Article
Chemistry, Multidisciplinary
Yu-Yang Zhou, Yang-Ming Ding, Wei Zhao, Jian-Hua Dong, Liang-Zhi Li, Hong-Yuan Chen, Jing-Juan Xu
Summary: Three new ruthenium(ii) complexes with N-heterocyclic carbene ligands have been synthesized and shown to be efficient near-infrared ECL luminophores. These complexes demonstrate higher or comparable ECL efficiency compared to traditional Ru(bpy)(3)(2+), indicating great potential for future applications in NIR ECL imaging.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Inorganic & Nuclear
Moushakhi Ghosh, Shabana Khan
Summary: This article highlights the recent developments in silylene-coinage metal chemistry, focusing on synthetic approaches, unusual properties, and catalytic efficiency of these complexes. Further research is needed to explore the potential of silylene-coinage metal complexes in various chemical reactions.
DALTON TRANSACTIONS
(2021)
Article
Biochemical Research Methods
Fady Nahra, Nikolaos Tzouras, Alba Collado, Steven P. Nolan
Summary: N-heterocyclic carbene gold(I) chloride and hydroxide complexes are commonly used as synthetic reagents and efficient catalysts. This study describes a straightforward and practical method for synthesizing mononuclear gold complexes with high yields, as well as the synthesis of a mononuclear gold(I) hydroxide complex and an improved synthesis method for a dinuclear gold(I) hydroxide complex. This methodology offers advantages such as the use of sustainable reaction solvents and commercially available starting materials.
Article
Chemistry, Multidisciplinary
Chiara Masaro, Giammarco Meloni, Marco Baron, Claudia Graiff, Cristina Tubaro, Beatriz Royo
Summary: A series of Mn(I) complexes with different ligand structures have been studied for their catalytic performance in the reductive N-formylation and N-methylation of amines, showing high selectivity and good catalytic activity.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Applied
Vanessa Vethacke, Vanessa Claus, Martin C. Dietl, Daniel Ehjeij, Arne Meister, Jonas F. Huber, Leon K. Paschai Darian, Matthias Rudolph, Frank Rominger, A. Stephen K. Hashmi
Summary: A variety of unsymmetric diaryl gold N-acyclic carbene (NAC) complexes were successfully synthesized by three different methods, allowing access to new complexes and overcoming previous limitations in the isonitrile route. These new complexes also proved to be successful as pre-catalysts in gold-catalyzed phenol synthesis.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Review
Chemistry, Inorganic & Nuclear
Halliru Ibrahim, Muhammad D. Bala, Holger B. Friedrich
Summary: This review elaborates on the chronological development of imino-NHC ligands and their complexes with late first-row transition metals utilized in homogeneous catalysis. Imino-NHC ligands have gained popularity due to their general stability, better resistance to degradation, and suitable coordinative and electronic properties for various catalytic transformations.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Multidisciplinary Sciences
Tong Liu, Sha Bai, Le Zhang, F. Ekkehardt Hahn, Ying-Feng Han
Summary: Tuning the surface-embellishing ligands of metal nanoparticles can impact their catalytic activity and selectivity. The design and synthesis of a polytriazolium organic cage in this study stabilized PdNPs and showed excellent catalytic performance and recyclability.
NATIONAL SCIENCE REVIEW
(2022)
Article
Chemistry, Multidisciplinary
Paul Zaby, Jan Blasius, Anna K. Mueller, Steven P. Nolan, Oldamur Holloczki
Summary: The formation mechanism of metal-N-heterocyclic carbene (NHC) complexes from imidazolium salts in the presence of weak bases was investigated through theoretical methods. Quantum chemical calculations revealed that both sodium acetate and trimethylamine facilitate complex formation. Molecular dynamics simulations showed that the ionic nature of the [AuCl2](-) and imidazolium ions, as well as the sodium acetate base, keep these species associated in the reaction mixture through ion pairing. The neutral amine, however, remains mostly separated from the other reaction partners, making it a significantly less effective base.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Ichraf Slimani, Serap Sahin-Bolukbasi, Mustafa Ulu, Enes Evren, Nevin Gurbuz, Ilknur Ozdemir, Naceur Hamdi, Ismail Ozdemir
Summary: A series of rhodium(i) complexes with N-heterocyclic carbene ligands showed high in vitro cytotoxic activity against human cancer cells, with complex 2b exhibiting the most selective cytotoxic activity. These complexes demonstrated greater cytotoxicity against cancer cells compared to established anticancer agents cisplatin and 5-fluorouracil.
