Review
Materials Science, Biomaterials
Nuh Yildirim, Amina Amanzhanova, Gulzada Kulzhanova, Fariza Mukasheva, Cevat Erisken
Summary: Osteochondral defects are a major clinical problem, and the importance of the tidemark, a selectively permeable membrane in the osteochondral interface, has been largely overlooked in previous research. This review focuses on the structure, composition, and function of the osteochondral interface, as well as the challenges in regenerative engineering. The formation of the tidemark, which separates the avascular and vascular regions of the interface, is a major challenge in regeneration.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Physical
Prince Gollapalli, J. Varalakshmi, P. S. V. R. A. Kishor, Prajeet Oza, Satyesh Kumar Yadav
Summary: Contrary to common belief, chemically graded interface is thermodynamically preferred over sharp interface between metal and its nitride. Diffusion of N from nitride to metal reduces the internal energy of the heterostructure and leads to the formation of atomically chemically graded interface.
APPLIED SURFACE SCIENCE
(2022)
Article
Polymer Science
Ehsan Rostami-Tapeh-Esmaeil, Sahar Shojaei, Denis Rodrigue
Summary: Uniform and graded polyolefin elastomer (POE) foams were prepared using a single-step technology, and the effects of molding temperature on the foams' morphology, mechanical properties, and thermal conductivity were investigated. The results showed that the foam's properties can be easily controlled by the cellular structure, and graded samples are more interesting for thermal insulation applications.
Review
Biochemistry & Molecular Biology
Clemens Goegele, Judith Hahn, Gundula Schulze-Tanzil
Summary: The firm integration of anterior cruciate ligament (ACL) grafts into bones remains a challenging issue in ACL reconstruction. To achieve a functional-tissue-engineered ACL substitute, robust bone attachment sites need to be re-established. This review discusses the peculiarities of synovioentheseal complexes at the femoral and tibial attachment sites and explores tissue engineering strategies to address them. Various material composites and manufacturing techniques have been applied to mimic the ACL enthesis tissue gradients, and functionalized materials and growth factors have been integrated for zone-dependent differentiation of precursor cells. However, the individual and asymmetric histoarchitectures of ACL entheses present a unique biomechanical microenvironment that must be considered in future ACL interface tissue engineering approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Xianliang Zhang, Liang Chen, Zhigang Li, Guoqun Zhao, Cunsheng Zhang
Summary: TiB2 particle reinforced 7075Al based composite was successfully fabricated by powder metallurgy and hot extrusion. The addition of TiB2 particles refined the grain structure and retarded the precipitation kinetics. TiB2/7075Al composite exhibited lower friction coefficient and higher wear resistance, with the highest wear resistance in the peak aging state.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Materials Science, Multidisciplinary
Xin Bao, Shuaihang Hou, Zhixin Wu, Xiaodong Wang, Li Yin, Yijie Liu, Huolun He, Sichen Duan, Baolin Wang, Jun Mao, Feng Cao, Qian Zhang
Summary: To meet the requirements of practical applications, thermoelectric generators need to be efficient and mechanically robust. Progress has been made in designing high-performance thermoelectric generators, but their mechanical properties still need improvement. This review summarizes studies on the mechanical properties of thermoelectric generators. It discusses the mechanical properties of bulk thermoelectric generators, the strategies for improving their mechanical properties, and the joint strength of electrodes and thermoelectric materials. It also examines the mechanical properties of inorganic thin-film thermoelectric devices and the synthesis methods of thin-film thermoelectric materials. Finally, it discusses flexible organic thermoelectric devices and flexible devices using bulk legs.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Forestry
Po Ning, Xin Xia, Yuanjun Jiang
Summary: Roots can be considered as natural soil reinforcement material, and the bonding effect of the root-soil interface is a key factor for vegetation slope protection. The shear strength of root-permeated soil can be quantified by interfacial cohesion and friction angle, and it can be increased with the root area ratio.
Article
Chemistry, Multidisciplinary
Mengmeng Wu, Wanwan Wang, Hongmei Cai, Jilei Liang, Jiawei Hua, Haoyan Dong, Lin Zhao, Yuzhen Zhang
Summary: The mechanical properties of open-graded friction courses (OGFCs) containing lignin and mineral fiber were investigated. The fiber increased the air voids in OGFCs and the different specific gravities of the fibers influenced the results. Both lignin and mineral fibers had high asphalt absorption, resulting in larger asphalt content in OGFCs. The study also found that lignin and mineral fibers can enhance the moisture damage resistance and rutting resistance of OGFCs at high temperatures.
