Article
Chemistry, Multidisciplinary
Ingrid Popovici, Elise Lognon, Nicolas Casaretto, Antonio Monari, Audrey Auffrant
Summary: In this study, the influence of iminophosphorane N substituent on palladium(II) complexes was investigated. Different N substituents were found to have an impact on the stability and reactivity of the complexes.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Gurunath Sahu, Atanu Banerjee, Rajib Samanta, Monalisa Mohanty, Sudhir Lima, Edward R. T. Tiekink, Rupam Dinda
Summary: Five new anionic aqueous dioxidovanadium(V) complexes were synthesized and characterized, showing high selectivity and cytotoxicity against colon cancer cells. Complex 1 exhibited greater anticancer activity compared to cisplatin.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Reike Clauss, Saral Baweja, Dmitri Gelman, Evamarie Hey-Hawkins
Summary: A series of novel heterobimetallic Pd-II/M-II complexes were synthesized and exhibited a cooperative effect in catalyzing coupling reactions, leading to improved catalytic activity and selectivity for the formation of various Z-alkenes. The homogeneous nature of the catalytically active species was also demonstrated in the study.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Binoy Kar, Utpal Das, Sourav De, Sudhindra Pete, Ajay S. Sharma, Nilmadhab Roy, Ashok S. K. Kumar, Debashis Panda, Priyankar Paira
Summary: Researchers have been trying to design Ru(ii)-arene complexes resistant to GSH as potential anticancer agents to overcome the side effects of platinum-based drugs, and luminescent ruthenium(ii)-p-cymene-imidazophenanthroline complexes show promise as highly cytoselective cancer therapeutic agents for HeLa and Caco-2 cells.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Jose Luis Serrano
Summary: Modification of unprotected nucleosides has been attracting continuous interest, with Pd-catalyzed cross-coupling reactions playing an important role, while the team's synthesis of water-soluble Pd-imidates complexes has yielded interesting results.
Article
Chemistry, Multidisciplinary
Nithya Mohan, C. V. Vidhya, V Suni, Jimna Mohamed Ameer, Naresh Kasoju, P. Mohanan, S. S. Sreejith, M. R. Prathapachandra Kurup
Summary: In this work, four Cu(II) salen compounds were systematically designed and synthesized. Characterization of the compounds was done using various spectroscopic and analytical techniques. The compounds were found to have a water molecule enclosed/pseudo-enclosed in the N2O4 cavity. The compounds exhibited high binding affinity towards both DNA and proteins and showed cytotoxic effects.
NEW JOURNAL OF CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
Monireh Ghorbanpour, Ali Shayanfar, Behzad Soltani
Summary: This study explores the anticancer potential of pyrazole-based copper complexes and investigates their mechanism of action at the molecular level. The results suggest that these complexes have promising applications as effective anticancer agents with lower side effects compared to approved drugs. However, the inhibitory effects of these complexes can be influenced by various laboratory conditions.
COORDINATION CHEMISTRY REVIEWS
(2024)
Article
Chemistry, Multidisciplinary
Muhammad Jbara, Jacob Rodriguez, Heemal H. Dhanjee, Andrei Loas, Stephen L. Buchwald, Bradley L. Pentelute
Summary: Organometallic reagents have enabled practical strategies for bioconjugation in water, with a focus on peptides, proteins, and oligonucleotides. The development of bifunctional palladium(II)-oxidative addition complexes allows for high-yielding and chemoselective oligonucleotide bioconjugation reactions, even with a broad range of native thiol-containing biomolecules at low micromolar concentrations. This approach provides a versatile method for creating various oligonucleotide conjugates with other biomolecules, such as peptides, proteins, and small molecules, and allows for the conjugation of multiple copies of oligonucleotides onto a monoclonal antibody.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Dafnianna Tsakaraki, Aikaterini K. Andreopoulou, Georgios Bokias
Summary: The synthesis and characterization of water-soluble copolymers containing N,N-dimethylacrylamide (DMAM) and an Ir(III)-complexed vinylic monomer have been reported. The optical properties of these copolymers in aqueous solution were studied in detail, and it was found that they exhibit different emission characteristics under different pH conditions.
