Article
Chemistry, Inorganic & Nuclear
Raphael Bigler, Daniel Spiess, Joel Wellauer, Martin Binder, Victor Carre, Serena Fantasia
Summary: This study presents an efficient synthesis method for biaryl phosphine palladium(0) complexes with dvtms ligands, which exhibit good catalytic activity in Buchwald-Hartwig couplings for (hetero)aryl bromides and chlorides.
Article
Chemistry, Organic
Jia-Sheng Ouyang, Xinhuan Zhang, Bendu Pan, Haobin Zou, Albert S. C. Chan, Liqin Qiu
Summary: A highly efficient and easy-to-operate solvent-free Buchwald-Hartwig amination method was developed using a robust N-heterocyclic carbene-palladium complex, with catalyst amount as low as 0.05 wt %. The method was successfully applied to the synthesis of commercial pharmaceuticals and candidate drugs with high yields.
Article
Chemistry, Organic
Stephane Sengmany, Farah Daili, Ibtihal Kribii, Eric Leonel
Summary: Arylamines are a type of compounds commonly found in natural products and pharmaceuticals. Nickel-catalyzed amination of aryl halides is often used for their synthesis, but it requires complex and expensive nickel complexes. To address this issue, an electrochemical method based on sacrificial anode process is developed to generate a catalytic amount of nickel salts, enabling the amination of aryl halides under mild reaction conditions and providing access to a wide range of arylamines.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Haowen Ma, Jiajie Feng, Wei Zhou, Chen Chen, Zhuoji Deng, Fengtao Zhou, Yifan Ouyang, Xinhao Zhang, Qian Cai
Summary: Utilizing ureas as co-catalysts, a cooperative catalytic strategy has been developed for copper-catalyzed asymmetric intramolecular C-arylation reaction. By forming hydrogen bonds with 1,3-dicarbonyl structures, ureas activate the substrates, stabilize the intermediates and products, and improve reactivity and enantioselectivities.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Francesca Bartoccini, Alessio Regni, Michele Retini, Giovanni Piersanti
Summary: The practical and asymmetric synthesis of (R)-4-amino-5-oxo-1,3,4,5-tetrahydrobenz[cd]indole, a key enantiopure framework in ergot alkaloids, was achieved using a Rh(i)-catalyzed cyclization and a Cu(i)-ABNO-catalyzed oxidation. This new method offers significant advantages over previous approaches, including brevity, mild reaction conditions, chiral integrity preservation, high yield, and avoidance of stoichiometric amounts of strong basic and pyrophoric reagents.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Si-Chang Wang, Qi-Long Han, Meng Xing, Ming Yuan, Rui Sun, Wujuan Sun, Xun-li Zhang, Qun-Zheng Zhang, Cong-Yu Ke
Summary: A practical method for Pd-catalyzed intramolecular aryl-aryl coupling reaction through hydrodehalogenation is reported, providing new mechanism for intramolecular coupling and hydrodehalogenation of aryl halides.
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
William Clegg
Summary: This article discusses the research on benzene ring structure in organic chemistry, highlighting deviations from planarity that may arise from various factors. It reviews stories of structural distortions in a wide range of chemical topics, while also addressing issues such as poor experiments, data misinterpretation, and scientific bias. The article aims to both showcase interesting research results and serve an educational purpose.
Article
Chemistry, Organic
Matokah M. Abualnaja, Joseph Cowell, John D. Jolliffe, Corinne Wills, Paul G. Waddell, William Clegg, Michael J. Hall
Summary: This study introduces a method for preparing 4-substituted 2,3,4,9-tetrahydro-1H-carbazoles using a rearomative diastereoselective etherification/amination reaction, which can be accessed via the Diels-Alder reaction. Through a one-pot reaction sequence, the diastereoselectivity of the reaction can be controlled.
Article
Chemistry, Inorganic & Nuclear
Jonathan Bould, Michael G. S. Londesborough, Miroslava Litecka, Ramon Macias, Suzanne L. Shea, Thomas D. McGrath, William Clegg, John D. Kennedy
Summary: High yields of novel macropolyhedral selenaboranes have been synthesized and characterized. These selenaboranes exhibit unique structural features, including different numbers of vertices, connectivity between subclusters, and the presence of special structural motifs within the subclusters.
