Article
Multidisciplinary Sciences
Ankita Gupta, Ludovica Chiavaccini, Laura M. Minnema, King Wa Chiu, David Knazovicky, Jonathan A. Hash, Santosh K. Mishra, B. Duncan X. Lascelles
Summary: The study did not find a significant association between ARTN levels and sensitivity or pain levels in dogs with osteoarthritis-associated pain.
SCIENTIFIC REPORTS
(2021)
Review
Orthopedics
B. R. da Costa, P. Saadat, R. M. Basciani, A. Agarwal, B. C. Johnston, P. Juni
Summary: Study findings suggest that the Visual Analogue Scale (VAS) for global osteoarthritis pain has slightly higher assay sensitivity compared to the Western Ontario and McMaster University (WOMAC) pain subscale, without a significant increase in between-trial heterogeneity.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Biochemistry & Molecular Biology
Colombe Otis, Emilie Bouet, Sokhna Keita-Alassane, Marilyn Frezier, Alienor Delsart, Martin Guillot, Agathe Bedard, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Bertrand Lussier, Francis Beaudry, Eric Troncy
Summary: Validating animal pain models is crucial for enhancing translational research and pharmacological treatment response. This study found that a calibrated slight exercise protocol combined with multimodal analgesia had positive effects on the MI-RAT model, particularly when used in conjunction with positive analgesics, reducing sensitivity to pain and improving joint structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Ryo Ikeda, Daigo Arimura, Mitsuru Saito
Summary: Knee osteoarthritis impairs daily activities and causes pain, with involvement of mechanical allodynia and hyperalgesia. The role of Piezo channels in mechanically induced pain in osteoarthritis remains unclear, as studies have shown conflicting results regarding its expression levels in affected joints. Further research is needed to understand the mechanisms behind pain sensitization in knee osteoarthritis.
Article
Food Science & Technology
Yves Henrotin, Christophe Antoine, Elodie Zwerts, Thibaut Neutelings, Elodie Bouvret
Summary: The study aimed to evaluate the effects of oral fish cartilage hydrolysate (FCH) on symptoms and joint tissue structure in rats with surgically induced osteoarthritis. FCH did not significantly affect cartilage lesion severity but tended to accelerate pain relief and joint function recovery. This positive trend may lead to further research on FCH as a potential treatment for joint discomfort associated with osteoarthritis.
FOOD SCIENCE & NUTRITION
(2021)
Article
Biotechnology & Applied Microbiology
Jiazi Gao, Pengling Ren, He Gong
Summary: This study investigated the morphological and mechanical changes in articular cartilage and subchondral bone during spontaneous hip osteoarthritis in guinea pigs. The results showed that the micromechanical properties of articular cartilage were the lowest at 1 month of age, and the earliest degeneration of articular cartilage occurred at 6 months of age. No degeneration in the micro- or nanostructure of subchondral bone was observed before 9 months. These findings provide valuable insights into the formation and progression of hip osteoarthritis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell Biology
Tae-Hwan Gil, Haiyan Zheng, Hyo Gyeong Lee, Ji-Won Shin, Sun Wook Hwang, Ki-Mo Jang, Ok Hee Jeon
Summary: Aging is a risk factor for osteoarthritis (OA) development. The therapeutic effect of senolytic drugs on OA is limited in aged mice. However, a drug combination of ABT263 and D+Q can reduce OA-related pain and peripheral sensitization.
