Article
Hematology
Takumi Tsuchida, Mineji Hayakawa, Shota Kawahara, Osamu Kumano
Summary: This study aimed to investigate the effects of antithrombin (AT) deficiency on coagulation balance using a thrombin generation assay. The results showed that the ability to generate thrombin increased as AT activity decreased, and thrombin generation was significantly suppressed when AT activity was equal to or below 50%. Particularly, thrombin generation was remarkable when AT activity was below 30%, indicating a poor prognosis due to organ failure from thrombotic tendency.
THROMBOSIS JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Sara Reda, Jens Muller, Anna Pavlova, Behnaz Pezeshkpoor, Johannes Oldenburg, Bernd Potzsch, Heiko Ruhl
Summary: The study investigated the impact of AT mutations on thrombin inhibition kinetics, finding that patients with AT mutations had significantly prolonged plasma half-life of thrombin. Interestingly, compared with controls, patients with AT mutations had higher AT levels in plasma despite reaching a comparable thrombin half-life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Reidun Aarsetoy, Hugo Ten Cate, Henri Spronk, Rene Van Oerle, Hildegunn Aarsetoy, Harold Staines, Dennis W. T. Nilsen
Summary: The study found that complexes of FXIa-AT were independently associated with 30-days survival in patients with out-of-hospital cardiac arrest, and the levels were correlated with the survival rate.
THROMBOSIS RESEARCH
(2021)
Article
Hematology
Shravan Morla, Hiroshi Deguchi, John H. Griffin
Summary: The study found that skeletal muscle myosin and cardiac myosin can neutralize the enhancement of antithrombin's anticoagulant activity by unfractionated heparin, but the length of the heparin chain can have different effects on this interaction.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
William J. Wulftange, Erdem Kucukal, Yuncheng Man, Ran An, Karamoja Monchamp, Charlotte D. Sevrain, Himanshu R. Dashora, Amma T. Owusu-Ansah, Allison Bode, Anton Ilich, Jane A. Little, Nigel S. Key, Umut A. Gurkan
Summary: This study utilized a biomimetic microfluidic device to investigate the role of endothelial cell damage and red blood cell adhesion in sickle cell disease, and found that the use of antithrombin-III (ATIII) can alleviate these symptoms.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Hematology
Jacob Lund, Kasper Jensen, Laurent Burnier, Mirella Ezban
Summary: This study aimed to investigate the response of Mim8 in thrombin generation assays and its combination with other hemostatic proteins. The results showed that Mim8 has a similar mode of action with FVIII and the concomitant use of FVIII and Mim8 for bleed treatment is safe.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cell Biology
Ekaterina M. Koltsova, Anna D. Kuprash, Natalya M. Dashkevich, David M. Vardanyan, Artem Chernyakov, Maria A. Kumskova, Sukesh C. Nair, Alok Srivastava, Fazoil Ataullakhanov, Mikhail A. Panteleev, Anna N. Balandina
Summary: Thrombodynamics-4D is a new method for assessing the roles of plasma and platelets in clotting, allowing for the determination of plasma or platelet disorders and the effects of drugs on these processes. The assay involves clot formation in platelet-rich plasma or platelet-free plasma, activation with tissue factor, and registration of spatial fibrin clot growth and thrombin concentration dynamics through light scattering and fluorescence measurements.
Article
Medicine, Research & Experimental
Wen-yi Lin, Ruiqi Zhu, Zhen Zhang, Xuan Lu, Huafang Wang, Wenjuan He, Yu Hu, Liang Tang
Summary: The study targeted HCII using RNA interference and GalNAc-HCII for liver-specific delivery, showing promising results as a new therapeutic option for hemophilia patients by effectively reducing HCII levels and improving the bleeding phenotype.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Ivan A. Muravlev, Anatoly B. Dobrovolsky, Olga A. Antonova, Svetlana G. Khaspekova, Alexey Mazurov
Summary: This study demonstrates that platelets play a significant role in the acceleration of fibrin formation, and their activation with different agonists enhances this effect. The effects of platelets on fibrin formation and thrombin generation correlate with each other and depend on the level of phosphatidylserine exposure on their surface. These findings highlight the importance of considering platelet procoagulant effects in investigations of hemostatic and thrombotic reactions, as well as in the evaluation of antiplatelet drugs.
Article
Immunology
Takeshi Wada, Atsushi Shiraishi, Satoshi Gando, Daijiro Kabata, Kazuma Yamakawa, Seitaro Fujishima, Daizoh Saitoh, Shigeki Kushimoto, Hiroshi Ogura, Toshikazu Abe, Toshihiko Mayumi, Yasuhiro Otomo, AAM FORECAST Grp
Summary: Trauma-induced coagulopathy is worsened by decreased antithrombin activity and is associated with poor outcomes, including the onset of disseminated intravascular coagulation (DIC).
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Michal Zabczyk, Joanna Natorska, Anetta Undas
Summary: FXIII is crucial in the modulation of fibrin clot properties in patients with VTE, impacting clot structure and function. FXIII activity is significantly reduced in acute PE and DVT patients, but gradually increases after the acute phase. Reduced FXIII activity is associated with impaired clot permeability and hypofibrinolysis in acute PE patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Akitada Ichinose, Tsukasa Osaki, Masayoshi Souri
Summary: Autoimmune factor XIII deficiency is a rare and life-threatening bleeding disorder that primarily affects the elderly. Research shows that patients with AiF13D have lower levels of FXIII antigen, and specific screening tests can effectively differentiate this condition from others.
