Article
Chemistry, Inorganic & Nuclear
Kelvin K. H. Tong, Mie Riisom, Euphemia Leung, Muhammad Hanif, Tilo Sohnel, Stephen M. F. Jamieson, Christian G. Hartinger
Summary: In this study, organometallic complexes with a piano-stool structure and di- or tridentate ligand systems were reported, showing improved biological activity and impact on cytotoxic activity.
INORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jinfeng Liu, Yuting Wu, Ge Yang, Zhe Liu, Xicheng Liu
Summary: In this study, four half-sandwich iridium(III) (IrIII) and ruthenium(II) (RuII) diphenylphosphino ferro-cene (dppf) complexes with potential applications in anticancer were prepared. These complexes exhibited favorable anti-proliferation activity against A549 cell lines and inhibited cell migration effectively compared to cisplatin. They were taken up by cells through an energy dependence mechanism, accumulated in mitochondria, disrupted mitochondrial membrane potential, induced reactive oxygen species production, disrupted cell cycle, and ultimately led to apoptosis. Western blot assay confirmed that these complexes induced apoptosis through a mitochondrial pathway. Overall, half-sandwich IrIII and RuII dppf complexes show promise as a new multifunctional therapeutic platform for mitochondrial targeted imaging and anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Xicheng Liu, Ao Lv, Pei Zhang, Jiaying Chang, Ruixiao Dong, Mengxian Liu, Jiayi Liu, Xiaoqing Huang, Xiang-Ai Yuan, Zhe Liu
Summary: In this study, eight novel ferrocenyl organometallic complexes were synthesized and their anticancer mechanism was investigated. It was found that these complexes inhibited cell proliferation and induced apoptosis through catalytic oxidation. Further experiments confirmed their low toxicity and anti-migration ability in vivo.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Lukas Masaryk, Ivan Nemec, Jana Kasparkova, Viktor Brabec, Pavel Starha
Summary: In this study, model compounds such as Ru-dca and Ir-dca were used to investigate the behavior of complexes containing bioactive substituents like dichloroacetate (dca) in solution, with characterization done using techniques such as single-crystal X-ray analysis. However, these complexes did not demonstrate antiproliferative activity in four human cancer cell lines.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Lukas Masaryk, Jakub Orvos, Karolina Sloczynska, Radovan Herchel, Jan Moncol, David Milde, Petr Halas, Radka Krikavova, Paulina Koczurkiewicz-Adamczyk, Elzbieta Pekala, Robert Fischer, Ivan Salitros, Ivan Nemec, Pavel Starha
Summary: The study investigated the interactions of newly developed metallodrugs with various biomolecules, revealing the reduction and oxidation reactions of azo bonds in the presence of certain biologically relevant molecules. The complexation of the metallodrugs played a crucial role in facilitating these redox reactions, shedding light on the mechanisms of action in extracellular and intracellular environments.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Biochemistry & Molecular Biology
Zihan Wang, Zexuan Lv, Xicheng Liu, Yuting Wu, Jiaying Chang, Ruixiao Dong, Caiyue Li, Xiang-Ai Yuan, Zhe Liu
Summary: This paper investigates the use of ferrocene-modified half-sandwich iridium(III) pyridine complexes as potential anticancer agents. The results show that these complexes exhibit excellent anticancer activity against A549 cells and disrupt cellular functions, leading to apoptosis.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Sonia Infante-Tadeo, Vanessa Rodriguez-Fanjul, Cintia C. Vequi-Suplicy, Ana M. Pizarro
Summary: The passage describes the rapid hydrolysis and high basicity of complexes [Os(eta 6-arene)(C,N-phenylpyridine)Z] with chlorido or tethered oxygen as the ligand. It also reveals the structure-activity relationship between Os-CN and Os-NN complexes.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Roman I. Nekrasov, Tat'yana A. Peganova, Ivan V. Fedyanin, Evgenii I. Gutsul, Oleg A. Filippov, Natalia V. Belkova, Alexander M. Kalsin
Summary: A series of pentamethylcyclopentadienyl rhodium complexes were synthesized and characterized, and some complexes were found to have low stability and high nucleophilicity and reactivity.