Article
Chemistry, Applied
Anais Coffinet, Vincent Levacher, Isabelle Gillaizeau, Jean-Francois Briere, Sylvain Oudeyer
Summary: A metal-catalyzed cyanomethylation of isatins and activated ketones using Ni-II-complexes with a pyridine(dicarboxamide) pincer ligand is reported. High isolated yields (up to 99%) were obtained at room temperature with various acetonitrile derivatives. The involvement of cation part (Cs+ or n-Bu4N+) likely enhances the formation and catalytic activity of the proposed ion paired catalysts [NiCR2CN](-)Cat(+).
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Inorganic & Nuclear
Tania Hidalgo, David Fabra, Raul Allende, Ana I. Matesanz, Patricia Horcajada, Tarita Biver, Adoracion G. Quiroga
Summary: Cancer is a leading cause of death worldwide, with nearly 10 million deaths in 2020. Palladium complexes have great potential as anticancer agents, offering advantages over platinum drugs such as better speciation control and lower toxicity. This study developed two novel complexes and thoroughly investigated their speciation in solution, demonstrating their stability and behavior towards nucleic acid models and serum proteins. Furthermore, these complexes showed higher efficiency and specificity compared to the benchmark cisplatin drug due to their lower toxicity to healthy cells.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Review
Chemistry, Inorganic & Nuclear
Maura Pellei, Fabio Del Bello, Marina Porchia, Carlo Santini
Summary: Zinc is an essential element for humans, and any malfunctions of its homeostasis can lead to different disease states, including cancer. Zinc complexes have shown promising biological activities, such as preventive effects on infectious diseases and low toxicity, making them appealing for applications in medicinal chemistry.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Inorganic & Nuclear
Pritam Dolui, Ashutosh Verma, Parul Saini, Abhishek Nair, Sajesh P. Thomas, Anil J. Elias
Summary: In this study, new water soluble neutral and cationic palladium complexes were synthesized and their catalytic properties were evaluated. The neutral trimeric complexes showed catalytic activity for the oxidation of benzyl alcohols, while the cationic palladium complexes were efficient catalysts for the oxidation of styrenes to methyl ketones.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
C. Claudia P. Villamizar, Pankaj Sharma, Bertin Anzaldo, Rodary Gonzalez, Rene Gutierrez, Arun Kumar
Summary: In this study, novel ferrocenylated selenoether and telluroether ligands and their palladium complexes were synthesized and characterized. The structures of the complexes were determined using X-ray crystallography, revealing the bidentate coordination mode of the ligands. The chalcogenoether ligands exhibited interesting solubility and nuclear magnetic resonance properties, while cyclic voltammograms showed different electrochemical processes for selenoether and telluroether ligands and their complexes.
Review
Chemistry, Multidisciplinary
Huma Khan, Muhammad Faizan, Salamat Ullah Khan Niazi, Madiha Niaz Muhammad, Weiqiang Zhang
Summary: Carbon monoxide-releasing molecules (CORMs) have potential therapeutic applications in the mammalian body by producing controlled levels of CO. The use of lower doses of CO can provide cellular signaling for necessary pharmacokinetic and pathological activities, while higher concentrations can be harmful. The development of efficient CO insertion methods and the production of novel CORMs aim to achieve therapeutic targets with reduced toxicity.
TOPICS IN CURRENT CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Andres Luengo, Marta Redrado, Isabel Marzo, Vanesa Fernandez-Moreira, M. Concepcion Gimeno
INORGANIC CHEMISTRY
(2020)
Article
Oncology
Chantal Reina-Ortiz, Michael Constantinides, Alexis Fayd-Herbe-de-Maudave, Jessy Presumey, Javier Hernandez, Guillaume Cartron, Rosana Diez, Isabel Izquierdo, Gemma Azaceta, Luis Palomera, Isabel Marzo, Javier Naval, Alberto Anel, Martin Villalba, David Giraldosa
Summary: The study evaluated the potential of expanded NK cells from two sources combined with mAbs to target primary multiple myeloma cells. Results indicate that umbilical cord blood eNKs are highly cytotoxic against MM cells, while peripheral blood eNKs have significant cytotoxic advantage when combined with daratumumab.
