期刊
ORGANIC LETTERS
卷 16, 期 15, 页码 4028-4031出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol501856v
关键词
-
资金
- National Natural Science Foundation of China [81172958]
- State Key Laboratory of Phytochemistry and Plant Resources in West China [P2012-KF01]
Peganumine A (1), a new dimeric beta-carboline alkaloid characterized by a unique 3,9-diazatetracyclo-[6.5.2.0(1,9).0(3,8)]pentadec-2-one scaffold, was isolated from the seeds of Peganum harmala. The structure including the absolute configuration was determined by spectroscopic data, X-ray crystallography, ECD calculation, and CD exciton chirality approaches. Compound 1 showed moderate cytotoxic activity against MCF-7, PC-3, and HepG2 cells and selective effects on HL-60 cells with an IC50 value of 5.8 mu M.
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