Article
Hematology
Maria Eugenia de la Morena-Barrio, Pierre Suchon, Eva Marie Jacobsen, Nina Iversen, Antonia Minano, Belen de la Morena-Barrio, Carlos Bravo-Perez, Jose Padilla, Rosa Cifuentes, Susana Asenjo, Jean Francois Deleuze, David Alexandre Tregouet, Maria Luisa Lozano, Vicente Vicente, Per Morten Sandset, Pierre Emmanuel Morange, Javier Corral
Summary: This study identified two new variants in the SERPINC1 gene, which may cause antithrombin deficiency but cannot be detected by routine methods. These variants affect the glycosylation and function of antithrombin, leading to increased thrombin generation. The study suggests that antithrombin deficiency is underestimated and highlights the need for new diagnostic tests.
Article
Hematology
Amir A. Shamshirsaz, Karin A. Fox, Hadi Erfani, Karen Bruzdoski, Vadim Kostousov, Steven L. Clark, Lisa Hensch, Shiu-Ki (Rocky) Hui, Jun Teruya
Summary: ROTEM parameters vary across trimesters of pregnancy and differ from the nonpregnant state. Developing and using pregnancy-specific values are critical for the proper clinical interpretation of ROTEM in women with serious hemorrhage during different stages of pregnancy. TAT is the earliest laboratory marker for coagulation activation among others.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2021)
Review
Anesthesiology
Patricia Guilabert, Lars Asmis, Vicente Cortina, Joan P. Barret, Maria J. Colomina
Summary: Factor XIII (FXIII) is the final factor in the coagulation cascade and its deficiency can lead to surgical bleeding. Congenital FXIII deficiency is rare, while acquired FXIII deficiency is more common. This review provides guidance on the diagnosis and treatment of FXIII deficiency in preoperative consultation and surgical settings.
MINERVA ANESTESIOLOGICA
(2022)
Article
Orthopedics
Sotcheadt Sim, Anik Chevrier, Martin Garon, Eric Quenneville, Patrick Lavigne, Alex Yaroshinsky, Caroline D. Hoemann, Michael D. Buschmann
JOURNAL OF ORTHOPAEDIC RESEARCH
(2017)
Article
Orthopedics
Angela D. Bell, Mark B. Hurtig, Eric Quenneville, Georges-Etienne Rivard, Caroline D. Hoemann
Article
Biochemistry & Molecular Biology
Caroline D. Hoemann, Catherine Marchand, Georges-Etienne Rivard, Hani El-Gabalawy, Patrice E. Poubelle
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2017)
Article
Engineering, Biomedical
Xian Li, Nima Ghavidel Mehr, Jessica Guzman-Morales, Basil D. Favis, Gregory De Crescenzo, Nandadeva Yakandawala, Caroline D. Hoemann
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2017)
Article
Cell & Tissue Engineering
A. Chevrier, V. Darras, G. Picard, M. Nelea, D. Veilleux, M. Lavertu, C. D. Hoemann, M. D. Buschman
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)
Article
Orthopedics
Garima Dwivedi, Anik Chevrier, Caroline D. Hoemann, Michael D. Buschmann
Article
Orthopedics
Garima Dwivedi, Anik Chevrier, Mohamad-Gabriel Alameh, Caroline D. Hoemann, Michael D. Buschmann
Summary: The research found a strong positive correlation between cell number, clonogenic, chondrogenic, and matrix production potential of BMSCs and in vivo cartilage repair scores. Donor-dependent variation and a strong correlation were observed between interdonor repair variation and in vitro properties of BMSCs. The variability in cartilage repair outcomes can be attributed to the variation in BMSC properties in the subchondral bone.
Article
Biophysics
Angel Contreras-Garcia, Noelia L. D'Elia, Maxime Desgagne, Charles-Hubert Lafantaisie-Favreau, Georges-Etienne Rivard, Juan-Carlos Ruiz, Michael R. Wertheimer, Paula Messina, Caroline D. Hoemann
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Article
Cell & Tissue Engineering
Garima Dwivedi, Anik Chevrier, Caroline D. Hoemann, Michael D. Buschmann
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2019)
Article
Engineering, Biomedical
Leili Ghazi Zadeh, Anik Chevrier, Martin Lamontagne, Michael D. Buschmann, Caroline D. Hoemann, Marc Lavertu
BIO-MEDICAL MATERIALS AND ENGINEERING
(2019)
Article
Orthopedics
V. P. Mantripragada, W. Gao, N. S. Piuzzi, C. D. Hoemann, G. F. Muschler, R. J. Midura
Summary: This study aimed to evaluate collagen orientation and arrangement in articular cartilage using polarized light microscopy, comparing it with standard histopathological methods. The results showed that PLM was effective in identifying early collagen alterations in the cartilage and could aid in improving the characterization of early primary OA cartilage.
Article
Engineering, Biomedical
Caroline D. Hoemann, Javier Rodriguez Gonzalez, Jessica Guzman-Morales, Gaoping Chen, Ebrahim Jalali Dil, Basil D. Favis
Summary: This study found that non-inflammatory chitosan coatings promoted cartilage infiltration into and over a bioplastic scaffold, and were compatible with trabecular bone integration. Compared to drill-only defects, the 83-99-PCL scaffold induced angiogenesis and slight bone resorption, with the smallest change in bone volume fraction.
BIOACTIVE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Caroline D. Hoemann, Jessica Guzman-Morales, Genevieve Picard, Gaoping Chen, Daniel Veilleux, Anik Chevrier, Sotcheadt Sim, Martin Garon, Eric Quenneville, Charles-Hubert Lafantaisie-Favreau, Michael D. Buschmann, Mark B. Hurtig
Article
Engineering, Biomedical
David Fong, Pascal Gregoire-Gelinas, Alexandre P. Cheng, Tal Mezheritsky, Marc Lavertu, Sachiko Sato, Caroline D. Hoemann
Article
Biochemistry & Molecular Biology
David Fong, Nicholas Duceppe, Caroline D. Hoemann
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)