Article
Orthopedics
Jani Puhakka, Teemu Paatela, Eve Salonius, Virpi Muhonen, Anna Meller, Anna Vasara, Hannu Kautiainen, Jussi Kosola, Ilkka Kiviranta
Summary: In an animal cartilage repair model, the ICRS scoring system demonstrated poor to moderate reliability. The results showed disagreement among observers, with poor to moderate interrater and intrarater reliability for ICRS total scores and individual subscores.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Engineering, Biomedical
Hannah M. Zlotnick, Ryan C. Locke, Sanjana Hemdev, Brendan D. Stoeckl, Sachin Gupta, Ana P. Peredo, David R. Steinberg, James L. Carey, Daeyeon Lee, George R. Dodge, Robert L. Mauck
Summary: This study develops a gravity-based approach to pattern bioactive factors along the osteochondral interface, and applies this novel biofabrication strategy to preserve bone structure after osteochondral injury.
Article
Cell & Tissue Engineering
Yanxue Wang, Shuo Luan, Ze Yuan, Shaoling Wang, Shengnuo Fan, Chao Ma, Shaoling Wu
Summary: This study aimed to evaluate the combinatorial therapeutic effects of platelet-rich plasma clot releasate (PRCR) and umbilical cord mesenchymal stem cells (UC-MSCs) on glucocorticoid-induced osteonecrosis of the femoral head (ONFH). The results showed that the combination of PRCR and UC-MSCs improved cell proliferation, migration, and differentiation while resisting apoptosis. In the ONFH rat model, the combination therapy also significantly improved bone loss and necrosis. These findings provide important information for future clinical management of ONFH.
STEM CELLS INTERNATIONAL
(2022)
Review
Engineering, Biomedical
Peyman Karami, Theofanis Stampoultzis, Yanheng Guo, Dominique P. Pioletti
Summary: The drive to develop cartilage implants for major defects in the musculoskeletal system has led to an increased focus on developing biomaterial devices for cartilage repair. However, there has been limited attention on the preclinical validation process and approval procedures for these devices. This review paper aims to highlight the various considerations regarding preclinical validation of hydrogel devices for cartilage repair, including regulatory requirements, implantation strategies, device performance aspects, and characterizations.
ACTA BIOMATERIALIA
(2023)
Review
Cell Biology
Rachel C. Nordberg, Gaston A. Otarola, Dean Wang, Jerry C. Hu, Kyriacos A. Athanasiou
Summary: Despite numerous studies on animal cartilage repair, long-term clinical repair of articular cartilage remains challenging. This article identifies the challenges in translating cell-based cartilage repair strategies and technologies and emphasizes the importance of understanding these barriers and finding solutions.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Yiwei Li, Chun Xu, Chang Lei
Summary: Bone regeneration is a complex process involving different stages, and growth factors (GFs) are essential for this process. Nanomaterials have emerged as promising vehicles for delivering GFs, as they can protect and control the release of GFs, as well as activate endogenous GFs to modulate the regeneration process.
Article
Multidisciplinary Sciences
Jiawei Li, Huiming Jiang, Zhongyang Lv, Ziying Sun, Chaoqun Cheng, Guihua Tan, Maochun Wang, Anlong Liu, Heng Sun, Hu Guo, Fufei Chen, Zizheng Liu, Yuxiang Fei, Yuan Liu, Rui Wu, Xingquan Xu, Wenjin Yan, Qing Jiang, Dongquan Shi
Summary: This study proposed a new strategy for cartilage regeneration by hyalinizing fibrocartilage through stabilizing the cytoskeleton. The use of docetaxel was found to inhibit cartilage fibrosis and promote the regeneration of hyaline cartilage.
Article
Orthopedics
Genevieve Housman, Ellen E. Quillen, Anne C. Stone
Summary: This study compares DNA methylation variations and their relationship with knee osteoarthritis development between baboons and humans, revealing that cartilage epigenetics may play a more significant role in OA than bone epigenetics. Genes containing OA-related DMPs in baboons show similar methylation patterns to those in humans, indicating a mixture of evolutionarily conserved and divergent OA-related methylation patterns in primates.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Review
Biotechnology & Applied Microbiology
Sheeba Shakoor, Eleyna Kibble, Jehan J. El-Jawhari
Summary: This review discusses the roles of growth factors in bone and cartilage regeneration, as well as the methods of delivering these factors. Different tools such as scaffolds, encapsulation, layer-by-layer assembly, and hydrogels are used to deliver growth factors. Considering the advantages and limitations of these methods is crucial for the development of regenerative therapies.
BIOENGINEERING-BASEL
(2022)
Article
Engineering, Biomedical
David C. Browe, Ross Burdis, Pedro J. Diaz-Payno, Fiona E. Freeman, Jessica M. Nulty, Conor T. Buckley, Pieter A. J. Brama, Daniel J. Kelly
Summary: This study demonstrates that ECM derived biomaterials can successfully treat articular cartilage defects in a clinically relevant large animal model. In vivo, these scaffolds promote superior articular cartilage regeneration. Loading transforming growth factor (TGF)-β3 into the scaffolds can further improve the quality of repair.
MATERIALS TODAY BIO
(2022)
Article
Orthopedics
H. Willcockson, H. Ozkan, L. Arbeeva, E. Mucahit, L. Musawwir, L. Longobardi
Summary: Deletion of Ccr2 in aggrecan-expressing cells reduces the initiation but not the progression of post-traumatic osteoarthritis.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Endocrinology & Metabolism
Mohammed A. Alharbi, Dana T. Graves
Summary: Diabetes mellitus is associated with higher risks of fractures and delayed bone healing. FOXO1 plays a key role in diabetes-impaired angiogenesis and chondrocyte apoptosis. This study found that diabetic mice had fewer blood vessels and increased chondrocyte apoptosis, while FOXO1 deletion partially rescued these effects.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Orthopedics
Jani Puhakka, Eve Salonius, Teemu Paatela, Virpi Muhonen, Anna Meller, Anna Vasara, Hannu Kautiainen, Jussi Kosola, Ilkka Kiviranta
Summary: This study compares the arthroscopic and histological ICRS scoring methods in an animal cartilage repair model and finds a moderate correlation between the two methods, indicating that both methods can be used to evaluate the quality of repaired articular cartilage.
Article
Orthopedics
E. Salonius, A. Meller, T. Paatela, A. Vasara, J. Puhakka, M. Hannula, A-M Haaparanta, I Kiviranta, V Muhonen
Summary: The study evaluated the performance of a composite biomaterial scaffold in a large porcine cartilage defect, showing that the lateral half of the defect had better repair than the medial half in the operated groups. The use of the rhCo-PLA scaffold did not differ significantly from spontaneous healing, and the repair was affected by the spatial properties within the defect, with different weightbearing conditions impacting the repair outcomes.
Article
Cell & Tissue Engineering
P. Kostesi, A. Vukasovic Barisic, I Erjavec, M. Pusic, D. Hudetz, D. Maticic, D. Vnuk, M. Vuckovic, A. Ivkovic
Summary: No single approach has proven to be satisfactory for long-term treatment of osteochondral defects. However, the use of bioreactormanufactured autologous osteochondral grafts, particularly those seeded with nasal chondrocytes, has shown promising results in subchondral bone repair.
EUROPEAN CELLS & MATERIALS
(2022)