Article
Chemistry, Multidisciplinary
Xiangyu Chen, Shiyong Teng, Jinming Li, Xuezhi Qiao, Weidong Zhao, Zhengjie Xue, Xudong Shi, Yuguang Wang, Wensheng Yang, Tie Wang
Summary: Magnetic resonance imaging (MRI) contrast agents, such as Magnevist (Gd-DTPA), have limited blood circulation time due to rapid clearance by the kidney, which hinders the improvement of contrast between tumors and normal tissue. To address this issue, a novel MRI contrast agent using deformable mesoporous organosilica nanoparticles (D-MON) incorporating Gd-DTPA is fabricated. In vivo distribution studies show that the D-MON-based contrast agent can prolong blood circulation time and achieve high-contrast imaging in tumor tissue, surpassing the performance of the clinical contrast agent Gd-DTPA.
ADVANCED MATERIALS
(2023)
Review
Nanoscience & Nanotechnology
Tuyen Duong Thanh Nguyen, Ramesh Marasini, Santosh Aryal
Summary: Recent advancements in clinical bioimaging have significantly impacted the diagnosis, treatment, and prevention of diseases, particularly through early intervention and precise therapy. Various organic and inorganic materials have been engineered as contrast agents to improve image resolution for detecting abnormalities like cancer and vascular occlusion. Biologically derived contrast agents coupled with innovative imaging agents show promising applications in the biomedical field for drug delivery and bioimaging.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xiaoqing Wei, Dan Mu, Yingping Li, Jingya Zhao, Shaobing Zhou
Summary: Researchers have developed a magnetic exosome that responds to bacteria associated with tumors, enabling sensitive tumor imaging. The magnetic exosome can rapidly respond in the tumor microenvironment and release iron oxide nanoparticles for dynamic MRI of tumors. After MRI, the iron oxide nanoparticles can be eliminated through renal clearance to avoid potential toxicity.
Article
Biotechnology & Applied Microbiology
Xiaoming Wang, Shiwei Guo, Zhiqian Li, Qiang Luo, Yan Dai, Hu Zhang, Yun Ye, Qiyong Gong, Kui Luo
Summary: The concept of non-metallic MRI contrast agents has emerged to address the potential toxicity of metal-based contrast agents. Paramagnetic nitroxides are being studied for their stability and imaging mechanisms similar to metal-based agents, with the challenge of lower relaxivity and rapid in vivo metabolism. Macromolecular nitroxides contrast agents have been shown to increase stability and improve water relaxation, with the potential for expanding application in tumor, liver, kidney, and cardiovascular imaging.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ken-ichiro Matsumoto, Ikuo Nakanishi, Zhivko Zhelev, Rumiana Bakalova, Ichio Aoki
Summary: The use of nitroxyl radicals based on a cyclic redox mechanism as an index of tissue redox status has significant implications. Recent advances have focused on developing in vivo redox imaging using nitroxyl radicals as redox-sensitive contrast agents. Additionally, the development of nitroxyl radical contrast agents and drugs for theranostics has shown promise.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Chemistry, Multidisciplinary
Zhongtao Li, Jing Guo, Mengmeng Zhang, Guohua Li, Liguo Hao
Summary: Magnetic resonance molecular imaging can provide anatomical, functional, and molecular information. This study presents a novel T-1 contrast agent, Gd2O3@MSN, which utilizes gadolinium-doped mesoporous silica nanoparticles for magnetic imaging. The results show that Gd2O3@MSN has a higher T-1 relaxivity, making it a potential candidate for in-vivo MRI contrast agents.
