Article
Chemistry, Inorganic & Nuclear
Lachlan J. Watson, Anthony F. Hill
Summary: The pro-ligands react with [RhCl(CE)(PPh3)2] to form bimetallic complexes, which undergo double C-H activation to form N-heterocyclic carbene (NHC) pincer complexes. Reduction and treatment with tritylium, ferrocenium or triphenylcyclopropenium tetrafluoroborates result in the formation of mononuclear NHC pincer complex salts. Treatment with lithium (trimethylsilyl)acetylide provides another bimetallic species, which can be obtained from [RhCl(RPm)] and LiCuCSiMe3.
DALTON TRANSACTIONS
(2023)
Review
Chemistry, Inorganic & Nuclear
Yidan Wang, Bo Zhang, Shuai Guo
Summary: The combination of NHC and pincer framework in transition metal complexes has been widely studied and applied in various fields, including catalysis and optical material chemistry. This minireview focuses on the synthesis, reactivity study and applications of metal pincer NHCs.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ludivine Poyac, Stefano Scoditti, Xavier Dumail, Michel Granier, Sebastien Clement, Rafael Gramage-Doria, Charles H. Devillers, Sebastien Richeter
Summary: The electronic and steric properties of NHC ligands functionalized with porphyrins were investigated. It was found that when porphyrins are used as NHC-wingtips, the catalytic activity of the neighboring NHC-Rh(I) complex in the conjugate addition reaction is significantly improved.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Rajeev C. Nishad, Shashi Kumar, Arnab Rit
Summary: A bis(azolium salt [L1-H-2]Br-2 was synthesized as a suitable platform for heterobimetallic Ir-III-M (M = Pd-II/Au-I) complexes. The heterobimetallic Ir-III-Pd-II complex 7 showed better catalytic activity in one-pot tandem organic transformations compared to the corresponding homobimetallic counterparts. The study suggests some sort of cooperativity between the connected Ir and Pd metal centers via a single ligand framework.
Article
Chemistry, Physical
Arun Dixith Reddy Shada, Alexander J. M. Miller, Thomas J. Emge, Alan S. Goldman
Summary: The method of alkane dehydrogenation using iridium complexes achieves up to 97% yield and up to 15 catalytic turnovers, utilizing proton-coupled electron transfer. This approach offers a promising way to selectively dehydrogenate alkanes with practical implications.
Article
Chemistry, Inorganic & Nuclear
David Rendon-Nava, Deyanira Angeles-Beltran, Arnold L. Rheingold, Daniel Mendoza-Espinosa
Summary: The synthesis of a CCC-pincer palladium(II) complex 2 and tris(carbene) dicationic palladium complex 3 containing multiple NHCs was reported, which showed excellent catalytic performance in cross coupling reactions and hydrosilylation of terminal alkynes.
Article
Chemistry, Inorganic & Nuclear
Diana V. Aleksanyan, Svetlana G. Churusova, Valentina V. Brunova, Alexander S. Peregudov, Aleksander M. Shakhov, Ekaterina Yu. Rybalkina, Zinaida S. Klemenkova, Elena G. Kononova, Gleb L. Denisov, Vladimir A. Kozlov
Summary: The study examined the cyclopalladation characteristics of a series of non-classical pincer-type ligands based on monothiooxalyl amides under conventional solution-based synthesis conditions and in solvent-free solid-phase methodology involving mechanochemical activation. The results showed that grinding functionalized monothiooxamides with PdCl2(NCPh)(2) in a mortar can serve as an efficient and environmentally friendly alternative to the synthesis of complex metal-organic systems. The confirmation of the coordination of S,N,N- or S,N,S-monoanionic tridentate in the resulting pincer complexes was achieved through various spectroscopic methods and SEM/EDS analysis, while preliminary evaluation demonstrated high cytotoxic activity against cancer cells for some cyclopalladated derivatives.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Lakshay Kathuria, Ashoka G. Samuelson
Summary: The enantioselective reduction of imines to chiral secondary amines was studied using chiral half-sandwich iridium complexes with N-heterocyclic carbene ligands. The optimized conditions showed good yields for ketimines with moderate enantiomeric excess. The Ir complex with phenylglycine-derived chiral NHC exhibited the highest catalytic activity and enantiomeric excess compared to other NHCs in the series.