Article
Chemistry, Multidisciplinary
Marta Redrado, Andrea Benedi, Isabel Marzo, Angel L. Garcia-Otin, Vanesa Fernandez-Moreira, M. Concepcion Gimeno
Summary: A new class of emissive cyclometallated Ir-III-Au-I complexes with a bis(diphenylphosphino) methanide bridging ligand was synthesized successfully. These complexes showed different bioactivity in A549 lung carcinoma cells versus endothelial cells, mainly affecting the mitochondrial and lysosomal distribution within the cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Alfonso Serrano-del Valle, Chantal Reina-Ortiz, Andrea Benedi, Alberto Anel, Javier Naval, Isabel Marzo
Summary: Developing new therapies targeting cell cycle regulation and mitosis has shown potential, despite many being discontinued during clinical trials. Future efforts could focus on increasing cell death signals, targeting senescent cells, and promoting antitumor immune response to enhance the efficacy of these treatments.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Marta Redrado, Andrea Benedi, Isabel Marzo, M. Concepcion Gimeno, Vanesa Fernandez-Moreira
Summary: Photodynamic therapy (PDT) is a cancer treatment method with great potential for improvement, with a focus on developing photosensitizers (PSs) that can target tumor cells and generate high levels of reactive oxygen species (ROS). Novel bifunctional Ir(III) complexes have been developed as trackable PSs agents, with complex 4 showing dual emissive patterns and effective accumulation in mitochondria for potential cancer treatment. Activation of these complexes with different light wavelengths can lead to therapeutic effects and enhanced sensitivity in lung cancer cells.
Article
Biochemistry & Molecular Biology
Guillermo Canudo-Barreras, Lourdes Ortego, Anabel Izaga, Isabel Marzo, Raquel P. Herrera, M. Concepcion Gimeno
Summary: The study found that gold complexes are more cytotoxic than silver compounds, with gold complexes showing better cytotoxic effects on cancer cells. The ancillary ligand bound to the metal plays a crucial role in the cytotoxic activity of the complexes, with the bis(thiourea) complex being the most active species.
Review
Cell Biology
Chantal Reina-Ortiz, David Giraldos, Gemma Azaceta, Luis Palomera, Isabel Marzo, Javier Naval, Martin Villalba, Alberto Anel
Summary: NK cell-based therapies show promise as anticancer treatments. The review compares autologous and allogeneic NK cell treatments for MM and their combination with existing therapies. The placement of these treatments in clinical regimens is discussed based on patient immune profiles.
Article
Chemistry, Applied
Andres Luengo, Isabel Marzo, Vanesa Fernandez-Moreira, M. Concepcion Gimeno
Summary: In this study, five heterobimetallic Re-I/Au-I species and one tri-metallic Re-I/Au-I/Re-I species were synthesized and fully characterized. The resultant complexes exhibited luminescence in the orange region, and the emission properties were found to be associated with the electronic properties of the gold ancillary ligand. Antiproliferative activity studies showed that only complex 4, containing a specific gold ancillary ligand, exhibited cytotoxicity in lung and cervical cancer cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Olaia Akesolo, Berta Buey, Manuel Beltran-Visiedo, David Giraldos, Isabel Marzo, Eva Latorre
Summary: Despite biomedical improvements, multiple myeloma remains incurable. Dysregulated signalling of Toll like receptors (TLRs) may play a critical role in its progression. Strategic targeting of TLRs could improve treatment response and reduce relapses.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Patricia Guerrero-Ochoa, Raquel Ibanez-Perez, German Berbegal-Pinilla, Diederich Aguilar, Isabel Marzo, Francisco Corzana, Martha Minjarez-Saenz, Javier Macias-Leon, Blanca Conde, Javier Raso, Ramon Hurtado-Guerrero, Alberto Anel
Summary: Two granulysin-based immunotoxins (SM3GRNLY and AR20.5GRNLY) were generated to target and induce cell death in Tn antigen-expressing tumor cells. The immunotoxins demonstrated stronger cell-killing effects compared to GRNLY alone and induced cell death through apoptotic, necroptotic, and necrotic mechanisms. In a xenograft model, the immunotoxins showed tumor-targeting ability and significantly reduced tumor volume. These findings highlight the potential of these immunotoxins as drugs for Tn-expressing cancers.