Article
Medicine, Research & Experimental
Cemal Orhan, Mehmet Tuzcu, Ali Said Durmus, Nurhan Sahin, Ibrahim Hanifi Ozercan, Patrick Brice Defo Deeh, Abhijeet Morde, Prakash Bhanuse, Manutosh Acharya, Muralidhara Padigaru, Kazim Sahin
Summary: This study evaluated the anti-inflammatory and antioxidant effects of a novel joint health formula (JHF) containing curcumin, Boswellia, and Ashwagandha in rats with knee osteoarthritis. The results showed that JHF could alleviate arthritic conditions, reduce inflammation markers in the serum, and improve the structure of the knee joint.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Xiao Liu, David A. Leopold, Yifan Yang
Summary: The resting brain consumes a large amount of energy and exhibits highly organized spontaneous activity. An analysis of single neuron spiking activities revealed a ubiquitous, temporally sequenced cascade synchronized with global events. These findings suggest that the large-scale coordination of low-frequency spontaneous activity in the brain is underpinned by sequential, large-scale temporal cascades of neuronal spiking.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Integrative & Complementary Medicine
Alexa P. Spittler, Maryam F. Afzali, Richard B. Martinez, Lauren A. Culver, Sarah E. Leavell, Ariel E. Timkovich, Joseph L. Sanford, Melinda R. Story, Kelly S. Santangelo
Summary: The study suggests that EA has a positive effect on symptoms in a rodent model of OA, but does not modify the disease itself. Additionally, there may be a decrease in inflammatory biomarkers in the serum due to EA treatment. Further investigation into the mechanistic pathways of EA's efficacy in this animal model is needed.
ACUPUNCTURE IN MEDICINE
(2021)
Article
Oncology
Caroline M. Sawicki, Malvin N. Janal, Samuel J. Nicholson, Angie K. Wu, Brian L. Schmidt, Donna G. Albertson
Summary: Patients with oral cancer experience higher sensitivity to mechanical and chemical stimuli at the cancer site compared to a normal site.
Article
Orthopedics
Charlotte Sylwander, Ingrid Larsson, Emma Haglund, Stefan Bergman, Maria L. E. Andersson
Summary: This study investigated pain sensitivity among women and men with knee pain and found that pain sensitivity was associated with female sex, multiple pain sites, chronic widespread pain, and higher visceral fat area and body fat percentage.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Orthopedics
Holly T. Philpott, Garth Blackler, Joseph Daniel Klapak, Kyle K. Pitchers, Madison Tomlinson, Niall Smith, Jaclyn Viehweger, Joseph U. Umoh, David W. Holdsworth, Tristan Maerz, Christopher Thomas Appleton
Summary: Contrasting pain patterns in rat models of experimental knee osteoarthritis (OA) exposed to different OA-inducing risk factors including acute joint trauma, chronic instability, or obesity/metabolic syndrome revealed that OA risk factors influenced pain experiences differently, which hampers the translatability of preclinical OA pain research to clinical contexts.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yuan Tian, Tomohiro Onodera, Mohamad Alaa Terkawi, Koji Iwasaki, Ryosuke Hishimura, Dawei Liang, Takuji Miyazaki, Norimasa Iwasaki
Summary: The study found that low-dose NGF antibody injections can alleviate pain in rats with OA, while local treatment does not worsen OA progression. Local administration may serve as an alternative treatment for patients with OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rehabilitation
Khalid Jaber, Michael McAuliffe, Ashley Pedler, Michele Sterling, Shaun O'Leary
Summary: This study examined the relationship between Pressure Pain Threshold (PPT) measures and knee function in individuals with advanced knee osteoarthritis (KOA) undergoing total knee arthroplasty. The results showed that higher PPT scores were associated with better self-reported knee function and physical function. However, PPT measures could only explain a small portion of the variance in knee function.