INORGANIC CHEMISTRY
(2022)
Article
Spectroscopy
Zyad H. J. Al-Qaisi, Zahraa S. Al-Garawi, Ahmed Jasim M. Al-Karawi, Ali JAsim Hammood, Abanoub Mosaad Abdullah, William Clegg, Gehad G. Mohamed
Summary: Two new water-soluble thiadiazole compounds were synthesized via Mannich reaction and showed potential as inhibitors for urease enzyme. The compounds were characterized and analyzed using various techniques, and molecular docking studies were conducted to investigate their interactions with the urease enzyme.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Correction
Spectroscopy
Zyad H. J. Al-Qaisi, Zahraa S. Al-Garawi, Ahmed Jasim M. Al-Karawi, Ali Jasim Hammood, Abanoub Mosaad Abdallah, William Clegg, Gehad G. Mohamed
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
Bernard T. Golding, Manuel Abelairas-Edesa, Rowena D. Tilbury, Joanne P. Wilson, Daping Zhang, Alistair P. Henderson, Christine Bleasdale, William Clegg, William P. Watson
Summary: In this study, the reactions of the epoxides of 1,3-butadiene and isoprene with oxygen, nitrogen, and sulfur nucleophiles were compared to better understand their relative human toxicities. The results showed that the epoxides of isoprene exhibited different reactivities compared to those of butadiene in hydrolysis and addition reactions. This is important for understanding their toxicological properties.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Multidisciplinary Sciences
Bernhard Kepplinger, Lina Mardiana, Joseph Cowell, Stephanie Morton-Laing, Yousef Dashti, Corinne Wills, Emma C. L. Marrs, John D. Perry, Joe Gray, Michael Goodfellow, Jeff Errington, Michael R. Probert, William Clegg, Jonathan Bogaerts, Wouter Herrebout, Nick E. E. Allenby, Michael J. Hall
Summary: The extremophile Amycolatopsis sp. DEM30355's metabolome was analyzed using genomic and bioactivity information, leading to the discovery and isolation of polyketide antibiotic tatiomicin. The identification of the biosynthetic gene cluster was confirmed, and the structural elucidation, including absolute stereochemical assignment, was performed. Tatiomicin shows antibiotic activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and its mode of action is suggested to involve membrane depolarization and chromosomal decondensation.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Inorganic & Nuclear
Shay P. P. Docherty, Sumanta Banerjee, William Clegg, Fiona J. J. Palin, Alan R. R. Kennedy, Stuart D. D. Robertson, Robert E. E. Mulvey
Summary: Co-complexation of equimolar amounts of 1-alkali-metal-2tertbutyldihydropyridines with AlMe3 in the presence of a polydentate N-donor ligand has resulted in the synthesis of four crystallographically verified alkali-metal aluminates. The monomeric complexes (1, 2) and the polymeric complex (4) are thermally stable, while the dimeric complex (3) undergoes a disproportionation process. TMEDA and PMDETA ligands yield different solid-state aggregated forms of aluminate.
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
(2023)
Article
Chemistry, Inorganic & Nuclear
Jonathan Bould, Oleg Tok, William Clegg, Michael G. S. Londesborough, Miroslava Litecka, Marcel Ehn
Summary: The diselenaundecaborate anion, [Se2B9H10]- (1), is obtained in 49% yield from a one-pot reaction involving nido-B10H14, Proton Sponge, and selenium. In solution, compound 1 undergoes a fluxional interchange between symmetry-equivalent positions of its two selenium atoms and open-face 'bridging' hydrogen atom, which is resolved through solid-state boron-11 NMR spectroscopy. Treatment of two equivalents of 1 with HgCl2 leads to the formation of the conjoined binary cluster anion [(Se2B9H10)(SeB9H11)]- (2). This metal-mediated linking of selenaborane clusters has the potential to generate new macropolyhedral heteroborane assemblies.
INORGANICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Marcel Ehn, Dmytro Bavol, Jonathan Bould, Vojtech Strnad, Miroslava Litecka, Kamil Lang, Kaplan Kirakci, William Clegg, Paul G. Waddell, Michael G. S. Londesborough
Summary: The reaction of AlCl3 with room-temperature tetrachloromethane solutions of anti-B18H22 resulted in the formation of fluorescent isomers, 3,3'-Cl-2-B18H20 and 3,4'-Cl-2-B18H20, with 76% yield. These isomers exhibited stable blue light emission under UV excitation. Other dichlorinated and monochlorinated derivatives, as well as trichlorinated species, were also isolated. The molecular structures and photophysical properties of these chlorinated derivatives were investigated, providing valuable insight into the effect of chlorine substitution on the luminescence of anti-B18H22.
Article
Chemistry, Physical
Mark R. J. Elsegood, William Clegg, Carl Redshaw
Summary: The interaction between [VO(OiPr)(3)] and 6-bis(o-hydroxyaryl)pyridine, 2,6-{HOC(Ph)(2)CH2}(2)(NC5H3), LH2, resulted in the formation of [VO(OiPr)L] (1) with high yield. The reaction between LNa2, generated in-situ from LH2 and NaH, and [VCl3(THF)(3)] led to the isolation of [VL2] (2) with cis-pyridyl nitrogen atoms. In the case of [VCl2(TMEDA)(2)], a regioisomer 3.2THF with trans-pyridyl nitrogen atoms was obtained.
Biographical-Item
Crystallography
William Clegg
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2023)
Meeting Abstract
Chemistry, Multidisciplinary
William Clegg
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES
(2022)
Meeting Abstract
Chemistry, Multidisciplinary
William Clegg
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES
(2022)
Meeting Abstract
Chemistry, Multidisciplinary
William Clegg
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES
(2021)
