☆ 4.6 Article

The Development of a Scalable, Chemoselective Nitro Reduction

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2012)

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ORGANIC PROCESS RESEARCH & DEVELOPMENT

卷 16, 期 10, 页码 1665-1668

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AMER CHEMICAL SOC

DOI: 10.1021/op3002239

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Chemistry, Applied Chemistry, Organic

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We have demonstrated a scalable chemoselective reduction of a nitro functional group in the presence of an aryl imine using (NH4)(2)S/EtOH or hydrogenation (Sponge Nickel) to afford the corresponding amino-imines in moderate to excellent yields. Other reducible groups such as aryl halides, styryl olefins, and ether linkages Survived as well

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