Article
Chemistry, Multidisciplinary
Ryohei Kawazu, Takeru Torigoe, Yoichiro Kuninobu
Summary: New ligands have been discovered for iridium-catalyzed C(sp(3))-H borylation of aliphatic compounds. A phenanthroline-based NNSi pincer ligand has shown excellent performance and enables efficient conversion of aliphatic compounds to borylated products using an Ir/NNSi pincer catalyst system.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Inorganic & Nuclear
Hugo Valdes, Juan M. German-Acacio, Gerard van Koten, David Morales-Morales
Summary: This study explores the synthesis and applications of bimetallic complexes by merging a metallocene and a (cyclopentadienyl/aryl) pincer metal complex, discussing their importance in tuning electronic properties, catalytic reactions, and chiral catalysis. Various approaches to merge metallocene and pincer-metal motifs are explored, showcasing the potential for creating diastereomerically pure derivatives through post-functionalization strategies. The authors aim to inspire further research in this field by highlighting the synthetic, physico-chemical properties, and remarkable catalytic activities of metallocene-based pincer-metal complexes.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Yafei Gao, Maren Pink, Veronica Carta, Jeremy M. Smith
Summary: In this study, we report the previously unknown reactions of an Fe(II) imido complex with internal alkynes and isobutyronitrile, resulting in the formation of novel Fe amido allenyl and keteniminate complexes. Compound 1, as a catalyst, exhibits efficient selective α-deuteration of nitriles and alkynes. These findings reveal a new reactivity mode for metal imido complexes and provide new insights into the use of imido ligands in catalysis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Diep Thi Hong Nguyen, Lorianne R. Shultz, Titel Jurca, Ali Nazemi
Summary: N-heterocyclic carbenes (NHCs) have gained attention for stabilizing metallic nanoparticles, particularly gold nanoparticles, but the stability of silver nanoparticles (AgNPs) with NHCs has been overlooked. This study reports the synthesis of monomeric and polymeric NHC-Ag(I) complexes as precursors to NHC-tethered AgNPs. The stability of these NHC-functionalized AgNPs was investigated and their application in catalysis was demonstrated.
Article
Chemistry, Inorganic & Nuclear
M. Ortiz-Hernandez, V. Salazar-Pereda, D. Mendoza-Espinosa, M. A. Gomez-Bonilla, C. Cristobal, M. C. Ortega-Alfaro, A. Suarez, C. I. Sandoval-Chavez
Summary: This article investigates the reaction between the complex and aromatic ketones, and finds that Ir(iii)-metallacycles can be obtained through CH activation, which highlights the significance of the Ir-H bond.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Qingyang Wang, Richard A. Manzano, Hendrik Tinnermann, Simon Sung, Baptiste Leforestier, Tobias Kraemer, Rowan D. Young
Summary: The use of PCcarbeneP pincer ligands allows for metal-ligand cooperative reactivity and support for a variety of iron oxidation states, making it potentially useful in catalytic applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Jonathan De Tovar, Ashta C. Ghosh, Tom Di Santo, Mathieu Curtil, Dmitry Aldakov, Matthieu Koepf, Marcello Gennari
Summary: Immobilizing well-defined homogenous (electro)catalysts onto conductive supports is an attractive strategy for designing advanced functional materials for energy conversion. This study introduces a pyrene anchoring group on a PNP-pincer Ir-I complex and compares its CO2 reduction activity with two pyrene-free reference complexes in DMF/water mixtures. Surprisingly, all three catalysts produce HCOO- instead of CO as the main product in homogeneous conditions. After immobilization on carbon nanotubes (CNTs), the complex is still capable of driving CO2 reduction and producing HCOO- with lower overpotential in aqueous media.
Article
Oncology
David A. Drew, Allen Mo, James J. Grady, Richard G. Stevens, Joel B. Levine, Bruce M. Brenner, Joseph C. Anderson, Faripour Forouhar, Michael J. O'Brien, Thomas J. Devers, Daniel W. Rosenberg
MOLECULAR CANCER RESEARCH
(2018)
Article
Oncology
Allen Mo, Rong Wu, James P. Grady, Matthew P. Hanley, Margaret Toro, Helen Swede, Thomas J. Devers, Terryl J. Hartman, Daniel W. Rosenberg
CANCER CAUSES & CONTROL
(2018)
Article
Oncology
William S. Chen, Ranjit S. Bindra, Allen Mo, Thomas Hayman, Zain Husain, Joseph N. Contessa, Stephen G. Gaffney, Jeffrey P. Townsend, James B. Yu
FRONTIERS IN ONCOLOGY
(2018)
Article
Chemistry, Inorganic & Nuclear
Linh Le, Jiachen Liu, Tianyi He, Daniel Kim, Eric J. Lindley, Tia N. Cervarich, Jack C. Malek, John Pham, Matthew R. Buck, Anthony R. Chianese
Article
Chemistry, Inorganic & Nuclear
Linh Le, Jiachen Liu, Tianyi He, Jack C. Malek, Tia N. Cervarich, John C. Buttner, John Pham, Jason M. Keith, Anthony R. Chianese
Article
Chemistry, Multidisciplinary
Tianyi He, John C. Buttner, Eamon F. Reynolds, John Pham, Jack C. Malek, Jason M. Keith, Anthony R. Chianese
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Otorhinolaryngology
Arielle G. Thal, Bradley A. Schiff, Yasmina Ahmed, Angela Cao, Allen Mo, Vikas Mehta, Richard V. Smith, Hillel W. Cohen, Thomas J. Ow
Summary: Performing tracheotomy in patients with COVID-19 carries a risk of transmission to the surgical team, but the study found that with the use of standard personal protective equipment, the risk of transmission to surgical providers was minimal. Timing of tracheotomy following onset of symptoms may require further study to determine its impact on transmission risk.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Oncology
Allen Mo, Julie Chung, Jeremy Eichler, Sarah Yukelis, Sheldon Feldman, Jana Fox, Madhur Garg, Shalom Kalnicki, Nitin Ohri, Joseph A. Sparano, Jonathan Klein
Summary: The study revealed a significant disruption in breast cancer survivorship follow-up during the COVID-19 pandemic, with younger patients, those receiving adjuvant radiation therapy, and those with lower household income more likely to continue follow-up during the pandemic.
