Review
Biochemistry & Molecular Biology
Alexia Tialiou, Jiamin Chin, Bernhard K. Keppler, Michael R. Reithofer
Summary: This review summarizes the latest advances in NHCAu(I/III) complexes that interact with DNA and presents the latest research on acyclic diamino carbene gold complexes with anticancer activity, which offer additional design possibilities in targeted therapy.
Article
Chemistry, Inorganic & Nuclear
Erik G. Rojo-Gomez, Francisco J. Zuno-Cruz, Gloria Sanchez-Cabrera, Mariana Carpio-Granillo, Daniel O. Gonzalez-Abrego, Claudia Coronel-Olivares, Jose G. Alvarado-Rodriguez, Maria J. Rosales-Hoz
Summary: Synthetic, structural, and antibacterial studies were conducted on a series of functionalized monocarbene NHC of silver(I) and gold(I) complexes. The silver NHC compounds were synthesized using Ag2O and 3-substituted 1-(2-methylallyl)imidazolium chloride salts, while the monocarbene NHC-Au(I) complexes were obtained by transmetalation using NHC-Ag(I) compounds and [AuCl(SMe2)] as a source of gold(I). Spectroscopic and analytic techniques were used for characterization, and the molecular structures of selected compounds were confirmed by single-crystal X-ray diffraction. In vitro antibacterial assays showed that the gold complexes exhibited superior activity against various bacterial strains compared to the silver complexes.
INORGANICA CHIMICA ACTA
(2023)
Article
Chemistry, Inorganic & Nuclear
Riccardo De Marco, Marco Dal Grande, Marco Baron, Laura Orian, Claudia Graiff, Thierry Achard, Stephane Bellemin-Laponnaz, Alexander Pothig, Cristina Tubaro
Summary: A series of gold complexes with N-heterocyclic carbene ligands functionalized with a pendant thioether group were synthesized and characterized, showing moderate in vitro cytotoxicity towards breast cancer cells MCF7. The experimental aspects were rationalized through relativistic DFT calculations.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Thomas Scattolin, Giovanni Tonon, Eleonora Botter, Sebastien G. Guillet, Nikolaos V. Tzouras, Steven P. Nolan
Summary: The review focuses on the design of gold-based synthons that enable the synthesis of target complexes through simple steps under mild conditions. Mechanistic aspects of their synthesis and reactivity, as well as applications as efficient pre-catalysts, antitumor agents, and photo-emissive materials, are discussed.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Priyanka Sahu, Narayan Ch. Jana, Sahadev Barik, Hemanta K. Kisan, Avtar Changotra, Anvarhusein A. Isab, Joydev Dinda
Summary: A novel synthetic approach was used to synthesize a heterobimetallic cluster, and its structure was confirmed through experiments. It was found that Au(i) preferred to bind with the C-carbene donor. In addition, metal-metal interactions in the clusters were further investigated using computational methods, and one of the clusters was found to be more aromatic.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Applied
Andrea Longhi, Marco Baron, Marzio Rancan, Gregorio Bottaro, Laura Orian, Claudia Graiff, Marco Roverso, Ileana Menegazzo, Lidia Armelao, Sara Bogialli, Cristina Tubaro
Summary: This study explored the coordinating properties of the bis(1,4-dimethyl-1,2,4-triazol-5-ylidene) ligand (bitz) towards silver(I) and gold(I) centers. Results showed that bitz behaves as a bridging ligand, forming both dinuclear and trinuclear complexes, which were supported by X-ray diffraction analysis, NMR spectroscopy, and mass spectrometry evidence.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Stefano Scoditti, Francesco Chiodo, Gloria Mazzone, Sebastien Richeter, Emilia Sicilia
Summary: The photophysical properties of two classes of porphyrins and metalloporphyrins linked to N-heterocyclic carbene (NHC) Au(I) complexes were investigated for their potential application in photodynamic therapy. Results showed that these compounds possess appropriate properties for generating cytotoxic singlet molecular oxygen and can be used as photosensitizers. The heavy atom effect in promoting the intersystem crossing process was found to vary depending on the identity and position of the metal center in the porphyrin core or linked to the peripheral NHC.
Article
Chemistry, Inorganic & Nuclear
Zakariae Asbai, Anna Bonfiglio, Pierluigi Mercandelli, Federico Polo, Matteo Mauro
Summary: A novel family of photoactive cationic tris-carbonyl rhenium complexes has been successfully synthesized and characterized using various techniques. These complexes exhibit different photophysical properties under different conditions, providing important insights for studying the properties of metal complexes.
Article
Biochemical Research Methods
Fady Nahra, Nikolaos Tzouras, Alba Collado, Steven P. Nolan
Summary: N-heterocyclic carbene gold(I) chloride and hydroxide complexes are commonly used as synthetic reagents and efficient catalysts. This study describes a straightforward and practical method for synthesizing mononuclear gold complexes with high yields, as well as the synthesis of a mononuclear gold(I) hydroxide complex and an improved synthesis method for a dinuclear gold(I) hydroxide complex. This methodology offers advantages such as the use of sustainable reaction solvents and commercially available starting materials.
