Review
Immunology
Lin Shang, Siqi Zhao, Huijuan Shi, Xinzhu Xing, Jingya Zhang, Yanling He
Summary: Pruritus is a common and painful symptom in psoriasis that greatly affects quality of life. Neurogenic inflammation induced pruritus is the predominant mechanism in psoriasis, with the nerve growth factor (NGF)-mediated TRPV1 pathway playing a crucial role. However, the development of systemic TRPV1 antagonists has been hindered by elevated core temperature. Therefore, topical application of TRPV1 antagonists and interference with TRPV1 activation pathway mediators could be promising therapeutic options. This review focuses on recent advances in understanding the complex regulation of the NGF-mediated TRPV1 pathway in psoriatic pruritus and the potential therapeutic approaches derived from this knowledge.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Renata Voltolini Velho, Eliane Taube, Jalid Sehouli, Sylvia Mechsner
Summary: Endometriosis is a chronic and debilitating disease affecting women's fertility and health, with unclear etiology and pathogenesis. Recent evidence shows that the peripheral nervous system plays a crucial role in the development of the disease, presenting new therapeutic approaches and targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Luciapia Farina, Gaetana Minnone, Stefano Alivernini, Ivan Caiello, Lucy MacDonald, Marzia Soligo, Luigi Manni, Barbara Tolusso, Simona Coppola, Erika Zara, Libenzio Adrian Conti, Angela Aquilani, Silvia Magni-Manzoni, Mariola Kurowska-Stolarska, Elisa Gremese, Fabrizio De Benedetti, Luisa Bracci-Laudiero
Summary: The study shows that the activation of the p75NTR/proNGF axis promotes pro-inflammatory responses in synovial fibroblasts, contributing to chronic synovial inflammation. Inhibiting the p75NTR receptor may be a novel therapeutic approach for chronic arthritis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Francesco De Logu, Gaetano De Siena, Lorenzo Landini, Matilde Marini, Daniel Souza Monteiro de Araujo, Valentina Albanese, Delia Preti, Antonia Romitelli, Martina Chieca, Mustafa Titiz, Luigi F. Iannone, Pierangelo Geppetti, Romina Nassini
Summary: This study investigated the role of the TRPA1 channel in mechanical allodynia in rats. The findings suggest that TRPA1 mediates mechanical allodynia associated with neurogenic inflammation and moderate nerve injury. This discovery contributes to the understanding of the role of TRPA1 in mechanical pain sensitivity and can potentially be explored in humans.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Lolita Dokshokova, Mauro Franzoso, Anna Di Bona, Nicola Moro, Jose Luis Sanchez Alonso, Valentina Prando, Michele Sandre, Cristina Basso, Giuseppe Faggian, Hugues Abriel, Oriano Marin, Julia Gorelik, Tania Zaglia, Marco Mongillo
Summary: Cardiomyocytes release nerve growth factor (NGF) to support innervating sympathetic neurons in the heart, with neuro-cardiac junctions (NCJ) playing a crucial role in supporting retrograde neurotrophic signaling. The direct link between sympathetic neuron survival and neurotrophin release by cardiomyocytes is essential for heart cellular homeostasis.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Multidisciplinary Sciences
Hirotaka Tsuno, Nobuho Tanaka, Masashi Naito, Satoru Ohashi, Mitsuyasu Iwasawa, Tomoyasu Kadoguchi, Hiroyuki Mitomi, Toshihiro Matsui, Hiroshi Furukawa, Naoshi Fukui
Summary: This study identified the proteins released from osteoarthritis (OA) cartilage by using antibody array analyses and a quantitative proteomic analysis. The results revealed that various biologically active proteins, including alarmins, complement proteins and angiogenic proteins, are released from degenerated areas of OA cartilage. These findings provide valuable insights into the pathology of OA.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Yi-jun Liu, Xiao-feng Chen, Li-ping Zhou, Feng Rao, Dian-ying Zhang, Yan-hua Wang
Summary: This study aimed to analyze the effect and mechanism of Wnt5a-loaded fibrin hydrogel on a 10-mm rat sciatic nerve defect. Results showed that Wnt5a could promote Schwann cell proliferation and the expression of various neurotrophic factors, and the Wnt5a/Fn group outperformed the control groups in terms of nerve regeneration and functional recovery 12 weeks after the operation. The Wnt5a/Fn nerve conduit may promote peripheral nerve defect regeneration by facilitating multiple neurotrophin secretion, combining vascularization and neurotrophic growth cues.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Cell Biology
Binay Kumar Shah, Bivek Singh, Yukun Wang, Shuanshuan Xie, Changhui Wang
Summary: Most COPD patients suffer from excessive production of airway mucus, leading to symptoms such as cough and expectoration. This chronic mucus hypersecretion (CMH) is a major contributor to the increased morbidity and mortality in certain subsets of COPD patients. It is crucial to develop medications that can effectively suppress mucus hypersecretion to improve their outcomes.
