mass may not be beneficial to cardiovascular health.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Clinical Neurology
Zhuoting Zhu, Yifan Chen, Wei Wang, Yueye Wang, Wenyi Hu, Xianwen Shang, Huan Liao, Danli Shi, Yu Huang, Jason Ha, Zachary Tan, Katerina Kiburg, Xueli Zhang, Shulin Tang, Honghua Yu, Xiaohong Yang, Mingguang He
Summary: The study found a significant association between retinal age gap and arterial stiffness index as well as incident cardiovascular disease events, indicating the potential of this novel biomarker in identifying individuals at high risk of future CVD events.
Article
Peripheral Vascular Disease
Qianhui Ling, Qirui Song, Jingjing Bai, Shouling Wu, Weili Zhang, Mulei Chen, Jun Cai
Summary: This study examined the temporal relationship between arterial stiffness and systolic blood pressure (SBP), and found that arterial stiffening precedes SBP, particularly in the intensive treatment group, and leads to difficulty in achieving the target SBP.
Article
Geriatrics & Gerontology
Stephen M. Fischer, Alexei Wong, Arun Maharaj, Salvador J. Jaime, Arturo Figueroa
Summary: The study demonstrates that impaired pulsatile hemodynamics (PPA and AIx) are negatively associated with ASMI and LegLM, while arterial stiffness is negatively associated with ASMI and ArmLM in overweight and obese postmenopausal women.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Biology
Soran AminiAghdam, Reinhard Blickhan, Kiros Karamanidis
Summary: The study compared running mechanics during uneven running on varied surfaces, finding specific biomechanical adjustments related to step nature and trunk posture. Running with a posterior trunk lean resulted in increased leg stiffness and compression, while the step down phase was dominated by center-of-mass height changes. These findings emphasize the importance of trunk posture in human locomotion for the design of robots.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Lijuan Yang, Huihui Deng, Wei Pan, Xiaoyan Huang, Ke Xu, Xingxing Zhang, Xiang Hu, Xuejiang Gu
Summary: The study found that higher levels of leg fat were associated with a lower risk of osteoporosis, independent of total lean mass.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Lin Jin, Yichao Du, Mengjiao Zhang, Jianxiong Chen, Lei Sha, Mengmeng Cao, Lanyue Tong, Qingqing Chen, Cuiqin Shen, Lianfang Du, Dingqian Wang, Zhaojun Li
Summary: This study explored the relationship between arterial stiffness parameters and cardiovascular disease risk in Chinese females based on age and body mass index. The findings revealed a significant J-shaped relationship between age and arterial pressure volume index (API) and arterial velocity pulse index (AVI). There was also a linear association between API and BMI. Additionally, the study demonstrated that API and BMI are correlated with 10-year cardiovascular risk in females. Therefore, API can serve as an early detection tool for cardiovascular disease and enable preventive therapy.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Nipith Charoenngam, Caroline M. Apovian, Chatlert Pongchaiyakul
Summary: This study aims to determine the association of lean mass and fat mass with bone mineral density in Thais. The results show that in men, lean mass index is positively correlated with lumbar spine and femoral neck bone density, while fat mass index is negatively correlated with femoral neck bone density. In women, both lean mass and fat mass index are positively correlated with lumbar spine and femoral neck bone density. These findings indicate a sex-specific influence of fat mass on bone density in Thais.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Mengyi Liu, Zhuxian Zhang, Chun Zhou, Ziliang Ye, Panpan He, Yuanyuan Zhang, Huan Li, Chengzhang Liu, Xianhui Qin
Summary: This study explores the association between predicted fat mass and lean mass with mortality in the US general population, finding that both fat mass and lean mass are independent predictors of overall and cause-specific mortality. Age was found to significantly modify the associations.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Peripheral Vascular Disease
Simon Toupance, Carlos Labat, Mohamed Temmar, Patrick Rossignol, Masayuki Kimura, Abraham Aviv, Athanase Benetos
Article
Cardiac & Cardiovascular Systems
Silke Thul, Carlos Labat, Mohamed Temmar, Athanase Benetos, Magnus Back
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2017)
Article
Public, Environmental & Occupational Health
Nelly Agrinier, Marie-Line Erpelding, Carlos Labat, Sylvie Gautier, Francis Guillemin, Athanase Benetos
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2018)
Article
Peripheral Vascular Disease
Jean-Jacques Mourad, Davide Agnoletti, Carlos Labat, Sylvie Gautier, Paolo Salvi, Filippo Valbusa, Olivier Hanon, Olivier Toulza, Patrick Manckoundia, Francesco Fantin, Yves Rolland, Athanase Benetos
AMERICAN JOURNAL OF HYPERTENSION
