Article
Biochemistry & Molecular Biology
Ichiro Yamauchi, Yoriko Sakane, Takafumi Yamashita, Takuro Hakata, Taku Sugawa, Haruka Fujita, Kentaro Okamoto, Daisuke Taura, Keisho Hirota, Yohei Ueda, Toshihito Fujii, Akihiro Yasoda, Nobuya Inagaki
Summary: This study aimed to investigate the effects of peripheral iodothyronine deiodinases (DIOs) on thyroid hormone economy. The results showed that D2 could enhance local thyroid hormone action and promote its circulation, while D3 could decrease circulating T3 and T4 levels with elevated reverse T3, leading to consumptive hypothyroidism. Additionally, the D3 mice are expected to be a novel hypothyroidism model.
Article
Environmental Sciences
Xiao Liang, Yin Wang, Lu Liu, Xi Zhang, Li Li, Rong Tang, Dapeng Li
Summary: This study investigated the effects of nitrite exposure on thyroid hormone levels and intestinal iodothyronine deiodinases activity in grass carp. The results showed that nitrite exposure altered thyroid hormone levels, morphology of thyroid follicles, and gene expressions related to thyroid hormone metabolism.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Ana Lamuedra, Paula Gratal, Lucia Calatrava, Victor Luis Ruiz-Perez, Adrian Palencia-Campos, Sergio Portal-Nunez, Aranzazu Mediero, Gabriel Herrero-Beaumont, Raquel Largo
Summary: Inactivation of Evc partially prevents chondrocyte hypertrophy in osteoarthritis (OA), but does not improve cartilage damage. Chondrocyte hypertrophy itself is not a pathogenic event in the progression of OA.
Review
Biotechnology & Applied Microbiology
Christian Shigley, Jay Trivedi, Ozair Meghani, Brett D. Owens, Chathuraka T. Jayasuriya
Summary: Current clinical strategies for restoring cartilage defects fail to address the formation of hypertrophic tissue, which leads to negative long-term outcomes. Understanding the biological mechanisms behind cartilage hypertrophy can help develop better strategies for managing osteoarthritis. This article provides a comprehensive review of these mechanisms and cutting-edge strategies for preventing hypertrophic tissue formation.
BIOENGINEERING-BASEL
(2023)
Article
Endocrinology & Metabolism
Yan Wang, Mengqi Zhang, Zhikun Huan, Shanshan Shao, Xiujuan Zhang, Dehuan Kong, Jin Xu
Summary: The study revealed that follicle-stimulating hormone (FSH) plays a critical role in chondrocyte dedifferentiation and cartilage destruction by decreasing type II collagen synthesis and inducing cytoskeletal reorganization. Inhibition of ERK-1/2 and activation of p38 signaling pathways were found to be involved in this process. Knocking down the FSH receptor (Fshr) and inhibiting the Gai protein also affected chondrocyte dedifferentiation. Overall, high circulating FSH, independent of estrogen, is identified as an important regulator in chondrocyte dedifferentiation and cartilage destruction.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Min Joo Kim, Sohyeon Choi, Sunmi Kim, Inae Lee, Min Kyong Moon, Kyungho Choi, Jeongim Park, Yoon Hee Cho, Young Min Kwon, Jiyoung Yoo, Gi Jeong Cheon, Young Joo Park
Summary: This study examined the associations between persistent organic pollutants (POPs) and thyroid hormone levels in humans, and found that these associations are influenced by sex, menopausal status, and age. Different POPs had different effects on different hormones, and the associations varied in different population groups. Furthermore, the study also suggested that thyroxine-binding globulin (TBG) and peripheral deiodinase activity (G(D)) may play important roles in explaining the changes in total T4 and total T3.
ENVIRONMENTAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Jorge Hidalgo-Alvarez, Federico Salas-Lucia, Diana Vera Cruz, Tatiana Fonseca, Antonio Bianco
Summary: The timed surge in DIO2-T3 signaling is critical in determining the fate of developing human hepatoblasts and the transcriptome of maturing hepatocytes, with physiological and clinical implications for how the liver handles energy substrates.