NEW JOURNAL OF CHEMISTRY
(2021)
Review
Chemistry, Inorganic & Nuclear
Sai Zhao, Zhibing Yang, Guizhi Jiang, Sheng Huang, Mianli Bian, Yunlong Lu, Wukun Liu
Summary: NHCs have been introduced as a new platform for the development of anticancer metal complexes, with platinum NHC complexes showing comparable activities to cisplatin and exhibiting different mechanisms of action, including the induction of biochemical hallmarks of immunogenic cell death (ICD) as a type II ICD inducer. These features make them promising candidates in the field of anticancer research.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Inorganic & Nuclear
Clemens Kaussler, Darren Wragg, Claudia Schmidt, Guillermo Moreno-Alcantar, Christian Jandl, Johannes Stephan, Roland A. Fischer, Stefano Leoni, Angela Casini, Riccardo Bonsignore
Summary: This study focuses on improving the design of metal complexes as stabilizers of noncanonical DNA secondary structures. A series of cyclic dinuclear Au(I) N-heterocyclic carbene complexes based on xanthine and benzimidazole ligands have been synthesized and characterized. The compounds show stabilization properties towards G-quadruplexes (G4s) and moderate antiproliferative activity in human cancer cells. The binding modes and free energy landscape of the most active compound have been studied using metadynamics.
INORGANIC CHEMISTRY
(2022)
Review
Chemistry, Applied
Eve M. Poland, Curtis C. Ho
Summary: This Minireview presents recent developments in photoactive/photoluminescent N-heterocyclic carbene (NHC) transition metal complexes and discusses their viability as catalysts in bond-forming photocatalysis. Key structural motifs and photophysical properties of these complexes are summarized. Representative examples of their applications as catalysts in bond-forming photochemical reactions are showcased, highlighting the state-of-the-art and future opportunities for this exciting class of NHC transition metal complexes.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Kseniya V. Arsenyeva, Kira I. Pashanova, Olesya Yu. Trofimova, Irina V. Ershova, Maxim G. Chegerev, Alyona A. Starikova, Anton V. Cherkasov, Mikhail A. Syroeshkin, Anna Ya. Kozmenkova, Alexandr V. Piskunov
Summary: The newly synthesized monomeric O,N-heterocyclic germylene (Ad)APGe (1) shows weak interactions between molecules in the crystal and exhibits excellent redox activity and catalytic properties.
NEW JOURNAL OF CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Zikun Wang, Nikolaos V. Tzouras, Steven P. Nolan, Xihe Bi
Summary: Silver N-heterocyclic carbenes (Ag-NHCs) have good biocompatibility and are widely used in medicine and coordination chemistry, but their coordination with silver can weaken the Lewis acidity of Ag(I), resulting in slow development as catalysts. Future opportunities lie in further research on the catalytic mechanisms of Ag-NHCs to enhance their catalytic activity.
