Review
Biochemistry & Molecular Biology
Priti Gupta, Shilpa Sharma, Shagufta Jabin, Sapana Jadoun
Summary: Regenerative medicine and tissue engineering have great potential in addressing the limitations of traditional medical approaches. Chitosan, as a naturally derived biocompatible biomaterial, has played a significant role in tissue regeneration. It has unique properties and can be applied in various fields, such as agriculture, nutraceuticals, biomedicine, and food. Chitosan is also an important material for developing next-generation hydrogels and bio-scaffolds. Furthermore, chitosan can be easily modified to enhance its mechanical strength, biodegradability, and controlled release of bioactive molecules. Blending chitosan with other polymers or incorporating nanoparticles expands its possibilities in tissue engineering applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Chemistry, Multidisciplinary
Koichiro Hayashi, Toshiki Yanagisawa, Ryo Kishida, Kunio Ishikawa
Summary: This study investigates the effects of scaffold shape on tissue generation. The results show that even tiny protuberances on the scaffold surface can affect the percentage of interscaffold space, thereby exerting dominant effects on osteogenesis.
Article
Chemistry, Physical
Ramon Rial, Natalia Hassan, Zhen Liu, Juan M. Ruso
Summary: The study successfully produced hydrogel microparticles with different morphologies and compositions by combining experimental and computational methods, incorporating drug-doped Hydroxyapatite in their inner matrix. The use of a microfluidic system to obtain crosslinked HMPs with homogeneous sizes and morphologies, as well as the adsorption kinetics and desorption profiles of the chosen drug models, were key aspects of the research. The development of these hydrogel microparticles with improved functionalities is crucial for innovative and sustainable solutions in regenerative medicine.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Engineering, Biomedical
Qi Feng, Dingguo Li, Qingtao Li, Xiaodong Cao, Hua Dong
Summary: This mini-review summarizes the fabrication strategies, unique characteristics, and applications of microgel assembly in tissue engineering and regenerative medicine, with a focus on 3D printing. The challenges for further applications of microgel assembly are also discussed.
BIOACTIVE MATERIALS
(2022)
Review
Engineering, Biomedical
Michelle Koerselman, Lisanne C. M. Morshuis, Marcel Karperien
Summary: This article discusses the application of small molecules such as peptides, aptamers, and variable antigen-binding domain of heavy chain only antibodies in tissue engineering and regenerative medicine. It compares these biological functionalities with conventional antibodies and provides an overview of recent work in this area. The article focuses on the structural differences, modifications, and conjugation strategies of these biologicals, as well as the clinical trials involving them. The challenges associated with each of these biologicals are also highlighted.
ACTA BIOMATERIALIA
(2023)
Review
Engineering, Biomedical
Daniel Salthouse, Katarina Novakovic, Catharien M. U. Hilkens, Ana Marina Ferreira
Summary: This review highlights the importance of the immune response to biomaterials and discusses challenges and opportunities in the development and standardized assessment of the immune response to biomaterials, including the importance of endotoxin levels. It also explores the properties of biomaterials that impact the host immune response and the use of immunomodulatory biomaterials in regenerative medicine. Finally, a standardized in vitro pathway for evaluating the immune response to biomaterials (hydrogels) and their regenerative potential is proposed to ensure safety, consistency, and reduce costs and animal use.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Nikita Voloshin, Pyotr Tyurin-Kuzmin, Maxim Karagyaur, Zhanna Akopyan, Konstantin Kulebyakin
Summary: Immortalized cells are increasingly used in practical medicine due to their advantages, such as the ability to produce larger amounts of cells and use them for longer periods of time. However, they also have drawbacks, like the possibility of malignant transformation or major phenotype change. This review discusses ways to overcome these barriers and highlights specific fields of application where these concerns are minimal.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sunena Dhania, Manju Bernela, Ruma Rani, Minakshi Parsad, Sapna Grewal, Santosh Kumari, Rajesh Thakur
Summary: Tissue engineering technology utilizes biopolymer materials like polyhydroxyalkanoates to mimic and replace damaged tissues, with excellent biocompatibility and biodegradability. This technology has vast potential applications in areas such as bone grafts, cardiovascular repair, and nerve regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Susana Correia, Cristiana Goncalves, Joaquim M. Oliveira, Hajer Radhouani, Rui L. Reis
Summary: Kefiran, an exopolysaccharide produced by the microflora of kefir grains, has shown potential for tissue engineering and regenerative medicine applications. High-quality kefiran polysaccharides can be extracted and used to create scaffolds with desirable properties for biomedical use.
