Article
Mathematics, Interdisciplinary Applications
Zijian Wang, Jian Liu, Zongyun Gu, Chuanfu Li
Summary: In this study, we developed an efficient model powered by deep convolutional neural networks to automate the scoring of hand X-rays for rheumatoid arthritis patients. The experimental results showed that the model achieved high efficiency and accuracy, with no statistical difference compared to ratings from experienced radiologists.
Article
Rheumatology
Angel Y. S. Wong, Brian MacKenna, Caroline E. Morton, Anna Schultze, Alex J. Walker, Krishnan Bhaskaran, Jeremy P. Brown, Christopher T. Rentsch, Elizabeth Williamson, Henry Drysdale, Richard Croker, Seb Bacon, William Hulme, Chris Bates, Helen J. Curtis, Amir Mehrkar, David Evans, Peter Inglesby, Jonathan Cockburn, Helen McDonald, Laurie Tomlinson, Rohini Mathur, Kevin Wing, Harriet Forbes, Rosalind M. Eggo, John Parry, Frank Hester, Sam Harper, Stephen J. W. Evans, Liam Smeeth, Ian J. Douglas, Ben Goldacre
Summary: Two cohort studies were conducted to assess the association between routinely prescribed NSAIDs and COVID-19 related deaths, finding no evidence of a harmful effect. Therefore, the risks of COVID-19 do not need to influence decisions about the routine therapeutic use of NSAIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Immunology
Kang-Jia Yin, Ji-Xiang Huang, Peng Wang, Xiao-Ke Yang, Sha-Sha Tao, Hong-Miao Li, Jing Ni, Hai-Feng Pan
Summary: This study using Mendelian randomization analysis found no causal association between periodontitis and arthritis, despite previous observational studies reporting a link between the two.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Mingyue Cheng, Yan Zhao, Yazhou Cui, Chaofang Zhong, Yuguo Zha, Shufeng Li, Guangxiang Cao, Mian Li, Lei Zhang, Kang Ning, Jinxiang Han
Summary: This study investigated the role of microbial dysbiosis and metabolic disorders in different stages of rheumatoid arthritis (RA). The findings suggest that microbial dysbiosis and metabolic disorders exhibit distinct patterns and play stage-specific roles in RA. This provides new insights for prognosis and therapy of RA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Iona J. MacDonald, Chien-Chung Huang, Shan-Chi Liu, Yen-You Lin, Chih-Hsin Tang
Summary: The CCN family of matricellular proteins play essential roles in processes like angiogenesis, wound healing, and inflammation, particularly in the inflammatory pathologies of rheumatoid arthritis and osteoarthritis. Several proteins within the CCN family are thought to be potential therapeutic targets for these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Theoharris Frangos, Wolfgang Maret
Summary: Zinc and cadmium play crucial roles in osteoarthritis and rheumatoid arthritis, affecting the immune system, inflammation, and metabolism. The mutations in proteins involved in zinc homeostasis and cadmium exposure through inhalation may contribute to joint destruction.
Article
Public, Environmental & Occupational Health
Desheng Zhao, Jian Cheng, Ping Bao, Yanwu Zhang, Fengjuan Liang, Hao Wang, Xu Wang, Shiyuan Fang, Hong Su
Summary: This study found a significant association between temperature decrease and RA admission, with females and patients aged 41-65 years being more vulnerable to the effect. However, no significant association between temperature and OA admission was observed.
