4.8 Article

Palladium-Catalyzed Phthalazinone Synthesis Using Paraformaldehyde as Carbon Source

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ORGANIC LETTERS
卷 16, 期 20, 页码 5324-5327

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AMER CHEMICAL SOC
DOI: 10.1021/ol502498y

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资金

  1. National Natural Science Foundation of China [21172185, 21372187]
  2. New Century Excellent Talents in University from Ministry of Education of China [NCET-11-0974]
  3. Scientific Research Foundation for Returned Scholars, Ministry of Education of China [2011-1568]

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A palladium-catalyzed one-pot synthesis of phthalazinones from 2-halomethyl benzoates, paraformaldehyde, and aryl hydrazines is described. Various substituted phthalazinones were selectively obtained in good yields using paraformaldehyde as the cheap carbon source (CH).

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