Review
Medicine, Research & Experimental
Xinyue Zhang, Xiaohua Pu, Caixia Pi, Jing Xie
Summary: FGF7, also known as KGF, plays a crucial role in tissue development, wound repair, tumorigenesis, and immune reconstruction. It directs cellular synaptic extension and facilitates functional gap junction communication in the skeletal system. Additionally, it promotes osteogenic differentiation and regulates key molecules in cartilage. However, the molecular mechanism of FGF7 in chondrocyte behaviors and cartilage diseases remains unknown.
Article
Orthopedics
Christelle Sanchez, Cecile Lambert, Jean-Emile Dubuc, Jessica Bertrand, Thomas Pap, Yves Henrotin
Summary: The research found biochemical differences between articular cartilage in different joint locations, and syndecan-4 could be a biochemical marker specific to knee osteoarthritis.
Article
Pharmacology & Pharmacy
Min Liu, Zhenlong Yu, Zikuang Zhao, Fangyu Yang, Meirong Zhou, Chao Wang, Xiangge Tian, Baojing Zhang, Guobiao Liang, Xiaohui Liu, Jing Shao
Summary: This study investigated the underlying mechanism of BDE47 neurotoxicity in human SK-N-AS neuronal cells. The results showed that BDE47 induced thyroid hormone metabolism disorder in neuronal cells by inhibiting the expression of the main enzyme, Dio3. Further research revealed that BDE47 up-regulated miR-24-3p, which binds to the 3'-UTR of Dio3 and inhibits its expression. BDE47 also inhibited the deiodinase activity of Dio3. Overall, this study provides new insights into the role of miRNAs in neurodevelopmental toxicity mediated by environmental pollutants.
Article
Cell Biology
Annunziata Gaetana Cicatiello, Serena Sagliocchi, Annarita Nappi, Emery Di Cicco, Caterina Miro, Melania Murolo, Mariano Stornaiuolo, Monica Dentice
Summary: Thyroid hormones regulate glutamine metabolism and anaplerotic fluxes in skeletal muscle, playing a role in muscle weight regulation and protection against muscle loss during atrophy.
Article
Engineering, Biomedical
Shibo Xu, Linna Chang, Xingjun Zhao, Yanan Hu, Yiyi Lin, Zhenhua Chen, Xiuli Ren, Xifan Mei
Summary: In this study, a multifunctional heterostructure nanoplatform with near-infrared sensitivity was developed for the treatment of osteoarthritis. The results showed that this nanoplatform could reduce cartilage damage and promote cartilage regeneration, providing a promising strategy for osteoarthritis treatment.
ACTA BIOMATERIALIA
(2022)
Article
Orthopedics
A. Abou-Jaoude, M. Courtes, L. Badique, D. Elhaj Mahmoud, C. Abboud, M. Mlih, H. Justiniano, M. Milbach, M. Lambert, A. Lemle, S. Awan, J. Terrand, A. Niemeier, A. Barbero, X. Houard, P. Boucher, R. L. Matz
Summary: This study investigates the role of ShcA protein in chondrocyte hypertrophic differentiation and osteoarthritis. Deletion of ShcA reduces the hypertrophic zone of the growth plate and alters the endochondral ossification process, leading to dwarfism. ShcA promotes ERK1/2 activation and nuclear translocation of RunX2, while keeping the Runx2 inhibitor, YAP1, inactive in the cytosol. Furthermore, loss of ShcA protects mice from age-related osteoarthritis development.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Review
Biochemistry & Molecular Biology
Maria Angela De Stefano, Raffaele Ambrosio, Tommaso Porcelli, Gianfranco Orlandino, Domenico Salvatore, Cristina Luongo
Summary: Skeletal muscle atrophy is characterized by altered protein turnover, with protein degradation exceeding synthesis, leading to muscle mass loss and weakness. Thyroid hormone plays a key role, regulating TH levels in muscle through deiodinases. Modulation of deiodinases may offer a therapeutic approach for treating muscle atrophy.
Review
Endocrinology & Metabolism
Zihuan Yang, Weishi Li, Chunli Song, Huijie Leng
Summary: CTGF is a multifunctional protein that plays different roles in different cells and conditions. CTGF antibodies have the potential to be a new drug for osteoarthritis. Abnormal CTGF expression is associated with inflammation and cartilage degeneration, making CTGF a potential therapeutic target for osteoarthritis treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)