A nonsymmetric pincer-type palladium catalyst in Suzuki, Sonogashira, and Hiyama couplings in neat water

A new PCN palladium pincer complex containing a phosphinoamino group has been synthesized, fully characterized, and applied to Hiyama, copper-free Sonogashira, and Suzuki cross-coupling reactions performed in water. The use of the latter catalyst provides competitive yields, catalyst loadings, and reaction media.