Article
Chemistry, Medicinal
Rui Liu, Shiling Hu, Yuanyuan Ding, Jue Wang, Yuejin Wang, Jiapan Gao, Langchong He
Summary: The study identified dictamnine as an effective anti-anaphylactoid compound from Cortex dictamni extracts, which significantly suppressed MC intracellular Ca2+ mobilization and release of de novo degranulated substances, and inhibited PKC-PLC gamma-IP3R-associated protein signaling molecules. Hence, dictamnine is a novel therapeutic candidate for anaphylactoid reactions via MrgX2.
PHYTOTHERAPY RESEARCH
(2021)
Article
Allergy
Nithya A. Fernandopulle, Stephanie S. Zhang, Paul F. Soeding, Graham A. Mackay
Summary: The study found that sugammadex can reduce MRGPRX2 activation induced by NMBAs and other MRGPRX2 agonists, but may be ineffective in controlling acute symptoms. However, sugammadex may have some benefits in reducing MRGPRX2-induced release of CCL2.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Medicine, General & Internal
Genevieve R. Mazza, Ariane C. Youssefzadeh, Maximilian Klar, Mirjam Kunze, Shinya Matsuzaki, Rachel S. Mandelbaum, Joseph G. Ouzounian, Koji Matsuo
Summary: This study examined the clinical, pregnancy, and delivery characteristics of amniotic fluid embolism (AFE) and its maternal outcomes. The study found that factors such as older age, Asian and Black race, and pregestational hypertension were associated with AFE. The study also showed that placental accreta spectrum (PAS) had the strongest association with AFE. Additionally, the study found that the presence of other severe maternal morbidity indicators increased the failure-to-rescue rate after AFE.
Review
Biochemistry & Molecular Biology
Antonio Giovanni Solimando, Vanessa Desantis, Domenico Ribatti
Summary: Mast cells are crucial for inflammatory diseases and tumor growth, as they can secrete a wide range of biologically active cytokines. This review article aims to analyze the complex involvement of mast cells in interleukin secretion and the role of interleukins in regulating mast cell activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Barry A. A. Hedgespeth, Douglas B. Snider, Katie J. Bitting, Glenn Cruse
Summary: This article introduces a oligonucleotide called KitStop, which can safely reduce the severity and duration of anaphylactic response by reducing the number of mast cells in tissues. The study shows that KitStop significantly reduces mast cell numbers in the skin and peritoneum, and mice treated with KitStop experience a significantly diminished anaphylactic response in a model of passive systemic anaphylaxis compared to control mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Mariela Jimenez, Daniel Cervantes-Garcia, Laura E. Cordova-Davalos, Marian Jesabel Perez-Rodriguez, Claudia Gonzalez-Espinosa, Eva Salinas
Summary: Mast cells are immune cells strategically located in tissues close to the external environment, playing a key role in the host defense against invading pathogens. They release biologically active mediators to induce inflammation, promote antimicrobial activities, and shape innate and adaptive immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Katerina Kalkusova, Sindija Smite, Elea Darras, Pavla Taborska, Dmitry Stakheev, Luca Vannucci, Jirina Bartunkova, Daniel Smrz
Summary: The immune checkpoint inhibitors are crucial in cancer immunotherapy, but their efficacy is limited in solid tumors. Mast cells and dendritic cells play important roles in the tumor immune microenvironment and controlling these cells may help overcome the resistance of solid tumors to immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Pingwei Zhao, Peiwen Zhou, Tongyu Tang, Rui Si, Yiding Ji, Xintong Hu, Ang Li, Yanfang Jiang
Summary: The study found that circulating MCps levels were lower in patients with CRC, but significantly increased after surgery; however, the frequency of mast cells in tumor tissues was lower and not associated with CRC progression.
Article
Biochemistry & Molecular Biology
Marco Maccarana, Juan Jia, Honglian Li, Xiao Zhang, Israel Vlodavsky, Jin-Ping Li
Summary: Heparin, a polysaccharide expressed in animal connective tissue, specifically binds to antithrombin and enhances its inhibitory activity. This study examined the heparin isolated from different mast cells and found differences in molecular size and antithrombin-binding activity. Heparanase expression affected the production of glycosaminoglycans and the proportion between heparin and other glycosaminoglycans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Elizabeth Proano-Perez, Laia Olle, Yanru Guo, Cristina Aparicio, Mario Guerrero, Rosa Munoz-Cano, Margarita Martin
Summary: Activating mutations in KIT (CD117) are associated with various diseases, and recent research found that the SH3BP2 pathway regulates MITF through miR-1246 and miR-5100, suggesting that MITF may be a potential therapeutic target for gastrointestinal stromal tumors and mastocytosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Tongqian Wu, Shirong Yan, Yu-Wen Yeh, Yu Fang, Zou Xiang
Summary: This study found that mast cells expressing only FcγRIIB or FcγRIIIA undergo caspase-independent apoptosis in response to IgG immune complex treatment. Lower frequencies of connective tissue mast cells (CTMC) were recorded in mice lacking either FcγRIIB or FcγRIIIA compared with wild-type mice, especially in aged mice. This suggests that FcγR-mediated mast cell apoptosis may explain the more robust persistence of CTMC compared to mucosal mast cells (MMC). The results were replicated in a mast cell engraftment model, ruling out possible confounding effects of mast cell recruitment or FcγR expression by other cells on mast cell number regulation.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dmitri Atiakshin, Andrey Kostin, Igor Buchwalow, Vera Samoilova, Markus Tiemann
Summary: This study investigates the expression and secretory pathways of proteases in MCs in melanoma. The development of melanoma leads to the appearance of specific protease pools in the tumor-associated MC population, which is crucial for understanding the pathogenesis, classification, and prognosis of melanoma, as well as evaluating the effectiveness of antitumor therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Sina Kaag, Axel Lorentz, Katarina Stevanovic, Torsten Zuberbier
Summary: This review summarizes the anti-inflammatory effects of dietary components on mast cells and the signaling pathways involved, providing potential nutraceuticals for the prevention and treatment of allergies.
Review
Pharmacology & Pharmacy
Roberta Sulsenti, Elena Jachetti
Summary: Tumor development, progression, and resistance to therapies are influenced by the interactions between tumor cells and the surrounding microenvironment, comprising fibroblasts, immune cells, and extracellular matrix proteins. In this context, mast cells (MCs) have recently emerged as important players. The role of MCs in promoting or inhibiting cancer growth is still controversial, and targeting MCs for cancer immunotherapy has become a potential strategy.
Article
Agricultural Engineering
Sampurna Nandy, Upasana Arora, Pranay Tarar, Signe Viggor, Merike Joesaar, Maia Kivisaar, Atya Kapley
Summary: Bioaugmentation in wastewater treatment plants faces challenges of low survival and persistence of applied microbes. This study demonstrates that encapsulated Pseudomonas oleovorans ICTN13 showed enhanced phenol removal efficiency and sustained high removal efficacy and survival compared to free cells, highlighting the importance of bioaugmented strains in WWTPs.
BIORESOURCE TECHNOLOGY
(2021)