Article
Cell & Tissue Engineering
L. Shu, N. Abe, S. Li, N. Sugita
Summary: This study aimed to investigate the effects of posterior tibial slope (PTS) angles on joint kinematics and contact mechanics of intact and anterior cruciate ligament-deficient (ACLD) knees. The results showed that increasing PTS angles significantly affected the tensile force on the ACL in the intact knee and led to differences in kinematics and increased loading on the medial meniscus.
BONE & JOINT RESEARCH
(2022)
Article
Orthopedics
W. Wirth, F. Eckstein, A. G. Culvenor, M. Hudelmaier, L. Stefan Lohmander, R. B. Frobell
Summary: This study compared the 5-year change in femorotibial cartilage thickness in young active adults with an acute ACL tear. The timing of ACL reconstruction did not affect the overall cartilage thickness increase, but did impact the cartilage ChangeScore.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Orthopedics
B. A. M. Snoeker, M. A. Bowes, F. W. Roemer, A. Turkiewicz, L. S. Lohmander, R. B. Frobell, M. Englund
Summary: The study found a approximately 1% increase in bone surface area in the compartment with meniscal pathology after ACL injury, suggesting a potentially important association between meniscal integrity and early bone surface area changes.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Orthopedics
A. M. Davis, R. Wong, K. Steinhart, L. Cruz, D. Cudmore, T. Dwyer, L. Li, P. Marks, R. McGlasson, N. Urquhart, J. A. Wilson, L. Nimmon, D. Ogilvie-Harris, J. Chahal
Summary: An intervention to support individuals with ACL injury to limit and manage knee OA requires content embedded within an easily accessible, multi-media delivery model with capacity for check-back with HCPs that is appealing to different age groups and personal preferences over the lifespan post injury. Delivery timing reflects a lifespan approach from time of injury through symptomatic knee OA management.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Biochemistry & Molecular Biology
Laura Rizzi, Marco Turati, Elena Bresciani, Filippo Maria Anghilieri, Ramona Meanti, Laura Molteni, Massimiliano Piatti, Nicolo Zanchi, Silvia Coco, Francesco Buonanotte, Luca Rigamonti, Giovanni Zatti, Vittorio Locatelli, Robert J. J. Omeljaniuk, Marco Bigoni, Antonio Torsello
Summary: This study investigated the changes in microRNA expression profiles in knee synovial fluid of patients with osteoarthritis (OA) and anterior cruciate ligament (ACL) rupture. The results showed that specific microRNAs were expressed differently in OA and ACL tear samples. These findings may contribute to further research on the mechanisms and treatments of osteoarthritis and ACL rupture.
Article
Orthopedics
Ashley A. Williams, Jayme C. B. Koltsov, Alan Brett, Jade He, Constance R. Chu
Summary: Even in the absence of radiographic osteoarthritis, patients who underwent unilateral anterior cruciate ligament reconstruction (ACLR) showed greater bone shape scores and subchondral areas consistent with pre-osteoarthritis in their ACLR knees just 2 years after the surgery. Moreover, greater medial femur bone areas were weakly associated with worse symptoms. Patients who are younger, taller, have meniscal tears, or have bone-patellar tendon-bone grafts may be at increased risk for bony asymmetries 2 years after ACLR.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Orthopedics
Tomomasa Nakamura, Brandon D. Marshall, Taylor M. Price, Yongtao Mao, Monica A. Linde, Hideyuki Koga, Patrick Smolinski, Freddie H. Fu
Summary: The study aimed to evaluate the kinematic effects of arthroscopic centralization on an irreparable lateral meniscal defect, and found that this method reduced knee laxity and improved rotational stability in a cadaveric model under laboratory conditions.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Chemistry, Analytical
Mazhar Javed Awan, Mohd Shafry Mohd Rahim, Naomie Salim, Amjad Rehman, Begonya Garcia-Zapirain
Summary: This study applies deep learning to automatically segment ACL tears from MRI images. By using the U-Net architecture and semantic segmentation technique, high accuracy segmentation results have been achieved. The method shows promising potential in the field of medical image analysis.
Article
Immunology
Zhiwen Li, Shiyong Zhang, Guping Mao, Yiyang Xu, Yunze Kang, Linli Zheng, Dianbo Long, Weishen Chen, Minghui Gu, Zhiqi Zhang, Yan Kang, Puyi Sheng, Ziji Zhang
Summary: ACL plays an important role in knee homeostasis and disease progression. Degeneration of the ACL alters knee joint homeostasis and influences the microenvironment, contributing to the progression of KOA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Adrian Guerra-Gonzalez, Carmen da Casa, Inigo Crespo, David Pescador, Lorena Benito-Garzon, Juan F. Blanco
Summary: The study found that ACL degeneration and innervation deficit may play a role in the onset of primary knee osteoarthritis, but the lack of a defining relationship among the different parameters assessed justifies further research in larger populations.