INORGANIC CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Ana R. Rubio, Rocio Gonzalez, Natalia Busto, Monica Vaquero, Ana L. Iglesias, Felix A. Jalon, Gustavo Espino, Ana M. Rodriguez, Begona Garcia, Blanca R. Manzano
Summary: In the field of anticancer chemotherapy, a study has been conducted to synthesize metal complexes with bioactive ligands to overcome drug resistance. The results show that one of the complexes has high cytotoxicity, induces apoptosis, overcomes drug resistance, and displays selectivity towards cancer cells through DNA binding and ROS generation pathways.
Review
Chemistry, Inorganic & Nuclear
Klaudia Malikova, Lukas Masaryk, Pavel Starha
Summary: Platinum-based anticancer drugs have led to the development of ruthenium and rhodium compounds with potential anticancer activity, with rhodium complexes showing promising in vitro potency as alternatives to conventional platinum and ruthenium-based metallodrugs. The review focuses on half-sandwich Rh(III) complexes, which exhibit higher in vitro potency and different mechanisms of action compared to cisplatin or clinically studied Ru drug candidates. Additionally, some of the discussed Rh(III) arenyl complexes have shown anticancer activity in vivo, highlighting the potential of organorhodium compounds in anticancer therapies.
Article
Chemistry, Multidisciplinary
Li Wei, Rajesh Kushwaha, Anyi Dao, Zhongxian Fan, Samya Banerjee, Huaiyi Huang
Summary: A novel axisymmetric bis-tridentate Ir(iii) photocatalyst (Ir3) with synergetic type I/II photosensitization and photocatalytic activity was reported. Ir3 exhibited high photocytotoxicity against drug-resistant cancer cells under normoxia and hypoxia. The photoactivated anticancer mechanism of Ir3 was investigated in detail. Overall, this new photo-redox catalyst can overcome hypoxia and drug resistance-related problems in clinical anticancer therapy.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Jian Guo, Maoliang Li, Chengkai Yin, Dulin Zhong, Yuguan Zhang, Xiaobin Li, Yilin Wang, Jingcheng Yuan, Haijiao Xie, Tiangui Qi
Summary: A series of Cp*Ir complexes with amidated 8-aminoquinoline ligands were synthesized and tested for formic acid dehydrogenation. The results showed improved activities compared to pristine ligands. The amidation changed the coordination sphere and the proton-responsive catalyst exhibited enhanced activity by lowering the reaction energy barrier.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Yuliang Yang, Xiaofeng Zou, Yanyan Sun, Feihong Chen, Jian Zhao, Shaohua Gou
Summary: This article presents a rational design of half-sandwich Ru(II) complexes for mitochondria-targeted anticancer and antimetastatic agents by introducing the NDI unit into the N,N-chelating ligand of these complexes, which exhibit excellent emission performance. These complexes have potential applications in the design of multifunctional theranostic agents and fluorescent biomarkers.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Russell J. Needham, Ivan Prokes, Abraha Habtemariam, Isolda Romero-Canelon, Guy J. Clarkson, Peter J. Sadler
Summary: In this study, the synthesis and characterization of an organo-osmium anticancer complex, along with its potent activity against human ovarian cancer cells, were reported. The X-ray crystal structure confirmed the unique configuration of the complex, and analysis of the isotopically-enriched compound provided insights into its chemical shifts and bonding interactions.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Noemi Pagliaricci, Riccardo Pettinari, Fabio Marchetti, Claudio Pettinari, Loredana Cappellacci, Alessia Tombesi, Massimiliano Cuccioloni, Mouna Hadiji, Paul J. Dyson
Summary: In this study, a series of half-sandwich ruthenium(ii) complexes with curcuminoid ligands were prepared and investigated for their cytotoxic activities. The introduction of a long hydrophobic chain by replacing the OH-groups in curcumin and bisdemethoxycurcumin with palmitic acid ester was found to enhance the cytotoxicity. The complexes showed potent and selective cytotoxic activity against ovarian carcinoma cells and their cisplatin-resistant form.
DALTON TRANSACTIONS
(2022)