期刊
ORGANIC LETTERS
卷 16, 期 17, 页码 4658-4661出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol5022417
关键词
-
资金
- NSF [CHE-136273]
- NIH [GM-47480]
Proto-boryl additions to 1,1-disubstituted allenes in the presence of 1.0-5.0 mol % of chiral NHC-Cu complexes, B-2(pin)(2), and t-BuOH proceed to afford allcenyl-B(pin) products in up to 98% yield, >98:2 site selectivity, and 98:2 er. The enantiomerically enriched alkenylboron products can be converted to otherwise difficult-to-access alkenyl bromides, methyl ketones or carboxylic acids. What's more, the corresponding boronic acids may be used in highly stereoselective NHC-Cu-catalyzed allylic substitution reactions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据