Article
Chemistry, Multidisciplinary
Di Zhang, Shuichi Suzuki, Takeshi Naota
Summary: This study found that luminescence from a gold(I) complex with an N-heterocycliccarbene-based ligand increased rapidly upon a one-shot needlestick-stimulus, transitioning from weakly orange-emitting to intensively violet-blue-emitting. The complex could repeatedly transition between stable solid, liquid, and metastable solid states without measurable degradation, potentially due to flexible intermolecular interactions in kinetically generated aggregates and strong Au-Au interactions in thermodynamically stable crystals.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Inorganic & Nuclear
Darius Dumitra, Alexandra Pop, Anca Silvestru
Summary: New pyridine-based ligands with organoselenium groups were synthesized and used to form corresponding metal complexes with gold(I) and silver(I) ions. The coordination behavior of the ligands was studied using NMR spectroscopy and mass spectrometry. X-ray crystallography revealed different coordination modes of the ligands in the metal complexes. The metal complexes exhibited metallophilic interactions in the solid state.
Review
Chemistry, Physical
Annaluisa Mariconda, Marco Sirignano, Rubina Troiano, Simona Russo, Pasquale Longo
Summary: This review summarizes the research progress from 2007 to 2022 on the nucleophilic addition of amines and water to terminal and internal alkynes catalyzed by N-heterocyclic carbene gold (I/III) complexes. These reactions are environmentally sustainable and lead to important intermediates in the chemical and pharmaceutical industry.
Article
Pharmacology & Pharmacy
Adrian Sanchez, Carlos J. Carrasco, Francisco Montilla, Eleuterio Alvarez, Agustin Galindo, Maria Perez-Aranda, Eloisa Pajuelo, Ana Alcudia
Summary: In this study, a series of imidazole silver complexes with different alkyl groups were prepared and their antimicrobial properties were evaluated. The results showed that the antimicrobial activity of the complexes was related to their structure and the steric properties of the alkyl groups.
Article
Chemistry, Inorganic & Nuclear
Andrew M. Romine, Matthew J. Demer, Milan Gembicky, Arnold L. Rheingold, Keary M. Engle
Summary: Tetrahydrothiophene-functionalized N, S-heterocyclic carbene palladium(II) complexes were synthesized through an unexpected rearrangement using palladium(II) trifluoroacetate instead of other palladium(II) compounds, and their catalytic capabilities in C-C coupling reactions were demonstrated.
Review
Pharmacology & Pharmacy
Juzheng Zhang, Yanping Li, Ronghao Fang, Wei Wei, Yong Wang, Jiamin Jin, Feng Yang, Jian Chen
Summary: Metal compounds, especially gold complexes, have attracted attention as possible therapeutics for lung cancer. This review summarizes examples of anticancer gold(I) and gold (III) complexes for lung cancer treatment and discusses their mechanisms of action and approaches to improve their efficiency.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Organic
Daniel Timelthaler, Wolfgang Schoefberger, Christoph Topf
Summary: A novel cobalt corrole catalyst was reported for the homogeneous hydrogenation of structurally diverse nitroarenes to amines, without the need for additional reagents, and can be easily assembled in a regular laboratory atmosphere.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Thomas Hofbeck, Thomas A. Niehaus, Michel Fleck, Uwe Monkowius, Hartmut Yersin
Summary: In this study, an overview of eight brightly luminescent Cu(I) dimers is presented, focusing mainly on their photo-luminescence properties. The compounds exhibit a combination of thermally activated delayed fluorescence (TADF) and phosphorescence at ambient temperature, with emission color, decay time and quantum yield varying significantly. The interplay between different emission paths, including singlet and triplet transitions, is discussed for potential OLED applications to improve device performance.
Article
Chemistry, Multidisciplinary
Petra Gruendlinger, Cezarina Cela Mardare, Thorsten Wagner, Uwe Monkowius
Summary: This study demonstrates that intramolecular hydrogen bonding can be used to stabilize tri-coordinated phosphane-gold(I) complexes, such as [L3Au]X complex, which is stabilized by intramolecular hydrogen bonds.
MONATSHEFTE FUR CHEMIE
(2021)
Article
Chemistry, Inorganic & Nuclear
Felix Mueller, Lucas Wickemeyer, Jan Schwabedissen, Martin Ertl, Beate Neumann, Hans-Georg Stammler, Uwe Monkowius, Norbert W. Mitzel
Summary: Two gold(I) dimers were synthesized using tin-gold exchange reactions, characterized by various experiments, and further investigated using computational and photophysical methods.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Physical
Thomas Vielhaber, Christian Heizinger, Christoph Topf
Summary: This study reports a simple catalytic method for the hydrogenation of quinolines using a tungsten precursor. The method is operationally simple and avoids the use of expensive and oxygen-sensitive phosphine ligands and auxiliary hydride reagents.