Article
Chemistry, Physical
Xinchang Zhang, Qiang Wang, Joshua J. Kane, Jorgen F. Rufner, Cheng Sun
Summary: In this study, Fe-Cr alloys were fabricated using the spark plasma sintering (SPS) technique. The effects of thermal annealing on the microstructure and mechanical properties of the alloys were investigated. It was found that SPS coupled with subsequent heat treatment can tailor the graded microstructure and control the mechanical properties of FeCr alloys, showing potential applications in other alloy systems.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Engineering, Manufacturing
E. Tenuta, A. Nycz, M. Noakes, S. Simunovic, M. H. A. Piro
Summary: Metal Big Area Additive Manufacturing is based on Gas Metal Arc Welding and allows for printing different materials in the same component. Different print strategies were designed to highlight material and mechanical property changes, with observations of non-homogeneous deformation and microstructural differences near interfaces. Analysis showed that transformation induced plasticity was not the cause of non-homogeneous deformation.
ADDITIVE MANUFACTURING
(2021)
Article
Multidisciplinary Sciences
Alberto Pappalardo, David Alvarez Cespedes, Shuyang Fang, Abigail R. Herschman, Eun Young Jeon, Kristin M. Myers, Jeffrey W. Kysar, Hasan Erbil Abaci
Summary: Despite advancements in skin bioengineering, the current 3D skin constructs do not effectively cover complex body sites and cannot mimic the fully enclosed geometry of human skin. In this study, researchers engineered wearable edgeless skin constructs (WESCs) that can be shaped to fit different body parts and seamlessly transplanted as biological clothing. The WESCs showed improved dermal extracellular matrix (ECM) deposition and mechanical properties compared to traditional constructs, and successfully replaced skin in full-thickness wounds with minimal suturing and shorter surgery time. This technology has the potential to significantly improve wound care by recapitulating tissue macroanatomy and enhancing biological function.
Article
Materials Science, Multidisciplinary
S. Saeb, S. Firooz, P. Steinmann, A. Javili
Summary: Traditional interface models assume the interface is located at the middle of finite-thickness interphases, but this may not be applicable in graded or inhomogeneous interphases. New research extends the interface model to consider arbitrary interface positions and proves that interface position does not necessarily coincide with the mid-layer. The importance of interface position is demonstrated through a series of examples.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2021)
Article
Engineering, Multidisciplinary
Baoshou Liu, Xiaodong Huang, Yinan Cui
Summary: The rapid development of additive manufacturing provides new opportunities for fabricating multi-material structures. However, the graded-interface assumption between different materials often poses challenges in topology optimization. This study proposes a new element-based topology optimization algorithm that explicitly considers interface types and allows precise control of interface width. Numerical examples demonstrate that the optimized designs using this method achieve lower compliance compared to traditional multi-material designs.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2022)
Article
Polymer Science
Lifeng Ma, Chunxiao Li, Congchao Liu
Summary: This work presents a novel representative volume element (RVE) model for thermoplastic vulcanizate (TPV) based on polypropylene (PP)/ethylene propylene diene monomer (EPDM) blends. The study demonstrates that an elastic-plastic interface model provides a better description of the mechanical behavior of TPV. Additionally, a bivariate partial dependence plot reveals the influence mechanism between the interface structure-properties for TPV.
Article
Forestry
Antonio Yeste, Juan A. Blanco, J. Bosco Imbert, Helena Zozaya-Vela, Martin Elizalde-Arbilla
Summary: Tree species, such as Scots pine and European beech, have different effects on soil properties, with beech showing a competitive advantage in terms of soil dominance and higher fine root biomass in mixed areas, leading to higher decomposition rates and microbial biomass.
