Article
Chemistry, Medicinal
Nissrine Ballout, Agnes Boullier, Walaa Darwiche, Katia Ait-Mohand, Eric Trecherel, Theo Gallego, Cathy Gomila, Linda Yaker, Isabelle Gennero, Jose Kovensky, Jerome Ausseil, Sylvestre Toumieux
Summary: Bone fracture healing is a complex process involving hematoma formation, tissue formation, bony callus formation, and bone remodeling. Current therapeutic strategies for fracture repair include autografts, allografts, and tissue engineering. This study suggests that DP2, a disaccharide compound, may enhance fracture healing by promoting osteoblast differentiation and earlier mineralization in vitro. DP2 might serve as a potential therapeutic candidate for bone fracture repair.
Article
Oncology
Wangyang Meng, Han Xiao, Rong Zhao, Dong Li, Kuo Li, Yunchong Meng, Jiaping Chen, Yangwei Wang, Yongde Liao
Summary: In lung adenocarcinoma, BMP5 was identified as an independent protective prognostic factor, significantly correlated with EGFR expression and mutations, and potentially involved in targeted therapy. By co-expression with hub genes, the re-established risk model showed improved prognostic correlation and value.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Mi Eun Kim, Jong Keun Seon, Ju Yeon Kang, Taek Rim Yoon, Jun Sik Lee, Hyung Keun Kim
Summary: BFP-4 induces stronger osteogenic differentiation of BMSCs compared to BMP-7, as well as enhancing ALP activity, calcium concentration, and osteogenic factor production. This suggests that BFP-4-stimulated cell therapy may be a more efficient and cost-effective approach to bone regeneration and formation than BMP-7-based therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Agriculture, Dairy & Animal Science
Agata Wawrzyniak, Krzysztof Balawender
Summary: This article examines the development, structure, and remodeling of bone tissue. As an essential component of the skeleton, bone provides support and protection and maintains the concentration of calcium and phosphate in body fluids. Bone metabolism involves the balance of bone formation and resorption, regulated by various factors. Secretion of biologically active substances in bone tissue also influences bone function and metabolism.
Article
Multidisciplinary Sciences
Binisha H. Mishra, Pashupati P. Mishra, Emma Raitoharju, Saara Marttila, Nina Mononen, Harri Sievanen, Jorma Viikari, Markus Juonala, Marika Laaksonen, Nina Hutri-Kahonen, Mika Kahonen, Olli T. Raitakari, Terho Lehtimaki
Summary: This study analysed gene co-expression modules shared by early traits of osteoporosis and atherosclerosis, identifying two modules with significant joint association with both diseases. The significant member genes from these modules are involved in biological processes related to bone metabolism or atherosclerosis, potentially providing new joint biomarkers for both diseases.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Anirban Sardar, Alisha Ansari, Sampa Gupta, Shradha Sinha, Shubham Pandey, Divya Rai, Mukesh Kumar, Rabi Sankar Bhatta, Ritu Trivedi, Koneni Sashidhara
Summary: A series of compounds were designed and synthesized using molecular hybridization approach. Among them, compound 47 was identified as the most potent osteoanabolic agent, promoting osteogenesis via the non-canonical p38 pathway mediated by RUNX2 and BMP2. It has the potential to be used as a lead for future bone metabolic disorder treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Anthony Estienne, Lauriane Relav, Morad Benkoura, Danielle Monniaux, Fanny Morin, Stephane Fabre, Christopher A. Price
Summary: Increasing the efficiency of farm animal reproduction is important for reducing the environmental impact of food production systems. This study investigates the factors that decrease oocyte health and how fibroblast growth factor 18 (FGF18) is regulated in the ovarian follicle. The researchers found that FGF18 secretion is controlled by intrafollicular factors and is linked to fertility. They also discovered that BMP4 stimulates FGF18 secretion from thecal endothelial cells, which affects fertility. Understanding these processes can help improve reproductive efficiency in farm animals.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Rheumatology
Elise Descamps, Anna Molto, Didier Borderie, Rik Lories, Corinne Miceli Richard, Marion Pons, Christian Roux, Karine Briot
Summary: This study found that serum levels of BMP-7 and sclerostin in early axSpA patients significantly increased over time, while DKK-1 showed no significant changes. Furthermore, inflammation was associated with changes in serum BMP-7 levels.
