期刊
ORGANIC LETTERS
卷 16, 期 4, 页码 1264-1267出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol500310u
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资金
- University of New Mexico (UNM)
- NSF [CHE08-40523, CHE09-46690]
- NSF CRIF:MU [CHE04-43580]
An efficient Cu-I-catalyzed Suzuki-Miyaura reaction was developed for the coupling of aryl- and heteroarylboronate esters with aryl and heteroaryl iodides at low catalyst loadings (2 mol %). The reaction proceeds under ligand-free conditions for aryl heteroaryl and heteroaryl heteroaryl couplings. We also conducted the first detailed mechanistic studies by synthesizing [(PN-2)CuI](2), [(PN-2)CuF](2), and (PN-2)CuPh (PN-2 = o-(di-tert-butylphosphino)-N,N-dimethylaniline) and demonstrated that [(PN-2)CuF](2) is the species that undergoes transmetalation with arylboronate esters.
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