MEDIATORS OF INFLAMMATION
(2023)
Article
Polymer Science
Qiuxia Li, Litao Sun, Xiaobei Huang, Shuai Liu, Haiyang Yong, Chenfei Wang, Jianzhong Li, Dezhong Zhou
Summary: Biodegradable and lipid-like highly branched poly(beta-amino ester)s (HPAESA) were developed to enhance the biological functions of adipose-derived stem cells by gene transfection. HPAESA showed significantly higher efficiency and cell viability, as well as the ability to promote neurite outgrowth.
Review
Cell Biology
Ling-Ping Cen, Tsz Ng, Wai Chu, Chi Pang
Summary: Both agonists and antagonists of the growth hormone-releasing hormone receptor have been found to alleviate death of ocular neural cells in experimental models, showing potent anti-inflammatory properties and protection against inflammatory responses induced by extrinsic agents or neurologic injuries in ocular animal models.
NEURAL REGENERATION RESEARCH
(2022)
Article
Neurosciences
Simona Capsoni, Antonino Cattaneo
Summary: The article explores the potential of delivering NGF to the brain through intranasal delivery as a promising strategy for treating Alzheimer's disease and related cognitive disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Immunology
Yaseen Awad-Igbaria, Shilo Dadon, Alon Shamir, Alejandro Livoff, Mark Shlapobersky, Jacob Bornstein, Eilam Palzur
Summary: This study aimed to examine the role of mast cells (MCs), nerve growth, and TRPV1 and TRPA1 in the development of provoked vulvodynia (PV). The findings suggest that vulvar hypersensitivity is mediated by the accumulation of MCs, nerve growth, and neuromdulation of TRPV1 and TRPA1. Additionally, treatment with ketotifen fumarate (KF) during the critical period of inflammation can prevent the development of chronic vulvar pain.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Ibtesam Rajpar, Gaurav Kumar, Paolo Fortina, Ryan E. Tomlinson
Summary: In mature bone, NGF produced by osteoblasts following mechanical loading signals through TrkA receptor on sensory nerves to support bone formation. TLR4, a key receptor in NF-KB signaling pathway, is required for initiating NGF-TrkA signaling for load-induced bone formation. Loss of TLR4 signaling reduces lamellar bone formation and dysregulates inflammatory signaling after mechanical loading, revealing the important role of osteoblastic TLR4 in skeletal adaptation to mechanical forces.
Article
Microbiology
Izabela Ciaston, Joanna Budziaszek, Dorota Satala, Barbara Potempa, Andrew Fuchs, Maria Rapala-Kozik, Danuta Mizgalska, Ewelina Dobosz, Richard J. Lamont, Jan Potempa, Joanna Koziel
Summary: The study found that inactive gingipains still elicit a strong inflammatory response in gingival tissues, which may contribute to the progression of periodontitis and bone resorption. Moreover, host molecules were identified as receptors for proteolytically inactivated gingipains. The broad distribution of these receptors in human tissues suggests their involvement in systemic diseases associated with periodontal pathogens.
Review
Medicine, Research & Experimental
Zhenxing Liu, Haiwei Wu, Shengyun Huang
Summary: NGF and its receptors play a crucial role in the wound healing process, especially in promoting the healing of different types of wounds.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Endocrinology & Metabolism
Chenlin Dai, Junjing Jia, Alexander Kot, Xueping Liu, Lixian Liu, Min Jiang, Nancy E. Lane, Barton L. Wise, Wei Yao
Article
Rheumatology
Sharon L. Kolasinski, Tuhina Neogi, Marc C. Hochberg, Carol Oatis, Gordon Guyatt, Joel Block, Leigh Callahan, Cindy Copenhaver, Carole Dodge, David Felson, Kathleen Gellar, William F. Harvey, Gillian Hawker, Edward Herzig, C. Kent Kwoh, Amanda E. Nelson, Jonathan Samuels, Carla Scanzello, Daniel White, Barton Wise, Roy D. Altman, Dana DiRenzo, Joann Fontanarosa, Gina Giradi, Mariko Ishimori, Devyani Misra, Amit Aakash Shah, Anna K. Shmagel, Louise M. Thoma, Marat Turgunbaev, Amy S. Turner, James Reston
ARTHRITIS CARE & RESEARCH
(2020)
Article
Rheumatology
Sharon L. Kolasinski, Tuhina Neogi, Marc C. Hochberg, Carol Oatis, Gordon Guyatt, Joel Block, Leigh Callahan, Cindy Copenhaver, Carole Dodge, David Felson, Kathleen Gellar, William F. Harvey, Gillian Hawker, Edward Herzig, C. Kent Kwoh, Amanda E. Nelson, Jonathan Samuels, Carla Scanzello, Daniel White, Barton Wise, Roy D. Altman, Dana DiRenzo, Joann Fontanarosa, Gina Giradi, Mariko Ishimori, Devyani Misra, Amit Aakash Shah, Anna K. Shmagel, Louise M. Thoma, Marat Turgunbaev, Amy S. Turner, James Reston
ARTHRITIS & RHEUMATOLOGY
(2020)
Article
Orthopedics
Barton L. Wise, Jingbo Niu, Yuqing Zhang, Felix Liu, Joyce Pang, John A. Lynch, Nancy E. Lane
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2020)
Article
Rehabilitation
Marc J. Heronemus, Kaitlin Rabe, Irina Tolstykh, K. Douglas Gross, Barton L. Wise, Michael C. Nevitt, Cora E. Lewis, Howard J. Hillstrom, Neil A. Segal
Summary: The study found a positive correlation between parity and increased dynamic foot pronation, with greater pronation observed with higher parity levels. However, after adjusting for age and BMI, these associations were no longer statistically significant.