Article
Engineering, Electrical & Electronic
Ahmad Mobed, Sanam Dolati, Seyed Kazem Shakouri, Bina Eftekharsadat, Behzad Izadseresht
Summary: OA and RA are two most frequent types of degenerative joint diseases in adults, with common symptoms but differences in pathological manifestations. Biomarker detection can identify disease development at early stages, benefiting patients with prompt diagnosis.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Review
Rheumatology
Christopher McMaster, Alix Bird, David F. L. Liew, Russell R. Buchanan, Claire E. Owen, Wendy W. Chapman, Douglas E. Pires
Summary: Deep learning has become the leading method in machine learning and has great potential for applications in rheumatology, particularly for handling unstructured data such as images and text. It is important for rheumatologists to understand the methods and limitations of deep learning algorithms and contribute to the development of relevant clinical applications.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Orthopedics
Le Kang, Chengqian Dai, Lihong Wang, Xinling Pan
Summary: Analysis of differentially expressed genes in rheumatoid arthritis (RA) and osteoarthritis (OA) can provide potential targets for molecular diagnosis and treatment. ADAMDEC1 in synovial fluid is a good biomarker of RA.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Pharmacology & Pharmacy
Kailin Yang, Liuting Zeng, Zhiyong Long, Qi He, Wang Xiang, Anqi Ge, Huang Zhen, Wei Xiao, Jinwen Ge
Summary: This study evaluated the efficacy and safety of total glucosides of paeony (TGP) in the treatment of 5 types of inflammatory arthritis. The results showed that TGP can improve symptoms and inflammation levels in patients with inflammatory arthritis. However, larger and more high-quality clinical trials are still needed for further validation.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Djedjiga Ait Eldjoudi, Alfonso Cordero Barreal, Maria Gonzalez-Rodriguez, Clara Ruiz-Fernandez, Yousof Farrag, Mariam Farrag, Francisca Lago, Maurizio Capuozzo, Miguel Angel Gonzalez-Gay, Antonio Mera Varela, Jesus Pino, Oreste Gualillo
Summary: White adipose tissue is a specialized tissue involved in lipid synthesis and storage. It serves as an active organ that secretes hormones and cytokines called adipokines, with leptin being a key molecule. Leptin not only regulates energy balance and food intake, but also plays roles in reproduction, glucose metabolism, hematopoiesis, and immune system interactions. It is involved in innate and adaptive immunity and contributes to the pathogenesis of chronic inflammation and immune-related diseases like osteoarthritis and rheumatoid arthritis. This review summarizes recent findings on the involvement of leptin in immunity and inflammatory responses in these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Peraphan Pothacharoen, Rujirek Chaiwongsa, Theerawut Chanmee, Orapin Insuan, Thanchanok Wongwichai, Phornpimon Janchai, Pilanee Vaithanomsat
Summary: Bromelain, a protease mixture found in pineapple, has beneficial biological properties and exhibits anti-arthritic activities. It protects cartilage from degradation and decreases the expression of inflammatory cytokines in synovial fibroblasts by suppressing NF-kappa B and MAPK signaling pathways.
Review
Endocrinology & Metabolism
Yifan Zhang, Jun Ma, Xingfu Bao, Min Hu, Xiaoxi Wei
Summary: This article summarizes the roles and mechanisms of RORs in skeletal diseases, providing evidence for potential therapeutic strategies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Ruobing Zhao, Yan Chen, Dongxue Wang, Chunyu Zhang, Henan Song, Guoxin Ni
Summary: Bone diseases are common and detrimental to the daily activities and quality of life of middle-aged and elderly individuals. It is essential to identify key regulatory factors and potential therapeutic targets for bone diseases. Irisin, a newly discovered myokine, has been found to have beneficial effects on various diseases, especially bone-related disorders. Research has indicated that irisin plays a role in bone diseases such as osteoarthritis and osteoporosis, suggesting its potential as a molecule for the prevention and treatment of bone diseases. This review summarizes the specific regulatory mechanisms of irisin in different bone diseases and provides a theoretical basis for its application in the diagnosis and treatment of these conditions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Letter
Rheumatology
Ian J. Wallace, David T. Felson, Steven Worthington, Daniel E. Lieberman
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Letter
Rheumatology
Paul Studenic, David T. Felson, Maarten de Wit, Josef S. Smolen, Daniel Aletaha
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Letter
Rheumatology
David Felson, Diane Lacaille, Michael P. LaValley, Daniel Aletaha
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Orthopedics
J. -P. Zertuche, G. Rabasa, A. H. Lichtenstein, N. R. Matthan, M. Nevitt, J. Torner, C. E. Lewis, Z. Dai, D. Misra, D. Felson
Summary: Higher fiber intake is associated with a lower risk of osteoarthritis (OA). The study found a possible association between levels of alkylresorcinol (AR), a marker of whole grain intake, and OA. High AR levels may have a protective effect against OA.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Rheumatology
S. Reza Jafarzadeh, Tuhina Neogi, Daniel K. White, David T. Felson
Summary: Appropriate pain interventions can significantly reduce the need for knee replacement surgery in patients with osteoarthritis, with larger reductions in risk achieved when pain is reduced to a greater extent and interventions are introduced at lower pain levels.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
David Felson, Vivi Feathers, Chinmayi Naik, Daniel H. Solomon, Michael E. Weinblatt, Nancy Shadick
Summary: In rheumatoid arthritis patients with low 28-joint tender and swollen joint counts but who perceive their disease as active, there may be pain in uncounted joints that could respond to rheumatoid arthritis treatment.
