期刊
ORGANIC LETTERS
卷 16, 期 18, 页码 4944-4947出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol5024689
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资金
- NIGMS [R01 GM-081376]
An effective protocol toward the O-arylation of beta-hydroxy-alpha-amino acid substrates serine and threonine has been developed via Chan-Lam cross-coupling. This Cu(II)-catalyzed transformation involves benign open-flask conditions that are well-tolerated with a variety of protected (Boc., Cbz-, Tr-, and Fmoc-) serine and threonine derivatives and various potassium organotrifluoroborates and boronic acids.
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