Article
Biochemistry & Molecular Biology
Ruth Soler-Agesta, Patricia Guerrero-Ochoa, Joaquin Marco-Brualla, Raquel Ibanez-Perez, Isabel Marzo, Luis Martinez-Lostao, Alberto Anel
Summary: This study developed lipid nanoparticles that can enhance the cytotoxicity of recombinant granulysin, and demonstrated that the mitochondrial apoptotic pathway is the main mechanism of cell death induced by the nanoparticle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Alfonso Serrano Del Valle, Manuel Beltran-Visiedo, Victoria de Poo-Rodriguez, Nelia Jimenez-Alduan, Gemma Azaceta, Rosana Diez, Beatriz Martinez-Lazaro, Isabel Izquierdo, Luis Palomera, Javier Naval, Alberto Anel, Isabel Marzo
Summary: Immunogenic cell death (ICD) is an important process for antitumor immunosurveillance, characterized by the exposure and emission of Damage Associated Molecular Patterns (DAMP) such as calreticulin (CRT). In certain cancers, high levels of CRT have been found to be associated with improved immune surveillance and better patient prognosis. This study evaluated CRT levels in CD38(+) bone marrow mononuclear cells (BMMCs) of multiple myeloma (MM) patients and found that increased cell surface-CRT levels were associated with aggressive clinical features and worse prognosis in MM.
Article
Chemistry, Multidisciplinary
Maria Gil-Moles, M. Elena Olmos, Miguel Monge, Manuel Beltran-Visiedo, Isabel Marzo, Jose M. Lopez-de-Luzuriaga, M. Concepcion Gimeno
Summary: Silver complexes with substituted terpyridine or tetra-2-pyridinylpyrazine ligands were synthesized and characterized. Despite the potential of combining metal properties and ligand's ability for DNA binding, studies on the anticancer properties of these silver complexes are limited. This study investigated the antiproliferative activity, stability, CT-DNA binding, and mechanism of cell death of these derivatives. The results showed high cytotoxicity against different tumor cells and a notable selectivity index between tumor cells and healthy lymphocytes T for certain compounds. The derivatives were found to moderately intercalate with CT-DNA and promote apoptosis through a mitochondrial pathway.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Cell Biology
Oscar Gonzalo, Andrea Benedi, Laura Vela, Alberto Anel, Javier Naval, Isabel Marzo
Summary: Evasion of apoptosis is a hallmark of cancer cells, which involves alterations in Bcl-2 family proteins. The BiFC technique was used to study interactions between different Bcl-2 family members in living cells, revealing a complex network of interactions. Differences in the regulation of Bax and Bak activation by antiapoptotic and BH3-only proteins were observed. Mutations lacking the BH3 domain did not affect the association between Bax and Bak, suggesting alternative surfaces of interaction.
Article
Multidisciplinary Sciences
Nerea Allende-Vega, Joaquin Marco Brualla, Paolo Falvo, Catherine Alexia, Michael Constantinides, Alexis Fayd'herbe de Maudave, Lois Coenon, Delphine Gitenay, Giulia Mitola, Paul Massa, Stefania Orecchioni, Francesco Bertolini, Isabel Marzo, Alberto Anel, Martin Villalba
Summary: Solid tumor cells have altered metabolism that can protect them from cytotoxic lymphocytes, but metformin can increase tumor cell sensitivity to cytotoxic lymphocytes. Research shows that metformin induces expression of NKG2DL and ICAM-1, promoting binding between lymphocytes and tumor cells, and reducing the growth of human hematological tumor cells.
SCIENTIFIC REPORTS
(2022)