Article
Rheumatology
Paul Studenic, Daniel Aletaha, Maarten de Wit, Tanja A. Stamm, Farideh Alasti, Diane Lacaille, Josef S. Smolen, David T. Felson
Summary: This study aimed to externally validate a revised Boolean remission criteria using a higher patient global assessment (PtGA) threshold and validate the provisionally endorsed index-based criteria. The results showed that using the higher PtGA threshold increased the proportion of patients classified as achieving remission under the "Boolean2.0" criteria, improved agreement with index-based criteria, and did not compromise predictive value for radiographic or functional outcomes. The study findings were endorsed by ACR and EULAR.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Patrick Corrigan, David T. Felson, Cara L. Lewis, Tuhina Neogi, Michael P. LaValley, K. Doug Gross, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Joshua J. Stefanik
Summary: The study aimed to investigate the relationship between unilateral knee pain severity and temporal asymmetry during walking, as well as the associations of temporal asymmetry with changes in ipsilateral and contralateral knee pain over 2 years in individuals with mild-to-moderate unilateral knee pain. The study included participants with unilateral knee pain from the Multicenter Osteoarthritis Study, and gait and pain assessments were conducted at baseline and 2 years. The results showed that unilateral knee pain severity was not associated with temporal asymmetry during walking. However, certain measures of temporal asymmetry during self-selected and fast walking were related to longitudinal knee pain outcomes.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Paul Studenic, Daniel Aletaha, Maarten de Wit, Tanja A. Stamm, Farideh Alasti, Diane Lacaille, Josef S. Smolen, David T. Felson
Summary: The revised Boolean remission criteria, using a higher patient global assessment threshold, classify more patients as achieving remission and increase the agreement with index-based remission criteria without jeopardizing predictive value for radiographic or functional outcomes.
ARTHRITIS & RHEUMATOLOGY
(2023)
Review
Orthopedics
David Felson, Tuhina Neogi
Summary: Knee osteoarthritis is a common and disabling disease. Diagnostic imaging is usually not necessary for diagnosis of chronic knee pain in individuals aged 45 and over, as treatment does not vary based on imaging results. However, imaging may be helpful for atypical presentations or for locating the joint during corticosteroid injections. Guidelines currently discourage imaging in the diagnosis or management of most persons with OA, but this may change for individuals with correctible lesions or specific subtypes of the disease.
SKELETAL RADIOLOGY
(2023)
Letter
Rheumatology
Paul Studenic, Daniel Aletaha, Tanja A. Stamm, Maarten de Wit, Diane Lacaille, Josef S. Smolen, David Felson
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Matthew C. Baker, Khushboo Sheth, Rong Lu, Di Lu, Ericka P. von Kaeppler, Archana Bhat, David T. Felson, William H. Robinson
Summary: This retrospective cohort study found that patients with atopic disease have a higher incidence of osteoarthritis (OA) compared to non-exposed patients. The study showed that patients with asthma or atopic dermatitis had a higher risk of developing OA, particularly those with both conditions. These findings suggest a potential link between allergic pathways and the prevention or treatment of OA.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Sport Sciences
Kerry E. Costello, David T. Felson, S. Reza Jafarzadeh, Ali Guermazi, Frank W. Roemer, Neil A. Segal, Cora E. Lewis, Michael C. Nevitt, Cara L. Lewis, Vijaya B. Kolachalama, Deepak Kumar
Summary: This study developed a machine learning model that incorporates gait and physical activity to predict medial tibiofemoral cartilage worsening over 2 years in individuals without advanced knee osteoarthritis. The model showed good performance in predicting cartilage worsening and identified influential predictors in the outcome.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Rheumatology
Cara L. Lewis, Neil A. Segal, Gabriela V. Rabasa, Michael P. LaValley, Glenn N. Williams, Michael C. Nevitt, Cora E. Lewis, David T. Felson, Joshua J. Stefanik
Summary: This study aimed to evaluate the relationship between hip abductor strength and worsened or new-onset frequent knee pain. The study found that women with weaker hip abductor strength had a higher risk of worsened knee pain, but there was no association with incident frequent knee pain in men or women.
ARTHRITIS CARE & RESEARCH
(2023)
Editorial Material
Rheumatology
David Felson, Martin K. Lotz, Yuxuan Jin, Morgan Jones, Jason S. Kim, Kurt Spindler
Summary: Animal models have shown promising treatments for post traumatic osteoarthritis, but human trials have mostly failed to find effective treatments. This viewpoint suggests that the frequent failure in drug and treatment development for osteoarthritis may be due to the advanced disease stage of the patients in trials and proposes that mirroring the animal model approach could be more successful. It suggests selecting trial participants who are likely to quickly develop post traumatic osteoarthritis as a way forward.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