(2018)
Article
Biochemistry & Molecular Biology
Sanjeev Sabharwal, Simon Verhulst, George Guirguis, Jeremy D. Kark, Carlos Labat, Natalie E. Roche, Kristina Martimucci, Krunal Patel, Debra S. Heller, Masayuki Kimura, Donald Chuang, Anne Chuang, Athanase Benetos, Abraham Aviv
Article
Peripheral Vascular Disease
Jirar Topouchian, Carlos Labat, Sylvie Gautier, Magnus Back, Apostolos Achimastos, Jacques Blacher, Marcin Cwynar, Alejandro de la Sierra, Denes Pall, Francesco Fantin, Katalin Farkas, Luis Garcia-Ortiz, Zoya Hakobyan, Piotr Jankowski, Ana Jelakovic, Zhanna Kobalava, Alexandra Konradi, Yulia Kotovskaya, Marina Kotsani, Irina Lazareva, Alexander Litvin, Viktor Milyagin, Iveta Mintale, Oscar Persson, Rafael Ramos, Anatoly Rogoza, Ligita Ryliskyte, Angelo Scuteri, Yuriy Sirenko, Georges Soulis, Nebojsa Tasic, Maryna Udovychenko, Saule Urazalina, Peter Wohlfahrt, Parounak Zelveian, Athanase Benetos, Roland Asmar
JOURNAL OF HYPERTENSION
(2018)
Article
Cardiac & Cardiovascular Systems
Athanase Benetos, Simon Toupance, Sylvie Gautier, Carlos Labat, Masayuki Kimura, Pascal M. Rossi, Nicla Settembre, Jacques Hubert, Luc Frimat, Baptiste Bertrand, Mourad Boufi, Xavier Flecher, Nicolas Sadoul, Pascal Eschwege, Michele Kessler, Irene P. Tzanetakou, Ilias P. Doulamis, Panagiotis Konstantopoulos, Aspasia Tzani, Marilina Korou, Anastasios Gkogkos, Konstantinos Perreas, Evangelos Menenakos, Georgios Samanidis, Michail Vasiloglou-Gkanis, Jeremy D. Kark, Serguei Malikov, Simon Verhulst, Abraham Aviv
CIRCULATION RESEARCH
(2018)
Article
Multidisciplinary Sciences
Benoit Langlois, Ekaterina Belozertseva, Ara Parlakian, Mustapha Bourhim, Jacqueline Gao-Li, Jocelyne Blanc, Lei Tian, Dario Coletti, Carlos Labat, Zhor Ramdame-Cherif, Pascal Challande, Veronique Regnault, Patrick Lacolley, Li Zhenlin
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Simon Toupance, Maria G. Stathopoulou, Alexandros M. Petrelis, Vesna Gorenjak, Carlos Labat, Tsung-Po Lai, Sophie Visvikis-Siest, Athanase Benetos
Article
Geriatrics & Gerontology
Athanase Benetos, Tsung-Po Lai, Simon Toupance, Carlos Labat, Simon Verhulst, Sylvie Gautier, Marie-Noelle Ungeheuer, Christine Perret-Guillaume, Daniel Levy, Ezra Susser, Abraham Aviv
Summary: The study found that in COVID-19 patients, lymphocyte count is correlated with telomere length, while there is no such correlation in non-COVID-19 patients. Older individuals may reach the limits of their telomere reserves when infected with SARS-CoV-2.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Simon Toupance, Stephanie Simonici, Carlos Labat, Chloe Dumoulin, Tsung-Po Lai, Cecile Lakomy, Veronique Regnault, Patrick Lacolley, Francoise Dignat George, Florence Sabatier, Abraham Aviv, Athanase Benetos
Summary: The study found that individuals with longer telomeres have more self-renewing endothelial colony-forming cells. White blood cell telomere length can serve as a surrogate marker for endothelial repair capacity in clinical and laboratory practice, with potential applications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, General & Internal
Paolo Salvi, Filippo Valbusa, Anna Kearney-Schwartz, Carlos Labat, Andrea Grillo, Gianfranco Parati, Athanase Benetos
Summary: This study found a significant inverse correlation between carotid-femoral pulse wave velocity and carotid distensibility, indicating a close relationship between aortic stiffness evaluated by the propagative method and local carotid cross-sectional distensibility.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Stephanie Simoncini, Simon Toupance, Carlos Labat, Sylvie Gautier, Chloe Dumoulin, Laurent Arnaud, Maria G. Stathopoulou, Sophie Visvikis-Siest, Pascal M. Rossi, Athanase Benetos, Francoise Dignat-George, Florence Sabatier
Summary: This study investigates the relationship between atherosclerotic cardiovascular disease (ASCVD), inflammation markers, and circulating endothelial progenitor cells. The findings suggest that ASCVD impairs the colony forming capacity and angiogenic properties of endothelial colony forming cells (ECFC) in a severity-dependent manner. Additionally, alteration of ECFC is associated with increased senescent phenotype and IL-6 levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Troels Steenstrup, Jeremy D. Kark, Simon Verhulst, Mikael Thinggaard, Jacob V. B. Hjelmborg, Christine Dalgard, Kirsten Ohm Kyvik, Lene Christiansen, Massimo Mangino, Timothy D. Spector, Inge Petersen, Masayuki Kimura, Athanase Benetos, Carlos Labat, Ronit Sinnreich, Shih-Jen Hwang, Daniel Levy, Steven C. Hunt, Annette L. Fitzpatrick, Wei Chen, Gerald S. Berenson, Michelangela Barbieri, Giuseppe Paolisso, Shahinaz M. Gadalla, Sharon A. Savage, Kaare Christensen, Anatoliy I. Yashin, Konstantin G. Arbeev, Abraham Aviv
Article
Cell Biology
Janja Zupan, Peter Vrtacnik, Andrej Cor, Gregor Haring, Georges Weryha, Sophie Visvikis-Siest, Janja Marc