Review
Pharmacology & Pharmacy
Etienne Buscail, Celine Deraison
Summary: Postoperative ileus is a common complication after abdominal surgery, which can have serious consequences. Advances in peri-operative management have been made, but the rate of prolonged postoperative ileus remains high. The pathophysiology of postoperative ileus involves an early neurological phase, a later inflammatory phase, and a pharmacological phase. This review article describes these phases and discusses current pharmacological treatments and potential research areas for targeting.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Nils P. Sommer, Reiner Schneider, Sven Wehner, Joerg C. Kalff, Tim O. Vilz
Summary: Postoperative Ileus is a common complication after abdominal surgery, with various treatment strategies lacking strong evidence to support their effectiveness. Current preventive measures include multimodal, opioid-sparing analgesia, epidural catheters or transverse abdominis plane block.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Obstetrics & Gynecology
Ruth B. Hennebery, Christine A. Burke, Tracy Caroline Bank, Matthew K. Hoffman
Summary: This study aimed to identify factors associated with postoperative ileus following cesarean delivery. A retrospective case-control study was conducted, and potential risk factors including preeclampsia, exposure to general anesthesia, estimated blood loss >1 L, and transfusion of blood products were identified.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Article
Oncology
Zhenmeng Lin, Yangming Li, Jiansheng Wu, Huizhe Zheng, Chunkang Yang
Summary: A highly accurate nomogram was developed and validated in this study to predict individual risk of PPOI after colorectal resection, which can assist surgeons in making optimal treatment decisions.
Article
Medicine, General & Internal
Andreea Firut, Dragos Nicolae Margaritescu, Adina Turcu-Stiolica, Marius Bica, Ionela Rotaru, Ana-Maria Patrascu, Razvan Ilie Radu, Daniela Marinescu, Stefan Patrascu, Costin Teodor Streba, Valeriu Surlin
Summary: This study aimed to assess the role of immunocyte-derived ratios (IDRs) as markers for postoperative recovery of gastrointestinal function following colorectal cancer surgery. The results showed that certain IDRs may have potential as predictive determinants for postoperative gastrointestinal functional recovery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Etienne Buscail, Thibault Planchamp, Guillaume Le Cosquer, Manon Bouchet, Julie Thevenin, Nicolas Carrere, Fabrice Muscari, Olivier Abbo, Charlotte Maulat, Ariane Weyl, Jean Pierre Duffas, Antoine Philis, Laurent Ghouti, Cindy Canivet, Jean Paul Motta, Nathalie Vergnolle, Celine Deraison, Jason Shourick
Summary: This study conducted a network meta-analysis to compare the relative effectiveness of different treatments for postoperative ileus (POI) after abdominal surgery. The results showed that prokinetics and opioid antagonists are the two most effective pharmacological treatments for reducing POI.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Multidisciplinary Sciences
Federica Canzan, Arianna Caliaro, Maria Luisa Cavada, Elisabetta Mezzalira, Salvatore Paiella, Elisa Ambrosi
Summary: The effectiveness of early postoperative feeding in reducing the duration of postoperative ileus after gastrointestinal surgery is still debated.
Article
Biochemistry & Molecular Biology
Panagiotis Doukas, Gabriel Hellfritsch, Hanif Krabbe, Jelle Frankort, Michael J. Jacobs, Alexander Gombert, Florian Simon
Summary: Tissue injury during open thoracoabdominal aortic reconstructions can be predicted by measuring HSP70 serum levels, which is essential for the timely detection and management of abdominal complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Jun Watanabe, Atsushi Miki, Masaru Koizumi, Kazuhiko Kotani, Naohiro Sata
Summary: This study found that postoperative coffee consumption can reduce postoperative ileus and length of hospital stay, regardless of caffeine content. The impact is similar for patients undergoing colorectal and gynecological surgeries.
Review
Clinical Neurology
Logan A. Reed, Alexander K. Mihas, Travis A. Fortin, Guna Pratheep, Sakthivel Rajaram Manoharan, Steven M. Theiss, Vibhu Krishnan Viswanathan
Summary: This study comprehensively reviews the existing literature and evaluates the risk factors associated with postoperative ileus (POI) after thoracolumbar and lumbar fusion surgeries. It identifies older age, longer surgical times, higher estimated blood loss, longer lengths of stay, greater numbers of levels of fusion, and anterior surgical approach as risk factors associated with POI after spinal fusion surgery.
WORLD NEUROSURGERY
(2022)
Review
Gastroenterology & Hepatology
David Wattchow, Paul Heitmann, David Smolilo, Nick J. Spencer, Dominic Parker, Timothy Hibberd, Simon S. J. Brookes, Phil G. Dinning, Marcello Costa
Summary: This review combines animal studies with human patient studies on postoperative ileus, summarizing the conceptual advances in understanding the underlying mechanisms. It also evaluates the efficacy of treatments tested in human subjects and provides perspectives on how to move forward with this common yet debilitating condition.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Pharmacology & Pharmacy
Qi Liang, Jing-Wen Wang, Yu-Ru Bai, Ruo-Lan Li, Chun-Jie Wu, Wei Peng
Summary: TRPV1 and TRPA1 channels have beneficial effects in ameliorating postoperative ileus, making natural herbs a potential therapeutic option. Activation of these channels enhances gastrointestinal motility and relieves pain.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Angela Rodriguez-Padilla, German Morales-Martin, Rocio Perez-Quintero, Juan Gomez-Salgado, Rafael Balongo-Garcia, Carlos Ruiz-Frutos
Summary: The study evaluated the efficacy and safety of preoperative stimulation of the efferent loop with probiotics prior to ileostomy closure in colorectal carcinoma patients, showing a similar incidence of Postoperative ileus in both groups, regardless of stimulation.
