Systems Biology Reveals Cigarette Smoke-Induced Concentration-Dependent Direct and Indirect Mechanisms That Promote Monocyte–Endothelial Cell Adhesion

Smoking and Cardiovascular Disease

(2014) Barbara Messner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cigarette smoke condensate affects monocyte interaction with endothelium

(2014) I. Giunzioni et al.   ATHEROSCLEROSIS

Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models

(2014) Florian Martin et al.   BMC BIOINFORMATICS

A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes

(2014) Ulrike Kogel et al.   FOOD AND CHEMICAL TOXICOLOGY

The Response of Human Nasal and Bronchial Organotypic Tissue Cultures to Repeated Whole Cigarette Smoke Exposure

(2014) Marja Talikka et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Mechanism of an indirect effect of aqueous cigarette smoke extract on the adhesion of monocytic cells to endothelial cells in an in vitro assay revealed by transcriptomics analysis

(2014) Carine Poussin et al.   TOXICOLOGY IN VITRO

In vitrosystems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures

(2014) Walter K. Schlage et al.   TOXICOLOGY MECHANISMS AND METHODS

Endothelium and Its Alterations in Cardiovascular Diseases: Life Style Intervention

(2014) Gaia Favero et al.   Biomed Research International

Confero: an integrated contrast data and gene set platform for computational analysis and biological interpretation of omics data

(2013) Leandro Hermida et al.   BMC GENOMICS

Case study: the role of mechanistic network models in systems toxicology

(2013) Julia Hoeng et al.   DRUG DISCOVERY TODAY

Hydrogen sulfide reduces cell adhesion and relevant inflammatory triggering by preventing ADAM17-dependent TNF-α activation

(2013) Alessandra F. Perna et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Brain Microvascular Endothelium Supports T Cell Proliferation and Has Potential for Alloantigen Presentation

(2013) Julie Wheway et al.   PLoS One

Quantitative assessment of biological impact using transcriptomic data and mechanistic network models

(2013) Ty M. Thomson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion

(2013) A. Hochreiter-Hufford et al.   Cold Spring Harbor Perspectives in Biology

ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation

(2012) S. Weissmuller et al.   BLOOD

Inflammatory Transcriptome Profiling of Human Monocytes Exposed Acutely to Cigarette Smoke

(2012) William R. Wright et al.   PLoS One

Evaluation of cytotoxicity of different tobacco product preparations

(2012) Subhashini Arimilli et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Critical role of fractalkine (CX3CL1) in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium

(2012) Cristina Rius et al.   THORAX

Apoptosis and necrosis: two different outcomes of cigarette smoke condensate-induced endothelial cell death

(2012) B Messner et al.   Cell Death & Disease

APCluster: an R package for affinity propagation clustering

(2011) U. Bodenhofer et al.   BIOINFORMATICS

Cigarette smoke extract induces prolonged endoplasmic reticulum stress and autophagic cell death in human umbilical vein endothelial cells

(2011) Adam Csordas et al.   CARDIOVASCULAR RESEARCH

Oxidative Phosphorylation Flexibility in the Liver of Mice Resistant to High-Fat Diet-Induced Hepatic Steatosis

(2011) C. Poussin et al.   DIABETES

Reactive Oxygen Species and p38 Mitogen-activated Protein Kinase Mediate Tumor Necrosis Factor α-Converting Enzyme (TACE/ADAM-17) Activation in Primary Human Monocytes

(2011) Alasdair J. Scott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of fluorides on apoptosis and activation of human umbilical vein endothelial cells

(2011) M Szczepański et al.   ORAL DISEASES

p53 Mediates Cigarette Smoke–Induced Apoptosis of Pulmonary Endothelial Cells

(2010) Rachel Damico et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Endogenous enzymes (NOX and ECSOD) regulate smoke-induced oxidative stress

(2010) Angela K. Tollefson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidants Positively or Negatively Regulate Nuclear Factor κB in a Context-dependent Manner

(2010) Noureddine Loukili et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumour necrosis factor-α processing in interstitial lung disease: a potential role for exogenous proteinase-3

(2009) L. Armstrong et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY