Article
Biochemistry & Molecular Biology
Yolande F. M. Ramos, Rodrigo Coutinho de Almeida, Nico Lakenberg, Eka Suchiman, Hailiang Mei, Margreet Kloppenburg, Rob G. H. H. Nelissen, Ingrid Meulenbelt
Summary: The study identified and validated circulating miRNAs that mark gene expression changes early in osteoarthritis pathophysiology, showing strong correlations between plasma miRNA levels and gene expression levels in cartilage. A set of 7 miRNAs were found to have clinically relevant predictive value for osteoarthritis progression, with an AUC > 0.8 over 2 years and near-clinical value over 5 years.
Article
Agriculture, Dairy & Animal Science
M. Martin, M. D. Kleinhenz, K. S. Schwartzkopf-Genswein, D. Melendez, S. Marti, E. A. Pajor, E. D. Janzen, J. Coetzee
Summary: This study used ROC analysis to evaluate the predictive value of pain biomarkers in livestock. It found that plasma cortisol, hair cortisol, and IRT had higher AUC values, while salivary cortisol, MNT, substance P, kinematic gait analysis, and a visual analog scale for pain had lower AUC values.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Clinical Neurology
C. Leone, A. Di Lionardo, G. Di Pietro, G. Di Stefano, P. Falco, A. J. Blockeel, O. Caspani, L. Garcia-Larrea, A. Mouraux, K. G. Phillips, R. D. Treede, A. Truini
Summary: This neurophysiological study investigated the effects of high-frequency stimulation (HFS) and capsaicin on pain threshold and RIII reflex threshold in healthy humans. Both HFS and capsaicin were found to similarly modulate these thresholds without a concomitant inhibitory effect on the endogenous pain modulatory system.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
C. Leone, G. Di Pietro, Y. Salman, E. Galosi, G. Di Stefano, O. Caspani, L. Garcia-Larrea, A. Mouraux, R. -d. Treede, A. Truini
Summary: This study aimed to verify if the sensitivity of N13 SEP in detecting central sensitization is consistent across different experimental pain models. The results showed that while both HFS and LFS successfully induced secondary hyperalgesia, only LFS increased the amplitude of N13 SEP. These findings suggest that the sensitivity of N13 SEP for detecting dorsal horn excitability changes may critically depend on the different experimental pain models.
CLINICAL NEUROPHYSIOLOGY
(2023)
Review
Orthopedics
S. Zaki, C. L. Blaker, C. B. Little
Summary: Osteoarthritis is a disease with diverse phenotypes, and the selection and use of animal models in research should align with patient sub-types. This review discusses the importance of selecting animal models based on study objectives, alignment with sub-types, and available resources. It also proposes an experimental design checklist for choosing the optimal model.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Medicine, General & Internal
Philipp Luke, Eduard Kraft, Shahnaz Christina Azad
Summary: The study found that there is no direct correlation between the intensity of acute experimental pain and the concentration or changes of soluble intercellular adhesion molecule-1 (sICAM-1) in serum. However, short-term changes in sICAM-1 were observed after pain induction, indicating that this marker is part of a demand-oriented homeostatically controlled system.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anesthesiology
Ha-Jung Kim, Hyungtae Kim, Sooho Lee, Won Uk Koh, Soo-Sung Park, Youngjin Ro
Summary: We estimated the cephalad spread of injection volume by caudal route using dynamic ultrasound imaging in young pediatric patients. Local anesthetics of 0.223, 0.591, and 0.797 mL.kg(-1) could provide sufficient analgesia for localized foot, knee, and hip surgeries, respectively. Real-time dynamic flow tracking technique is recommended for caudal epidural block in young pediatric patients.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Review
Neurosciences
Ma Peihong, Qu Yuzhu, Yin Tao, He Zhaoxuan, Cheng Shirui, Teng Yuke, Xie Kunnan, Li Shenghong, Sun Ruirui, Zeng Fang
