期刊
TISSUE ENGINEERING PART A
卷 21, 期 1-2, 页码 62-74出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ten.tea.2014.0139
关键词
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资金
- National High Technology Research and Development Program (863 Program) of China [2013AA020106]
- National Natural Science Foundation of China [81301061, 81200916]
Brain-derived neurotrophic factor (BDNF) exerts therapeutic effects following intracerebral hemorrhage (ICH). However, it is difficult to maintain sufficient concentrations in the hemorrhage hemisphere. We demonstrated previously that BDNF fused to a collagen-binding domain (CBD) could bind to collagen in the ventricular ependyma and stimulate cell proliferation in the subventricular zone (SVZ). In this study, we verified the therapeutic effects of CBD-BDNF in the rat ICH model induced by bacterial collagenase by injecting CBD-BDNF into the lateral ventricle of ICH rats. The results demonstrated that CBD-BDNF was retained at high levels in the hemorrhage hemisphere, where it promoted neural regeneration and angiogenesis, reduced tissue loss, and improved functional recovery.
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