Article
Chemistry, Inorganic & Nuclear
Dmitry I. Pavlov, Denis G. Samsonenko, Laura Bonfili, Massimiliano Cuccioloni, Enrico Benassi, Riccardo Pettinari, Andrei S. Potapov, Vladislava V. Matveevskaya
Summary: Six new arene-ruthenium(II) complexes with different arene and oxime ligands were synthesized and characterized. The complexes exhibited a half-sandwich piano-stool geometry and showed promising anti-proliferative activity.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Sankar Monika, Rengan Ramesh
Summary: This study reports the synthesis of a new series of organometallic dinuclear ruthenium(ii) arene complexes and investigates their in vitro antiproliferative activity and cancer cell death mechanism. The formation of complexes was confirmed by various spectroscopic techniques. The synthesized complexes showed higher inhibition of cancer cells compared to the standard cisplatin drug, and apoptosis was confirmed through morphological changes and phosphatidylserine externalization.
NEW JOURNAL OF CHEMISTRY
(2023)
Review
Chemistry, Inorganic & Nuclear
Pavel Starha
Summary: The development of multinuclear homometallic biologically active complexes in modern bioinorganic chemistry offers increased therapeutic effects and variations in mechanism of action. Combining different metal centers within heterometallic complexes ensures unique modes of action, with comparisons between structurally similar analogues playing a key role in research.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Medicinal
Angelica E. Graminha, Cecilia Popolin, Joao Honorato de Araujo-Neto, Rodrigo S. Correa, Katia M. de Oliveira, Luani R. Godoy, Legna Colina Vegas, Javier Ellena, Alzir A. Batista, Marcia R. Cominetti
Summary: In this work, new ruthenium compounds with specific ligands were synthesized and characterized. The properties of these compounds in different solvents were studied, and their cytotoxicity against breast tumor cells and non-tumor cell lines was evaluated. One specific compound showed excellent selectivity towards the MDA-MB-231 cell line and induced apoptosis through the intrinsic pathway.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Emanuele Zanda, Natalia Busto, Lorenzo Biancalana, Stefano Zacchini, Tarita Biver, Begona Garcia, Fabio Marchetti
Summary: The study found that certain ruthenium complexes exhibited remarkable stability in water and cell culture medium, showing strong cytotoxicity against cancer cell lines, with RUCYN being the most promising one with significant selectivity compared to non-cancerous cells. The variability of affinity of the complexes for BSA and DNA binding was determined, with certain complexes showing enhanced cell internalization and cytotoxicity at the expense of selectivity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Stefan Nikolic, Jemma Arakelyan, Vladimir Kushnarev, Samah Mutasim Alfadul, Dalibor Stankovic, Yaroslav I. Kraynik, Sanja Grguric-Sipka, Maria V. Babak
Summary: The astable half-sandwich Ru-dipyridophenazine complex can significantly decrease tumor burden in mouse xenografts without causing kidney and liver toxicity, and its mechanism of action is linked to DNA degradation and ROS induction.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Abirami Arunachalam, Ramesh Rengan, Devan Umapathy, Antony Joseph Velanganni Arockiam
Summary: This study describes the synthesis and characterization of six new arene ruthenium(II) complexes containing biphenyl benzhydrazone ligands and evaluates their antiproliferative properties. The complexes demonstrated significant cytotoxicity against cancer cells and have the potential to be used as alternate anticancer drugs to platinum drugs.
Article
Chemistry, Inorganic & Nuclear
Luis Felipe Hernandez-Ayala, Cynthia Sinai Novoa-Ramirez, Miguel Reina, Lena Ruiz-Azuara
Summary: This study presents the synthesis, characterization, electrochemical studies, DFT calculations, and in vitro evaluation of four novel direct bonded ruthenium-selenium compounds, revealing the impact of intermediate properties and compound structure on cytotoxic activity, with 2c demonstrating the best inhibitory effect on cell proliferation.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Summary: The evolution of high virulence bacterial strains has led to the development of novel therapeutic agents. Metal-based therapeutics, with their structural variability and unique modes of action, show great promise. This study focused on the preparation and evaluation of ruthenium(ii)-arene complexes containing Schiff base ligands with an attached ferrocene, and identified a complex with prominent activity against clinically relevant bacterial strains.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Lorenzo Pietracci, Riccardo Pettinari, Alessia Tombesi, Fabio Marchetti, Claudio Pettinari, Agustiïn Galindo, Farzaneh Fadaei-Tirani, Mouna Hadiji, Paul J. Dyson
Summary: This study investigates the coordination mechanisms of pyrazolone ligands containing a pyridine ring with the (Ru(II)) fragment through experimental and theoretical calculations. The ligands were found to coordinate in an unusual N,O-chelating fashion with Ru(II), and various complexes were synthesized. The study provides important insights into the properties of the ligands and complexes.