Article
Chemistry, Inorganic & Nuclear
Fallyn L. Kirlin, Olivia J. Borden, Marianna C. Head, Sophie E. Kelly, Anthony R. Chianese
Summary: In recent years, the metal-catalyzed hydrogenolysis of epoxides to produce alcohols has made rapid progress, with some catalysts selectively giving linear or branched products. We report the highly active nature of PNN- and PNP-ruthenium pincer complexes containing N-H functional groups for the branched-selective hydrogenolysis of epoxides. The use of isopropyl alcohol as a solvent allows for excellent yields of branched alcohol products without the need for strongly basic additives, with catalyst loadings as low as 0.03%. The selectivity for branched products is very high for epoxides containing a directly attached secondary carbon, and the branched:linear ratios for aryl-substituted epoxides vary from 2.7 to 19.0. PNP-Ru catalysts exhibit a greater preference for branched products than PNN-Ru catalysts for aryl epoxides, and substrates with electron-rich aryl substituents show a lower preference for branched products.
Article
Oncology
Allen Mo, Christian Velten, Julie M. Jiang, Justin Tang, Nitin Ohri, Shalom Kalnicki, Parsa Mirhaji, Kei Nemoto, Boudewijn Aasman, Madhur Garg, Chandan Guha, N. Patrik Brodin, Rafi Kabarriti
Summary: This study aimed to develop a machine learning model for treatment recommendation in HCC patients previously treated with TACE. The results showed that additional treatment in line with the model recommendations significantly improved progression-free survival.
JCO CLINICAL CANCER INFORMATICS
(2022)
Article
Chemistry, Inorganic & Nuclear
Marianna C. Head, Benjamin T. Joseph, Jason M. Keith, Anthony R. Chianese
Summary: The homogeneous catalysis of epoxide hydrogenolysis to give alcohols has been extensively studied. Catalyst systems have been developed for the selective formation of either branched or linear alcohol products. The proposed mechanisms of epoxide ring-opening involve cooperative C-O bond hydrogenolysis, but a new study suggests that the previously proposed bifunctional pathway is energetically inaccessible for ruthenium catalysts.
Article
Oncology
Julie M. Jiang, Jeremy Eichler, William Bodner, Jana Fox, Madhur Garg, Ra fi Kabarriti, Allen Mo, Shalom Kalnicki, Keyur Mehta, Amanda Rivera, Justin Tang, Johnny Yap, Nitin Ohri, Jonathan Klein
Summary: The purpose of this study was to explore the association between financial toxicity (FT) and cancer patients undergoing concurrent, definitive chemoradiation therapy (CRT). Prospective data from three trials were reviewed, and the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire Core-30 was used to assess FT during CRT. The results showed that most patients reported FT before starting definitive treatment, suggesting that it should be assessed and addressed early in the cancer journey.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Bryn K. Werley, Xintong Hou, Evan P. Bertonazzi, Anthony Chianese, Timothy W. Funk
Summary: This study investigated the effect of cyclopentadienone electronics on the catalytic activity of (tetraarylcyclopentadienone)iron tricarbonyl compounds in transfer hydrogenations and dehydrogenations. The results showed that increasing the cyclopentadienone electron density enhanced the rates of both reactions. The study also proposed a trimethylamine-ligated compound as the primary catalyst resting state in dehydrogenations.
Article
Chemistry, Multidisciplinary
John Pham, Cole E. Jarczyk, Eamon F. Reynolds, Sophie. E. Kelly, Thao Kim, Tianyi He, Jason M. Keith, Anthony R. Chianese
Summary: The study demonstrates that the ruthenium catalyst for ester hydrogenation is activated through dehydroalkylation of the pincer ligand, supporting a proposed catalytic mechanism involving the NHEt-substituted derivative. Experimental results show a first-order dependence on ruthenium and hydrogen concentrations, saturation behavior in ester concentration, and inhibition by the product alcohol. The findings are in good agreement with DFT calculations and crystallographically characterized catalytic intermediates.
Article
Oncology
Bo-young Hong, Takayasu Ideta, Bruno S. Lemos, Yuichi Igarashi, Yuliana Tan, Michael DiSiena, Allen Mo, John W. Birk, Faripour Forouhar, Thomas J. Devers, George M. Weinstock, Daniel W. Rosenberg
NPJ PRECISION ONCOLOGY
(2019)
