期刊
ORGANOMETALLICS
卷 33, 期 22, 页码 6614-6622出版社
AMER CHEMICAL SOC
DOI: 10.1021/om5009296
关键词
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资金
- Ministry of Science and Technology of China (973 Programs) [2011CB935902, 2014CB845604]
- National Natural Science Foundation of China [21132001, 21272122]
We have developed two novel synthetic methods, by which two types of mononuclear Fe model complexes for the active site of [Fe]hydrogenase are successfully synthesized. The first type of 2-acylmethyl-6-hydroxymethylpyridine-containing complexes, [2-COCH2-6-HOCH2C5H3N]Fe(CO)(2)G (1 , G = PhCO2; 2 , PhCOS; 3 , PhCS2; 4 , 2-S-6-MeC5H3N), were prepared by a one-pot method involving reaction of 2-TsO-6-HOCH2C5H3N (Ts = 4-MeC6H4SO2) with Na2Fe(CO)(4) followed by treatment of the resulting Fe(0) intermediate [Na(2-CH2-(6)-HOCH2C5H3N)Fe(CO)(4)] (M1 ) with (PhCO2)(2), (PhCOS)(2), (PhCS2)(2), and (2-S-6-MeC5H3N)(2) in 4972% yields, respectively. The second type of 2-acylmethyl-6-hydroxypyridine-containing complexes, (2-COCH2-6-HOC5H3N)Fe(CO)(2)(2-SCO-6-RC5H3N) (9a , R = MeO; 9b , R = PhS), could be prepared via a multiple-step synthetic method. This method involves (i) treatment of 2-ClCO-6-RC5H3N (R = MeO, PhS) with NaSH followed by acidification with diluted HCl to give 2-HSCO-6-RC5H3N (5a , R = MeO; 5b , R = PhS); (ii) further treatment of 5a ,b with KOH to afford 2-KSCO-6-RC5H3N (6a , R = MeO; 6b , R = PhS); (iii) treatment of 2-TsOCH2-6-PMBOC5H3N (PMB = 4-MeOC6H4CH2) with Na2Fe(CO)4 followed by treatment of the resulting Fe(0) intermediate [Na(2-CH2-6-PMBOC5H3N)Fe(CO)(4)] (M-2 ) with Br2 or I2 to produce (2-COCH2-6-PMBOC5H3N)Fe(CO)3X (7a , X = Br; 7b , X = I); (iv) further treatment of 7a ,b with 6a ,b to yield (2-COCH2-6-PMBOC5H3N)Fe(CO)(2)(2-S-6-RC5H3N) (8a , R = MeO; 8b , R = PhS); and (v) finally, removal of the PMB groups from 8a ,b under the action of deprotecting reagent CF3CO2H/EtSH to give complexes 9a ,b . All compounds 14 and 5a ,b9a ,b with the exception of 7b are new and have been characterized by elemental analysis, spectroscopy, and, particularly for 1 , 4 , and 7a9a , X-ray crystallography.
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