Review
Cell & Tissue Engineering
Umber Cheema
Summary: Tissue engineering is a multidisciplinary approach to building 3D human tissues in the laboratory. Despite three decades of advancements in medical sciences, there is limited use of tissue-engineered organs in humans. This position paper outlines the challenges and advancements in engineering specific tissues and organs, as well as the most successful technologies in tissue engineering.
JOURNAL OF TISSUE ENGINEERING
(2023)
Review
Biotechnology & Applied Microbiology
Fatemeh Dadkhah Tehrani, Arezoo Firouzeh, Iman Shabani, Azadeh Shabani
Summary: The amniotic membrane, as the innermost layer of the fetal placenta, has unique properties that make it valuable in regenerative medicine applications. Beyond sterilization and preservation, additional modifications are being explored to enhance its properties and durability, presenting a new area of study in its applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Lin Bao, Xuejing Cui, Monika Mortimer, Xiaoyu Wang, Junguang Wu, Chunying Chen
Summary: The severe imbalance between supply and demand in organ resection or severe tissue damage poses life-threatening risks. Carbon nanotubes (CNTs) have emerged as promising platforms due to their unique properties. CNTs are commonly used as additives in tissue engineering scaffolds to modify structure, porosity, mechanical strength, and more. This review summarizes the applications and design strategies of CNTs in various tissue engineering fields and discusses their potential biosafety risks and solutions. Future developments of CNTs in tissue engineering are also speculated.
Review
Polymer Science
Prasanna Phutane, Darshan Telange, Surendra Agrawal, Mahendra Gunde, Kunal Kotkar, Anil Pethe
Summary: The limited ability of human tissues to regenerate has led to the exploration of alternatives, such as tissue engineering and regenerative medicine (TERM). Nanofibers, with their ability to mimic the extracellular matrix (ECM) and customizable structure, have emerged as a promising candidate for tissue engineering. This review discusses the use of natural and synthetic polymers in constructing nanofibers, as well as their application in various tissues.
Review
Cell & Tissue Engineering
Hoda Elkhenany, Azza El-Derby, Mohamed Abd Elkodous, Radwa A. Salah, Ahmed Lotfy, Nagwa El-Badri
Summary: The amniotic membrane (Amnio-M) has multiple applications in regenerative medicine, serving as a biocompatible scaffold, a source of stem cells and growth factors, and a nanoreservoir for drug delivery. Its use has evolved from simple sheet applications to more advanced forms, and nanotechnology is playing a role in expanding its applications in tissue engineering and clinical settings.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Engineering, Biomedical
Yiting Lou, Huiming Wang, Guanchen Ye, Yongzheng Li, Chao Liu, Mengfei Yu, Binbin Ying
Summary: This review discusses the important role of periosteum in bone defect repair and regeneration, as well as the need for developing tissue-engineered periosteum (TEP). The construction strategies for TEP are explored from the perspectives of materials, mechanical properties, cell-based strategies, and combination with growth factors. Current challenges and future perspectives for TEP development are also discussed.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Xi Zhuo Jiang, Liwei Guo, Kai H. Luo, Yiannis Ventikos
ANNALS OF BIOMEDICAL ENGINEERING
(2020)
Article
Physiology
Xi Zhuo Jiang, Kai H. Luo, Yiannis Ventikos
Article
Engineering, Multidisciplinary
Liwei Guo, John C. Vardakis, Dean Chou, Yiannis Ventikos
INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE
(2020)
Article
Computer Science, Interdisciplinary Applications
Nikolaos Bempedelis, Yiannis Ventikos
JOURNAL OF COMPUTATIONAL PHYSICS
(2020)
Article
Engineering, Biomedical
Bin Zhang, Liwei Guo, Hongyi Chen, Yiannis Ventikos, Roger J. Narayan, Jie Huang
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2020)
Article
Mechanics
N. Bempedelis, Y. Ventikos
JOURNAL OF FLUID MECHANICS
(2020)
Article
Engineering, Biomedical
John C. Vardakis, Dean Chou, Liwei Guo, Yiannis Ventikos
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
(2020)
Article
Computer Science, Interdisciplinary Applications
Nikolaos Bempedelis, Yiannis Ventikos
Summary: A novel method for implementing surface tension effects in sharp-interface compressible flow models is proposed in this study, with the aim of addressing problems where liquid compressibility and capillarity are both important. The method is based on the principles of the grid-aligned formulation for ghost fluid techniques, and formulates Riemann problems along the grid instead of in a normal-to-the-interface direction, making the method simpler. The performance of the method is thoroughly examined after being implemented in a well-established front tracking framework.
