Article
Chemistry, Inorganic & Nuclear
Dmitri Gelman, Ilya Kisets, Sofiya Zabelinskaya
Summary: The synthesis and catalytic studies of a prototypical coordinatively rigid carbometalated half-sandwich Ru(II) complex with a rigid polyaromatic tether were described. Despite its coordinatively and electronically saturated nature, the complex demonstrated the ability to activate and transfer hydrogen to polar and nonpolar double bonds. The catalytic activity was benchmarked in the Ru-catalyzed chemoselective hydrogenation of alpha,beta-unsaturated ketones, with initial mechanistic studies suggesting an inner-sphere mechanism via dihydride intermediates.
Article
Chemistry, Multidisciplinary
Sonia Infante-Tadeo, Vanessa Rodriguez-Fanjul, Abraha Habtemariam, Ana M. Pizarro
Summary: This study introduces a new family of osmium arene complexes and investigates their mechanism of action inside cells. The complexes are shown to catalyze the conversion of organic substrates, demonstrating potential anti-cancer drug activity.
Article
Chemistry, Multidisciplinary
Rong-Jian Li, Yang Wang, Yan Jin, Wei Deng, Zhen-Jiang Liu, Zi-Jian Yao
Summary: Neutral C,C-chelate half-sandwich iridium(iii) complexes with NHC ligands containing pendant aromatic rings show excellent catalytic activity for acceptorless dehydrogenation reactions and transfer hydrogenation reactions of alcohols and ketones. These complexes are efficient in producing aldehydes from primary alcohols and alcohols from ketones and aldehydes under mild conditions. The exact structure and bonding mode of these NHC-based iridium complexes have been identified using various spectroscopic methods and single crystal X-ray analysis.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
M. C. Joseph, A. J. Swarts, S. F. Mapolie
Summary: A series of novel cationic ruthenium half-sandwich complexes with 1-substituted-4-pyridyl-1H-1,2,3-triazole ligands were synthesized and found to be efficient catalyst precursors for transfer hydrogenation reactions. With a low concentration of base, these complexes could hydrogenate acetophenone with excellent conversions within a short reaction time. The catalytic efficiency of the most effective catalyst was further demonstrated in the transfer hydrogenation of a small library of ketones.
Article
Chemistry, Inorganic & Nuclear
Nida Shahid, Rahul Kumar Singh, Navdeep Srivastava, Amrendra K. K. Singh
Summary: A series of Ru(III)-NHC complexes have been prepared through a base-free route. These air and moisture-stable complexes, which represent rare examples of paramagnetic Ru(III)-NHC complexes, were shown to be excellent metal precursors for the synthesis of new Ru(II)-NHC complexes. This work allows easy access to new Ru-NHC complexes for the study of new properties and novel applications.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Physical
K. Naveenkumar, Patil Akshay Ravindra, B. Archana, Neppoliyan Kannan, G. Pavithran, Arup Sinha
Summary: This study presents the synthesis and characterization of two ruthenium(II) half-sandwich complexes (1 & BULL;PF6 and 2 & BULL;PF6) with phosphine-free ligands N-(pyridin-2-yl)quinolin-2-amine (L-1) and N-(4-methylpyridin-2-yl) quinolin-2-amine (L-1). The molecular structures of both complexes were determined using single-crystal X-ray diffraction. These complexes acted as excellent phosphine-free catalytic systems for the mild synthesis of aryl amines from nitroarenes using sodium borohydride in ethanol. Spectroscopic studies confirmed the intermediacy of [Ru-H], and the reduction showed good chemo selectivity in the presence of -COOH and -NHCOMe functionalities.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Inorganic & Nuclear
Wen-Rui Lv, Rong-Jian Li, Zhen-Jiang Liu, Yan Jin, Zi-Jian Yao
Summary: A series of N,O-coordinate iridium(III) complexes with Schiff base ligands were synthesized for catalytic hydrogenation of nitro and carbonyl substrates, showing efficient catalytic activity and high yields. The molecular structures of the complexes were well characterized and the highest TON values were achieved for the hydrogenation reactions of carbonyl and nitro substrates.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Dana Josa, David Aguila, Pere Fontova, Vanessa Soto-Cerrato, Piedad Herrera-Ramirez, Laia Rafols, Arnald Grabulosa, Patrick Gamez
Summary: Five metal-arene complexes and nine cyclometalated half-sandwich complexes were synthesized, characterized, and evaluated for cytotoxicity against human cancer cells. The complexes showed notable cytotoxic properties, particularly against lung adenocarcinoma cells. One of the complexes also exhibited significant toxic effects on other cell lines. Furthermore, the study identified a complex that impacted the cell cycle of lung adenocarcinoma cells.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Franck Ulm, Saurabh Shahane, Lai Truong-Phuoc, Thierry Romero, Vasiliki Papaefthimiou, Matthieu Chesse, Michael J. Chetcuti, Cuong Pham-Huu, Christophe Michon, Vincent Ritleng