HISTOLOGY AND HISTOPATHOLOGY
(2022)
Article
Medicine, General & Internal
Zhong Chen, Yuheng Li, Yichi Zhang, Zhengzheng Zhang, Jingsong Wang, Xinghao Deng, Chengxiao Liu, Na Chen, Chuan Jiang, Weiping Li, Bin Song
Summary: This study found that visual function defect, especially low visual fusion range, is a risk factor for knee anterior cruciate ligament (ACL) sports injury. Quick turn, sudden stop, and jump during sports activities are also major risk factors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Line Lindanger, Torbjorn Strand, Anders Odd Molster, Eirik Solheim, Cornelia Fischer-Bredenbeck, Olga Therese Ousdal, Eivind Inderhaug
Summary: At 25 years after ACLR with a bone-patellar tendon-bone autograft, 60% of patients developed osteoarthritis (OA) in the involved knee. Medial and lateral meniscal surgery were independent predictors of OA development.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Sport Sciences
Matthew J. Best, Bashir A. Zikria, John H. Wilckens
Summary: The increasing rate of anterior cruciate ligament (ACL) tears in individuals over 40 has led to a rise in surgical reconstructions, with ACL reconstruction showing potential to improve function and facilitate the return to sports for physically demanding athletes. However, more research is needed to determine the long-term effects of both nonoperative and operative treatments as well as the role of ACL reconstruction in the development of osteoarthritis in older athletes.
SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
James F. Griffith
Summary: This article discusses five knee injuries commonly overlooked in knee MRI evaluations, emphasizing the potential patient symptoms and increased risk of further knee injury they may cause.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Multidisciplinary Sciences
Gisela Sole, Todd Pataky, Niels Hammer, Peter Lamb
Summary: The study examined the effects of wearing a knee sleeve on ground reaction forces and knee joint power during a step-down hop task after anterior cruciate ligament reconstruction. The results showed that wearing a knee sleeve increased knee joint power during the task but had inconsistent effects on ground reaction forces.
Article
Rheumatology
Andrea Dell'Isola, Tom Appleyard, Dahai Yu, Clara Hellberg, Geraint Thomas, Aleksandra Turkiewicz, George Peat, Martin Englund
Summary: This study compared the prevalence and timing of knee surgery in the 10 years prior to primary total knee replacement (TKR) between England and Sweden. The study found that meniscal surgeries were the most frequent procedure before TKR in both countries, and the prevalence increased in the years approaching TKR. In England, there was a decrease in the utilization of this procedure in the 4 years preceding TKR.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Orthopedics
Maria Lindeus, Aleksandra Turkiewicz, Karin Magnusson, Martin Englund, Ali Kiadaliri
Summary: Previous studies have found a negative correlation between educational attainment and different outcomes of osteoarthritis (OA). However, these studies did not account for potential confounding variables such as early-life environment and genetics. Therefore, this study aimed to examine the association between educational attainment and knee and hip OA surgery using twin data.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
I. Hellberg, V. -P. Karjalainen, M. A. J. Finnilä, E. Jonsson, A. Turkiewicz, P. Önnerfjord, V. Hughes, J. Tjörnstrand, M. Englund, S. Saarakkala
Summary: This study proposed a micro-computed tomography (mu CT) based 3D analysis of meniscal calcifications ex vivo, including a new grading system. The results showed that mu CT images can effectively depict meniscal calcifications, and the new grading system can accurately measure the severity of meniscal calcification. Two different patterns of degeneration were observed.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
A. Kamps, J. Runhaar, M. A. J. de Ridder, M. de Wilde, J. van der Lei, W. Zhang, D. Prieto-Alhambra, M. Englund, E. I. T. de Schepper, S. M. A. Bierma-Zeinstra
Summary: This study examined the risk of comorbidity following diagnosis of knee or hip osteoarthritis (OA) using a large database of electronic health records. The results showed that patients diagnosed with knee or hip OA were more likely to have other long-term conditions. This suggests the importance of considering the risk of comorbidities in the management of OA.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
Anders Isacsson, Ola Olsson, Martin Englund, Richard B. Frobell
Summary: This study aimed to present the age- and sex-specific cumulative annual incidences of primary traumatic lateral patellar dislocation (LPD) and to detail patient characteristics and concomitant chondral injuries including osteochondral fractures, as visualized on magnetic resonance imaging (MRI), in a large consecutive cohort of knee-injured individuals. The results showed that the annual incidence of first-time patellar dislocation was 14 per 100,000 individuals, with the highest incidence found among those aged 13-15 years. Primary LPD was more common among males and was sustained during sports activity in 55% of the cases. Associated injuries to the chondral surfaces should be expected in 43% of knees with primary LPD where 18% represent osteochondral fractures.