Review
Medicine, Research & Experimental
TianRong Ma, XiaoLei Xue, Hui Tian, XinXiu Zhou, JunKe Wang, ZhiWen Zhao, MingFei Wang, JiYuan Song, RenXiang Feng, Leping Li, Changqing Jing, Feng Tian
Summary: Gut microbiota plays a vital role in maintaining normal intestinal peristalsis, and disruptions caused by antibiotics or opioid anesthetics during surgical procedures can impact intestinal motility. However, the precise mechanisms behind this dysbiosis are still not fully understood. This review focuses on the effects of gut microbiota and their metabolites on postoperative intestinal motility, specifically the regulation of the enteric nervous system, 5-hydroxytryptamine neurotransmitter, and aryl hydrocarbon receptor.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Luke Traeger, Michalis Koullouros, Sergei Bedrikovetski, Hidde M. Kroon, Michelle L. Thomas, James W. Moore, Tarik Sammour
Summary: This study aimed to measure the cost of postoperative ileus (POI) after colorectal surgery and found that POI is associated with increased complications, longer hospital stays, and higher healthcare resource utilization.
COLORECTAL DISEASE
(2022)
Article
Critical Care Medicine
Brittany D. Bissell, Carolyn Magee, Peter Moran, Melissa L. Thompson Bastin, Alexander H. Flannery
JOURNAL OF INTENSIVE CARE MEDICINE
(2019)
Article
Critical Care Medicine
Brittany D. Bissell, Jason E. Davis, Alexander H. Flannery, David A. Adkins, Melissa L. Thompson Bastin
JOURNAL OF INTENSIVE CARE MEDICINE
(2018)
Article
Critical Care Medicine
Jordan A. Woolum, Erin L. Abner, Andrew Kelly, Melissa L. Thompson Bastin, Peter E. Morris, Alexander H. Flannery
CRITICAL CARE MEDICINE
(2018)
Article
Critical Care Medicine
Carolyn A. Magee, Melissa L. Thompson Bastin, Melanie E. Laine, Brittany D. Bissell, Gavin T. Howington, Peter R. Moran, Emily J. McCleary, Gary D. Owen, Lauren E. Kane, Emily A. Higdon, Cathy A. Pierce, Peter E. Morris, Alexander H. Flannery
CRITICAL CARE MEDICINE
(2018)
Article
Critical Care Medicine
Mary K. La, Melissa L. Thompson Bastin, Jenee T. Gisewhite, Carrie A. Johnson, Alexander H. Flannery
JOURNAL OF CRITICAL CARE
(2018)
Review
Critical Care Medicine
Alexander H. Flannery, Melissa L. Thompson Bastin, Ashley Montgomery-Yates, Corrine Hook, Evan Cassity, Phillip M. Eaton, Peter E. Morris
JOURNAL OF INTENSIVE CARE MEDICINE
(2019)
Article
Pharmacology & Pharmacy
Ishaq Lat, Mitchell J. Daley, Anand Shewale, Mark H. Pangrazzi, Drayton Hammond, Keith M. Olsen, Ishaq Lat, Anand J. Shewale, Little Rock
Article
Critical Care Medicine
Melissa L. Thompson Bastin, Grant Tyler Short, Aaron M. Cook, Katie Rust, Alexander H. Flannery
AMERICAN JOURNAL OF CRITICAL CARE
(2019)
Article
Neurosciences
Carolyn A. Magee, Melissa L. Thompson Bastin, Katelyn Graves, Donna Burgess, Melissa Nestor, John R. Lamm, Aaron M. Cook
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2019)
Review
Hematology
Nicholas R. Nelson, Madeline G. Tompkins, Melissa L. Thompson Bastin
TRANSFUSION AND APHERESIS SCIENCE
(2019)
Editorial Material
Pharmacology & Pharmacy
Brooke Barlow, Ashley Barlow, Melissa L. Thompson Bastin, Karen Berger, Deepali Dixit, Mojdeh S. Heavner
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2020)
Article
Critical Care Medicine
Brittany D. Bissell, Melanie E. Laine, Melissa L. Thompson Bastin, Alexander H. Flannery, Andrew Kelly, Jeremy Riser, Javier A. Neyra, Jordan Potter, Peter E. Morris
Letter
Critical Care Medicine
Melanie E. Laine, Alexander H. Flannery, Breanna Moody, Melissa L. Thompson Bastin
Article
Pharmacology & Pharmacy
Emily J. McCleary, Melissa L. Thompson Bastin, Brittany D. Bissell, Aaron M. Cook, Catherine A. Pierce, Alexander H. Flannery
Article
Pharmacology & Pharmacy
Samuel H. Fu, Alexander H. Flannery, Melissa L. Thompson Bastin