Article
Allergy
Jin Youp Kim, Suha Lim, Hee-Suk Lim, Yi-Sook Kim, Kyoung Mi Eun, Roza Khalmuratova, Yuju Seo, Joon Kon Kim, Young Seok Kim, Min-Kyung Kim, Siyeon Jin, Seung Cheol Han, Suyeon Pyo, Seung-No Hong, Jong-Wan Park, Hyun-Woo Shin, Dae Woo Kim
Summary: The role of BMPs in osteitis in patients with CRSwNPs and their associations with inflammatory markers are not fully investigated. Among the 6 BMPs studied, BMP-2 may be a novel biomarker for refractory CRSwNP with potential implications for mucosa and bone remodeling.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nikola Stokovic, Natalia Ivanjko, Igor Erjavec, Anita Breski, Mihaela Peric, Slobodan Vukicevic
Summary: The study found that adding Zoledronate (ZOL) to autologous bone graft substitute (ABGS) enhances the quality and quantity of newly formed bone, and also prolongs its longevity to a certain extent.
Article
Biochemistry & Molecular Biology
Ratchapol Jenjob, Hong-Phuong Nguyen, Min-Kyoung Kim, Yixin Jiang, Jung Joo Kim, Su-Geun Yang
Summary: This study designed bisphosphonate-conjugated polyanionic hyaluronic acid microbeads for the controlled delivery of bone morphogenetic protein 2, which displayed highly efficient promotion of bone formation.
Review
Polymer Science
Elena Iulia Oprita, Andreea Iosageanu, Oana Craciunescu
Summary: This paper reviews the complex structure of osteochondral tissue, the importance of icariin in osteochondral regeneration, and the recent development of hydrogels and scaffolds enriched with icariin. Icariin has chondrogenic and osteogenic effects, making it a promising alternative to growth factors. The use of icariin as a therapeutic approach in regenerative medicine is low-cost and has potential.
Article
Cell Biology
Lishan Zhang, Ziqi Fang, Guangdong Cheng, Mengting He, Yanliang Lin
Summary: A novel missense mutation (NM_000523: exon2: c.G917T: p.R306L) of Hoxd13 gene was identified in a Chinese family with synpolydactyly (SPD). Mice carrying the corresponding Hoxd13 mutation exhibited synpolydactyl phenotype. Further analysis revealed that this mutation promoted osteoclast differentiation and bone loss by regulating Smad5/p65/c-Fos/Rank axis, providing new insights into the development of SPD.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Mi Gyeom Kim, Che Lin Kim, Young Sik Kim, Ju Woong Jang, Gyun Min Lee
Summary: Cell surface HSPG-mediated endocytosis leads to low yields of recombinant human bone morphogenetic proteins (rhBMPs) in CHO cell cultures, but blocking internalization significantly increases the production of rhBMP-2.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Suni Tang, Dominique Cope, Yasmin M. Vasquez, Diana Monsivais
Summary: The biological processes that control endometrial receptivity and embryo implantation are critical for the successful outcome of pregnancy. Researchers found that the uterine epithelial BMP/SMAD1/5 signaling pathway plays a key role during early pregnancy and its deletion may lead to defects in endometrial receptivity and embryo implantation issues.