INTERNATIONAL ORTHOPAEDICS
(2023)
Review
Medicine, General & Internal
Martin Englund
Summary: Osteoarthritis is a chronic joint disease caused by various factors that disrupt joint homeostasis. It is characterized by degradation of cartilage, inflammation, and can result in pain, reduced function, and disability. The disease is increasing globally due to aging and rising obesity rates. Current management relies on contextual factors and the development of disease-modifying treatments is challenging.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sevgi Emin, Edwin H. G. Oei, Martin Englund, Pernilla Peterson
Summary: This study aims to demonstrate the feasibility and accuracy of chemical shift-encoded imaging for evaluating the fatty acid composition of human bone marrow adipose tissue at 7 T. The noise performance and accuracy were assessed using simulations and a phantom experiment. In vivo imaging of knee-healthy subjects showed regional differences in the fatty acid fractions, with the constrained model providing better accuracy and lower intersubject variation. In conclusion, quantifying bone marrow adipose tissue fatty acid composition using chemical-shift encoding is feasible at 7 T, with the constrained signal model being superior in terms of noise performance and accuracy.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Review
Orthopedics
Jean W. Liew, Lauren K. King, Armaghan Mahmoudian, Qiuke Wang, Hayden F. Atkinson, David B. Flynn, C. Thomas Appleton, Martin Englund, Ida K. Haugen, L. Stefan Lohmander, Jos Runhaar, Tuhina Neogi, Gillian Hawker
Summary: Early-stage knee osteoarthritis (KOA) classification criteria are important for identifying and recruiting patients with early-stage KOA. However, the definition of early-stage KOA varies in the literature, with most studies including individuals with KL grade 2 or higher, indicating established or later-stage OA.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Editorial Material
Orthopedics
M. Englund, A. Turkiewicz
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Forestry
Felix A. Dreger, Martin Englund, Florian Hartsch, Thilo Wagner, Dirk Jaeger, Rolf Bjoerheden, Gerhard Rinkenauer
Summary: Highly mechanized forestry operations require skilled harvester operators for efficient timber harvesting. However, research has shown a lack of knowledge about the work practices of forest machine operators, emphasizing the need for systematic research and refinement of analytical methods. This paper introduces hierarchical task analysis (HTA) as a versatile method for describing the work objectives of forest machine operators and promoting efficient work practices, operator training, and evaluation of assistive technologies. The study focuses on clearcutting and thinning stand methods in European forestry, providing a structured approach to HTA for optimal human-machine collaboration in forestry application research.
Article
Rheumatology
Jens Rathmann, Marten Segelmark, Martin Englund, Aladdin J. Mohammad
Summary: The epidemiology of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) in southern Sweden was studied. The incidence of AAV remained stable over a 23-year period, while the prevalence increased, indicating improved management and treatment resulting in higher survival rates for AAV patients.
Article
Biophysics
Sana Jahangir, Amir Esrafilian, Mohammadhossein Ebrahimi, Lauri Stenroth, Tine Alkjaer, Marius Henriksen, Martin Englund, Mika E. Mononen, Rami K. Korhonen, Petri Tanska
Summary: In this study, the mechanical responses of knee cartilage were investigated using a finite element knee joint model with either human or bovine fibril-reinforced poroviscoelastic cartilage properties during walking. The results showed that bovine cartilage properties led to greater stresses and fluid pressures compared to human cartilage properties. The mechanical responses of cartilage were highly sensitive to variations in collagen fibril-related material parameters.
JOURNAL OF BIOMECHANICS
(2023)
Article
Rheumatology
Marta Pineda-Moncusi, Francesco Dernie, Andrea Dell'Isola, Anne Kamps, Jos Runhaar, Subhashisa Swain, Weiya Zhang, Martin Englund, Irene Pitsillidou, Victoria Y. Strauss, Danielle E. Robinson, Daniel Prieto-Alhambra, Sara Khalid
Summary: This study found that patients with a new diagnosis of OA can be divided into four clusters based on their comorbidity profile: low-morbidity, back/neck pain plus mental health, metabolic syndrome, and multimorbidity. The 'multimorbidity' cluster had the highest risk of 10-year mortality, followed by the 'metabolic syndrome' cluster and the 'back/neck pain plus mental health' cluster.
Article
Rheumatology
Melker S. Johansson, Anton Pottegard, Jens Sondergaard, Martin Englund, Dorte T. Gronne, Soren T. Skou, Ewa M. Roos, Jonas B. Thorlund
Summary: The aim of this study was to investigate the utilization patterns of prescribed analgesics before, during, and after an exercise therapy and patient education program among patients with knee or hip osteoarthritis. The study found that the majority of patients had an increase in analgesic use in the year before the intervention, but a decrease during and after the intervention. A small proportion of patients accounted for more than half of the total analgesic dispensed during the study period.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Sport Sciences
Stephanie Rose Filbay, Frank W. Roemer, L. Stefan Lohmander, Aleksandra Turkiewicz, Ewa M. Roos, Richard Frobell, Martin Englund
Summary: This study evaluated the natural course of ACL healing after ACL rupture within 5 years on MRI and compared the outcomes at 2 and 5 years based on healing status and treatment group. The results showed that ACL healing on MRI was associated with favorable outcomes, suggesting that the potential for spontaneous healing of the ACL may be greater than previously considered.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