TRENDS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Hang Shen, Michael B. Larsen, Allison G. Roessler, Paul M. Zimmerman, Andrew J. Boydston
Summary: A new flex-activated mechanophore has been discovered, which releases an N-heterocyclic carbene (NHC) under mechanical load. This design demonstrates a promising first step towards flex-activated designs with downstream reactivities, allowing for iterative activation increases in the material through non-destructive compression cycles. The potential modularity of the mechanophore design is highlighted by the demonstration of two different NHC structures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Applied
Ming-Tsz Chen, Yu-Yang Chen, Ting-Hsun Huang, Hui-Chu Pi, Ching-Han Hu, Chi-Tien Chen
Summary: This study describes a new mutual transformation mode between two aluminum complexes with different ligands, supported by density functional theory (DFT) studies. Their catalytic activities were investigated in the ring opening polymerization of ε-caprolactone and l-lactide, showing potential applications in these processes.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Marion Wrackmeyer, Adam P. O'Rourke, Thomas Pugh, Michael L. Turner, Simon J. Webb
Summary: A library of closely related diacetylenes has been synthesized, with color changes analyzed using various analytical techniques. The diacetylenes with cycloalkyl substituents show greater sensitivity to changes in molecular structure and higher stability compared to those with n-alkyl substituents.
Article
Chemistry, Inorganic & Nuclear
Yu-Cheng Hsu, Ming-Tsz Chen
Summary: The N-heterocyclic carbene-palladium(II) amine complexes synthesized in this study showed good catalytic activities for the Buchwald-Hartwig amination reaction of aryl chlorides, yielding 21 expected coupling products in moderate to high yields under mild conditions. The complexes were characterized by single crystal X-ray diffraction and NMR spectroscopy, and the reactions were conducted in air without purification of starting materials.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jincheng Tong, Amadou Doumbia, Raja U. Khan, Aiman Rahmanudin, Michael L. Turner, Cinzia Casiraghi
Summary: Quantitative measurements of molecular dynamics at the solid-liquid interface are crucial. However, the commonly used analytical techniques have limited sensitivity. By using electrolyte-gated organic field-effect transistors (EGOFETs), it is possible to monitor the crystallization process in real-time and quantify changes in solute concentration and molecular transport rate at the solid-liquid interface.
Article
Chemistry, Organic
Scott T. Shreiber, Gabriella I. Puchall, David A. Vicic
Summary: The homoleptic trifluoromethyl nickel complex catalyzes a stereoselective trifluoromethylation of brucine, leading to a trifluoromethylated derivative. The reaction also involves the isomerization of its alkenyl double bond, and a minor difunctionalization product is detected, suggesting a parallel radical addition process. Stoichiometric reactions between the nickel(II) catalyst precursor and brucine show no reactivity, but a reaction with a high-valent nickel(IV) complex results in the formation of trifluoromethylated derivative.
TETRAHEDRON LETTERS
(2022)
Article
Nanoscience & Nanotechnology
Amadou Doumbia, Michelle Webb, Jonathan M. Behrendt, Richard J. Wilson, Michael L. Turner
Summary: Electrolyte-gated organic field-effect transistors (EGOFETs) have great potential in biosensing applications. They can sensitively and selectively quantify various chemical and biological molecules, but the real-time monitoring of analyte-receptor interactions has been rarely explored. In this study, an EGOFET array integrated with a microfluidic device is presented for the real-time detection of DNA hybridization. The integrated devices exhibit highly reproducible electrical performance and can operate under different electrical stresses for extended periods of time.
ADVANCED ELECTRONIC MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Ming-Tsz Chen, Mu Hsu, Mei-Chen Lin, Yu-Cheng Lien, Kuan-Wei Chen
Summary: The HSAB principle is applied in designing NHC Pd complexes in this study. N-donor ligands as hard bases enhance the catalytic activities of NHC Pd complexes in Suzuki and Buchwald-Hartwig reactions. The Pd complex with tertiary amine ligands exhibits better performance in coupling reactions.
Article
Chemistry, Inorganic & Nuclear
Teng Xue, Scott T. Shreiber, Roger E. Cramer, David A. Vicic
Summary: In this study, solvent-coordinated perfluoroethyl and n-perfluoropropyl cobalt complexes were synthesized and characterized. The electrochemical analysis revealed that [(MeCN)(4)Co(C2F5)(2)][PF6] is more easily reduced compared to [(MeCN)(3)Co (C2F5)(3)], which has significant implications for the development of redox-triggered reactions involving cobalt(II) intermediates.