Article
Chemistry, Physical
Hozumi Takahashi, Mayu Yamaji, Jun Ikeyama, Makoto Nakajima, Hideaki Kitahara, Syouei Tetsukawa, Naritaka Kobayashi, Mihoko Maruyama, Teruki Sugiyama, Shuji Okada, Yusuke Mori, Seiichiro Nakabayashi, Masashi Yoshimura, Hiroshi Y. Yoshikawa
Summary: The study found that femtosecond laser ablation has an impact on the shape and nonlinear optical properties of organic crystals. Ablation can generate new crystal steps on the surface, but does not deteriorate the nonlinear optical properties. Controlling crystal shape through damage-less ablation process may potentially enhance the nonlinear optical properties of organic crystals.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Chemistry, Physical
Hiromasa Niinomi, Teruki Sugiyama, An-Chieh Cheng, Miho Tagawa, Toru Ujihara, Hiroshi Y. Yoshikawa, Ryuzo Kawamura, Jun Nozawa, Junpei T. Okada, Satoshi Uda
Summary: Analysis of the plasmonic near-field revealed that the chiral optical gradient force plays a crucial role in the formation of giant crystal enantiomeric excess, rather than enantioselective optical trapping.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Chemistry, Physical
Chih-Hao Huang, Tetsuhiro Kudo, Teruki Sugiyama, Hiroshi Masuhara, Johan Hofkens, Roger Bresoli-Obach
Summary: Optical trapping at an interface can control the shape and distribution of gold nanoparticles, and altering the optical conditions and beam direction can manipulate the evolution of swarming NPs. The study demonstrates that by adjusting the position of the laser focus and the angle of the radiation, the shape of the assemblies can be modified.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Chemistry, Physical
Po-Wei Yi, Wei-Hsiang Chiu, Tetsuhiro Kudo, Teruki Sugiyama, Roger Bresoli-Obach, Johan Hofkens, Eri Chatani, Ryohei Yasukuni, Yoichiroh Hosokawa, Shuichi Toyouchi, Hiroshi Masuhara
Summary: Optical trapping can generate different types of assemblies from dielectric and metal particles, with the potential to create hybrid materials for applications in various fields such as colloid science, protein chemistry, and soft matter. The cooperative trapping of particles and proteins leads to unique long assemblies and expanded layers, demonstrating the versatility and potential of this method in material fabrication.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Chemistry, Multidisciplinary
Abdullah Kamit, Ching-Shiang Tseng, Tetsuhiro Kudo, Teruki Sugiyama, Johan Hofkens, Roger Bresoli-Obach, Hiroshi Masuhara
Summary: Researchers used a dual-objective lens microscope to study the three-dimensional shape and dynamics of disk-like assemblies formed by trapping microparticles or nanoparticles at an interface, revealing new insights such as particle fluctuation, assembly shape, and interparticle distance. This higher resolution system with fast image acquisition provides novel insights that were not accessible with a conventional inverted microscope.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Wen-Chi Wang, Shun-Fa Wang, Teruki Sugiyama
Summary: This study demonstrates polymorph control of amino acids using high-repetition-rate femtosecond laser pulses, showing that two types of L-serine polymorphs can be produced by irradiating a saturated aqueous solution of L-serine. Different polarization of the laser leads to the formation of different polymorphs, with left-circular polarization producing Form 1 and all other polarizations producing Form 2.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2022)
Article
Engineering, Biomedical
Takashi Kamatani, Hiroki Hagizawa, Seido Yarimitsu, Miho Morioka, Saeko Koyamatsu, Michihiko Sugimoto, Joe Kodama, Junko Yamane, Hiroyuki Ishiguro, Shigeyuki Shichino, Kuniya Abe, Wataru Fujibuchi, Hiromichi Fujie, Takashi Kaito, Noriyuki Tsumaki
Summary: The implantation of hiPS cell-derived cartilaginous tissue can restore the loss of nucleus pulposus and prevent intervertebral disk degeneration, indicating its potential for regenerating NP and preserving IVD function.
Article
Materials Science, Multidisciplinary
Jhih-Hao Ho, Yi-Fan Chen, Ming-Hsuan Chang, Tsung-Wei Shih, Chih-Ting Liu, Hung-Chieh He, Yu-Liang Lin, Lin-Ruei Lee, Yu-Hsuan Tseng, Teruki Sugiyama, Jiun-Tai Chen
Summary: This study demonstrates a versatile approach to fabricate elliptical and bent polymer nanorod arrays through laser-induced photo-fluidization of azobenzene-containing polymers. The shape manipulation and tailored properties of the nanorod arrays can be controlled by the trans-to-cis and cis-to-trans isomerization of the azobenzene groups. The research provides a beneficial route for preparing ordered arrays of anisotropic polymer nanostructures for advanced applications.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Physics, Applied
Po-Wei Yi, Wei-Hsiang Chiu, Shuichi Toyouchi, Roger Bresoli-Obach, Johan Hofkens, Eri Chatani, Yoichiroh Hosokawa, Teruki Sugiyama, Hiroshi Masuhara
Summary: Optical trapping at interfaces is becoming increasingly important, particularly for proteins with submillimeter structures. Initially, lysozyme clusters are trapped on the surface, gradually forming a thicker layer over time. However, once a concentration threshold is reached, lysozyme clusters in the solution are collected and transported towards the focus, invading the lysozyme layer and creating a border between them, without any detectable concentration jump. This two-stage optical trapping is due to the long-range interaction originating from the focus.