Summary: The preparation of cationic nickel complexes with bidentate coordination and their activity in aldehyde reduction are studied. The nanoparticles involving NHC-picolyl-Ni are observed under specific conditions, showing potential applications in catalysis.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Lukas Masaryk, Darina Muthna, Petr Halas, Pavel Zoufaly, Eva Peterova, Radim Havelek, Bohuslav Drahos, David Milde, Alena Mrkvicova, Pavel Starha
Summary: In the presence of carboxypeptidase, the hydrolytically stable complex partially released the bioactive substituent indomethacin, which was bound through the amide bond to the chelating moiety. The stability in the presence of other relevant biomolecules and cancer cell viability were also investigated in this study.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Tianyu Han, Yuying Wu, Weinan Han, Kaiwen Yan, Jian Zhao, Yanyan Sun
Summary: The facile modification of ligands in organometallic Ru(II)-arene complexes provides more opportunities for optimizing their pharmacological profiles. This study designed and synthesized three Ru(II)-arene complexes containing a GST inhibitor (NBDHEX), with in vitro results showing increased activities against tumor cells, especially in complex 3 which demonstrated the highest activity. Complex 3, with more alkyl groups in the arene ligand, exhibited increased electron density at the Ru(II) center leading to improved hydrolysis rate and higher anticancer activity.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Sonia Infante-Tadeo, Vanessa Rodriguez-Fanjul, Cintia C. Vequi-Suplicy, Ana M. Pizarro
Summary: The passage describes the rapid hydrolysis and high basicity of complexes [Os(eta 6-arene)(C,N-phenylpyridine)Z] with chlorido or tethered oxygen as the ligand. It also reveals the structure-activity relationship between Os-CN and Os-NN complexes.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Ramya Prabaharan, Ramesh Rengan, Devan Umapathy, Antony Joseph Velanganni Arockiam, Jan Grzegorz Malecki
Summary: The study synthesized six new arene ruthenium (II) complexes and evaluated their anticancer activity through MTT assay and staining techniques, demonstrating good cytotoxicity against cancer cell lines, particularly with complex 6 showing potential anticancer activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Betty Y. T. Lee, Matthew P. Sullivan, Ena Yano, Kelvin K. H. Tong, Muhammad Hanif, Tomoyo Kawakubo-Yasukochi, Stephen M. F. Jamieson, Tilo Soehnel, David C. Goldstone, Christian G. Hartinger
Summary: N-Heterocyclic carbene (NHC) ligands have been widely studied in medicinal inorganic chemistry. In this study, a series of half-sandwich [M(L)(NHC)Cl-2] complexes with N-flanking anthracenyl moiety were prepared and their anticancer activities were investigated, showing cytotoxicity in low micromolar range. The Ru derivative 1a exhibited stability and specific interactions with biomolecules.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Kenan Buldurun, Nevin Turan, Ghodrat Mahmoudi, Ercan Bursal
Summary: Five new Ru(II)(η(6)-p-cymene) complexes were synthesized and characterized. They were found to have effective inhibitions against enzymes and strong antioxidant potentials.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Inorganic & Nuclear
Clara S. B. Gomes, Paramasivam Krishnamoorthy, Leonel C. Silva, Sandra I. Costa, Pedro T. Gomes, Manuel Jimenez-Tenorio, Pedro Valerga, M. Carmen Puerta
DALTON TRANSACTIONS
(2015)
Article
Chemistry, Inorganic & Nuclear
Vinay K. Singh, M. Carmen Puerta, Pedro Valerga
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2015)
Article
Chemistry, Inorganic & Nuclear
Manuel Jimenez-Tenorio, M. Carmen Puerta, Pedro Valerga
Article
Chemistry, Inorganic & Nuclear
Manuel Jimenez-Tenorio, M. Carmen Puerta, Pedro Valerga
Article
Chemistry, Inorganic & Nuclear
Lourdes Benitez Junquera, Francys E. Fernandez, M. Carmen Puerta, Pedro Valerga
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2017)
Article
Chemistry, Inorganic & Nuclear
Clara S. B. Gomes, Sandra I. Costa, Leonel C. Silva, Manuel Jimenez-Tenorio, Pedro Valerga, M. Carmen Puerta, Pedro T. Gomes
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Rashmi Dubey, Praveen Singh, Ajeet K. Singh, Manoj K. Yadav, D. Swati, Manjula Vinayak, Carmen Puerta, Pedro Valerga, K. Ravi Kumar, B. Sridhar, Ashish K. Tewari
CRYSTAL GROWTH & DESIGN
(2014)
Article
Chemistry, Inorganic & Nuclear
Manuel Jimenez-Tenorio, M. Carmen Puerta, Pedro Valerga, Manuel A. Ortuno, Gregori Ujaque, Agusti Lledos
Article
Chemistry, Multidisciplinary
Sunil Kumar Rai, Priyanka Srivastava, Hariom Gupta, Maria del C. Puerta, Pedro Valerga, Ashish Kumar Tewari
STRUCTURAL CHEMISTRY
(2015)
Article
Chemistry, Inorganic & Nuclear
Andres G. Algarra, Juan Carlos G. Galindo, M. Carmen Puerta, Pedro Valerga, Manuel Jimenez-Tenorio
Summary: At room temperature, the dinitrogen complex [{Cp*Ru(L)}(2)(mu-N-2)]-[BPh4](2) (L = bis(3-methylimidazol-2-ylidene) reacts with dichloromethane to form the diene derivative [Ru(eta(4), kappa(1)-Cl-C5Me5CH2Cl)Cl(L)][BPh4]. DFT computations revealed that while the cleavage of the C-Cl bond is not thermodynamically favored, the subsequent migration step is exergonic, driving the formation of the observed product.