FOREST ECOLOGY AND MANAGEMENT
(2021)
Review
Materials Science, Biomaterials
Ryan C. Locke, Adam C. Abraham, Megan L. Killian
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2017)
Review
Materials Science, Biomaterials
Ryan C. Locke, Adam C. Abraham, Megan L. Killian
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2017)
Article
Engineering, Biomedical
Christopher M. McAndrew, Avinesh Agarwalla, Adam C. Abraham, Eric Feuchtbaum, William M. Ricci, Simon Y. Tang
CLINICAL BIOMECHANICS
(2018)
Article
Cell Biology
Adam C. Abraham, Shivam A. Shah, Mikhail Golman, Lee Song, Xiaoning Li, Iden Kurtaliaj, Moeed Akbar, Neal L. Millar, Yousef Abu-Amer, Leesa M. Galatz, Stavros Thomopoulos
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Multidisciplinary Sciences
Iden Kurtaliaj, Mikhail Golman, Adam C. Abraham, Stavros Thomopoulos
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Orthopedics
Helen L. Moser, Adam C. Abraham, Kristen Howell, Damien Laudier, Matthias A. Zumstein, Leesa M. Galatz, Alice H. Huang
Summary: This study investigated clinically relevant features of a mouse model of supraspinatus tendon injury to determine outcomes, including pain, function, and structure. Lineage tracing revealed the involvement of two specific cell populations in the healing process after tendon injury and repair. Scar formation after surgery was mainly mediated by a specific cell population, leading to permanently reduced functional and structural properties.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Orthopedics
Mikhail Golman, Xiaoning Li, Dimitrios Skouteris, Adam A. Abraham, Lee Song, Yousef Abu-Amer, Stavros Thomopoulos
Summary: In this study, inhibition of IKK beta was shown to successfully suppress excessive inflammation and enhance tendon-to-bone healing after rotator cuff repair in a rat model. The treatment led to improved tenogenesis, extracellular matrix production, and overall repair quality. Additionally, the IKK beta inhibitor prevented bone loss near the tendon attachment, ultimately leading to increased toughness, failure load, and strength in the repaired area.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Adam C. Abraham, Fei Fang, Mikhail Golman, Panagiotis Oikonomou, Stavros Thomopoulos
Summary: Analysis of different load-dependent rotator cuff tendinopathy models revealed that underuse and destabilization resulted in changes in forepaw weight-bearing, decreased tendon-to-bone attachment strength, and reduced tendon strength, while overuse activity caused alterations in walking patterns, increased tendon stiffness, and suppression of wound healing-related gene expression.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Multidisciplinary Sciences
Mikhail Golman, Adam C. Abraham, Iden Kurtaliaj, Brittany P. Marshall, Yizhong Jenny Hu, Andrea G. Schwartz, X. Edward Guo, Victor Birman, Philipp J. Thurner, Guy M. Genin, Stavros Thomopoulos
Summary: Enthesis connects tendon and bone exhibiting excellent toughness, with a fibrous architecture balancing strength and toughness. In vivo models show optimization of trade-offs through various cross-scale mechanisms.
Article
Orthopedics
Alexander J. Vervaecke, Andrew D. Carbone, Adam Abraham, Zachary Bernstein, Damien Laudier, Olivier Verborgt, Leesa M. Galatz, Alice H. Huang
Summary: This study investigated the effects of delivering neonatal tendon progenitor cells (TPCs) into an adult injured environment on the healing of supraspinatus tendon. The results showed that TPC delivery improved functional gait recovery, reduced scar formation, improved enthesis collagen alignment, and altered bony composition response. However, TPCs did not integrate into the healing tissue, suggesting that the improved healing may be due to paracrine effects.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2022)
Article
Chemistry, Multidisciplinary
Robert N. Kent, Mohamed Said, Megan E. Busch, Ethan R. Poupard, Ariane Tsai, Jingyi Xia, Daniel L. Matera, William Y. Wang, Samuel J. DePalma, Harrison L. Hiraki, Megan L. Killian, Adam C. Abraham, Jae-Won Shin, Alice H. Huang, Ariella Shikanov, Brendon M. Baker
Summary: This study demonstrates that a synthetic hydrogel with controlled topographical and soluble features can enhance the migration of tendon progenitor cells, facilitating tissue regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Orthopedics
Arya Ahmady, Lindsay C. Rosenthal, Adam C. Abraham, Bianca T. Parker, Jaysson T. J. Brooks, Patrick J. T. Cahill, John T. D. Smith, Paul D. F. Sponseller, Peter F. Sturm, Ying Li
Summary: This study aimed to determine whether pelvic fixation is necessary in children with hypotonic neuromuscular scoliosis (NMS) treated with growth-friendly instrumentation. The study found that pelvic fixation is necessary for nonambulatory children and can effectively control the major curve when combined with trunk fixation. Additionally, it was found that additional surgery is not needed for children with hypotonic NMS using magnetically controlled and traditional growing rods.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2023)
Meeting Abstract
Physiology
Leeann Hold, Jessica Chen, Breanna Campbell, Tessa Phillips, Paige Cordts, Paul Talusan, Adam Abraham, Megan Killian
Article
Multidisciplinary Sciences
Elahe Ganji, Syeda N. Lamia, Matthew Stepanovich, Noelle Whyte, Robert W. Goulet, Adam C. Abraham, Megan L. Killian
Summary: The enthesis adapts differently to muscle loading in young and adult mice, with optogenetic-induced muscle contraction leading to weaker enthesis and structural changes in young mice, but little change in adult mice. RNA sequencing revealed different pathways associated with increased mechanical loading in tendon and bone.
Article
Orthopedics
Adam C. Abraham, Shivam A. Shah, Stavros Thomopoulos
TECHNIQUES IN SHOULDER AND ELBOW SURGERY
(2017)