Summary: With the advancement of neuroimaging techniques, the central mechanism of acupuncture analgesia has gained increasing attention. Analysis of 27 studies revealed that heat stimulation and electroacupuncture were commonly used pain modeling methods, with the anterior cingulate cortex and insula being frequently reported brain regions associated with acupuncture analgesia.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Neurosciences
Hannah King, Maria Reiber, Vanessa Philippi, Helen Stirling, Katharina Aulehner, Marion Bankstahl, Andre Bleich, Verena Buchecker, Aylina Glasenapp, Paulin Jirkof, Nina Miljanovic, Katharina Schoenhoff, Lara von Schumann, Cathalijn Leenaars, Heidrun Potschka
Summary: This review examined 2235 studies published between 2009 and 2019 on the management of craniotomy-associated pain in laboratory mice and rats. The results showed a lack of adequate analgesia and a low reporting rate of pharmacologic pain management, with monotherapeutic approaches being more common. These findings highlight the need for enhanced training for individuals working with animal models of experimental intracranial surgery.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Medicine, General & Internal
Dmitriy Viderman, Karina Tapinova, Fatima Nabidollayeva, Ramil Tankacheev, Yerkin G. Abdildin
Summary: This study compares the use of intravenous and epidural routes for patient-controlled analgesia in abdominal surgery. The results show that there is no significant difference in pain control and side effects between the two methods. However, epidural analgesia is associated with a shorter length of hospital stay, while intravenous analgesia is associated with fewer episodes of hypotension.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
U. T. Timur, H. Jahr, J. Anderson, D. C. Green, P. J. Emans, A. Smagul, L. W. van Rhijn, M. J. Peffers, T. J. M. Welting
Summary: This study identified tissue-dependent secreted proteins from intra-articular human knee osteoarthritis tissues, which may serve as novel candidates for osteoarthritis biomarker development on a tissue-specific basis.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Neurosciences
Xue Deng, Chuyao Jian, Qinglu Yang, Naifu Jiang, Zhaoyin Huang, Shaofeng Zhao
Summary: This study investigated the analgesic effect of different virtual reality interactive modes using functional near-infrared spectroscopy (fNIRS). It found that both the active mode and motor imagery (MI) mode had a larger analgesic effect compared to the passive mode. The activated cortical regions involved motor and cognitive functions.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Anesthesiology
Tibor M. Szikszay, Waclaw M. Adamczyk, Alexandra Hoegner, Nele Woermann, Kerstin Luedtke
Summary: The study investigated the influence of acute pain on offset analgesia using two experimental models. Both cold water and exercise-induced pain stimuli resulted in reduced offset analgesia compared to the control condition. The findings suggest that temporal contrast of pain perception is inhibited in acute pain states.
EUROPEAN JOURNAL OF PAIN
(2021)
Article
Anesthesiology
G. Pascarella, F. Costa, R. Del Buono, R. Pulitano, A. Strumia, C. Piliego, E. De Quattro, R. Cataldo, F. E. Agro, M. Carassiti
Summary: The pericapsular nerve group block significantly reduced pain and opioid consumption, improved hip motion range, and promoted early functional recovery in patients undergoing total hip arthroplasty.
Article
Agriculture, Dairy & Animal Science
Miriam S. Martin, Michael D. Kleinhenz, Abbie V. Viscardi, Andrew K. Curtis, Blaine T. Johnson, Shawnee R. Montgomery, Maria E. Lou, Johann F. Coetzee
Summary: This study evaluated the effectiveness of using bupivacaine liposome suspension as a cornual nerve block at the time of dehorning compared to current industry standard analgesic approaches. The results showed that administration of bupivacaine liposome suspension was as effective at controlling pain as a multimodal approach of lidocaine and meloxicam.
