Article
Chemistry, Inorganic & Nuclear
Payal Srivastava, Madhu Verma, Anmol Kumar, Priyanka Srivastava, Ramranjan Mishra, Sri Sivakumar, Ashis K. Patra
Summary: Two water-soluble piano-stool shaped ruthenium(ii)-arene complexes were designed as emissive photocytotoxic agents tagged with morpholine as the lysosome targeting moiety. They showed enhanced photo-cytotoxicity under low-power blue LED light irradiation, preferentially localized in lysosomes and nuclei, effectively targeting and damaging nuclear DNA for photodynamic therapy. Due to enhanced lipophilicity of one complex, it showed higher internalization into cancer cells, with possible binding through histidine residues and internalization via endocytosis. Luminescence properties were utilized to study cellular uptake mechanisms via endocytosis.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Sankar Monika, Rengan Ramesh
Summary: This study reports the synthesis of a new series of organometallic dinuclear ruthenium(ii) arene complexes and investigates their in vitro antiproliferative activity and cancer cell death mechanism. The formation of complexes was confirmed by various spectroscopic techniques. The synthesized complexes showed higher inhibition of cancer cells compared to the standard cisplatin drug, and apoptosis was confirmed through morphological changes and phosphatidylserine externalization.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Arunachalam Abirami, Umapathy Devan, Rengan Ramesh, Arockiam Antony Joseph Velanganni, Jan Grzegorz Malecki
Summary: This study synthesized six arene ruthenium(ii) complexes and evaluated their inhibitory effects on breast cancer cells. The complexes exhibited good antiproliferative activities by inducing apoptotic cell death through an intrinsic mitochondrial pathway.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Christoph A. Riedl, Alexander Rosner, Sophia Harringer, Philipp Salomon, Michaela Hejl, Michael A. Jakupec, Wolfgang Kandioller, Bernhard K. Keppler
Summary: The use of bisphosphonate-functionalized ligands in the synthesis of trithiolato-bridged dinuclear ruthenium(II) and osmium(II) arene complexes improved aqueous solubility but decreased antiproliferative activity in vitro.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Emanuele Zanda, Natalia Busto, Lorenzo Biancalana, Stefano Zacchini, Tarita Biver, Begona Garcia, Fabio Marchetti
Summary: The study found that certain ruthenium complexes exhibited remarkable stability in water and cell culture medium, showing strong cytotoxicity against cancer cell lines, with RUCYN being the most promising one with significant selectivity compared to non-cancerous cells. The variability of affinity of the complexes for BSA and DNA binding was determined, with certain complexes showing enhanced cell internalization and cytotoxicity at the expense of selectivity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Xuling Xue, Ying Fu, Liang He, Luca Salassa, Ling-Feng He, Yuan-Yuan Hao, Madeleine J. Koh, Clement Soulie, Russell J. Needham, Abraha Habtemariam, Claudio Garino, Kirill A. Lomachenko, Zhi Su, Yong Qian, Martin J. Paterson, Zong-Wan Mao, Hong-Ke Liu, Peter J. Sadler
Summary: Half-sandwich Os-arene complexes exhibit promising anticancer activity, especially the OsCUR-2 complex, which shows remarkable photocytotoxicity towards a range of cancer cell lines and has the potential for further development as a photosensitizer for anticancer photoactivated chemotherapy (PACT). The photochemistry of these complexes involves selective photodissociation of the arene ligand and oxidation of Os(II) to Os(III) under blue light or UVA excitation.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Stefan Nikolic, Jemma Arakelyan, Vladimir Kushnarev, Samah Mutasim Alfadul, Dalibor Stankovic, Yaroslav I. Kraynik, Sanja Grguric-Sipka, Maria V. Babak
Summary: The astable half-sandwich Ru-dipyridophenazine complex can significantly decrease tumor burden in mouse xenografts without causing kidney and liver toxicity, and its mechanism of action is linked to DNA degradation and ROS induction.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Oscar A. Lenis-Rojas, M. Paula Robalo, Ana Isabel Tomaz, Alexandra R. Fernandes, Catarina Roma-Rodrigues, Ricardo G. Teixeira, Fernanda Marques, Monica Folgueira, Julian Yanez, Anabel Alba Gonzalez, Martin Salamini-Montemurri, Dawrin Pech-Puch, Digna Vazquez-Garcia, Margarita Lopez Torres, Alberto Fernandez, Jesus J. Fernandez
Summary: Ruthenium(II) complexes, considered as attractive alternatives to platinum-based drugs, demonstrated significant cytotoxicity against breast cancer cells with lower toxicity towards normal cells, possibly through induction of reactive oxygen species and interaction with protein targets.
INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Runjhun Tandon, Vijay Luxami, Nitin Tandon, Kamaldeep Paul
Summary: This review discusses the preparation of derivatives by substituting at different positions of the 1,8-naphthalimide ring and explores their potential as anticancer drugs. Different substituent modifications can affect the activity and selectivity of the derivatives, providing guidance for the design and development of 1,8-naphthalimide derivatives with desired drug profiles.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Franco Bisceglie, Giorgio Pelosi, Nicolo Orsoni, Marianna Pioli, Mauro Carcelli, Paolo Pelagatti, Silvana Pinelli, Peter J. Sadler
Summary: We synthesized and characterized three half-sandwich Ru(II) arene complexes with different ligands, where one of the complexes exhibited good phototoxicity towards lung cancer cells upon blue light irradiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Inorganic & Nuclear
Xian-Tao Jiang, Xiao-Hui Wang, Pei-Yuan Li, Wei Su
Summary: Three ruthenium-arene complexes with curcuminoids were synthesized and found to exhibit significant inhibitory effects on human liver cancer cells under light conditions, with their anticancer activity greatly improved by light exposure.
CHINESE JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Stefan Latis, Christoph Marschner, Judith Baumgartner, Sharon Prince, Supratim Biswas, Suparna Chakraborty, Kimberly G. Garcia, Ron M. A. Heeren, Sebastiaan Van Nuffel, Burgert Blom
Summary: This study reports the synthesis and characterisation of piano-stool triphenylstibine and triphenylarsine arene complexes, and their in vitro cytotoxic evaluation on breast cancer cell lines. The tin containing complexes demonstrate remarkable activity and selectivity.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jakob Kljun, Mihaela Rebernik, Lucia M. Balsa, Jerneja Kladnik, Uros Rapus, Tomaz Trobec, Kristina Sepcic, Robert Frangez, Ignacio E. Leon, Iztok Turel
Summary: Organoruthenium pyrithione complexes, such as [(eta(6)-p-cymene)Ru(pyrithionato)(pta)]PF6, show promise as a new class of anticancer drugs. Our study focuses on finding alternatives to the pta ligand and discovering new structural elements to improve the biological properties of ruthenium anticancer drugs. By replacing the pta ligand with different phosphine, phosphite, and arsine ligands, we identified improved inhibitory potency against the enzyme glutathione S-transferase, as well as investigated cytotoxicity in breast, bone, and colon cancers.
Article
Chemistry, Inorganic & Nuclear
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Summary: The evolution of high virulence bacterial strains has led to the development of novel therapeutic agents. Metal-based therapeutics, with their structural variability and unique modes of action, show great promise. This study focused on the preparation and evaluation of ruthenium(ii)-arene complexes containing Schiff base ligands with an attached ferrocene, and identified a complex with prominent activity against clinically relevant bacterial strains.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Shubhajit Das, Roland C. Turnell-Ritson, Paul J. Dyson, Clemence Corminboeuf
Summary: Despite recent progress in the chemistry of frustrated Lewis pairs (FLPs), direct FLP-catalyzed hydrogenation of CO2 remains elusive. The authors propose a mapping method to link the chemical composition of FLPs with their activity in catalytic hydrogenation of CO2, and they experimentally validate a combination with high catalytic turnover.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Pavel Culik, Keith Brooks, Cristina Momblona, Martin Adams, Sachin Kinge, Francois Marechal, Paul J. Dyson, Mohammad Khaja Nazeeruddin
ACS ENERGY LETTERS
(2022)
Article
Chemistry, Physical
Gabriela Gastelu, David Savary, Martin Hulla, Daniel Ortiz, Jorge G. Uranga, Paul J. Dyson
Summary: The article introduces an alternative reaction pathway for the O-formylation of alcohols and bio-alcohols, which produces industrially relevant formate esters. The reaction is catalyzed by formic acid, which can be produced from CO2 captured in the reaction. The in situ produced formic acid improves the reaction rate, and each catalyst can be recycled for reuse.
Editorial Material
Chemistry, Organic
Xiao-Feng Wu, Paul J. Dyson, Bruce A. Arndtsen
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Lorenzo Pietracci, Riccardo Pettinari, Alessia Tombesi, Fabio Marchetti, Claudio Pettinari, Agustiïn Galindo, Farzaneh Fadaei-Tirani, Mouna Hadiji, Paul J. Dyson
Summary: This study investigates the coordination mechanisms of pyrazolone ligands containing a pyridine ring with the (Ru(II)) fragment through experimental and theoretical calculations. The ligands were found to coordinate in an unusual N,O-chelating fashion with Ru(II), and various complexes were synthesized. The study provides important insights into the properties of the ligands and complexes.
Article
Chemistry, Inorganic & Nuclear
Alfonso Annunziata, Maria Elena Cucciolito, Maddalena Di Ronza, Giarita Ferraro, Mouna Hadiji, Antonello Merlino, Daniel Ortiz, Rosario Scopelliti, Farzaneh Fadaei Tirani, Paul J. Dyson, Francesco Ruffo
Summary: This article reports a series of Ruthenium(II) complexes with a three-legged piano-stool structure based on an arene ring and an N-heterocyclic carbene(NHC)-carbene ligand with a peracetylated glucose moiety. The complexes undergo hydrolysis in water and show reactivity towards model nucleophiles and biological macromolecules. However, they exhibit low anti-tumor activity against human ovarian carcinoma cells and cisplatin-resistant cells.