Review
Rheumatology
Barton L. Wise, Matthias F. Seidel, Nancy E. Lane
Summary: NGF is an important neurotrophin involved in pain signal transmission, and inhibitors have shown efficacy in reducing joint pain in osteoarthritis patients, but higher doses may increase the risk of rapidly progressive osteoarthritis. Ongoing studies aim to better understand the mechanisms involved in this adverse event.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Article
Rheumatology
Bo Hu, DongBai Han, Michael C. Nevitt, Barton L. Wise, Neil A. Segal
Summary: This study aimed to determine if the amount of physical activity is a determinant of joint space narrowing (JSN) worsening in knee osteoarthritis patients over 48 months. The results showed that compared to moderate physical activity, both higher and lower amounts of physical activity are associated with an increased risk of JSN worsening in men and participants with K/L grade 2 knees.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Orthopedics
Qiang Liu, Zhikun Li, Manuela Ferreira, Barton Wise, David J. Hunter, Ke Tao, Jianhao Lin, Yuqing Zhang
Summary: Recent knee injury, more severe radiographic osteoarthritis, and lower quadriceps strength were associated with an increased risk of knee pain exacerbation during walking.
JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
(2021)
Article
Oncology
Muhammad Umar Jawad, Brad H. Pollock, Barton L. Wise, Lauren N. Zeitlinger, Edmond F. O' Donnell, Janai R. Carr-Ascher, Amy Cizik, Betty Ferrell, Steven W. Thorpe, R. Lor Randall
Summary: The study analyzed disparities in the incidence of metastatic bone disease (MBD) based on sex, race/ethnicity, and socioeconomic status, finding higher rates among lower socioeconomic groups and specific racial/ethnic populations. This suggests delays in diagnosis and limited access to screening modalities for these populations.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Manmeet Kaur, Daniel Black, Jeffrey Fine, Barton L. Wise
Summary: This study found a significant reduction in PT referrals for OA in 2020 during the COVID-19 pandemic, especially in the months following state-mandated actions and closures. Factors contributing to this outcome may include increased difficulty in accessing primary care providers, decreased awareness of PT availability among healthcare providers, reduced mobility limiting access to clinic and PT appointments, and patients' willingness to engage in PT during the pandemic.
Article
Oncology
Muhammad Umar Jawad, Brad H. Pollock, Barton L. Wise, Lauren N. Zeitlinger, Edmond F. O' Donnell, Janai R. Carr-Ascher, Amy Cizik, Betty Ferrell, Steven W. Thorpe, R. Lor Randall
Summary: This study explores the impact of socioeconomic status and insurance status on survival disparities among patients with metastatic bone disease. The results demonstrate that lower socioeconomic status and lack of insurance are associated with worse disease-specific survival in patients with primary tumors in the lung, prostate, breast, and colon.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Mary Claire B. Manske, Machelle D. Wilson, Barton L. Wise, Joy Melnikow, Herman L. Hedriana, Michelle A. James, Daniel J. Tancredi
Summary: The study aimed to evaluate the incidence of brachial plexus birth injury (BPBI) and its associations with maternal demographic factors. The incidence of BPBI between 1991 and 2012 was 1.28 per 1,000 live births, with variations in different demographic groups. Infants of Black, Hispanic, and advanced-age mothers had higher risks of BPBI compared to other groups.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Multidisciplinary Sciences
Micaela White, Lauren Hisatomi, Alex Villegas, Dagoberto Pina, Alec Garfinkel, Garima Agrawal, Nisha Punatar, Barton L. Wise, Polly Teng, Hai Le
Summary: This study aimed to determine whether the initiation of pharmacologic treatment for newly diagnosed osteoporosis patients was delayed during the COVID-19 pandemic. The study found that only 40.5% of newly diagnosed patients started pharmacologic therapy within six months of diagnosis, and the pandemic did not significantly affect treatment rates.
Meeting Abstract
Orthopedics
A. Mathur, J. B. Driban, T. E. McAlindon, F. Guillemin, T. Neogi, C. Kwoh, A. Mobasheri, M. C. Nevitt, P. G. Conaghan, B. L. Wise, Y. Zhang, D. J. Hunter, L. Huxham, C. Scotti
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Rheumatology
Lixian Liu, Junjing Jia, Min Jiang, Xueping Liu, Chenling Dai, Barton L. Wise, Nancy E. Lane, Wei Yao
ARTHRITIS RESEARCH & THERAPY
(2020)