JOURNAL OF CATALYSIS
(2021)
Article
Chemistry, Organic
Daniel Timelthaler, Christoph Topf
Summary: This catalytic method allows for the pressure hydrogenation of quinolines in aqueous solution using a cobalt-based catalyst prepared from Co(OAc)(2)center dot 4H(2)O and zinc powder. The synthesis process is time-saving and operationally simple, with all reagents readily available from commercial sources. The reaction setup and autoclave charging are conducted outside an inert-gas-operated containment system for convenience.
SYNTHESIS-STUTTGART
(2022)
Article
Chemistry, Analytical
Gang Cheng, Dongling Zhou, Uwe Monkowius, Hartmut Yersin
Summary: Luminescent copper(I) complexes with thermally activated delayed fluorescence (TADF) have shown potential as emitter materials for OLEDs. A study on a luminescent dimer showed both TADF and phosphorescence, leading to warm white emission in a solution-processed OLED with moderate EQE. Strategies for improving EQE were discussed for future optimization.
Article
Chemistry, Physical
Jessica Michalke, Michael Haas, Dominik Krisch, Thomas Boegl, Stephan Bartling, Nils Rockstroh, Wolfgang Schoefberger, Christoph Topf
Summary: We describe the synthesis of a novel heterogenous non-noble metal catalyst based on a well-defined phosphine-tagged cobalt corrole complex. The active material is obtained through wet-impregnation of the relevant metal macrocycle onto carbon black followed by controlled pyrolysis under an inert gas atmosphere. The resulting catalyst was successfully used for the hydrogenation of various nitroarenes, yielding valuable aniline derivatives.
Article
Biochemistry & Molecular Biology
Jessica Michalke, Kirill Faust, Thomas Bogl, Stephan Bartling, Nils Rockstroh, Christoph Topf
Summary: In this study, the assembly of a Ce-promoted Ni-based solid composite catalyst for the hydrogenation of nitroarenes was communicated. The catalyst showed advantages such as simple preparation, operational simplicity, and easy separation and recycling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Daniel Timelthaler, Christoph Topf
Summary: This study presents a simple method for the transfer hydrogenation of aromatic aldehydes in i-PrOH using the cost-effective and easy-to-handle [Cr(CO)(6)] as a catalyst. The reactions can be carried out in normal atmosphere without the need for special equipment, and various functional groups are tolerated. Furthermore, the addition of TMAO can further promote the catalytic transformations. This method is also suitable for processing thermo-labile substrates.
JOURNAL OF CATALYSIS
(2022)
Article
Chemistry, Physical
Thomas Vielhaber, Kirill Faust, Thomas Boegl, Wolfgang Schoefberger, Christoph Topf
Summary: We disclose the synthesis, characterization, and catalytic application of a triphos-tagged, non-pincer-type tungsten complex. The complex is used for hydrogenation reactions of ketones and esters to produce alcohols, as well as for conjugate reduction reactions of enoates to yield esters without carbon-carbon bond. The successful reduction of carbonyl ester groups is achieved by changing the cation in the auxiliary base from Na' to Li'. The organometallic complex is conveniently weighable and can be handled without a sealed glove box system.
JOURNAL OF CATALYSIS
(2022)
Article
Chemistry, Inorganic & Nuclear
Samuel Redl, Daniel Timelthaler, Paul Sunzenauer, Kirill Faust, Christoph Topf
Summary: We present a general method for synthesizing acenaphthene-fused imidazolinium salts, which are direct precursors to augmented N-heterocyclic carbenes with a fixed cis geometry. The reduction of bis(imino)acenaphthene ligands with a LiAlH4/AlCl3 reagent mix first produced the corresponding 1,2-diamines. Subsequent ring-closing reaction with triethyl orthoformate in acidic solution generated the required ionic intermediates. Preparation of selected [Cu(NHC)] complexes using the respective imidazolinium salt as a starting material and treatment with base in the presence of a Cu(I) source confirmed the formation of the carbenes.
Article
Chemistry, Multidisciplinary
Thorsten Wagner, Michael Gyoeroek, Sebastian Wolfmayr, Petra Gruendlinger, Uwe Monkowius, Peter Zeppenfeld
Summary: This study explores the potential of aurophilicity for self-assembly in thin films and investigates the formation of ultrathin films of chlorido(2-naphthyl isonitrile) gold(I) on gold surfaces. The results show a similar packing motif in the thin films compared to the bulk.
Article
Chemistry, Multidisciplinary
Michael Gyoeroek, Thorsten Wagner, Petra Gruendlinger, Uwe Monkowius, Peter Zeppenfeld
Summary: In this paper, the interaction between chlorido(2-naphthyl isonitrile)gold(I) and Au(110) surfaces is investigated using photoelectron emission microscopy (PEEM) and optical reflectance techniques. Structural data obtained from STM and LEED indicate that the molecular arrangement changes multiple times during thin-film deposition.
Article
Polymer Science
Paul Strasser, Marina Russo, Pauline Stadler, Patrick Breiteneder, Guenther Redhammer, Markus Himmelsbach, Oliver Brueggemann, Uwe Monkowius, Petr Klan, Ian Teasdale
Summary: This study reports the design of easily accessible, photocleavable meso-methyl BODIPY monomers for incorporation into macromolecules, demonstrating their potential value in photosensitive materials.