Article
Chemistry, Multidisciplinary
Shunlin Zhang, Yuxin Xie, Rosie J. J. Somerville, Farzaneh Fadaei Tirani, Rosario Scopelliti, Zhaofu Fei, Dunru Zhu, Paul J. J. Dyson
Summary: This study reports a new family of proton conductors based on MIL-101 and protic ionic liquid polymers (PILPs) containing different anions. The PILP@MIL-101 composites maintain the nanoporous cavities and water stability of MIL-101, while providing much-improved proton transport. The PILP@MIL-101 composite with HSO4- anions shows superprotonic conductivity (6.3 x 10(-2) S cm(-1)) at 85 degrees C and 98% relative humidity.
Article
Chemistry, Multidisciplinary
Haodan Guo, Yanyan Fang, Yan Lei, Jinpeng Wu, Minghua Li, Xiangrong Li, Hong Bo Cheng, Yuan Lin, Paul J. Dyson
Summary: This study demonstrates the use of a self-assembled ionic insulating layer to improve the performance of wide-bandgap perovskite solar cells. The layer effectively suppresses halide phase separation, reducing open-circuit voltage loss and improving device stability.
Article
Multidisciplinary Sciences
Mingyang Liu, Paul J. Dyson
Summary: Efficient valorization of lignin, a sustainable and renewable source, is essential for reducing dependence on fossil-derived feedstocks. This study presents a highly efficient strategy for extracting aromatic monomers and generating functionalized diaryl ethers from lignin using oxidative cross-coupling reactions.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Gabriela Gastelu, Pritha Saha, Paul J. Dyson, Martin Hulla, Jorge G. Uranga
Summary: Autocatalytic reactions play a key role in the beginning of life and carbon capture and utilization, providing inspiration for the development of advanced systems for the synthesis of value-added chemicals.
Article
Chemistry, Multidisciplinary
Yue Hu, Xinmin Li, Mingyang Liu, Stephan Bartling, Henrik Lund, Paul J. Dyson, Matthias Beller, Rajenahally V. Jagadeesh
Summary: Catalytic hydrodeoxygenation is a crucial technology for converting biomass-based feedstocks into essential chemicals and fuels. This study reports the preparation and application of Ni nanoparticles supported on ZSM-5 as an efficient hydrodeoxygenation catalyst. The Ni-based nanoparticles exhibit selective hydrodeoxygenation of various functional substrates, showcasing their versatility.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Patrick Doerflinger, Yong Ding, Valentin Schmid, Melina Armer, Roland C. Turnell-Ritson, Bin Ding, Paul J. Dyson, Mohammad Khaja Nazeeruddin, Vladimir Dyakonov
Summary: This study investigates the effect of a stabilizing additive on the charge carrier mobility and lifetime in triple cation perovskite thin films under thermal stress. The results reveal different conductivity behaviors in two temperature regions and identify two dominant scattering mechanisms. The stabilizing additive limits temperature-activated mobile ions and retards degradation of the perovskite film, leading to improved performance and stability.
Article
Chemistry, Inorganic & Nuclear
Sarah A. P. Pereira, Jan Romano-deGea, Ana Isabel Barbosa, Sofia A. Costa A. Lima, Paul J. J. Dyson, M. Lucia M. F. S. Saraiva
Summary: The study demonstrates that ruthenium-based compounds, especially [Ru(& eta;(6)-toluene)(PPh3)(2)Cl]Cl, show high selectivity and cytotoxicity against breast cancer cells. This compound has potential as a promising candidate for breast cancer treatment.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Alberto Gobbo, Sarah A. P. Pereira, Lorenzo Biancalana, Stefano Zacchini, M. Lucia M. F. S. Saraiva, Paul J. Dyson, Fabio Marchetti
Summary: Compared with Ru-II-arene compounds, the medicinal potential of homologous Ru-II-tpm compounds [tpm = tris(pyrazolyl)methane] is not well explored. A series of [RuCl(kappa(3)-tpm)(PPh3)(L)]Cl complexes were synthesized by reacting pyridine, 4-pyridinemethanol, and four functionalized pyridines with the precursor [RuCl(kappa(3)-tpm)(PPh3)(2)]Cl. The complexes exhibited antiproliferative activity against cancerous cell lines and inhibition towards COX-2 and GSTP1 enzymes.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Noemi Pagliaricci, Riccardo Pettinari, Fabio Marchetti, Claudio Pettinari, Loredana Cappellacci, Alessia Tombesi, Massimiliano Cuccioloni, Mouna Hadiji, Paul J. Dyson
Summary: In this study, a series of half-sandwich ruthenium(ii) complexes with curcuminoid ligands were prepared and investigated for their cytotoxic activities. The introduction of a long hydrophobic chain by replacing the OH-groups in curcumin and bisdemethoxycurcumin with palmitic acid ester was found to enhance the cytotoxicity. The complexes showed potent and selective cytotoxic activity against ovarian carcinoma cells and their cisplatin-resistant form.
DALTON TRANSACTIONS
(2022)