Article
Chemistry, Applied
Komal M. Vyas, Deepu Sharma, Sri Krishna Jayadev Magani, Shaikh M. Mobin, Suman Mukhopadhyay
Summary: Two new arene ruthenium(II) complexes were synthesized and screened for cytotoxic activity, with one showing higher cytotoxicity against cancer cell lines and the other exhibiting anti-migratory properties.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Marianna Pioli, Cecilia Loffi, Paolo Pio Mazzeo, Alessia Bacchi, Paolo Pelagatti
Summary: Two different N-substituted naphthalimide ligands have been synthesized and reacted with a cationic organometallic fragment, showing different coordination behaviors. One ligand forms a sandwich complex with six coordination sites, while the other forms two isomeric complexes with different stabilities.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Binoy Kar, Priyankar Paira
Summary: We have developed a synthetic protocol for selective cancer therapy using half-sandwich Ru(II)-p-cymene dipyrido[3,2-a:2',3'-clphenazine analogues. Under irradiation, the cytotoxicity of all complexes is doubled and they exhibit significant selectivity against cancer cells. One complex (RuL4) shows the best phototoxicity. These complexes also have strong binding capacity to serum albumin and DNA, and display good stability.
DALTON TRANSACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Dalila Iacopini, Jan Vanco, Sebastiano Di Pietro, Vittorio Bordoni, Stefano Zacchini, Fabio Marchetti, Zdenek Dvorak, Tomas Malina, Lorenzo Biancalana, Zdenek Travnicek, Valeria Di Bussolo
Summary: Glycoconjugation is a powerful strategy to enhance the anticancer activity of metal complexes. In this study, glycoconjugated ruthenium(II) p-cymene complexes were synthesized by modifying commercial arylphosphanes with carbohydrate-derived fragments. These complexes exhibited significant cytotoxicity against various cancer cell lines and showed potential as novel anticancer agents.
BIOORGANIC CHEMISTRY
(2022)
Editorial Material
Chemistry, Inorganic & Nuclear
Emma Gallo, Anna Proust, Claudio Pettinari
Summary: Since 1893, coordination chemistry has continuously evolved and become a fundamental pillar in the field of chemical sciences, playing a crucial role in catalysis and materials. After two years of restrictions, the 44th International Conference on Coordination Chemistry (ICCC) was held in Rimini, Italy in August 2022, providing a platform for over a thousand chemists to present their research projects, some of which are summarized in this Special Collection.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Daphne Romani, Fabio Marchetti, Corrado Di Nicola, Massimiliano Cuccioloni, Chunmei Gong, Anna Maria Eleuteri, Agustin Galindo, Farzaneh Fadaei-Tirani, Massimo Nabissi, Riccardo Pettinari
Summary: A series of Ga(Q(n))(3) coordination compounds were synthesized and characterized through various techniques. Cytotoxicity studies showed interesting results in terms of selectivity and toxicity values compared with cisplatin. Mechanistic investigations revealed that the gallium(III) complexes induced cancer cell death through ferroptosis, triggering various cell death signals and altering cell redox homeostasis.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Editorial Material
Chemistry, Organic
Xiao-Feng Wu, Paul J. Dyson, Bruce A. Arndtsen
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Lorenzo Pietracci, Riccardo Pettinari, Alessia Tombesi, Fabio Marchetti, Claudio Pettinari, Agustiïn Galindo, Farzaneh Fadaei-Tirani, Mouna Hadiji, Paul J. Dyson
Summary: This study investigates the coordination mechanisms of pyrazolone ligands containing a pyridine ring with the (Ru(II)) fragment through experimental and theoretical calculations. The ligands were found to coordinate in an unusual N,O-chelating fashion with Ru(II), and various complexes were synthesized. The study provides important insights into the properties of the ligands and complexes.
Article
Chemistry, Inorganic & Nuclear
Alfonso Annunziata, Maria Elena Cucciolito, Maddalena Di Ronza, Giarita Ferraro, Mouna Hadiji, Antonello Merlino, Daniel Ortiz, Rosario Scopelliti, Farzaneh Fadaei Tirani, Paul J. Dyson, Francesco Ruffo
Summary: This article reports a series of Ruthenium(II) complexes with a three-legged piano-stool structure based on an arene ring and an N-heterocyclic carbene(NHC)-carbene ligand with a peracetylated glucose moiety. The complexes undergo hydrolysis in water and show reactivity towards model nucleophiles and biological macromolecules. However, they exhibit low anti-tumor activity against human ovarian carcinoma cells and cisplatin-resistant cells.
Article
Chemistry, Multidisciplinary
Shunlin Zhang, Yuxin Xie, Rosie J. J. Somerville, Farzaneh Fadaei Tirani, Rosario Scopelliti, Zhaofu Fei, Dunru Zhu, Paul J. J. Dyson
Summary: This study reports a new family of proton conductors based on MIL-101 and protic ionic liquid polymers (PILPs) containing different anions. The PILP@MIL-101 composites maintain the nanoporous cavities and water stability of MIL-101, while providing much-improved proton transport. The PILP@MIL-101 composite with HSO4- anions shows superprotonic conductivity (6.3 x 10(-2) S cm(-1)) at 85 degrees C and 98% relative humidity.