JOURNAL OF DAIRY SCIENCE
(2022)
Review
Orthopedics
Gabrielle Depres-tremblay, Anik Chevrier, Martyn Snow, Mark B. Hurtig, Scott Rodeo, Michael D. Buschmann
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2016)
Meeting Abstract
Orthopedics
M. Hurtig, M. Drangova, D. Holdsworth
OSTEOARTHRITIS AND CARTILAGE
(2016)
Meeting Abstract
Orthopedics
M. Hurtig, M. Shive, M. Kapoor, S. Grizot, N. Mahomed, G. Foster Roberts, W. Marshall
OSTEOARTHRITIS AND CARTILAGE
(2016)
Meeting Abstract
Orthopedics
M. Hurtig, M. Shive, M. Kapoor, N. Mahomed, W. Marshall
OSTEOARTHRITIS AND CARTILAGE
(2016)
Article
Cell & Tissue Engineering
Gianluca Carnevale, Alessandra Pisciotta, Massimo Riccio, Laura Bertoni, Sara De Biasi, Lara Gibellini, Alessio Zordani, Gian Maria Cavallini, Giovanni Battista La Sala, Giacomo Bruzzesi, Adriano Ferrari, Andrea Cossarizza, Anto de Pol
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)
Article
Cell & Tissue Engineering
Jonathan Iu, Eric Massicotte, Shu-Qiu Li, Mark B. Hurtig, Ehsan Toyserkani, J. Paul Santerre, Rita A. Kandel
TISSUE ENGINEERING PART A
(2017)
Meeting Abstract
Orthopedics
I. J. Villamagna, F. Beier, E. R. Gillies, M. Hurtig
OSTEOARTHRITIS AND CARTILAGE
(2018)
Meeting Abstract
Orthopedics
M. Hurtig, E. Cummins, E. Lamoure, C. Flynn
OSTEOARTHRITIS AND CARTILAGE
(2018)
Article
Orthopedics
Sandra Kolaczek, Christopher Hewison, Scott Caterine, Rebecca Berardelli, Tyler Beveridge, Ben Herman, Mark Hurtig, Karen Gordon, Alan Getgood
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2019)
Article
Orthopedics
Candace Flynn, Mark Hurtig, Emma Lamoure, Erin Cummins, Valeria Roati, Mark Lowerison, Sang Young Jeong, Wonil Oh, Alex Zur Linden
Article
Geriatrics & Gerontology
Felipe C. K. Duarte, Mark Hurtig, Andrea Clark, Jeremy Simpson, John Z. Srbely
EXPERIMENTAL GERONTOLOGY
(2019)
Article
Orthopedics
Candace Flynn, Mark Hurtig, Alex zur Linden
Summary: This study investigated the feasibility of using CE-mu CT to evaluate the physical and biochemical properties of cartilage in species with thin cartilage. The results showed that disruption of the superficial zone contributes to an increase in apparent density, which is negatively correlated with the concentration of sulfated glycosaminoglycan (sGAG).
Article
Geriatrics & Gerontology
Felipe C. K. Duarte, Mark Hurtig, Andrea Clark, Stephen Brown, Jeremy Simpson, John Srbely
Summary: The study found a potential causal association between experimentally-induced spine osteoarthritis and neurogenic inflammatory responses in muscle diseases, suggesting that inflammation caused by spine osteoarthritis may lead to central sensitization and sensory changes.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Cell & Tissue Engineering
Frank A. Petrigliano, Nancy Q. Liu, Siyoung Lee, Jade Tassey, Arijita Sarkar, Yucheng Lin, Liangliang Li, Yifan Yu, Dawei Geng, Jiankang Zhang, Ruzanna Shkhyan, Jacob Bogdanov, Ben Van Handel, Gabriel B. Ferguson, Youngjoo Lee, Svenja Hinderer, Kuo-Chang Tseng, Aaron Kavanaugh, J. Gage Crump, April D. Pyle, Katja Schenke-Layland, Fabrizio Billi, Liming Wang, Jay Lieberman, Mark Hurtig, Denis Evseenko
Summary: Osteoarthritis affects millions worldwide, with injuries to the articular surface being a major risk factor. Current cartilage repair strategies are only moderately effective, but a newly developed stem cell-derived formulation shows potential for long-term functional repair.
NPJ REGENERATIVE MEDICINE
(2021)
Article
Cell Biology
Wendy Pearson, Anna E. N. Garland, Ashley Nixon, John P. Cant, Mark B. Hurtig
MEDIATORS OF INFLAMMATION
(2020)