FRONTIERS IN CHEMISTRY
(2022)
Review
Toxicology
Ece Akbas, Fatma Unal, Deniz Yuzbasioglu
Summary: Contrast agents, specifically Gadolinium-based contrast agents (GBCAs), are commonly used in magnetic resonance imaging (MRI) to increase signal intensity. However, concerns have been raised regarding the cellular toxic risks of these agents. Accumulation of gadolinium after injection has been observed in humans, with or without renal impairment, and conflicting results have been obtained regarding the cytotoxic and genotoxic effects of GBCAs. Understanding the effects of GBCAs on cells is crucial for their safe usage in clinical applications.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Yongjie Xiong, Yi Qu, Zhe Min, Jun Wu, Suming Zhang, Zheng Xue
Summary: This study developed a novel MRI contrast agent by coupling ultrasmall superparamagnetic iron oxide nanoparticles with a functional protein. The contrast agent successfully penetrated biological membranes and bound to Aβ deposits, allowing for the visualization of Aβ deposits in Alzheimer's disease animal models by MRI.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Nanoscience & Nanotechnology
Can Chen, Jianxian Ge, Yun Gao, Lei Chen, Jiabin Cui, Jianfeng Zeng, Mingyuan Gao
Summary: USPIO nanoparticles, with their excellent MRI performance and remarkable biosafety profile, have shown considerable applications in developing T-1 contrast agents and T-2/T-1 switchable contrast agents, and have been widely used in the diagnosis of vascular pathological changes, inflammations, and malignant tumors.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Hossein Danafar, Yasamin Baghdadchi, Murat Barsbay, Mohammadreza Ghaffarlou, Navid Mousazadeh, Ali Mohammadi
Summary: Insufficient contrast is a limitation of MRI, which can be overcome by using contrast agents. Nano-sized contrast materials, such as Fe3O4-Au hybrid NPs, have unique advantages but suffer from aggregation and accumulation. Surface modifications, like coating with BSA, are necessary to improve their stability and biocompatibility. The synthesized Fe3O4-Au-BSA NPs showed a significant reduction in signal intensity on MR images, confirming their contrast ability.
Article
Chemistry, Multidisciplinary
Gaoji Wang, Goran Angelovski
Summary: A novel Gd3+ chelate has been developed that can selectively recognize Zn2+ and exhibit a significant increase in longitudinal relaxivity, representing a new momentum in developing suitable contrast agents for functional molecular imaging studies of Zn2+.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Chathuri J. Kombala, Aikaterini Kotrotsou, F. William Schuler, Jorge de la Cerda, Jacqueline C. Ma, Shu Zhang, Mark D. Pagel
Summary: AcidoCEST MRI can measure the extracellular pH of the tumor microenvironment using a nanoscale CEST agent, reducing the need for high delivery concentrations. The polymer agent showed superiority over the monomer agent and iopamidol in terms of concentration requirement for acidoCEST MRI studies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Toshimasa J. Clark, Gregory J. Wilson, Jeffrey H. Maki
Summary: This study utilized computer modeling to evaluate the impact of contrast signal intensity evolution under different injection strategies on CE-MRA imaging. The results indicate that shorter plateau lengths and lower tail heights lead to increased measurement errors and blurring in the imaging. Optimal contrast injection guidelines were proposed for minimal degradation in CE-MRA imaging.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christiane Kulinna-Cosentini, Michael A. Arnoldner, Wolfgang Schima, Ivan Kristo, Sebastian F. Schoppmann, Michael Weber, Enrico P. Cosentini
Summary: In evaluating image quality in MR swallowing, using LumiVision (R) undiluted showed similar results to gadolinium-buttermilk mixture, while LumiVision (R) water mixture performed significantly worse. Therefore, oral ingestion of LumiVision (R) undiluted is recommended for MR swallowing examinations.
EUROPEAN RADIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
S. A. Amali S. Subasinghe, Jonathan Romero, Cassandra L. Ward, Matthew D. Bailey, Donna R. Zehner, Prakrut J. Mehta, Fabio Carniato, Mauro Botta, Jason T. Yustein, Robia G. Pautler, Matthew J. Allen
Summary: The complexes described in this study act as contrast agents for magnetic resonance imaging thermometry, enhancing contrast between 275 and 325 K. The temperature response of the fluorinated contrast complex is primarily based on the modulation of water exchange caused by trifluoromethyl groups, which can be chemically controlled.
CHEMICAL COMMUNICATIONS
(2021)