JOURNAL OF COMPUTATIONAL PHYSICS
(2021)
Article
Computer Science, Artificial Intelligence
Duanduan Chen, Xuyang Zhang, Yuqian Mei, Fangzhou Liao, Huanming Xu, Zhenfeng Li, Qianjiang Xiao, Wei Guo, Hongkun Zhang, Tianyi Yan, Jiang Xiong, Yiannis Ventikos
Summary: This study introduced a new segmentation framework for reconstructing aortic dissection from CT-angiography, extracting true lumen, false lumen, and all branches using two cascaded neural networks and a straightening method. The method achieved high accuracy in segmenting the aorta and identified key features compared to previous deep learning methods.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Mechanics
T. A. Smith, Y. Ventikos
Summary: This study investigates the flow over a flat-tipped wing at different Reynolds numbers and shows significant changes in the number of trailing vortices and tip geometry across the Reynolds number range. The vortex dynamics change with Reynolds number, impacting the minimum vortex core pressure and its location. The influence of tip flow on the boundary layer and its effect on the character of trailing edge noise are also considered.
Article
Physics, Fluids & Plasmas
N. Bempedelis, J. Zhou, M. Andersson, Y. Ventikos
Summary: The aim of the study is to investigate the interaction between an oscillating bubble and a free surface, focusing on the mechanisms of bubble-induced atomization. The patterns and dynamics of liquid jets formed at the free surface are characterized, and observations on the evolution of the free surface are presented by measuring the jet's surface area and volume. A metric is introduced based on these quantities to predict late-time atomization of the interface.
PHYSICAL REVIEW FLUIDS
(2021)
Article
Cell Biology
Connor Cross, Roman H. Khonsari, Leila Galiay, Giovanna Patermoster, David Johnson, Yiannis Ventikos, Mehran Moazen
Summary: This study conducted sensitivity tests to understand the impact of various input parameters on predicting post-operative skull morphology in sagittal synostosis patients. Results showed that the choice of elastic modulus for craniotomies had the greatest influence on skull morphology, while bone formation modeling method across sutures/craniotomies had a considerable impact on brain pressure. The study lays the foundation for future comparative studies using FE method to compare outcomes of different reconstruction techniques for craniosynostosis management.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Xi Zhuo Jiang, Kai H. Luo, Yiannis Ventikos
Summary: Endothelial glycocalyx (EG) is a crucial structure on blood vessel walls, impacting health and diseases. Numerical modelling and computer simulation are valuable tools for understanding EG as a mechanotransducer, offering new perspectives for research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Acoustics
Tom A. Smith, Yiannis Ventikos
Summary: In this study, a versatile and general three-dimensional hybrid aeroacoustic model is proposed for low Mach number turbulent flows. The model adopts a dual-domain approach and solves the fluid and acoustic fields simultaneously. Incompressible large eddy simulations are used to compute the flow field and acoustic source terms, which are then interpolated onto the acoustic domain using radial basis functions. The acoustic perturbation equations are solved using a finite-volume Riemann-based solver. The model is validated with various cases and shows excellent agreement with experimental sources, demonstrating its robustness and accuracy. The trailing edge studies also provide insights into the origin of secondary tones in the acoustic spectra.
JOURNAL OF SOUND AND VIBRATION
(2022)
Editorial Material
Biochemical Research Methods
Himanshu Kaul