JOURNAL OF FLUORINE CHEMISTRY
(2022)
Article
Polymer Science
Yurachat Janpatompong, Andrew M. Spring, Venukrishnan Komanduri, Raja U. Khan, Michael L. Turner
Summary: This article reports the synthesis of 2,3-dialkoxyphenylenevinylene polymers by ring contraction and ring-opening metathesis polymerization, as well as the preparation of block copolymers of phenylene vinylene polymers, and the properties of the polymers were studied.
Article
Materials Science, Multidisciplinary
Vanessa Tischler, Piotr Dudek, Jayawan Wijekoon, Leszek A. Majewski, Yasunori Takeda, Shizuo Tokito, Michael L. Turner
Summary: This paper reports the fabrication of a simple neuromorphic circuit using solution-processed organic field-effect transistors (OFETs). The circuit has predictable behavior and allows for customized design, providing the basis for various flexible neuromorphic circuit designs.
ORGANIC ELECTRONICS
(2023)
Article
Chemistry, Inorganic & Nuclear
James P. Shanahan, David A. Vicic, William W. Brennessel, William D. Jones
Summary: Nickel-sulfur bonds are important in catalysis and biological systems. This study synthesized and characterized a new nickel complex, providing insight into its reaction mechanism.
Article
Polymer Science
Yurachat Janpatompong, Kamil Suwada, Michael L. Turner, Guillaume De Bo
Summary: Understanding the stability of conjugated polymers towards mechanical stimuli is crucial for optimizing their use in electronic and optoelectronic devices. Mechanochemistry is a field that aims to control mechanical forces for chemical changes, and it can also be used to study the stability of conjugated polymers. Ultrasonication is a technique that can be used to test the mechanical integrity of phenylenevinylene block copolymers and demonstrate their stability to mechanical forces, making them suitable for flexible organic electronics.
Article
Chemistry, Organic
Yurachat Janpatompong, Venukrishnan Komanduri, Raja U. U. Khan, Michael L. L. Turner
Summary: ortho-Diethylhexyloxyphenylene benzothiadiazole paracyclophane-1,9-diene, a mixture of diastereomers, was synthesized through benzyne-induced Stevens rearrangement, oxidation, and pyrolysis. These cyclophanedienes, when reacted with Grubbs catalyst, can be opened to alternating cis,trans-phenylenevinylene polymers. In situ NMR experiments showed that one isomer polymerized to 90% conversion, while the other isomer gave only 9% conversion due to steric hindrance. The resulting polymers can be easily isomerized to all-trans isomer using visible light, and their optical and electrochemical properties were investigated by theory and experiment.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Scott T. Shreiber, Fatema Amin, Sascha A. Schafer, Roger E. Cramer, Axel Klein, David A. Vicic
Summary: A series of new anionic nickelate complexes were synthesized and characterized, and their electrochemical properties were studied. The results showed that the complexes exhibited different oxidation-reduction behaviors, and the NHC ligand environment played an important role in the release of trifluoromethyl and perfluoroalkyl radicals.
DALTON TRANSACTIONS
(2022)
Article
Polymer Science
Venukrishnan Komanduri, Yurachat Janpatompong, Raymundo Marcial-Hernandez, Daniel J. Tate, Michael L. Turner
Summary: The synthesis of donor-acceptor di-, tri- and tetrablock copolymers via sequential ROMP using Grubbs ruthenium carbene initiator was discussed in the paper. The block copolymers initially had cis/trans alkene geometry, which could be easily converted to all trans forms. The optical and electrochemical properties of these block copolymers were examined, showing that the HOMO and LUMO energy levels are localized on the donor and acceptor blocks respectively.