APPLIED PHYSICS EXPRESS
(2023)
Article
Optics
Kohei Toyoda, Hao-Tse Su, Katsuhiko Miyamoto, Teruki Sugiyama, Takashige Omatsu
Summary: Researchers have successfully demonstrated the selective control of the chirality of sodium chlorate crystals by altering the helicity of an irradiating optical vortex laser beam. A high crystal enantiomeric excess of 57% is achieved. This study provides fundamental insights into the dynamics and mechanism of enantioselective control in chiral crystallization and the origin of homochirality.
Article
Chemistry, Multidisciplinary
Tsung-Wei Shih, Yi-Ren Chen, Xueqin Wei, Ming Rao, Cheng Yang, Yoshihisa Inoue, Teruki Sugiyama
Summary: Despite its potential, the optical trapping method has never been applied to supramolecular chemistry or chiral photochemistry. Here, we demonstrate that optical trapping using a focused laser beam boosts supramolecular assembly beyond the thermodynamic limitations and affords an unprecedented higher-order 2:4 complex through the otherwise-inaccessible dimerization of 1:2 complexes of g-cyclodextrin with two 2-anthracenecarboxylic acids (ACs). This process accelerates the chiral photocyclodimerization of ACs with switched regio-and enantio-selectivities.
CELL REPORTS PHYSICAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Boris Louis, Chih-Hao Huang, Rafael Camacho, Ivan G. Scheblykin, Teruki Sugiyama, Tetsuhiro Kudo, Marc Melendez, Rafael Delgado-Buscalioni, Hiroshi Masuhara, Johan Hofkens, Roger Bresoli-Obach
Summary: In this work, the 3D motion trajectories of 200 nm fluorescent polystyrene particles in an optical trapping site were resolved using a widefield multiplane microscope. The particles showed a shallow cone distribution following preferential 3D channels near the focus. The radial and axial flow speed components depended on the axial distance from the focus, which was directly related to the scattering/gradient optical forces. The trapping laser profile determined the particle velocities and trajectories, but collective effects resulting from hydrodynamic forces also played a role.
Article
Chemistry, Physical
Chih-Hao Huang, Ya-Chiao Lee, Tetsuhiro Kudo, Xu Shi, Kosei Ueno, Teruki Sugiyama, Hiroaki Misawa, Hiroshi Masuhara
Summary: In this study, optical trapping with fabricated gold nanodisk arrangement was used to observe the trapping and arrangement of gold nanoparticles between the nanodisks, as well as the bidirectional and unidirectional swarming behavior of the nanoparticles. These findings provide valuable insights into optical manipulation techniques coupled with fabricated nanostructures, expanding the possibilities for optical trapping and related research.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Proceedings Paper
Optics
An-Chieh Cheng, Christophe Pin, Teruki Sugiyama, Keiji Sasaki
Summary: The study designs and fabricates triangular trimer gold nanostructures with different edge lengths and investigates the effects of plasmon modes on crystallization behaviors. The location of the enhanced electric field is dependent on the edge lengths of the triangular trimer. It is found that polymorphic transformation occurs in the case of continuous laser irradiation on a 230 nm trimer, but not on a 170 nm trimer.
OPTICAL MANIPULATION AND STRUCTURED MATERIALS CONFERENCE (OMC 2022)
(2022)
Article
Materials Science, Multidisciplinary
Shun-Fa Wang, Bo-Wei Chen, Ayami Itagaki, Fumitaka Ishiwari, Takanori Fukushima, Hiroshi Masuhara, Teruki Sugiyama
Summary: This study investigates the manipulation of dual fluorescence behavior in aggregation-induced emission enhancement (AIEE) of a tetraphenylethene (TPE)-appended polymer by optical tweezers. The optical tweezers control the local environment around the fluorophore, resulting in dual fluorescence emissions of polymers that can be arbitrarily regulated by tuning the laser power.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)