Article
Polymer Science
Yury A. Belousov, Mikhail T. Metlin, Darya A. Metlina, Mikhail A. Kiskin, Ilya A. Yakushev, Trofim A. Polikovskiy, Ilya V. Taydakov, Andrei A. Drozdov, Fabio Marchetti, Claudio Pettinari
Summary: A new strategy for the easy polymerization of anionic [Ln(Q(cy))(4)](-) into two-dimensional layers of [AgLn(Q(cy))(4)](n) is proposed by binding the single molecular anions [Ln(Q(cy))(4)](-) to silver cations through coordination. The luminescent properties of [AgLn(Q(cy))(4)](n) have been studied, and it was found that LMCT quenching is effectively suppressed in the heterometallic [AgEu(Q(cy))(4)](n) polymer, explaining the low PLQY in [Eu(Q(cy))(4)](-). Sensibilization coefficients for H3O[Eu(Q(cy))(4)], [AgEu(Q(cy))(4)](n), and H3O[Sm(Q(cy))(4)] complexes were estimated via theoretical analysis and PLQY measurements.
Article
Biochemistry & Molecular Biology
Alessia Garufi, Riccardo Pettinari, Fabio Marchetti, Mara Cirone, Gabriella D'Orazi
Summary: Organometallic ruthenium (Ru)(II)-cymene complexes have potential pharmacological properties as alternative therapeutic agents. Polyphenols, such as curcumin and curcuminoids, also display beneficial properties in medicine, including chemoprevention. This study investigated the anticancer effect of a cationic Ruthenium (Ru)(II)-cymene Bisdemethoxycurcumin (Ru-bdcurc) complex, revealing that targeting the interconnection between the endoplasmic reticulum (ER)-resident chaperone GRP78/BiP and NRF2 pathways enhances the cytotoxic effect of Ru-bdcurc on colon cancer cells.
Article
Chemistry, Physical
Gabriela Gastelu, Pritha Saha, Paul J. Dyson, Martin Hulla, Jorge G. Uranga
Summary: Autocatalytic reactions play a key role in the beginning of life and carbon capture and utilization, providing inspiration for the development of advanced systems for the synthesis of value-added chemicals.
Article
Biochemistry & Molecular Biology
Sonila Xhafa, Laura Olivieri, Corrado Di Nicola, Riccardo Pettinari, Claudio Pettinari, Alessia Tombesi, Fabio Marchetti
Summary: In this study, a new synthetic protocol based on microwave-assisted synthesis was used to prepare higher yields of zinc and copper in MOFs with different ligands. The antibacterial activity of these MOFs was tested against Gram-negative and Gram-positive bacteria, and the results showed that they exhibited broad-spectrum activity and strong efficiency in inhibiting bacterial growth. The mechanism of action was found to be based on the surface contact of MOF particles with bacterial cells and the generation of reactive oxygen species.
Review
Chemistry, Physical
Patrizio Campitelli, Alessia Tombesi, Corrado Di Nicola, Claudio Pettinari, Anna Mauri, Simona Galli, Tongan Yan, Dahuan Liu, Jiaxin Dawn Duan, Subhadip Goswami, Giulia Tuci, Giuliano Giambastiani, Joseph T. Hupp, Andrea Rossin
Summary: The reaction of 3,5-diamino-4,4'-bis(1H-pyrazole) with copper(II) and nickel(II) acetates under solvothermal conditions produced four mixed-metal metal-organic frameworks. These frameworks have macroporous structures and high CO2 adsorption capacity. They were also tested as heterogeneous catalysts for CO2 electrochemical reduction, with Cu0.05Ni0.95 showing the best performance and producing CO and CH4 as the main reduction products.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
Sarah A. P. Pereira, Jan Romano-deGea, Ana Isabel Barbosa, Sofia A. Costa A. Lima, Paul J. J. Dyson, M. Lucia M. F. S. Saraiva
Summary: The study demonstrates that ruthenium-based compounds, especially [Ru(& eta;(6)-toluene)(PPh3)(2)Cl]Cl, show high selectivity and cytotoxicity against breast cancer cells. This compound has potential as a promising candidate for breast cancer treatment.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Corrado Di Nicola, Fabio Marchetti, Alessia Tombesi, Sonila Xhafa, Patrizio Campitelli, Marco Moroni, Simona Galli, Riccardo Pettinari, Claudio Pettinari
Summary: Novel copper(ii) coordination polymers were synthesized and their thermal behavior and structural features were investigated. The nanoparticles showed potential antibacterial activity through a contact kill mechanism involving ROS production.
NEW JOURNAL OF CHEMISTRY
(2023)