MUSCULOSKELETAL SCIENCE AND PRACTICE
(2022)
Review
Pharmacology & Pharmacy
David O. Bates, Jonathan C. Morris, Sebastian Oltean, Lucy F. Donaldson
PHARMACOLOGICAL REVIEWS
(2017)
Article
Neurosciences
Roger H. Watkins, Johan Wessberg, Helena Backlund Wasling, James P. Dunham, Hakan Olausson, Richard D. Johnson, Rochelle Ackerley
JOURNAL OF NEUROPHYSIOLOGY
(2017)
Editorial Material
Neurosciences
Lucy F. Donaldson, Bridget M. Lumb
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Article
Immunology
Nicholas Beazley-Long, Daryl Hodge, William Robert Ashby, Samuel Marcus Bestall, Fatimah Almahasneh, Alexandra Margaret Durrant, Andrew Vaughan Benest, Zoe Blackley, Kurt Ballmer-Hofer, Masanori Hirashima, Richard Phillip Hulse, David Owen Bates, Lucy Frances Donaldson
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Article
Cell Biology
Samuel M. Bestall, Richard P. Hulse, Zoe Blackley, Matthew Swift, Nikita Ved, Kenneth Paton, Nicholas Beazley-Long, David O. Bates, Lucy F. Donaldson
JOURNAL OF CELL SCIENCE
(2018)
Article
Neurosciences
N. Ved, M. E. Da Vitoria Lobo, S. M. Bestall, C. L. Vidueira, N. Beazley-Long, K. Ballmer-Hofer, M. Hirashima, D. O. Bates, L. F. Donaldson, R. P. Hulse
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Clinical Neurology
James P. Dunham, Anna C. Sales, Anthony E. Pickering
CLINICAL NEUROPHYSIOLOGY
(2018)
Article
Neurosciences
Charles M. Greenspon, Emma E. Battell, Ian M. Devonshire, Lucy F. Donaldson, Victoria Chapman, Gareth J. Hathway
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Neurosciences
Joyce Mendes-Gomes, Tatiana Paschoalin-Maurin, Lucy F. Donaldson, Bridget M. Lumb, D. Caroline Blanchard, Norberto Cysne Coimbra
Article
Genetics & Heredity
Aidan P. Nickerson, Laura J. Corbin, Nicholas J. Timpson, Keith Phillips, Anthony E. Pickering, James P. Dunham
Summary: This study proposes an adaptive recall-by-genotype (RbG) study design to assess the association between genetic variation in the TRPA1 gene and pain phenotypes. Adjusting the test group based on preliminary data increases the likelihood of observing smaller effect sizes.
BMC MEDICAL GENOMICS
(2022)
Article
Biochemical Research Methods
A. C. Sales, G. W. T. Newton, A. E. Pickering, J. P. Dunham
Summary: This study presents a method of conducting C-fiber recordings using multisite silicon electrodes, which greatly improves experimental yields and enhances fiber identification. Compared to traditional single electrode approaches, multisite recordings can better capture data, especially for studying small unmyelinated C-fibers.
JOURNAL OF NEUROSCIENCE METHODS
(2022)
Article
Multidisciplinary Sciences
Aidan P. Nickerson, Graeme W. T. Newton, James H. O'Sullivan, Manuel Martinez-Perez, Anna C. Sales, Gethin Williams, Anthony E. Pickering, James P. Dunham
Summary: Nociceptors are primary afferent neurons that transmit potentially harmful stimuli. The excitability of nociceptors increases in pain conditions, resulting in abnormal activity and reduced thresholds. We developed an application (APTrack) to measure nociceptor excitability and demonstrated its use in humans and rodents.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Medicine, Research & Experimental
Nikita Ved, Richard P. Hulse, Samuel M. Bestall, Lucy F. Donaldson, James W. Bainbridge, David O. Bates
Article
Biochemistry & Molecular Biology
Michele Di Stefano, Andrea Loreto, Giuseppe Orsomando, Valerio Mori, Federica Zamporlini, Richard P. Hulse, Jamie Webster, Lucy F. Donaldson, Martin Gering, Nadia Raffaelli, Michael P. Coleman, Jonathan Gilley, Laura Conforti
Article
Physiology
David O. Bates, Nicholas Beazley-Long, Andrew V. Benest, Xi Ye, Nikita Ved, Richard P. Hulse, Shaney Barratt, Maria J. Machado, Lucy F. Donaldson, Steven J. Harper, Maria Peiris-Pages, Domingo J. Tortonese, Sebastian Oltean, Rebecca R. Foster
COMPREHENSIVE PHYSIOLOGY
(2018)