4.8 Article

Asymmetric Chlorocyclization of Indole-3-yl-benzamides for the Construction of Fused Indolines

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ORGANIC LETTERS
卷 16, 期 9, 页码 2426-2429

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AMER CHEMICAL SOC
DOI: 10.1021/ol5007532

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资金

  1. National Basic Research Program of China (973 Program) [2010CB833300]
  2. National Natural Science Foundation of China [21025209, 21121062, 21272253, 21332009]

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(DHQD)(2)PHAL catalyzed enantioselective chlorocyclization of indole-3-yl-benzamides was realized. Fused indolines containing a continuous quaternary carbon center and tertiary carbon center were obtained in good yields with excellent enantioselectivity (up to 98% yield and >99% ee).

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